COMBINE ASPECTS: Comprehensive Observation and Modeling of Baseline Imaging and Neurological Evaluation for Advancing Stroke outcome Prediction and Evaluation using CT TechniqueS

Considering the trend toward simpler imaging approaches for patient selection for endovascular treatment in acute ischemic stroke, COMBINE ASPECTS seeks to improve our current understanding of ASPECTS-based stroke acute imaging to further optimize treatment selection strategies and make meaningful contributions to stroke care.

Within five subprojects, we aim to systematically assess and refine the diagnostic and prognostic capabilities of ASPECTS. The subprojects will explore a spectrum of critical areas:

1. the accuracy of native CT in estimating ischemic core
2. the impact of discordant baseline imaging findings on treatment decisions
3. the utility of ASPECTS in evaluating ischemic core reversibility
4. the potential of hypodensity mapping to predict functional outcomes, and
5. the reliability of ASPECTS assessment amidst moderate to severe small vessel disease