Closed-Loop Cardiovascular Teaching Simulator

CVS2 is an open-source closed-loop cardiovascular and pulmonary simulator written in MATLAB App Designer. It integrates a real-time hemodynamic engine (28 ODEs covering four cardiac chambers, valves, systemic and pulmonary Windkessel networks, pericardium, intrathoracic pressure, central sympathetic and parasympathetic autonomic integration, three afferent reflex arcs and twelve ICU drugs with receptor-level pharmacology) with bedside-monitor displays, PV-loop and Guyton analysis, a live HTML5 four-view echocardiography viewer and a literature-anchored scenario library (currently 39 calibrated presets). The tool is developed for ICU teaching and curriculum development. It is explicitly not a medical device.