Dr. Valentin Köhler

Rybakova, Olga, Reisinger, Josef, Rieser, Philipp, Geyer, Philipp, Gerlich, Stefan, Arndt, Markus, Kumar, Amal, Häussinger, Daniel, Mayor, Marcel, & Köhler, Valentin. (2025). Photocleavable Porphyrin Derivatives for Quantum Optics [Journal-article]. Helvetica Chimica Acta, 108(5). https://doi.org/10.1002/hlca.202500022

Hua, Y., Häussinger, D., Mayor, M., Köhler, V., Strauss, M., Mauser, M. F. X., Kostersitz, T., Geyer, P., & Arndt, M. (2025). Neutralization of an Oxytocin Derivative by 355 nm Photocleavage in High Vacuum. Helvetica Chimica Acta, 108(2). https://doi.org/10.1002/hlca.202400167

Zaitseva, S., & Köhler, V. (2024). Pyramidal Stereogenic Nitrogen Centers (SNCs). Synthesis (Germany), 57(7), 1237–1254. https://doi.org/10.1055/s-0043-1775422

Hua, Yong, Zou, Zhi, Prescimone, Alessandro, Ward, Thomas R, Mayor, Marcel, & Köhler, Valentin. (2024). NSPs: chromogenic linkers for fast, selective, and irreversible cysteine modification [Journal-article]. Chemical Science, 15(28), 10997–11004. https://doi.org/10.1039/d4sc01710b

Strauß, Marcel, Shayeghi, Armin, Mauser, Martin F. X., Geyer, Philipp, Kostersitz, Tim, Salapa, Julia, Dobrovolskiy, Oleksandr, Daly, Steven, Commandeur, Jan, Hua, Yong, Köhler, Valentin, Mayor, Marcel, Benserhir, Jad, Bruschini, Claudio, Charbon, Edoardo, Castaneda, Mario, Gevers, Monique, Gourgues, Ronan, Kalhor, Nima, et al. (2023). Highly sensitive single-molecule detection of macromolecule ion beams [Journal-article]. Science Advances, 9(48). https://doi.org/10.1126/sciadv.adj2801

Hua, Yong, Strauss, Marcel, Fisher, Sergey, Mauser, Martin F. X., Manchet, Pierre, Smacchia, Martina, Geyer, Philipp, Shayeghi, Armin, Pfeffer, Michael, Eggenweiler, Tim Henri, Daly, Steven, Commandeur, Jan, Mayor, Marcel, Arndt, Markus, Šolomek, Tomáš, & Köhler, Valentin. (2023). Giving the Green Light to Photochemical Uncaging of Large Biomolecules in High Vacuum [Journal-article]. JACS Au, 3(10), 2790–2799. https://doi.org/10.1021/jacsau.3c00351

Hua, Yong, Zou, Zhi, Prescimone, Alessandro, Ward, Thomas R., Mayor, Marcel, & Köhler, Valentin. (2023). Click, Lock & Dye: a chromogenic handle for selective cysteine modification [Posted-content]. In Chemrxiv. Cambridge University Press. https://doi.org/10.26434/chemrxiv-2023-83gph

Yu, Kun, Zou, Zhi, Igareta, Nico V., Tachibana, Ryo, Bechter, Julia, Köhler, Valentin, Chen, Dongping, & Ward, Thomas R. (2023). Artificial Metalloenzyme-Catalyzed Enantioselective Amidation via Nitrene Insertion in Unactivated C(sp3)-H Bonds [Journal-article]. Journal of the American Chemical Society, 145(30), 16621–16629. https://doi.org/10.1021/jacs.3c03969

Zaitseva, Snizhana, Prescimone, Alessandro, & Köhler, Valentin. (2023). Enantioselective Allylation of Stereogenic Nitrogen Centers. Organic Letters, 25(10), 1649–1654. https://doi.org/10.1021/acs.orglett.3c00195

Strauß, Marcel, Shayeghi, Armin, Mauser, Martin, Manchet, Pierre, Smacchia, Martina, Salapa, Julia, Kostersitz, Tim, Geyer, Philipp, Daly, Steven, Commandeur, Jan, Hua, Yong, di Silvestro, Alfredo, Mayor, Marcel, Köhler, Valentin, Benserhir, Jad, Bruschini, Claudio, Charbon, Edoardo, Castaneda, Mario, Gevers, Monique, et al. (2023). Superconducting quantum detectors and single photon charge control for mass spectrometry [Proceedings-article]. In Shahriar, Selim M.;Scheuer, Jacob (Ed.), SPIE Quantum West (Vol. 12447). SPIE. https://doi.org/10.1117/12.2657258

Gerlich, Stefan, Fein, Yaakov Y., Shayeghi, Armin, Köhler, Valentin, Mayor, Marcel, & Arndt, Markus. (2021). Otto Stern’s legacy in quantum optics: Matter waves and deflectometry. In Molecular Beams in Physics and Chemistry: From Otto Stern’s Pioneering Exploits to Present-Day Feat (pp. 547–573). Springer International Publishing. https://doi.org/10.1007/978-3-030-63963-1_24

Schätti, Jonas, Köhler, Valentin, Mayor, Marcel, Fein, Yaakov Y., Geyer, Philipp, Mairhofer, Lukas, Gerlich, Stefan, & Arndt, Markus. (2020). Matter-wave interference and deflection of tripeptides decorated with fluorinated alkyl chains. Journal of Mass Spectrometry, 55(6), e4514. https://doi.org/10.1002/jms.4514

Schätti, Jonas, Kriegleder, Moritz, Debiossac, Maxime, Kerschbaum, Michael, Geyer, Philipp, Mayor, Marcel, Arndt, Markus, & Köhler, Valentin. (2019). Neutralization of insulin by photocleavage under high vacuum. Chemical Communications, 55(83), 12507–12510. https://doi.org/10.1039/c9cc05712a

Debiossac, M., Schätti, J., Kriegleder, M., Geyer, P., Shayeghi, A., Mayor, M., Arndt, M., & Köhler, V. (2018). Tailored photocleavable peptides: fragmentation and neutralization pathways in high vacuum. Physical Chemistry Chemical Physics, 20(16), 11412–11417. https://doi.org/10.1039/c8cp01058g

Schätti, Jonas, Rieser, Philipp Rieser, Sezer, Ugur, Richter, Georg, Geyer, Philipp, Rondina, Gustavo G., Häussinger, Daniel, Mayor, Marcel, Shayeghi, Armin, Köhler, Valentin, & Arndt, Markus. (2018). Pushing the mass limit for intact launch and photoionization of large neutral biopolymers. Communications Chemistry, 1, 93. https://doi.org/10.1038/s42004-018-0095-y

Schwizer, Fabian, Okamoto, Yasunori, Heinisch, Tillmann, Gu, Yifan, Pellizzoni, Michela M., Lebrun, Vincent, Reuter, Raphael, Köhler, Valentin, Lewis, Jared C., & Ward, Thomas R. (2018). Artificial Metalloenzymes: Reaction Scope and Optimization Strategies. Chemical Reviews, 118(1), 142–231. https://doi.org/10.1021/acs.chemrev.7b00014

Schatti, J., Sezer, U., Pedalino, S., Cotter, J. P., Arndt, M., Mayor, M., & Kohler, V. (2017). Tailoring the volatility and stability of oligopeptides. Journal of Mass Spectrometry, 52(8), 550–556. https://doi.org/10.1002/jms.3959

Liu, Zhe, Lebrun, Vincent, Kitanosono, Taku, Mallin, Hendrik, Köhler, Valentin, Häussinger, Daniel, Hilvert, Donald, Kobayashi, Shu, & Ward, Thomas R. (2016). Upregulation of an Artificial Zymogen by Proteolysis. Angewandte Chemie International Edition, 55(38), 11587–11590. https://doi.org/10.1002/anie.201605010

Okamoto, Yasunori, Köhler, Valentin, Paul, Caroline E., Hollmann, Frank, & Ward, Thomas R. (2016). Efficient In Situ Regeneration of NADH Mimics by an Artificial Metalloenzyme. ACS Catalysis, 6(6), 3553–3557. https://doi.org/10.1021/acscatal.6b00258

Okamoto, Yasunori, Köhler, Valentin, & Ward, Thomas R. (2016). An NAD(P)H-Dependent Artificial Transfer Hydrogenase for Multienzymatic Cascades. Journal of the American Chemical Society, 138(18), 5782–5784. https://doi.org/10.1021/jacs.6b02470

Heinisch, Tillmann, Pellizzoni, Michaela, Dürrenberger, Marc, Tinberg, Christine E., Köhler, Valentin, Häussinger, Daniel, Klehr, Juliane, Baker, David, & Ward, Thomas R. (2015). Improving the catalytic performance of an artificial metalloenzyme by computational design. Journal of the American Chemical Society, 137(32), 9–10414. https://doi.org/10.1021/jacs.5b06622

Köhler, Valentin, & Turner, Nicholas J. (2015). Artificial concurrent catalytic processes involving enzymes. Chemical Communications, 51(3), 64–450. https://doi.org/10.1039/c4cc07277d

Quinto, Tommaso, Köhler, Valentin, Häussinger, Daniel, & Ward, Thomas R. (2015). Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H. Organic and Biomolecular Chemistry, 13, 357–360. https://doi.org/10.1039/c4ob02071e

Ward, Thomas R., & Koehler, Valentin. (2015). Editorial overview: Biocatalysis and biotransformation: Bio-inspired, bio-based and bio-linked catalys. Current Opinion in Chemical Biology, 25, v–vi. https://doi.org/10.1016/j.cbpa.2015.02.022

Genz, Maika, Köhler, Valentin, Krauss, Michael, Singer, David, Hoffmann, Ralf, Ward, Thomas R., & Sträter, Norbert. (2014). An Artificial Imine Reductase based on the Ribonuclease S Scaffold. ChemCatChem, 6(3), 736–740. https://doi.org/10.1002/cctc.201300995

Koehler, Valentin, & Ward, Thomas R. (2014). Concurrent Cross Metathesis and Enzymatic Oxidation: Enabling Off-Equilibrium Transformations. ChemCatChem, 6(8), 2191–2193. https://doi.org/10.1002/cctc.201402150

Quinto, Tommaso, Köhler, Valentin, & Ward, Thomas R. (2014). Recent Trends in Biomimetic NADH Regeneration. Topics in Catalysis, 57(5), 321–331. https://doi.org/10.1007/s11244-013-0187-y

Quinto, Tommaso, Schwizer, Fabian, Zimbron, Jeremy M., Morina, Albert, Köhler, Valentin, & Ward, Thomas R. (2014). Expanding the Chemical Diversity in Artificial Imine Reductases Based on the Biotin-Streptavidin Technology. ChemCatChem, 6(4), 1010–1014. https://doi.org/10.1002/cctc.201300825

Koehler, V., Wilson, Y. M., Duerrenberger, M., Ghislieri, D., Churakova, E., Quinto, T., Knoerr, L., Haeussinger, D., Hollmann, F., Turner, N. J., & Ward, Thomas R. (2013). Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes. Nature Chemistry, 5(2), 9–93. https://doi.org/10.1038/nchem.1498

Schwizer, Fabian, Köhler, Valentin, Dürrenberger, Marc, Knörr, Livia, & Ward, Thomas R. (2013). Genetic Optimization of the Catalytic Efficiency of Artificial Imine Reductases Based on the Biotin-Streptavidin Technology. ACS Catalysis, 3(8), 1752–1755. https://doi.org/10.1021/cs400428r

Köhler, Valentin, Mao, Jincheng, Heinisch, Tillmann, Pordea, Anca, Sardo, Alessia, Wilson, Yvonne, Knörr, Livia, Creus, Marc, Prost, Jean-Christophe, Schirmer, Tilman, & Ward, Thomas R. (2011). OsO4⋅Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective cis-Dihydroxylation of Olefins. Angewandte Chemie International Edition, 50(46), 6–10863. https://doi.org/10.1002/anie.201103632

O’Reilly, Elaine, Köhler, Valentin, Flitsch, Sabine L., & Turner, Nicholas J. (2011). Cytochromes P450 as useful biocatalysts: addressing the limitations. Chemical Communications, 47(9), 501–2490. https://doi.org/10.1039/c0cc03165h

Köhler, Valentin, & Ward, Thomas R. (2010). Design of a Functional Nitric Oxide Reductase within a Myoglobin Scaffold. Chembiochem : a European journal of chemical biology, 11(8), 51–1049. https://doi.org/10.1002/cbic.201000093

Köhler, Valentin, Wilson, Yvonne M., Lo, Cheikh, Sardo, Alessia, & Ward, Thomas R. (2010). Protein-based hybrid catalysts-design and evolution. Current Opinion in Biotechnology, 21(6), 52–744. https://doi.org/10.1016/j.copbio.2010.09.004

Köhler, Valentin, Mazet, Clément, Toussaint, Aurélie, Kulicke, Klaus, Häussinger, Daniel, Neuburger, Markus, Schaffner, Silvia, Kaiser, Stefan, & Pfaltz, Andreas. (2008). Chiral Boron-Bridged Bisoxazoline (Borabox) Ligands: Structures and Reactivities of Pd and Cu Complexes. Chemistry - A European Journal, 14(28), 9–8530. https://doi.org/10.1002/chem.200800822

Mazet, Clément, Roseblade, Stephen, Köhler, Valentin, & Pfaltz, Andreas. (2006). Kinetic Resolution of Diols and Pyridyl Alcohols by Cu(II)(borabox)-Catalyzed Acylation. Organic Letters, 8(9), 82–1879. https://doi.org/10.1021/ol060443t

Köhler, V. (2005). Neue ionische Liganden für Übergangsmetallkomplexe und deren Anwendung in der asymmetrischen Katalyse [Doctoral Thesis]. https://doi.org/10.5451/unibas-003679610

Mazet, Clément, Köhler, Valentin, & Pfaltz, Andreas. (2005). Chiral Boron-Bridged Bisoxazolines: Readily Available Anionic Ligands for Asymmetric Catalysis. Angewandte Chemie International Edition, 44(31), 91–4888. https://doi.org/10.1002/anie.200501111