Prof. Dr. med. Alexandar Tzankov

Cui, N., Leary, P., Ivanova, V.-S., Stirm, K., Kirsche, L., Aceto, N., Stenner, F., Dieterich, L. C., Detmar, M., Petrova, E., Mundt, S., Greter, M., Tzankov, A., & Müller, A. (2025). PDL1-expressing macrophages infiltrate diffuse large B-cell lymphoma and promote lymphoma growth in a MYC-driven experimental model. Blood Cancer Journal, 15(1). https://doi.org/10.1038/s41408-025-01281-1

Mendeville, M. S., Janssen, J., Los-de Vries, G. T., van Dijk, E., Richter, J., Nijland, M., Roemer, M. G. M., Stathi, P., Hijmering, N. J., Bladergroen, R., Pelaz, D. A., Diepstra, A., Eertink, C. J., Burggraaff, C. N., Kim, Y., Lugtenburg, P. J., van den Berg, A., Tzankov, A., Dirnhofer, S., et al. (2025). Integrating genetic subtypes with PET scan monitoring to predict outcome in diffuse large B-cell lymphoma [Journal-article]. Nature Communications , 16(1). https://doi.org/10.1038/s41467-024-55614-y

Anzic, N., Stoiber, W., Obermeyer, A., Mertz, K. D., Stalder, A., Haslbauer, J. D., & Tzankov, A. (2025). Two-sided Effects of Neutrophil Extracellular Traps and Changes in the Myeloid Compartment in Acute Covid-19: A Histopathological Study on Autopsy Cases from the First and Second Covid-19 Waves in Switzerland [Journal-article]. Journal of Leukocyte Biology. https://doi.org/10.1093/jleuko/qiaf056

Menter, T., Trebo, M., Fauser, J., Horvath, L., Pircher, A., Posch, B., Medinger, M., Seydoux, C., Sopper, S., Wolf, D., & Tzankov, A. (2025). Particular dysregulation of ‘don’t eat me’ immune checkpoints in haemophagocytic lymphohistiocytosis [Journal-article]. British Journal of Haematology. https://doi.org/10.1111/bjh.20152

Pirosa, M. C., Bruscaggin, A., Terzi di Bergamo, L., Salehi, M., Jauk, F., Forestieri, G., Bocchetta, S., Piffaretti, D., Moia, R., Cristaldi, V., di Trani, M., Galimberti, G. A., Pini, K., Spina, V., Giordano, C., Condoluci, A., Romano, I., Annunziata, S., Bergesio, F., et al. (2025). A Comprehensive Genetic Study of Classical Hodgkin Lymphoma Using Circulating Tumor DNA [Journal-article]. Blood Journal. https://doi.org/10.1182/blood.2024027355

Bonometti, A., Tzankov, A., Alborelli, I., Russkamp, N. F., Dertinger, S., & Dirnhofer, S. (2025). Intrasinusoidal bone marrow involvement in mantle cell lymphoma: a case series with review of the main differential diagnoses. Virchows Archiv, 486(3), 563–572. https://doi.org/10.1007/s00428-024-03885-7

Jenei, A., & Tzankov, A. (2025). Diagnostic approach to leukemia cutis : A differential diagnostic step-by-step algorithm [Journal-article]. American Journal of Clinical Pathology, 163(3), 395–405. https://doi.org/10.1093/ajcp/aqae133

Capoferri, G., Ghielmetti, G., Glatz, B., Mutke, M. R., Tzankov, A., Stephan, R., Keller, P. M., & Labhardt, N. D. (2025). Disseminated, fatal reactivation of bovine tuberculosis in a patient treated with adalimumab: a case report and review of the literature. Infection, 53(1), 481–487. https://doi.org/10.1007/s15010-024-02364-0

Ivanova, Vanesa-Sindi, Menter, Thomas, Cui, Ningxuan, Leary, Peter, Zinner, Carl, Halter, Jörg P., Stenner, Frank, Dirnhofer, Stefan, Müller, Anne, & Tzankov, Alexandar. (2025). Distinct subtypes of post-transplant lymphoproliferative disorders: CHIP-like mutations in early lesions and substantial mutational differences between EBV-positive and EBV-negative diffuse large B-cell lymphomas. British Journal of Haematology, 206, 484–504. https://doi.org/10.1111/bjh.19952

Young, K., Shi, W.-Y., Xu-Monette, Z., Jia, Y., Tzankov, A., Go, H., Li, L., Ponzoni, M., Wang, Y., Zhai, Q., Perry, A., Wang, S., Wang, X., Chiu, A., Xu, M., Visco, C., Dybkaer, K., Withers, H., Long, M., et al. (2025). Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma [Posted-content]. Springer Science and Business Media LLC. https://doi.org/10.21203/rs.3.rs-5732026/v1

Blombery, P., de Jong, D., Ferry, J. A., Hsi, E. D., Ondrejka, S. L., Seymour, J. F., Zamò, A., & Tzankov, A. (2025). Closing the gap between biology and classification in splenic B-cell lymphomas [Journal-article]. Histopathology, 86(1), 69–78. https://doi.org/10.1111/his.15323

Bonometti, A., Tzankov, A., Alborelli, I., Went, P., & Dirnhofer, S. (2025). CD1a + histiocytoses in primary myelofibrosis patients: just a casual association? A case report and systematic review of the literature [Journal-article]. Leukemia and Lymphoma, 66(1), 139–146. https://doi.org/10.1080/10428194.2024.2404247

Erzar, E., Tzankov, A., Ocvirk, J., Grčar Kuzmanov, B., Boltežar, L., Kloboves Prevodnik, V., & Gašljević, G. (2024). FoxP3+ Regulatory T-Cell Quantities in Nodal T-Follicular Helper Cell Lymphomas and Peripheral T-Cell Lymphomas Not Otherwise Specified and Their Impact on Overall Survival [Journal-article]. Cancers, 16(23), 4011. https://doi.org/10.3390/cancers16234011

Fischer, A., Albert, T. K., Moreno, N., Interlandi, M., Mormann, J., Glaser, S., Patil, P., de Faria, F. W., Richter, M., Verma, A., Balbach, S. T., Wagener, R., Bens, S., Dahlum, S., Göbel, C., Münter, D., Inserte, C., Graf, M., Kremer, E., et al. (2024). Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas. Nature Communications , 15(1). https://doi.org/10.1038/s41467-024-52826-0

Haslbauer, J.D., Wiegand, C., Hamelin, B., Ivanova, V.S., Menter, T., Savic Prince, S., Tzankov, A., & Mertz, K.D. (2024). Two cases demonstrate an association between Tropheryma whipplei and pulmonary marginal zone lymphoma. Infectious Agents and Cancer, 19. https://doi.org/10.1186/s13027-024-00597-0

Hench, J., Hultschig, C., Bratic Hench, I., Sadasivan, H., Yaldizli, Ö., Hutter, G., Dirnhofer, S., Tzankov, A., & Frank, S. (2024). Rapid brain lymphoma diagnostics through nanopore sequencing of cytology-negative cerebrospinal fluid. Acta Neuropathologica, 148(1). https://doi.org/10.1007/s00401-024-02793-z

Villalba, J., Villalba, J., Li, Y., Shih, A., Poli, S., Kunitoki, K., Alba, G., Mehta, A., Loyola-Rodríguez, G., Alcántara, I. R., Santana, M., Lacerda, M., Ferreira, L., Dell’Aquila, M., Arena, V., Stigliano, E., Calabrese, F., Pezzuto, F., Märkl, B., et al. (2024). Immune checkpoint dysregulation in COVID-19 pathogenesis and disease severity. [Posted-content]. Springer Science and Business Media LLC. https://doi.org/10.21203/rs.3.rs-3508654/v1

Ivanova, Vanesa-Sindi, Menter, Thomas, Zaino, Joel, Mertz, Kirsten D., Hamelin, Baptiste, Dirnhofer, Stefan, Kloboves-Prevodnik, Veronika, Tzankov, Alexandar, & Gašljevic, Gorana. (2024). The Genetic Landscape of Primary Breast Marginal Zone Lymphoma Identifies a Mutational-driven Disease with Similarities to Ocular Adnexal Lymphoma. American Journal of Surgical Pathology, 48, 1259–1269. https://doi.org/10.1097/PAS.0000000000002257

Ivanova, Vanesa-Sindi, Vela, Visar, Dirnhofer, Stefan, Dobbie, Michael, Stenner, Frank, Knoblich, Jan, Tzankov, Alexandar, & Menter, Thomas. (2024). Molecular Characterization and Genetic Subclassification Comparison of Diffuse Large B-Cell Lymphoma: Real-Life Experience with 74 Cases. Pathobiology, 91, 245–253. https://doi.org/10.1159/000535938

Schmidt-Barbo, P., Kalweit, G., Naouar, M., Paschold, L., Willscher, E., Schultheiß, C., Märkl, B., Dirnhofer, S., Tzankov, A., Binder, M., & Kalweit, M. (2024). Detection of disease-specific signatures in B cell repertoires of lymphomas using machine learning [Journal-article]. PLoS Computational Biology, 20(7 July), e1011570. https://doi.org/10.1371/journal.pcbi.1011570

Tzankov, Alexandar, & Tatarczuch, Maciej. (2024). Time to Be Launched 1 auXiliary Risk strat1fier in marginal zone lymphoma transformation: TBL1XR1. Cancer, 130(8), 1204–1207. https://doi.org/10.1002/cncr.35246

Haslbauer, J. D., Wiegand, C., Hamelin, B., Ivanova, V.-S., Menter, T., Prince, S. S., Tzankov, A., & Mertz, K. D. (2024). Two cases suggest Tropheryma whipplei as a causative agent of pulmonary marginal zone lymphoma [Posted-content]. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-4228227/v1

Bassani, Barbara, Simonetti, Giorgia, Cancila, Valeria, Fiorino, Antonio, Ciciarello, Marilena, Piva, Annamaria, Khorasani, Arman Mandegar, Chiodoni, Claudia, Lecis, Daniele, Gulino, Alessandro, Fonzi, Eugenio, Botti, Laura, Portararo, Paola, Costanza, Massimo, Brambilla, Marta, Colombo, Giorgia, Schwaller, Juerg, Tzankov, Alexandar, Ponzoni, Maurilio, et al. (2024). ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion. Cell Reports, 43(2). https://doi.org/10.1016/j.celrep.2024.113794

Faria C, & Tzankov A. (2024). Progression in Myeloid Neoplasms: Beyond the Myeloblast. Pathobiology, 91(1), 55–75. https://doi.org/10.1159/000530940

Ivanova, Vanesa-Sindi, Davies, John, Menter, Thomas, Wild, Damian, Müller, Anne, Krasniqi, Fatime, Stenner, Frank, Papachristofilou, Alexandros, Dirnhofer, Stefan, & Tzankov, Alexandar. (2024). Primary bone diffuse large B-cell lymphoma (PB-DLBCL): a distinct extranodal lymphoma of germinal centre origin, with a common EZB-like mutational profile and good prognosis. Histopathology, 84, 525–538. https://doi.org/10.1111/his.15096

Schoenenberger, Monica S., Halfter, Willi, Ferrand, Alexia, Halfter, Kathrin, Tzankov, Alexandar, Scholl, Hendrik P. N., Henrich, Paul Bernhard, & Monnier, Christophe A. (2024). The biophysical and compositional properties of human basement membranes. FEBS Journal, 291(3), 477–488. https://doi.org/10.1111/febs.17007

Brand, Michiel van den, Tzankov, Alexandar, Scheijde-Vermeulen, Marijn, Barbé, Ellis, Dirnhofer, Stefan, Stenner, Frank, Hebeda, Konnie, Chamuleau, Martine, & Jong, Daphne de. (2024). The diagnosis of Burkitt lymphoma: how do pathologists apply criteria in daily practice? Leukemia and Lymphoma, 65, 2211–2214. https://doi.org/10.1080/10428194.2024.2396542

Dietsche, L., Stirm, K., Lysenko, V., Schneidawind, C., Tzankov, A., Müller, A., & Theocharides, A. P. A. (2024). Loss of SMAD1 in acute myeloid leukemia with KMT2A::AFF1 and KMT2A::MLLT3 fusion genes [Journal-article]. Frontiers in Oncology, 14. https://doi.org/10.3389/fonc.2024.1481713

Madan, Esha, Palma, António M., Vudatha, Vignesh, Kumar, Amit, Bhoopathi, Praveen, Wilhelm, Jochen, Bernas, Tytus, Martin, Patrick C., Bilolikar, Gaurav, Gogna, Aenya, Peixoto, Maria Leonor, Dreier, Isabelle, Araujo, Thais Fenz, Garre, Elena, Gustafsson, Anna, Dorayappan, Kalpana Deepa Priya, Mamidi, Narsimha, Sun, Zhaoyu, Yekelchyk, Michail, et al. (2024). Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells. Nature Biotechnology. https://doi.org/10.1038/s41587-024-02453-3

Torlakovic, E. E., Calvo, K. R., George, T., Hyjek, E., Lee, S.-H., Porwit, A., Sabattini, E., Saft, L., Zhou, X., & Tzankov, A. (2024). Clinical Applications of Bone Marrow CD34 Immunohistochemistry (BM CD34 IHC) Assay: International Council for Standardization in Hematology (ICSH) Guidelines. International Journal of Laboratory Hematology. https://doi.org/10.1111/ijlh.14411

Xu-Monette, Z. Y., Luo, C., Yu, L., Li, Y., Bhagat, G., Tzankov, A., Visco, C., Fan, X., Dybkaer, K., Sakhdari, A., Wang, N. T., Yuan, A. F., Chiu, A., Tam, W., Zu, Y., Hsi, E. D., Perry, A. M., Song, W., O’Malley, D., et al. (2024). DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma [Journal-article]. OncoImmunology, 13(1). https://doi.org/10.1080/2162402X.2024.2384667

Juskevicius, Darius, Lundberg, Pontus, Tzankov, Alexandar, Dirnhofer, Stefan, & Stenner, Frank. (2023). Genetic Factors in Familial Manifestation of Primary Mediastinal Large B-Cell Lymphoma over Two Generations. Pathobiology, 90, 422–428. https://doi.org/10.1159/000532053

Mamot C, Wicki A, Hasler-Strub U, Riniker S, Li Q, Holer L, Bärtschi D, Zaman K, von Moos R, Dedes KJ, Boos LA, Novak U, Bodmer A, Ritschard R, Obermann EC, Tzankov A, Ackermann C, Membrez-Antonioli V, Zürrer-Härdi U, et al. (2023). A multicenter phase II trial of anti-EGFR-immunoliposomes loaded with doxorubicin in patients with advanced triple negative breast cancer. Scientific Reports, 13(1), 3705. https://doi.org/10.1038/s41598-023-30950-z

Pinton, Sandra, Vacchi, Elena, Chiaro, Giacomo, Raimondi, Andrea, Tzankov, Alexandar, Gerber, Bernhard, Gobbi, Claudio, Kaelin-Lang, Alain, & Melli, Giorgia. (2023). Amyloid detection and typing yield of skin biopsy in systemic amyloidosis and polyneuropathy. Annals of Clinical and Translational Neurology, 10(12), 2347–2359. https://doi.org/10.1002/acn3.51924

Pinton, Sandra, Vacchi, Elena, Chiaro, Giacomo, Raimondi, Andrea, Tzankov, Alexandar, Gerber, Bernhard, Gobbi, Claudio, Kaelin‐Lang, Alain, & Melli, Giorgia. (2023). Amyloid detection and typing yield of skin biopsy in systemic amyloidosis and polyneuropathy [Journal-article]. Annals of Clinical and Translational Neurology, 10(12), 2347–2359. https://doi.org/10.1002/acn3.51924

Sarhan, Mohamed S., Wurst, Christina, Tzankov, Alexandar, Bircher, Andreas J., Wittig, Holger, Briellmann, Thomas, Augsburger, Marc, Hotz, Gerhard, Zink, Albert, & Maixner, Frank. (2023). A nontuberculous mycobacterium could solve the mystery of the lady from the Franciscan church in Basel, Switzerland. BMC Biology, 21(1). https://doi.org/10.1186/s12915-022-01509-7

Sahanic, Sabina, Hilbe, Richard, Dünser, Christina, Tymoszuk, Piotr, Löffler-Ragg, Judith, Rieder, Dietmar, Trajanoski, Zlatko, Krogsdam, Anne, Demetz, Egon, Yurchenko, Maria, Fischer, Christine, Schirmer, Michael, Theurl, Markus, Lener, Daniela, Hirsch, Jakob, Holfeld, Johannes, Gollmann-Tepeköylü, Can, Zinner, Carl P., Tzankov, Alexandar, et al. (2023). SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19. Heliyon, 9(11). https://doi.org/10.1016/j.heliyon.2023.e21893

Ylstra, B., Mendeville, M., Janssen, J., Vries, G. T. L.-d., Dijk, E. v., Richter, J., Nijland, M., Roemer, M., Stathi, P., Hijmering, N., Bladergroen, R., Pelaz, D., Diepstra, A., Eertink, C., Burggraaff, C., Kim, Y., Lugtenburg, P., Berg, A. v. d., Tzankov, A., et al. (2023). The Impact of Genetic Subtypes of Diffuse Large B-Cell Lymphoma for Outcome Prediction and Interpretation of FDG-PET treatment Response Monitoring [Posted-content]. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-3480882/v1

Schmidt-Barbo, P., Kalweit, G., Naouar, M., Paschold, L., Willscher, E., Schultheiß, C., Märkl, B., Dirnhofer, S., Tzankov, A., Binder, M., & Kalweit, M. (2023, October 10). Detection of disease-specific signatures in B cell repertoires of lymphomas using machine learning [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.10.05.561150

Chung EYL, Sartori G, Ponzoni M, Cascione L, Priebe V, Xu-Monette ZY, Fang X, Zhang M, Visco C, Tzankov A, Rinaldi A, Sgrignani J, Zucca E, Rossi D, Cavalli A, Inghirami G, Scott DW, Young KH, & Bertoni F. (2023). ETS1 phosphorylation at threonine 38 is associated with the cell of origin of diffuse large B cell lymphoma and sustains the growth of tumour cells. British Journal of Haematology, 203(2), 244–254. https://doi.org/10.1111/bjh.19018

Konantz M, Williams M, Merkel T, Reiss A, Dirnhofer S, Meyer SC, Valent P, George TI, Tzankov A, & Hartmann K. (2023). Increased TIM-3 and galectin-9 serum levels in patients with advanced systemic mastocytosis. Journal of Allergy and Clinical Immunology, 152(4), 1019–1024. https://doi.org/10.1016/j.jaci.2023.07.001

Uzun, Sarp, Zinner, Carl P., Beenen, Amke C., Alborelli, Ilaria, Bartoszek, Ewelina M., Bartoszek, Ewelina M., Yeung, Jason, Calgua, Byron, Reinscheid, Matthias, Bronsert, Peter, Stalder, Anna K., Haslbauer, Jasmin D., Vosbeck, Juerg, Mazzucchelli, Luca, Hoffmann, Tobias, Terracciano, Luigi M., Hutter, Gregor, Manz, Michael, Panne, Isabelle, et al. (2023). Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics. Journal of Hepatology, 79(3), 666–676. https://doi.org/10.1016/j.jhep.2023.05.020

Haefliger S, & Tzankov A. (2023). Mycobacterial spindle cell pseudotumor mimicking Richter transformation in a patient with hairy cell leukemia (Patent No. 2). International Journal of Hematology, 118(2), Article 2. https://doi.org/10.1007/s12185-023-03628-5

Wang SA, Orazi A, Gotlib J, Reiter A, Tzankov A, Hasserjian RP, Arber DA, & Tefferi A. (2023). The international consensus classification of eosinophilic disorders and systemic mastocytosis. American Journal of Hematology, 98(8), 1286–1306. https://doi.org/10.1002/ajh.26966

Haslbauer, Jasmin D., Prince, Spasenija Savic, Stalder, Anna K., Matter, Matthias S., Zinner, Carl P., Jahn, Kathleen, Obermann, Ellen, Hanke, Jasmin, Leuzinger, Karoline, Hirsch, Hans H., & Tzankov, Alexandar. (2023). Differential Gene Expression of SARS-CoV-2 Positive Bronchoalveolar Lavages: A Case Series. Pathobiology, 91(2), 158–168. https://doi.org/10.1159/000532057

Bassani, B., Simonetti, G., Cancila, V., Ciciarello, M., Piva, A., Chiodoni, C., Lecis, D., Gulino, A., Fonzi, E., Botti, L., Portararo, P., Costanza, M., Schwaller, J., Tzankov, A., Ponzoni, M., Ciceri, F., Bolli, N., Curti, A., Tripodo, C., et al. (2023). ZEB1 shapes AML immunological niches suppressing CD8 T-cell activity while fostering Th17 cell expansion [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.07.08.548195

Dertschnig S, Passweg J, Bucher C, Medinger M, Medinger M, & Tzankov A. (2023). Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation. Cellular Immunology, 388-389, 104719. https://doi.org/10.1016/j.cellimm.2023.104719

Ivanova, V.-S., Davies, J., Menter, T., Wild, D., Müller, A., Krasniqi, F., Stenner, F., Papachristofilou, A., Dirnhofer, S., & Tzankov, A. (2023, May 15). Primary Bone Diffuse Large B-cell Lymphoma (PB-DLBCL) – a distinct extranodal lymphoma of germinal center origin, with an EZB-like mutational profile and good prognosis [Posted-content]. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-2927274/v1

Piqué-Borràs, Maria-Riera, Jevtic, Zivojin, Bagger, Frederik Otzen, Seguin, Jonathan, Sivalingam, Rathick, Bezerra, Matheus Filgueira, Louwagie, Amber, Juge, Sabine, Nellas, Ioannis, Ivanek, Robert, Tzankov, Alexandar, Moll, Ute M., Cantillo, Oriano, Schulz-Heddergott, Ramona, Fagnan, Alexandre, Mercher, Thomas, & Schwaller, Juerg. (2023). The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53. Blood, 141(18), 2245–2260. https://doi.org/10.1182/blood.2022017273

van den Berg, Jana, Haslbauer, Jasmin D., Stalder, Anna K., Romanens, Anna, Mertz, Kirsten D., Studt, Jan-Dirk, Siegemund, Martin, Buser, Andreas, Holbro, Andreas, & Tzankov, Alexandar. (2023). Von Willebrand factor and the thrombophilia of severe COVID-19: in situ evidence from autopsies. Research and Practice in Thrombosis and Haemostasis, 7(4). https://doi.org/10.1016/j.rpth.2023.100182

Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, et al. (2023). Inflammation and vascular remodeling in COVID-19 hearts. Angiogenesis, 26(2), 233–248. https://doi.org/10.1007/s10456-022-09860-7

Li Y, Xu-Monette ZY, Abramson J, Sohani AR, Bhagat G, Tzankov A, Visco C, Zhang S, Dybkaer K, Pan Z, Xu M, Tam W, Zu Y, Hsi ED, Hagemeister FB, Go H, van Krieken JH, Winter JN, Ponzoni M, et al. (2023). EBV-positive DLBCL frequently harbors somatic mutations associated with clonal hematopoiesis of indeterminate potential. Blood Advances, 7(7), 1308–1311. https://doi.org/10.1182/bloodadvances.2022008550

Deng, M., Xu-Monette, Z. Y., Pham, L. V., Wang, X., Tzankov, A., Fang, X., Zhu, F., Visco, C., Bhagat, G., Dybkaer, K., Chiu, A., Tam, W., Zu, Y., Hsi, E. D., You, H., Huh, J., Ponzoni, M., Ferreri, A. J. M., Møller, M. B., et al. (2023). Data from Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents [Posted-content]. American Association for Cancer Research (AACR). https://doi.org/10.1158/1541-7786.c.6545138.v1

Haslbauer JD, Bratic-Hench I, Cima K, Luger AK, Schmitz K, Augustin F, Krapf C, Hoefer D, Tancevski I, Tzankov A, & Löffler-Ragg J. (2023). Interstitial Pulmonary Fibrosis and Extensive Dendriform Ossification with Persistent Viral Load: A Rare Presentation of Post-COVID-19 Condition in Need of Lung Transplantation (Patent No. 2). Pathobiology, 90(2), Article 2. https://doi.org/10.1159/000525457

Xu-Monette, Z. Y., Wei, L., Fang, X., Au, Q., Nunns, H., Nagy, M., Tzankov, A., Zhu, F., Visco, C., Bhagat, G., Dybkaer, K., Chiu, A., Tam, W., Zu, Y., Hsi, E. D., Hagemeister, F. B., Sun, X., Han, X., Go, H., et al. (2023). Data from Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma [Posted-content]. American Association for Cancer Research (AACR). https://doi.org/10.1158/1078-0432.c.6532629

Stirm K, Leary P, Wüst D, Stark D, Joller N, Karakus U, Boyman O, Tzankov A, & Müller A. (2023). Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models. Journal for ImmunoTherapy of Cancer, 11(2). https://doi.org/10.1136/jitc-2022-006263

Hirsiger, Julia R., Tzankov, Alexandar, Alborelli, Ilaria, Recher, Mike, Daikeler, Thomas, Parmentier, Stefani, & Berger, Christoph T. (2023). Case Report: mRNA vaccination-mediated STAT3 overactivation with agranulocytosis and clonal T-LGL expansion. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1087502

de Rooij LPMH, Becker LM, Teuwen LA, Boeckx B, Jansen S, Feys S, Verleden S, Liesenborghs L, Stalder AK, Libbrecht S, Van Buyten T, Philips G, Subramanian A, Dumas SJ, Meta E, Borri M, Sokol L, Dendooven A, Truong AK, et al. (2023). The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution. Cardiovascular Research, 119(2), 520–535. https://doi.org/10.1093/cvr/cvac139

Pahima H, Zaffran I, Ben-Chetrit E, Jarjoui A, Gaur P, Manca ML, Reichmann D, Orenbuch-Harroch E, Tiligada E, Puxeddu I, Zinner C, Tzankov A, & Levi-Schaffer F. (2023). Patients with coronavirus disease 2019 characterized by dysregulated levels of membrane and soluble cluster of differentiation 48. Annals of Allergy, Asthma and Immunology, 130(2), 245–253. https://doi.org/10.1016/j.anai.2022.10.009

Zhu B, Chen S, Bai Y, Chen H, Liao G, Mukherjee N, Vazquez G, McIlwain DR, Tzankov A, Lee IT, Matter MS, Goltsev Y, Ma Z, Nolan GP, & Jiang S. (2023). Robust single-cell matching and multimodal analysis using shared and distinct features. Nature Methods, 20(2), 304–315. https://doi.org/10.1038/s41592-022-01709-7

Leguit RJ, Wang SA, George TI, Tzankov A, & Orazi A. (2023). The international consensus classification of mastocytosis and related entities. Virchows Archiv, 482(1), 99–112. https://doi.org/10.1007/s00428-022-03423-3

Menter, Thomas, Zinner, Carl P., Berger, Christoph T., Went, Philip, & Tzankov, Alexandar. (2023). Case Report: Gene expression profiling of COVID-19 vaccination-related lymphadenopathies reveals evidence of a dominantly extrafollicular immune response. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1285168

Sinnberg T, Lichtensteiger C, Ali OH, Pop OT, Jochum AK, Risch L, Brugger SD, Velic A, Bomze D, Kohler P, Vernazza P, Albrich WC, Kahlert CR, Abdou MT, Wyss N, Hofmeister K, Niessner H, Zinner C, Gilardi M, et al. (2023). Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19. American Journal of Respiratory and Critical Care Medicine, 207(1), 38–49. https://doi.org/10.1164/rccm.202201-0011OC

Tzankov A, Reichard KK, Hasserjian RP, Arber DA, Orazi A, & Wang SA. (2023). Updates on eosinophilic disorders. Virchows Archiv, 482(1), 85–97. https://doi.org/10.1007/s00428-022-03402-8

Xu-Monette, Zijun Y., Li, Yong, Snyder, Thomas, Yu, Tiantian, Lu, Tingxun, Tzankov, Alexandar, Visco, Carlo, Bhagat, Govind, Qian, Wenbin, Dybkaer, Karen, Chiu, April, Tam, Wayne, Zu, Youli, Hsi, Eric D., Hagemeister, Fredrick B., Wang, Yingjun, Go, Heounjeong, Ponzoni, Maurilio, Ferreri, Andrés J.M., et al. (2023). Tumor-Infiltrating Normal B Cells Revealed by Immunoglobulin Repertoire Clonotype Analysis Are Highly Prognostic and Crucial for Antitumor Immune Responses in DLBCL. Clinical Cancer Research, 29(23), 4808–4821. https://doi.org/10.1158/1078-0432.CCR-23-1554

Martínez-Colón GJ, Ratnasiri K, Chen H., Jiang S, Zanley E., Rustagi A, Verma R, Chen H., Andrews JR, Mertz KD, Tzankov A, Azagury D, Boyd J., Nolan GP, Schurch C.M., Matter M.S., Blish C.A., & McLaughlin TL. (2022). SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages. Science Translational Medicine, 14(674). https://doi.org/10.1126/scitranslmed.abm9151

Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, et al. (2022). Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nature Communications, 13(1), 3881. https://doi.org/10.1038/s41467-022-31355-8

Ercan, Caner, Coto-Llerena, Mairene, Gallon, John, Fourie, Lana, Marinucci, Mattia, Hess, Gabriel F., Vosbeck, Jürg, Taha-Mehlitz, Stephanie, Boldanova, Tuyana, Meier, Marie-Anne, Tzankov, Alexandar, Matter, Matthias S., Hoffmann, Martin H. K., Di Tommaso, Luca, von Flüe, Markus, Ng, Charlotte K. Y., Heim, Markus H., Soysal, Savas D., Terracciano, Luigi M., et al. (2022). Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report. Communications Medicine, 2(1). https://doi.org/10.1038/s43856-022-00074-y

Etter, Manina M., Martins, Tomás A., Kulsvehagen, Laila, Pössnecker, Elisabeth, Duchemin, Wandrille, Hogan, Sabrina, Sanabria-Diaz, Gretel, Müller, Jannis, Chiappini, Alessio, Rychen, Jonathan, Eberhard, Noëmi, Guzman, Raphael, Mariani, Luigi, Melie-Garcia, Lester, Keller, Emanuela, Jelcic, Ilijas, Pargger, Hans, Siegemund, Martin, Kuhle, Jens, et al. (2022). Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-34068-0

Nägele F, Graber M, Hirsch J, Pölzl L, Sahanic S, Fiegl M, Hau D, Engler C, Lechner S, Stalder AK, Mertz KD, Haslbauer JD, Tzankov A, Grimm M, Tancevski I, Holfeld J, & Gollmann-Tepeköylü C. (2022). Correlation between structural heart disease and cardiac SARS-CoV-2 manifestations. Communications Medicine, 2(1), 142. https://doi.org/10.1038/s43856-022-00204-6

Ackermann M, Kamp JC, Werlein C, Walsh CL, Stark H, Prade V, Surabattula R, Wagner WL, Disney C, Bodey AJ, Illig T, Leeming DJ, Karsdal MA, Tzankov A, Boor P, Kühnel MP, Länger FP, Verleden SE, Kvasnicka HM, et al. (2022). The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling. eBioMedicine, 85, 104296. https://doi.org/10.1016/j.ebiom.2022.104296

Araujo AM, Abaurrea A, Azcoaga P, López-Velazco JI, Manzano S, Rodriguez J, Rezola R, Egia-Mendikute L, Valdés-Mora F, Flores JM, Jenkins L, Pulido L, Osorio-Querejeta I, Fernández-Nogueira P, Ferrari N, Viera C, Martín-Martín N, Tzankov A, Eppenberger-Castori S, et al. (2022). Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment. The Journal of Clinical Investigation, 132(19). https://doi.org/10.1172/jci165107

Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, Wang SA, Bagg A, Barbui T, Branford S, Bueso-Ramos CE, Cortes JE, Dal Cin P, DiNardo CD, Dombret H, Duncavage EJ, Ebert BL, Estey EH, Facchetti F, et al. (2022). International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood, 140(11), 1200–1228. https://doi.org/10.1182/blood.2022015850

Brune MM, Vela V, Bratic Hench I, Dertinger S, Borgmann V, Dirnhofer S, & Tzankov A. (2022). H3K27m3 overexpression as a new, BCL2 independent diagnostic tool in follicular and cutaneous follicle center lymphomas. Virchows Archiv, 481(3), 489–497. https://doi.org/10.1007/s00428-022-03347-y

Engelhardt S, Dislich B, Zubler C, Maragkou T, Wartenberg M, & Tzankov A. (2022). [Myositis as a post-acute sequela of COVID-19 disease? : Even in times of the pandemic, muscle biopsies can only be assessed in the context of accurate clinical information]. Pathologie (Heidelberg, Germany), 43(5), 377–380. https://doi.org/10.1007/s00292-022-01063-7

Medinger M, Junker T, Heim D, Tzankov A, Jermann PM, Bobadilla M, Vigolo M, Lehal R, Vogl FD, Bauer M, & Passweg J. (2022). CB-103: A novel CSL-NICD inhibitor for the treatment of NOTCH-driven T-cell acute lymphoblastic leukemia: A case report of complete clinical response in a patient with relapsed and refractory T-ALL. (Patent No. 3). 3(3), Article 3. https://doi.org/10.1002/jha2.510

Murase T, Nakano S, Sakane T, Domen H, Chiyo M, Nagasaka S, Tanaka M, Kawahara Y, Toishi M, Tanaka T, Nakamura S, Sawabata N, Okami J, Mukaida H, Tzankov A, Szolkowska M, Porubsky S, Marx A, Roden AC, & Inagaki H. (2022). Thymic Mucoepidermoid Carcinoma: A Clinicopathologic and Molecular Study. American Journal of Surgical Pathology, 46(8), 1160–1169. https://doi.org/10.1097/PAS.0000000000001886

Menter T, Dirnhofer S, & Tzankov A. (2022). [Differential diagnosis of reactive cytopenias]. Pathologie (Heidelberg, Germany), 43(4), 263–270. https://doi.org/10.1007/s00292-022-01076-2

Jiang S, Chan CN, Rovira-Clavé X, Chen H., Bai Y, Zhu B, McCaffrey E, Greenwald NF, Liu C, Barlow GL, Weirather JL, Oliveria JP, Nakayama T, Lee IT, Matter M.S., Carlisle AE, Philips D, Vazquez G, Mukherjee N, et al. (2022). Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments. Immunity, 55(6), 1118–1134. https://doi.org/10.1016/j.immuni.2022.03.020

Girardin FR, Tzankov A, Pantaleo G, Livio F, & Greub G. (2022). Multifocal lymphadenopathies with polyclonal reactions primed after EBV infection in a mRNA-1273 vaccine recipient. Swiss Medical Weekly, 152(21-22), w30188. https://doi.org/10.4414/smw.2022.w30188

Haslbauer JD, Stalder A, Zinner C, Bassetti S, Mertz KD, Went P, Matter M, & Tzankov A. (2022). Immunohistochemical and Transcriptional Analysis of SARS-CoV-2 Entry Factors and Renin-Angiotensin-Aldosterone System Components in Lethal COVID-19. Pathobiology, 89(3), 166–177. https://doi.org/10.1159/000520221

Tzankov A, Facchetti F, Mühleisen B, & Dirnhofer S. (2022). IRF8 Is a Reliable Monoblast Marker for Acute Monocytic Leukemias, But Does Not Discriminate Between Monoblasts and Plasmacytoid Dendritic Cells (Patent No. 5). American Journal of Surgical Pathology, 46(5), Article 5. https://doi.org/10.1097/PAS.0000000000001874

Araujo AM, Abaurrea A, Azcoaga P, López-Velazco JI, Manzano S, Rodriguez J, Rezola R, Egia-Mendikute L, Valdés-Mora F, Flores JM, Jenkins L, Pulido L, Osorio-Querejeta I, Fernández-Nogueira P, Ferrari N, Viera C, Martín-Martín N, Tzankov A, Eppenberger-Castori S, et al. (2022). Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment. Journal of Clinical Investigation, 132(7). https://doi.org/10.1172/JCI148667

Bertram K, Leary PJ, Boudesco C, Fullin J, Stirm K, Dalal V, Zenz T, Tzankov A, & Müller A. (2022). Inhibitors of Bcl-2 and Bruton’s tyrosine kinase synergize to abrogate diffuse large B-cell lymphoma growth in vitro and in orthotopic xenotransplantation models. Leukemia, 36(4), 1035–1047. https://doi.org/10.1038/s41375-021-01470-4

Fernandez MR, Schaub FX, Yang C, Li W, Yun S, Schaub SK, Dorsey FC, Liu M, Steeves MA, Ballabio A, Tzankov A, Chen Z, Koomen JM, Berglund AE, & Cleveland JL. (2022). Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy. Cancer Research, 82(7), 1234–1250. https://doi.org/10.1158/0008-5472.CAN-21-1168

Pahima, H., Zaffran, I., Ben-Chetrit, E., Jarjoui, A., Gaur, P., Manca, M. L., Reichmann, D., Orenbuch-Harroch, E., Puxeddu, I., Zinner, C., Tzankov, A., & Levi-Schaffer, F. (2022). COVID-19 patients have increased levels of membrane-associated and soluble CD48 [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.03.18.484843

Etter, M., Martins, T., Kulsvehagen, L., Pössnecker, E., Duchemin, W., Hogan, S., Sanabria-Diaz, G., Müller, J., Chiappini, A., Rychen, J., Eberhard, N., Guzman, R., MarianI, L., Keller, E., Melie-Garcia, L., Jelcic, I., Pargger, H., Siegemund, M., Kuhle, J., et al. (2022, March 8). Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study [Posted-content]. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-1385593/v1

Etter, M. M., A. Martins, T., Kulsvehagen, L., Pössnecker, E., Duchemin, W., Hogan, S., Sanabria-Diaz, G., Müller, J., Chiappini, A., Rychen, J., Eberhard, N., Melie-Garcia, L., Keller, E., Jelcic, I., Pargger, H., Siegemund, M., Kuhle, J., Oechtering, J., Eich, C., et al. (2022, March 2). Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and signs of neurodegeneration: a prospective cross-sectional study [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.02.18.22271039

Tzankov A, Bhattacharyya S, Kotlo K, & Tobacman JK. (2022). Increase in Chondroitin Sulfate and Decline in Arylsulfatase B May Contribute to Pathophysiology of COVID-19 Respiratory Failure. Pathobiology, 89(2), 81–91. https://doi.org/10.1159/000519542

Tzankov A, & Rössle M. (2022). Extrafollicular proliferation of B-blasts: Morphologic correlate to Spikevax-induced lymphadenopathy. Clinical Case Reports, 10(3), e05398. https://doi.org/10.1002/ccr3.5398

Xu-Monette ZY, Wei L, Fang X, Au Q, Nunns H, Nagy M, Tzankov A, Zhu F, Visco C, Bhagat G, Dybkaer K, Chiu A, Tam W, Zu Y, Hsi ED, Hagemeister FB, Sun X, Han X, Go H, et al. (2022). Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma. Clinical Cancer Research, 28(5), 972–983. https://doi.org/10.1158/1078-0432.CCR-21-2949

Menter T, & Tzankov A. (2022). Tumor Microenvironment in Acute Myeloid Leukemia: Adjusting Niches. Frontiers in Immunology, 13, 811144. https://doi.org/10.3389/fimmu.2022.811144

Bonfiglio F, Bruscaggin A, Guidetti F, Terzi di Bergamo L, Faderl M, Spina V, Condoluci A, Bonomini L, Forestieri G, Koch R, Piffaretti D, Pini K, Pirosa MC, Cittone MG, Arribas A, Lucioni M, Ghilardi G, Wu W, Arcaini L, et al. (2022). Genetic and phenotypic attributes of splenic marginal zone lymphoma. Blood, 139(5), 732–747. https://doi.org/10.1182/blood.2021012386

Albitar M, Zhang H, Goy A, Xu-Monette ZY, Bhagat G, Visco C, Tzankov A, Fang X, Zhu F, Dybkaer K, Chiu A, Tam W, Zu Y, Hsi ED, Hagemeister FB, Huh J, Ponzoni M, Ferreri AJM, Møller MB, et al. (2022). Determining clinical course of diffuse large B-cell lymphoma using targeted transcriptome and machine learning algorithms. Blood Cancer Journal, 12(2), 25. https://doi.org/10.1038/s41408-022-00617-5

Carrasco-Garcia E, Lopez L, Moncho-Amor V, Carazo F, Aldaz P, Collado M, Bell D, Gaafar A, Karamitopoulou E, Tzankov A, Hidalgo M, Rubio Á, Serrano M, Lawrie CH, Lovell-Badge R, & Matheu A. (2022). SOX9 Triggers Different Epithelial to Mesenchymal Transition States to Promote Pancreatic Cancer Progression. Cancers, 14(4). https://doi.org/10.3390/cancers14040916

Genta S, Ghilardi G, Cascione L, Juskevicius D, Tzankov A, Schär S, Milan L, Pirosa MC, Esposito F, Ruberto T, Giovanella L, Hayoz S, Mamot C, Dirnhofer S, Zucca E, & Ceriani L. (2022). Integration of Baseline Metabolic Parameters and Mutational Profiles Predicts Long-Term Response to First-Line Therapy in DLBCL Patients: A Post Hoc Analysis of the SAKK38/07 Study. Cancers, 14(4). https://doi.org/10.3390/cancers14041018

Kamp JC, Neubert L, Ackermann M, Stark H, Werlein C, Fuge J, Haverich A, Tzankov A, Steinestel K, Friemann J, Boor P, Junker K, Hoeper MM, Welte T, Laenger F, Kuehnel MP, & Jonigk DD. (2022). Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19. International Journal of Molecular Sciences, 23(3). https://doi.org/10.3390/ijms23031583

Vela V, Juskevicius D, Dirnhofer S, Menter T, & Tzankov A. (2022). Mutational landscape of marginal zone B-cell lymphomas of various origin: organotypic alterations and diagnostic potential for assignment of organ origin. Virchows Archiv, 480(2), 403–413. https://doi.org/10.1007/s00428-021-03186-3

Haslbauer, Jasmin D., Zinner, Carl, Stalder, Anna K., Schneeberger, Jan, Menter, Thomas, Bassetti, Stefano, Mertz, Kirsten D., Went, Philip, Matter, Matthias S., & Tzankov, Alexandar. (2021). Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.763098

Zhu, B., Chen, S., Bai, Y., Chen, H., Mukherjee, N., Vazquez, G., McIlwain, D. R., Tzankov, A., Lee, I. T., Matter, M. S., Golstev, Y., Ma, Z., Nolan, G. P., & Jiang, S. (2021). Robust Single-cell Matching and Multi-modal Analysis Using Shared and Distinct Features Reveals Orchestrated Immune Responses [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.12.03.471185