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Pascal Gächter

Department of Clinical Research
Profiles & Affiliations

My research interests

I am an early-career clinical researcher and resident physician with a broad interest in clinical research, particularly in pediatric endocrinology and diabetology. I am thrilled to be part of the Pediatric Endocrinology and Diabetology research group, led by Professor Szinnai.

For more information on our research group visit:

https://universe.unibas.ch/org-units/94/research-groups/10369/overview

Selected Publications

Steffens, Britta, Koch, Gilbert, Gächter, Pascal, Claude, Fabien, Gotta, Verena, Bachmann, Freya, Schropp, Johannes, Janner, Marco, l’Allemand, Dagmar, Konrad, Daniel, Welzel, Tatjana, Szinnai, Gabor, & Pfister, Marc. (2023). Clinically practical pharmacometrics computer model to evaluate and personalize pharmacotherapy in pediatric rare diseases: application to Graves’ disease. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1099470

URLs
URLs

Koch, Gilbert, Steffens, Britta, Leroux, Stephanie, Gotta, Verena, Schropp, Johannes, Gächter, Pascal, Bachmann, Freya, Welzel, Tatjana, Janner, Marco, L’Allemand, Dagmar, Konrad, Daniel, Szinnai, Gabor, & Pfister, Marc. (2021). Modeling of levothyroxine in newborns and infants with congenital hypothyroidism: challenges and opportunities of a rare disease multi-center study. Journal of Pharmacokinetics and Pharmacodynamics, 48(5), 711–723. https://doi.org/10.1007/s10928-021-09765-w

URLs
URLs

Selected Projects & Collaborations

Project cover

LeukemiaCort: A Swiss prospective multicenter longitudinal assessment of hypothalamic-pituitary-adrenal axis suppression after glucocorticoid therapy for leukemia and lymphoblastic lymphoma in children. An explorative study.

Research Project  | 4 Project Members

Glucocorticoid therapy is an important component of the treatment regimen for childhood acute lymphoblastic leukaemia and lymphoblastic lymphoma by inducing apoptosis of lymphoblastic cells. However, the use of supraphysiological doses of glucocorticoids can lead to hypothalamic-pituitary-adrenal axis suppression. This suppression can result in a reduced cortisol response, leading to impaired stress response and inadequate host defence against infections, which can ultimately result in morbidity and mortality. To date, there is insufficient high-quality research to inform evidence-based guidelines for glucocorticoid replacement therapy in this populatioon.

Hence, in this prospective multicenter study, we aim to analyze the patterns of suppression of the hypothalamic-pituitary-adrenal axis suppression in children receiving glucocorticoid therapy for acute lymphoblastic leukaemia and lymphoblastic lymphoma.