Prof. Dr. David Berger

Buffle, Eric, Papadis, Athanasios, Blaser, Isaac, Nozica, Nikolas, Kassar, Mohammad, Ludwig, Roger, Berger, David, Hänggi, Matthias, Mauri, Marco, Obrist, Dominik, Seiler, Christian, & de Marchi, Stefano F. (2026). Relative Aortic Valve Stiffness: A New Parameter Quantifying Aortic Stenosis. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00804.2025

Hüser, Matthias, Lyu, Xinrui, Faltys, Martin, Pace, Alizée, Berger, David, Hoche, Marine, Hyland, Stephanie L., Yèche, Hugo, Burger, Manuel, Merz, Tobias M., & Rätsch, Gunnar. (2025). RMS: a ML-based system for ICU respiratory monitoring and resource planning. npj Digital Medicine, 8(1). https://doi.org/10.1038/s41746-025-02081-4

Hohmann, Friedrich, Fichtner, Falk, Becher, Tobias, Schaedler, Dirk, Putensen, Christian, Muders, Thomas, Schroeder, Ines, Karagiannidis, Christian, Wrigge, Hermann, Berger, David, Grupp, Margarethe, Grundeis, Felicitas, Buenger, Victoria, Sachkova, Alexandra, Henkel, Stefan, Habicher, Marit, Sander, Michael, Laudi, Sven, Weber-Carstens, Steffen, & Moerer, Onnen. (2025). Clinical Guideline for Treating Acute Respiratory Insufficiency with Invasive Ventilation and Extracorporeal Membrane Oxygenation: Updated Evidence-Based Recommendations for Choosing Modes and Setting Parameters of Mechanical Ventilation. Respiration, 1–17. https://doi.org/10.1159/000549732

Prazak, Josef, Schenk, Noëlle Valérie, Schefold, Joerg C., Bachmann, Kaspar F., & Berger, David. (2025). Effects of Preoxygenation With Intratracheal Suctioning During Extubation: An Alternating Cluster-Controlled Trial (INtratracheal suctioning and oxygenation AT Extubation [INNOVATE]). Critical Care Medicine, 53(11), e2179–e2190. https://doi.org/10.1097/ccm.0000000000006819

Bachmann, Kaspar F., & Berger, David. (2025). Estimation of Cardiac Output Under Venovenous Extracorporeal Membrane Oxygenation: Comparing Thermodilution Methods to 3D Echocardiography [Journal-article]. ASAIO Journal, 71(9). https://doi.org/10.1097/mat.0000000000002381

Jian, Zhongping, Liu, Xianfu, Kouz, Karim, Settels, Jos J., Davies, Simon, Scheeren, Thomas W.L., Fleming, Neal W., Veelo, Denise P., Vlaar, Alexander P.J., Sander, Michael, Cannesson, Maxime, Berger, David, Pinsky, Michael R., Sessler, Daniel I., Hatib, Feras, & Saugel, Bernd. (2025). Deep learning model to identify and validate hypotension endotypes in surgical and critically ill patients. British Journal of Anaesthesia, 134(2), 308–316. https://doi.org/10.1016/j.bja.2024.10.048

Bachmann, Kaspar F., Moller, Per Werner, Hunziker, Lukas, Maggiorini, Marco, & Berger, David. (2024). Mechanisms maintaining right ventricular contractility-to-pulmonary arterial elastance ratio in VA ECMO: a retrospective animal data analysis of RV–PA coupling. Journal of Intensive Care, 12(1). https://doi.org/10.1186/s40560-024-00730-6

Reiser, R., Brill, A.-K., Nakas, C. T., Hefti, U., Berger, D., Perret Hoigné, E., Kabitz, H.-J., Merz, T. M., & Pichler Hefti, J. (2024). Lung function parameters are associated with acute mountain sickness and are improved at high and extreme altitude. Respiratory Physiology and Neurobiology, 330. https://doi.org/10.1016/j.resp.2024.104318

Bachmann, Kaspar F., Haenggi, Matthias, Jakob, Stephan M., Takala, Jukka, Gattinoni, Luciano, & Berger, David. (2024). Comment on: “A novel ‘shunt fraction’ method to derive native cardiac output during liberation from central VA ECMO” by Lim, HS. ESC Heart Failure, 11(4), 2464–2466. https://doi.org/10.1002/ehf2.14804

Berger, David, Stanger, Elia J., Jenni, Hansjörg, Fried, Philipp D., & Bachmann, Kaspar F. (2024). Modified Thermodilution for Simultaneous Cardiac Output and Recirculation Assessment in Veno-venous Extracorporeal Membrane Oxygenation: A Prospective Diagnostic Accuracy Study. Anesthesiology, 140(5), 1002–1015. https://doi.org/10.1097/aln.0000000000004895

Levis, Anja, Gardill, Michael, Bachmann, Kaspar F., Berger, David, Schandl, Christian, Piquilloud, Lise, & Haenggi, Matthias. (2024). Bilateral phrenic nerve block to reduce hazardous respiratory drive in a mechanically ventilated patient with COVID ‐19—A case report [Journal-article]. Clinical Case Reports, 12(5). https://doi.org/10.1002/ccr3.8850

Petrucci, Mariafrancesca, Spadavecchia, Claudia, Bachmann, Kaspar F., Berger, David, Mirra, Alessandro, & Casoni, Daniela. (2024). The nociceptive withdrawal reflex during spinal analgesia in pigs undergoing veno-arterial extracorporeal membrane oxygenation: a prospective observational study. Frontiers in Veterinary Science, 11. https://doi.org/10.3389/fvets.2024.1449297

Messmer, Anna, Pietsch, Urs, Siegemund, Martin, Buehler, Philipp, Waskowski, Jan, Müller, Martin, Uehlinger, Dominik E., Hollinger, Alexa, Filipovic, Miodrag, Berger, David, Schefold, Joerg C., & Pfortmueller, Carmen A. (2023). Protocolised early de-resuscitation in septic shock (REDUCE): Protocol for a randomised controlled multicentre feasibility trial. BMJ Open, 13. https://doi.org/10.1136/bmjopen-2023-074847

Stanger, E. J., Berger, D. C., Jenni, H., & Bachmann, K. F. (2023). Behaviour and stability of thermodilution signals in a closed extracorporeal circuit: a bench study. Journal of Clinical Monitoring and Computing, 37(4), 1095–1102. https://doi.org/10.1007/s10877-023-01018-0

Berger, David, Wigger, Olivier, Bachmann, Kaspar F., & Bloechlinger, Stefan. (2023). Reply to La Via and colleagues. Clinical Research in Cardiology, 112(5), 702. https://doi.org/10.1007/s00392-022-02062-7

Berger, David C., Zwicker, Lena, Nettelbeck, Kay, Casoni, Daniela, Heinisch, Paul Phillipp, Jenni, Hansjörg, Haenggi, Matthias, Gattinoni, Luciano, & Bachmann, Kaspar F. (2023). Integral assessment of gas exchange during veno-arterial ECMO: accuracy and precision of a modified Fick principle in a porcine model. American Journal of Physiology - Lung Cellular and Molecular Physiology, 324(2), L102–L113. https://doi.org/10.1152/ajplung.00045.2022

Moller, P. W., & Berger, D. C. (2023). Commentary: Feasibility to estimate mean systemic filling pressure with inspiratory holds at the bedside. Frontiers in Physiology, 14. https://doi.org/10.3389/fphys.2023.1135769

Denault A, Couture EJ, De Medicis É, Shim JK, Mazzeffi M, Henderson RA, Langevin S, Dhawan R, Michaud M, Guensch DP, Berger D, Erb JM, Gebhard CE, Royse C, Levy D, Lamarche Y, Dagenais F, Deschamps A, Desjardins G, & Beaubien-Souligny W. (2022). Perioperative Doppler ultrasound assessment of portal vein flow pulsatility in high-risk cardiac surgery patients: a multicentre prospective cohort study. British Journal of Anaesthesia, 129(5), 659–669. https://doi.org/10.1016/j.bja.2022.07.053

Berger, D., Wigger, O., de Marchi, S., Grübler, M. R., Bloch, A., Kurmann, R., Stalder, O., Bachmann, K. F., & Bloechlinger, S. (2022). The effects of positive end-expiratory pressure on cardiac function: a comparative echocardiography-conductance catheter study. Clinical Research in Cardiology, 111(6), 705–719. https://doi.org/10.1007/s00392-022-02014-1

Werner-Moller, P., Heinisch, P. P., Hana, A., Bachmann, K. F., Sondergaard, S., Jakob, S. M., Takala, J., & Berger, D. (2022). Experimental validation of a mean systemic pressure analog against zero-flow measurements in porcine VA-ECMO. Journal of Applied Physiology, 132(3), 726–736. https://doi.org/10.1152/japplphysiol.00804.2021

Heliste, M., Pettilä, V., Berger, D., Jakob, S. M., & Wilkman, E. (2022). Beta-blocker treatment in the critically ill: a systematic review and meta-analysis. Annals of Medicine, 54(1), 1994–2010. https://doi.org/10.1080/07853890.2022.2098376

Bachmann, Kaspar Felix, Vasireddy, Rakesh, Heinisch, Paul Philipp, Jenni, Hansjörg, Vogt, Andreas, & Berger, David. (2021). Estimating cardiac output based on gas exchange during veno-arterial extracorporeal membrane oxygenation in a simulation study using paediatric oxygenators. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-90747-w

Berger-Estilita, J., Haenggi, M., Ott, D., & Berger, D. (2021). Accuracy of the end-expiratory lung volume measured by the modified nitrogen washout/washin technique: a bench study. Journal of Translational Medicine, 19(1). https://doi.org/10.1186/s12967-021-02703-x

Kuhn, K. F., Grunow, J. J., Leimer, P., Lorenz, M., Berger, D., Schefold, J. C., Weber-Carstens, S., & Schaller, S. J. (2021). Assessment of magnetic flux density properties of electromagnetic noninvasive phrenic nerve stimulations for environmental safety in an ICU environment. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-95489-3

Valenti, E., Moller, P. W., Takala, J., & Berger, D. (2021). Collapsibility of caval vessels and right ventricular afterload: Decoupling of stroke volume variation from preload during mechanical ventilation. Journal of Applied Physiology, 130(5), 1562–1572. https://doi.org/10.1152/japplphysiol.01039.2020

Zante, Bjoern, Berger, David C., Schefold, Joerg C., & Bachmann, Kaspar F. (2021). Dissociation of Arterial Oxygen Saturation and Oxygen Delivery in VV-ECMO: The Trend Is Your Friend. Journal of Cardiothoracic and Vascular Anesthesia, 35(3), 962–963. https://doi.org/10.1053/j.jvca.2020.06.084

Sweda, Romy, Berger, David, Heverhagen, Johannes T, & Hunziker, Lukas. (2020). Pulmonary haemorrhage on veno-arterial ECMO: Consequences of missed aortic valve regurgitation. European Heart Journal, 41(47), 4530. https://doi.org/10.1093/eurheartj/ehaa825

Berger, D., Hobi, J., Möller, P. W., Haenggi, M., Takala, J., & Jakob, S. M. (2020). Right ventricular stroke volume assessed by pulmonary artery pulse contour analysis. Intensive Care Medicine Experimental , 8(1). https://doi.org/10.1186/s40635-020-00347-7

Bachmann, Kaspar F, & Berger, David. (2020). Impaired membrane lung CO2 elimination: is it dead space, V/Q ratio or acidosis? Perfusion (United Kingdom), 35(8), 875–877. https://doi.org/10.1177/0267659120947379

Zdravkovic, M., Berger-Estilita, J., Zdravkovic, B., & Berger, D. (2020). Scientific quality of COVID-19 and SARS CoV-2 publications in the highest impact medical journals during the early phase of the pandemic: A case control study. PLoS ONE, 15(11 November). https://doi.org/10.1371/journal.pone.0241826

Zuercher, P., Schenk, N. V., Moret, C., Berger, D., Abegglen, R., & Schefold, J. C. (2020). Risk Factors for Dysphagia in ICU Patients After Invasive Mechanical Ventilation. Chest, 158(5), 1983–1991. https://doi.org/10.1016/j.chest.2020.05.576

Bachmann, Kaspar F., Zwicker, Lena, Nettelbeck, Kay, Casoni, Daniela, Heinisch, Paul Phillipp, Jenni, Hansjörg, Haenggi, Matthias, & Berger, David. (2020). Assessment of Right Heart Function during Extracorporeal Therapy by Modified Thermodilution in a Porcine Model. Anesthesiology, 133(4), 879–891. https://doi.org/10.1097/aln.0000000000003443

Mosbahi, S., Heinisch, P.-P., Schoenhoff, F. S., & Berger, D. C. (2020). COVID-19-associated aortic arch thrombus. European Journal of Cardio-Thoracic Surgery, 58(4). https://doi.org/10.1093/ejcts/ezaa304

Liu, S., do Amaral Campos, P. P. Z., Casoni, D., Berger, D., Kohler, A., Bloch, A., Bervini, D., Setzer, F., Cameron, D. R., Z’Graggen, W., Hana, A., Langer, R., Corrêa, T. D., Beldi, G., Takala, J., & Jakob, S. M. (2020). Defense mechanisms to increasing back pressure for hepatic oxygen transport and venous return in porcine fecal peritonitis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 319(3), G289–G302. https://doi.org/10.1152/ajpgi.00216.2020

Bachmann, Kaspar F., Haenggi, Matthias, Jakob, Stephan M., Takala, Jukka, Gattinoni, Luciano, & Berger, David. (2020). Gas exchange calculation may estimate changes in pulmonary blood flow during veno-arterial extracorporeal membrane oxygenation in a porcine model. American Journal of Physiology - Lung Cellular and Molecular Physiology, 318(6), L1211–L1221. https://doi.org/10.1152/ajplung.00167.2019

Liu, S., Moller, P. W., Kohler, A., Hana, A., Beldi, G., Obrist, D., Berger, D., Takala, J., & Jakob, S. M. (2020). Effects of Trendelenburg position and increased airway pressure on hepatic regional blood flow of normal and resected liver. Journal of Applied Physiology, 128(3), 667–680. https://doi.org/10.1152/japplphysiol.00705.2019

Werner-Moller, P., Berger, D., & Takala, J. (2020). Letter to the Editor: Venous return and the physical connection between distribution of segmental pressures and volumes. American Journal of Physiology - Heart and Circulatory Physiology, 318(1), H203–H204. https://doi.org/10.1152/ajpheart.00698.2019

Merz, T. M., Cioccari, L., Frey, P. M., Bloch, A., Berger, D., Zante, B., Jakob, S. M., & Takala, J. (2019). Continual hemodynamic monitoring with a single-use transesophageal echocardiography probe in critically ill patients with shock: a randomized controlled clinical trial. Intensive Care Medicine, 45(8), 1093–1102. https://doi.org/10.1007/s00134-019-05670-6

Moller, P. W., Hana, A., Heinisch, P. P., Liu, S., Djafarzadeh, S., Haenggi, M., Bloch, A., Takala, J., Jakob, S. M., & Berger, D. (2019). THE EFFECTS OF VASOCONSTRICTION AND VOLUME EXPANSION ON VENO-ARTERIAL ECMO FLOW. Shock, 51(5), 650–658. https://doi.org/10.1097/shk.0000000000001197

Berger, D., Moller, P. W., & Takala, J. (2019). Reply to “Is the Guytonian framework justified in explaining heart lung interactions?” and “Venous return, mean systemic pressure and getting the right answer for the wrong reason” [Journal-article]. Annals of Translational Medicine, 7(8), 186. https://doi.org/10.21037/atm.2019.04.50

Moller, P. W., & Berger, D. (2019). Reply to “What if what you are looking for is not there?” and “Towards a functional definition of euvolemia”. Journal of Applied Physiology, 127(1). https://doi.org/10.1152/japplphysiol.00229.2019

Werner-Moller, P., Sondergaard, S., Jakob, S. M., Takala, J., & Berger, D. (2019). Effect of volume status on the estimation of mean systemic filling pressure. Journal of Applied Physiology, 126(6), 1503–1513. https://doi.org/10.1152/japplphysiol.00897.2018

Cioccari, L., Zante, B., Bloch, A., Berger, D., Limacher, A., Jakob, S. M., Takala, J., & Merz, T. M. (2018). Correction to: Effects of hemodynamic monitoring using a single-use transesophageal echocardiography probe in critically ill patients - study protocol for a randomized controlled trial (Trials (2018) 19 (362) DOI: 10.1186/s13063-018-2714-4). Trials, 19(1). https://doi.org/10.1186/s13063-018-3001-0

Berger, D., & Takala, J. (2018). Determinants of systemic venous return and the impact of positive pressure ventilation [Journal-article]. Annals of Translational Medicine, 6(18), 350. https://doi.org/10.21037/atm.2018.05.27

Wigger, O., Bloechlinger, S., Berger, D., Häner, J., Zanchin, T., Windecker, S., Räber, L., & Schefold, J. C. (2018). Baseline serum bicarbonate levels independently predict short-term mortality in critically ill patients with ischaemic cardiogenic shock. European Heart Journal: Acute Cardiovascular Care, 7(1), 45–52. https://doi.org/10.1177/2048872616683526

Bloch, A., Von Arx, R., Etter, R., Berger, D., Kaiser, H., Lenz, A., & Merz, T. M. (2017). Impact of Simulator-Based Training in Focused Transesophageal Echocardiography: A Randomized Controlled Trial. Anesthesia and Analgesia, 125(4), 1140–1148. https://doi.org/10.1213/ane.0000000000002351

Moller, P. W., Winkler, B., Hurni, S., Heinisch, P. P., Bloch, A., Sondergaard, S., Jakob, S. M., Takala, J., & Berger, D. (2017). Right atrial pressure and venous return during cardiopulmonary bypass. American Journal of Physiology - Heart and Circulatory Physiology, 313(2), H408–H420. https://doi.org/10.1152/ajpheart.00081.2017

Bloch, A., Kohler, A., Posthaus, H., Berger, D., Santos, L., Jakob, S., Takala, J., & Haenggi, M. (2017). Gastrointestinal Impedance Spectroscopy to Detect Hypoperfusion during Hemorrhage. Shock, 48(2), 185–195. https://doi.org/10.1097/shk.0000000000000824

Jakob, S. M., Bütikofer, L., Berger, D., Coslovsky, M., & Takala, J. (2017). A randomized controlled pilot study to evaluate the effect of an enteral formulation designed to improve gastrointestinal tolerance in the critically ill patient-the SPIRIT trial. Critical Care, 21(1). https://doi.org/10.1186/s13054-017-1730-1

Berger, D., & Schefold, J. C. (2017). Life ain’t no SOFA-Considerations after yet another failed clinical sepsis trial. Journal of Thoracic Disease, 9(3), 438–440. https://doi.org/10.21037/jtd.2017.02.68

Karavana, V., Smith, I., Kanellis, G., Sigala, I., Kinsella, T., Zakynthinos, S., Liu, L., Chen, J., Zhang, X., Liu, A., Guo, F., Liu, S., Yang, Y., Qiu, H., Grimaldi, D. G., Kaya, E., Acicbe, O., Kayaalp, I., Asar, S., et al. (2017). 37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3) [Journal-article]. Critical Care, 21(S1). https://doi.org/10.1186/s13054-017-1628-y

Grübler Martin, R., Olivier, W., David, B., & Stefan, B. (2017). Basic concepts of heart-lung interactions during mechanical ventilation. Swiss Medical Weekly, 147(37-38). https://doi.org/10.4414/smw.2017.14491

Schefold, J. C., Berger, D., Zürcher, P., Lensch, M., Perren, A., Jakob, S. M., Parviainen, I., & Takala, J. (2017). Dysphagia in mechanically ventilated ICU patients (Dynamics): A prospective observational trial. Critical Care Medicine, 45(12), 2061–2069. https://doi.org/10.1097/ccm.0000000000002765

Bloch, A., Berger, D., & Takala, J. (2016). Understanding circulatory failure in sepsis. Intensive Care Medicine, 42(12), 2077–2079. https://doi.org/10.1007/s00134-016-4514-1

Berger, D., Bloechlinger, S., von Haehling, S., Doehner, W., Takala, J., Z’Graggen, W. J., & Schefold, J. C. (2016). Dysfunction of respiratory muscles in critically ill patients on the intensive care unit. Journal of Cachexia, Sarcopenia and Muscle, 7(4), 403–412. https://doi.org/10.1002/jcsm.12108

Berger, D., Moller, P. W., Weber, A., Bloch, A., Bloechlinger, S., Haenggi, M., Sondergaard, S., Jakob, S. M., Magder, S., & Takala, J. (2016). Effect of PEEP, blood volume, and inspiratory hold maneuvers on venous return. American Journal of Physiology - Heart and Circulatory Physiology, 311(3), H794–H806. https://doi.org/10.1152/ajpheart.00931.2015

Berger, D., & Takala, J. (2016). Hypotension and hypovolemia during hemodialysis: Is the usual suspect innocent? Critical Care, 20(1). https://doi.org/10.1186/s13054-016-1307-4

Berger, D., Moller, P. W., & Takala, J. (2016). Reply to “Letter to the editor: Why persist in the fallacy that mean systemic pressure drives venous return?”. American Journal of Physiology - Heart and Circulatory Physiology, 311(5), H1336–H1337. https://doi.org/10.1152/ajpheart.00622.2016

Berlet, T., Etter, R., Fehr, T., Berger, D., Sendi, P., & Merz, T. M. (2015). Sonographic patterns of lung consolidation in mechanically ventilated patients with and without ventilator-associated pneumonia: A prospective cohort study. Journal of Critical Care, 30(2), 327–333. https://doi.org/10.1016/j.jcrc.2014.11.021

Bloechlinger, S., Berger, D., Bryner, J., Roost, E., Jakob, S., Dünser, M. W., & Takala, J. (2015). Changes in Left Ventricular Torsion Early Postoperatively after Aortic Valve Replacement and at Long-Term Follow-up. Journal of Cardiothoracic and Vascular Anesthesia, 29(4), 860–867. https://doi.org/10.1053/j.jvca.2015.01.010

Berger, D., Bloechlinger, S., Takala, J., Sinderby, C., & Brander, L. (2014). Heart-lung interactions during neurally adjusted ventilatory assist. Critical Care, 18(5). https://doi.org/10.1186/s13054-014-0499-8

Bloechlinger, S., Berger, D., Bryner, J., Wiegand, J., Dünser, M. W., & Takala, J. (2013). Left ventricular torsion abnormalities in septic shock and corrective effect of volume loading: A pilot study. Canadian Journal of Cardiology, 29(12), 1665–1671. https://doi.org/10.1016/j.cjca.2013.10.007

Ceschi A, Berger D, Dickenmann M, & Bodmer M. (2013). Pharmacokinetics of meprobamate in overdose treated with continuous venovenous hemodiafiltration (CVVHDF). Hemodialysis International, 17(4), 656–659. https://doi.org/10.1111/hdi.12047

Cioccari, L., Baur, H.-R., Berger, D., Wiegand, J., Takala, J., & Merz, T. M. (2013). Hemodynamic assessment of critically ill patients using a miniaturized transesophageal echocardiography probe. Critical Care, 17(3). https://doi.org/10.1186/cc12793

Bernasconi M., Berger D., Tamm M., & Stolz D. (2012). Aquarism: An innocent leisure activity? Respiration, 84(5), 436–439. https://doi.org/10.1159/000338789

Berger, D., Rothen, H., & Brander, L. (2011). Acute Respiratory Distress Syndrome [Journal-article]. Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, 11(14). https://doi.org/10.4414/smf.2011.07482

Berger, D., Pichler, W., Savic, S., Schoenenberger, R., & Borer, H. (2007). Fever, pneumonia and eosinophilia. Praxis, 96, 1543–1547. https://doi.org/10.1024/1661-8157.96.40.1543