The PROPHECY Study - Urinary prostaglandin as a potential predictive marker for thiazide-induced hyponatremia: a prospective cohort study

Thiazides and thiazide-like diuretics are one of the five major classes of antihypertensive drugs. This study is to investigate whether urinary PGE2 concentration at baseline (prior to thiazide initiation) is associated with the development of TIH within the first four weeks of treatment.