Prof. Dr. Linda Simmler

Petrelli, Francesco, Zehnder, Tamara, Laugeray, Anthony, Mondoloni, Sarah, Calì, Corrado, Pucci, Luca, Molinero Perez, Alicia, Bondiolotti, Bianca Maria, De Oliveira Figueiredo, Eva, Dallerac, Glenn, Déglon, Nicole, Giros, Bruno, Magrassi, Lorenzo, Mothet, Jean-Pierre, Mameli, Manuel, Simmler, Linda D, & Bezzi, Paola. (2023). Disruption of Astrocyte-Dependent Dopamine Control in the Developing Medial Prefrontal Cortex Leads to Excessive Grooming in Mice. Biological Psychiatry, 93(11), 966–975. https://doi.org/10.1016/j.biopsych.2022.11.018

Simmler, Linda D, Li, Yue, Hadjas, Lotfi C, Hiver, Agnès, van Zessen, Ruud, & Lüscher, Christian. (2022). Dual action of ketamine confines addiction liability. Nature, 608(7922), 368–373. https://doi.org/10.1038/s41586-022-04993-7

Davis, Gwynne L, Minerva, Adelaide R, Lario, Argentina, Simmler, Linda D, Rodriguez, Carolyn I, & Gunaydin, Lisa A. (2021). Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice. Nature Communications, 12(1), 6040. https://doi.org/10.1038/s41467-021-26247-2

Li, Yue, Simmler, Linda D, Van Zessen, Ruud, Flakowski, Jérôme, Wan, Jin-Xia, Deng, Fei, Li, Yu-Long, Nautiyal, Katherine M, Pascoli, Vincent, & Lüscher, Christian. (2021). Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction. Science, 373(6560), 1252–1256. https://doi.org/10.1126/science.abi9086

Hadjas, Lotfi C, Schartner, Michael M, Cand, Jennifer, Creed, Meaghan C, Pascoli, Vincent, Lüscher, Christian, & Simmler, Linda D. (2020). Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice. Neuropsychopharmacology, 45(12), 2020–2029. https://doi.org/10.1038/s41386-020-0747-3

Hadjas, Lotfi C, Lüscher, Christian, & Simmler, Linda D. (2019). Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder. Scientific Reports, 9(1), 12061. https://doi.org/10.1038/s41598-019-48637-9

Simmler, Linda D, & Blakely, Randy D. (2019). The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action. ACS Chemical Neuroscience, 10(7), 3053–3060. https://doi.org/10.1021/acschemneuro.9b00005

Simmler, Linda D, & Ozawa, Takaaki. (2019). Neural circuits in goal-directed and habitual behavior: Implications for circuit dysfunction in obsessive-compulsive disorder. Neurochemistry International, 129, 104464. https://doi.org/10.1016/j.neuint.2019.104464

Simmler, Linda D., & Liechti, Matthias E. (2018). Pharmacology of MDMA- and Amphetamine-Like New Psychoactive Substances. Handbook of experimental pharmacology, 252, 143–164. https://doi.org/10.1007/164_2018_113

Nackenoff, Alex G, Simmler, Linda D, Baganz, Nicole L, Pehrson, Alan L, Sánchez, Connie, & Blakely, Randy D. (2017). Serotonin Transporter-Independent Actions of the Antidepressant Vortioxetine As Revealed Using the SERT Met172 Mouse. ACS Chemical Neuroscience, 8(5), 1092–1100. https://doi.org/10.1021/acschemneuro.7b00038

Simmler, Linda D, Anacker, Allison M J, Levin, Michael H, Vaswani, Nina M, Gresch, Paul J, Nackenoff, Alex G, Anastasio, Noelle C, Stutz, Sonja J, Cunningham, Kathryn A, Wang, Jing, Zhang, Bing, Henry, L Keith, Stewart, Adele, Veenstra-VanderWeele, Jeremy, & Blakely, Randy D. (2017). Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. British Journal of Pharmacology, 174(16), 2716–2738. https://doi.org/10.1111/bph.13899

Simmler, Linda D., & Liechti, Matthias E. (2017). Interactions of Cathinone NPS with Human Transporters and Receptors in Transfected Cells. Current Topics in Behavioral Neurosciences, 32, 49–72. https://doi.org/10.1007/7854_2016_20

Simmler, Linda D., Buchy, Danièle, Chaboz, Sylvie, Hoener, Marius C., & Liechti, Matthias E. (2016). In vitro characterization of psychoactive substances at rat, mouse, and human trace amine-associated receptor 1. The Journal of Pharmacology and Experimental Therapeutics, 357(1), 134–144. https://doi.org/10.1124/jpet.115.229765

Hysek, C. M., Schmid, Y., Simmler, L. D., Domes, G., Heinrichs, M., Eisenegger, C., Preller, K. H., Quednow, B. B., & Liechti, M. E. (2014). MDMA enhances emotional empathy and prosocial behavior. Social cognitive and affective neuroscience, 9(11), 1645–1652. https://doi.org/10.1093/scan/nst161

Hysek, C. M., Simmler, L. D., Schillinger, N., Meyer, N., Schmid, Y., Donzelli, M., Grouzmann, E., & Liechti, M. E. (2014). Pharmacokinetic and pharmacodynamic effects of methylphenidate and MDMA administered alone or in combination. International journal of neuropsychopharmacology, 17(3), 371–381. https://doi.org/10.1017/s1461145713001132

Schmid, Yasmin, Hysek, Cédric M., Simmler, Linda D., Crockett, Molly J., Quednow, Boris B., & Liechti, Matthias E. (2014). Differential effects of MDMA and methylphenidate on social cognition. Journal of psychopharmacology, 28(9), 847–856. https://doi.org/10.1177/0269881114542454

Simmler, L. D., Rickli, A., Hoener, M. C., & Liechti, M. E. (2014). Monoamine transporter and receptor interaction profiles of a new series of designer cathinones. Neuropharmacology, 79, 152–160. https://doi.org/10.1016/j.neuropharm.2013.11.008

Simmler, Linda D., Rickli, Anna, Schramm, York, Hoener, Marius C., & Liechti, Matthias E. (2014). Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives. Biochemical Pharmacology, 88(2), 237–244. https://doi.org/10.1016/j.bcp.2014.01.024

Vollbrecht, Peter J, Simmler, Linda D, Blakely, Randy D, & Deutch, Ariel Y. (2014). Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1. Journal of Neurochemistry, 130(1), 109–114. https://doi.org/10.1111/jnc.12697

Hysek, C. M., Fink, A. E., Simmler, L. D., Donzelli, M., Grouzmann, E., & Liechti, M. E. (2013). a-Adrenergic receptors contribute to the acute effects of MDMA in humans. Journal of Clinical Psychopharmacology, Vol. 33, H. 5, 658–666. https://doi.org/10.1097/jcp.0b013e3182979d32

Simmler, Linda D, Wandeler, Rebecca, & Liechti, Matthias E. (2013). Bupropion, methylphenidate, and 3,4-methylenedioxypyrovalerone antagonize methamphetamine-induced efflux of dopamine according to their potencies as dopamine uptake inhibitors: implications for the treatment of methamphetamine dependence. BMC Research Notes, 6, 220. https://doi.org/10.1186/1756-0500-6-220

Hysek, C. M., Brugger, R., Simmler, L. D., Bruggisser, M., Donzelli, M., Grouzmann, E., Hoener, M. C., & Liechti, M. E. (2012). Effects of the α₂-adrenergic agonist clonidine on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine in healthy volunteers. Journal of Pharmacology and Experimental Therapeutics, Vol. 340, H. 2, 286–294. https://doi.org/10.1124/jpet.111.188425

Hysek, C. M., Simmler, L. D., Nicola, V. G., Vischer, N., Donzelli, M., Krahenbuhl, S., Grouzmann, E., Huwyler, J., Hoener, M. C., & Liechti, M. E. (2012). Duloxetine inhibits effects of MDMA (“ecstasy”) in vitro and in humans in a randomized placebo-controlled laboratory study. PLoS ONE, 7(5). https://doi.org/10.1371/journal.pone.0036476

Hysek, C., Schmid, Y., Rickli, A., Simmler, L. D., Donzelli, M., Grouzmann, E., & Liechti, M. E. (2012). Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans. British Journal of Pharmacology, 166(8), 2277–2288. https://doi.org/10.1111/j.1476-5381.2012.01936.x

Simmler, L. D., Buser, T. A., Donzelli, M., Schramm, Y., Dieu, L. H., Huwyler, J., Chaboz, S., Hoener, M. C., & Liechti, M. E. (2012). Pharmacological characterization of designer cathinones in vitro. British Journal of Pharmacology, 168(2), 458–470. https://doi.org/10.1111/j.1476-5381.2012.02145.x

Hysek, C. M., Simmler, L. D., Ineichen, M., Grouzmann, E., Hoener, M. C., Brenneisen, R., Huwyler, J., & Liechti, M. E. (2011). The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA (“Ecstasy”) in Humans. Clinical Pharmacology and Therapeutics, 90(2), 246–255. https://doi.org/10.1038/clpt.2011.78

Simmler, L. D., Hysek, C. M., & Liechti, M. E. (2011). Sex differences in the effects of MDMA (ecstasy) on plasma copeptin in healthy subjects. Journal of clinical endocrinology and metabolism, 96(9), 2844–2850. https://doi.org/10.1210/jc.2011-1143

Vejnovic, Ivana, Simmler, Linda, & Betz, Gabriele. (2010). Investigation of different formulations for drug delivery through the nail plate. International Journal of Pharmaceutics, 386(1-2), 185–194. https://doi.org/10.1016/j.ijpharm.2009.11.019