Dr. Clémentine Le Magnen

Yanushko, Darya, German Falcon, Beatriz, El Bizri, Rana, Pervizou, Despoina, Dolgos, Robin, Keime, Céline, Ye, Tao, Thibault-Carpentier, Christelle, Le Magnen, Clementine, Henri, Sandrine, Laverny, Gilles, & Metzger, Daniel. (2025). p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment. Cell Death and Disease, 16(1). https://doi.org/10.1038/s41419-025-07361-1

Lampart, Franziska L., Vetter, Roman, Yamauchi, Kevin A., Wang, Yifan, Runser, Steve, Strohmeyer, Nico, Meer, Florian, Hussherr, Marie-Didiée, Camenisch, Gieri, Seifert, Hans-Helge, Rentsch, Cyrill A., Le Magnen, Clémentine, Müller, Daniel J., Bubendorf, Lukas, & Iber, Dagmar. (2025). Morphometry and mechanical instability at the onset of epithelial bladder cancer. Nature Physics, 21(2), 279–288. https://doi.org/10.1038/s41567-024-02735-2

Brennen, W. Nathaniel, Le Magnen, Clémentine, Karkampouna, Sofia, Anselmino, Nicolas, Bock, Nathalie, Choo, Nicholas, Clark, Ashlee K., Coleman, Ilsa M., Dolgos, Robin, Ferguson, Alison M., Goode, David L., Krutihof‐de Julio, Marianna, Navone, Nora M., Nelson, Peter S., O’Neill, Edward, Porter, Laura H., Ranasinghe, Weranja, Sunada, Takuro, Williams, Elizabeth D., et al. (2024). Defining the challenges and opportunities for using patient‐derived models in prostate cancer research [Journal-article]. The Prostate. https://doi.org/10.1002/pros.24682

Vlajnic, Tatjana, Müller, David C., Ruiz, Christian, Schönegg, René, Seifert, Hans-Helge, Thalmann, George N., Zellweger, Tobias, Le Magnen, Clémentine, Rentsch, Cyrill A., & Bubendorf, Lukas. (2024). Exploring the intratumoral heterogeneity of DNA ploidy in prostate cancer. Cancer Reports, 7(2). https://doi.org/10.1002/cnr2.1953

Bratic Hench, Ivana, Roma, Luca, Conticelli, Floriana, Bubendorf, Lenard, Calgua, Byron, Le Magnen, Clémentine, Piscuoglio, Salvatore, Rubin, Mark A., Chirindel, Alin, Nicolas, Guillaume P., Vlajnic, Tatjana, Zellweger, Tobias, Templeton, Arnoud J., Stenner, Frank, Ruiz, Christian, Rentsch, Cyrill, & Bubendorf, Lukas. (2024). Cell-Free DNA Genomic Profiling and Its Clinical Implementation in Advanced Prostate Cancer. Cancers, 16(1). https://doi.org/10.3390/cancers16010045

Bratic Hench, Ivana, Roma, Luca, Conticelli, Floriana, Bubendorf, Lenard, Calgua, Byron, Le Magnen, Clémentine, Piscuoglio, Salvatore, Rubin, Mark A., Chirindel, Alin, Nicolas, Guillaume P., Vlajnic, Tatjana, Zellweger, Tobias, Templeton, Arnoud J., Stenner, Frank, Ruiz, Christian, Rentsch, Cyrill, & Bubendorf, Lukas. (2024). Cell-Free DNA Genomic Profiling and Its Clinical Implementation in Advanced Prostate Cancer [Journal-article]. Cancers, 16(1), 45. https://doi.org/10.3390/cancers16010045

Dolgos, R., Parmentier, R., Wang, J., Servant, R., Templeton, A.J., Zellweger, T., Lamb, A.D., Mertz, K.D., Subotic, S., Vlajnic, T., Seifert, H. H., Mortezavi, M., Rentsch, C. A., Bubendorf, L., & Le Magnen, C. (2024). ECM-free patient-derived organoids preserve diverse prostate cancer lineages and uncover in vitro-enriched cell types. https://doi.org/https://doi.org/10.1101/2024.10.16.618617

Garioni, Michele, Tschan, Viviane J., Blukacz, Lauriane, Nuciforo, Sandro, Parmentier, Romuald, Roma, Luca, Coto-Llerena, Mairene, Pueschel, Heike, Piscuoglio, Salvatore, Vlajnic, Tatjana, Stenner, Frank, Seifert, Hans-Helge, Rentsch, Cyrill A., Bubendorf, Lukas, & Le Magnen, Clémentine. (2023). Patient-derived organoids identify tailored therapeutic options and determinants of plasticity in sarcomatoid urothelial bladder cancer. Npj Precision Oncology, 7(1). https://doi.org/10.1038/s41698-023-00466-w

Lawrence, Mitchell G., Taylor, Renea A., Cuffe, Georgia B., Ang, Lisa S., Clark, Ashlee K., Goode, David L., Porter, Laura H., Le Magnen, Clémentine, Navone, Nora M., Schalken, Jack A., Wang, Yuzhuo, van Weerden, Wytske M., Corey, Eva, Isaacs, John T., Nelson, Peter S., & Risbridger, Gail P. (2023). The future of patient-derived xenografts in prostate cancer research. Nature Reviews Urology, 20(6), 371–384. https://doi.org/10.1038/s41585-022-00706-x

Marhold M., Kramer G., Krainer M., & Le Magnen C. (2022). The prostate cancer landscape in Europe: Current challenges, future opportunities. Cancer Letters, 526, 304–310. https://doi.org/10.1016/j.canlet.2021.11.033

Servant R, Garioni M, Vlajnic T, Blind M, Pueschel H, Müller DC, Zellweger T, Templeton AJ, Garofoli A, Maletti S, Piscuoglio S, Rubin MA, Seifert H, Rentsch CA, Bubendorf L, & Le Magnen C. (2021). Prostate cancer patient-derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens. Journal of Pathology, 254(5), 543–555. https://doi.org/10.1002/path.5698

Federer-Gsponer, Joël R., Müller, David C., Zellweger, Tobias, Eggimann, Maurice, Marston, Katharina, Ruiz, Christian, Seifert, Hans‐Helge, Rentsch, Cyrill A., Bubendorf, Lukas, & Le Magnen, Clémentine. (2020). Patterns of stemness-associated markers in the development of castration-resistant prostate cancer. Prostate, 80(13), 1108–1117. https://doi.org/10.1002/pros.24039

Dugas SG, Müller DC, Le Magnen C, Federer-Gsponer J, Seifert HH, Ruiz C, Savic Prince S, Vlajnic T, Zellweger T, Mertz KD, Bacon JVW, Wyatt AW, Rentsch CA, & Bubendorf L. (2019). Immunocytochemistry for ARID1A as a potential biomarker in urine cytology of bladder cancer. Cancer Cytopathology, 127(9), 578–585. https://doi.org/10.1002/cncy.22167

Le Magnen, C., Virk, R. K., Dutta, A., Kim, J. Y., Panja, S., Lopez-Bujanda, Z. A., Califano, A., Drake, C. G., Mitrofanova, A., & Abate-Shen, C. (2018). Cooperation of loss of NKX3.1 and inflammation in prostate cancer initiation. DMM Disease Models and Mechanisms, 11(11). https://doi.org/10.1242/dmm.035139

Le Magnen, C., Shen, M. M., & Abate-Shen, C. (2018). Lineage Plasticity in Cancer Progression and Treatment. Annual Review of Cancer Biology, 2, 271–289. https://doi.org/10.1146/annurev-cancerbio-030617-050224

Zou, M., Toivanen, R., Mitrofanova, A., Floch, N., Hayati, S., Sun, Y., Le Magnen, C., Chester, D., Mostaghel, E. A., Califano, A., Rubin, M. A., Shen, M. M., & Abate-Shen, C. (2017). Transdifferentiation as a mechanism of treatment resistance in a mouse model of castration-resistant prostate cancer. Cancer Discovery, 7(7), 736–749. https://doi.org/10.1158/2159-8290.cd-16-1174

Dutta, A., Le Magnen, C., Mitrofanova, A., Ouyang, X., Califano, A., & Abate-Shen, C. (2016). Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science, 352(6293), 1576–1580. https://doi.org/10.1126/science.aad9512

Le Magnen, C., Dutta, A., & Abate-Shen, C. (2016). Optimizing mouse models for precision cancer prevention. Nature Reviews Cancer, 16(3), 187–196. https://doi.org/10.1038/nrc.2016.1

Bourgine, P., LeMagnen, C., Pigeot, S., Geurts, J., Scherberich, A., & Martin, I. (2014). Combination of immortalization and inducible death strategies to generate a human mesenchymal stromal cell line with controlled survival. Stem Cell Research, 12(2), 98–584. https://doi.org/10.1016/j.scr.2013.12.006

Irshad, S., Bansal, M., Castillo-Martin, M., Zheng, T., Aytes, A., Wenske, S., Le Magnen, C., Guarnieri, P., Sumazin, P., Benson, M.C., Shen, M.M., Califano, A., & Abate-Shen, C. (2013). A molecular signature predictive of indolent prostate cancer (Science Translational Medicine (2013) 5, (203er9)). Science Translational Medicine, 5(203). https://doi.org/10.1126/scitranslmed.3007585

Irshad, S., Bansal, M., Castillo-Martin, M., Zheng, T., Aytes, A., Wenske, S., Le Magnen, C., Guarnieri, P., Sumazin, P., Benson, M. C., Shen, M. M., Califano, A., & Abate-Shen, C. (2013). A molecular signature predictive of indolent prostate cancer. Science Translational Medicine, 5(202). https://doi.org/10.1126/scitranslmed.3006408

Le Magnen, Clémentine, Bubendorf, Lukas, Rentsch, Cyrill A, Mengus, Chantal, Gsponer, Joel, Zellweger, Tobias, Rieken, Malte, Thalmann, George N, Cecchini, Marco G, Germann, Markus, Bachmann, Alexander, Wyler, Stephen, Heberer, Michael, & Spagnoli, Giulio C. (2013). Characterization and clinical relevance of ALDHbright populations in prostate cancer. Clinical Cancer Research, 19(19), 71–5361. https://doi.org/10.1158/1078-0432.ccr-12-2857

Le Magnen, Clémentine, Bubendorf, Lukas, Ruiz, Christian, Zlobec, Inti, Bachmann, Alexander, Heberer, Michael, Spagnoli, Giulio C, Wyler, Stephen, & Mengus, Chantal. (2013). Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells. European Journal of Cancer, 49(4), 63–955. https://doi.org/10.1016/j.ejca.2012.09.023

Mengus, Chantal, Le Magnen, Clémentine, Trella, Emanuele, Yousef, Kawa, Bubendorf, Lukas, Provenzano, Maurizio, Bachmann, Alexander, Heberer, Michael, Spagnoli, Giulio C, & Wyler, Stephen. (2011). Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer. Journal of Translational Medicine, 9, 162. https://doi.org/10.1186/1479-5876-9-162

Schultz-Thater, Elke, Piscuoglio, Salvatore, Iezzi, Giandomenica, Le Magnen, Clémentine, Zajac, Paul, Carafa, Vincenza, Terracciano, Luigi, Tornillo, Luigi, & Spagnoli, Giulio C. (2011). MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies. International Journal of Cancer, 129(5), 48–1137. https://doi.org/10.1002/ijc.25777