Dr. Friederike Holze

Avram, Mihai, Fortea, Lydia, Wollner, Lea, Coenen, Ricarda, Korda, Alexandra, Rogg, Helena, Holze, Friederike, Vizeli, Patrick, Ley, Laura, Radua, Joaquim, Müller, Felix, Liechti, Matthias E., & Borgwardt, Stefan. (2025). Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine [Journal-article]. Molecular Psychiatry, 30(4), 1297–1307. https://doi.org/10.1038/s41380-024-02734-y

Gasser, P., Liechti, M. E., & Holze, F. (2025). Treatment of neuropathic pain with repeated low-dose MDMA: a case report. Frontiers in Psychiatry, 16. https://doi.org/10.3389/fpsyt.2025.1513022

Atila, Cihan, Straumann, Isabelle, Vizeli, Patrick, Beck, Julia, Monnerat, Sophie, Holze, Friederike, Liechti, Matthias E., & Christ-Crain, Mirjam. (2024). Oxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA network open, 7(11). https://doi.org/10.1001/jamanetworkopen.2024.45278

Avram, Mihai, Müller, Felix, Preller, Katrin H., Razi, Adeel, Rogg, Helena, Korda, Alexandra, Holze, Friederike, Vizeli, Patrick, Ley, Laura, Liechti, Matthias E., & Borgwardt, Stefan. (2024). Effective Connectivity of Thalamocortical Interactions Following d-Amphetamine, LSD, and MDMA Administration. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(5), 522–532. https://doi.org/10.1016/j.bpsc.2023.07.010

Holze, Friederike, Singh, Nirmal, Liechti, Matthias E., & D’Souza, Deepak Cyril. (2024). Serotonergic Psychedelics: A Comparative Review of Efficacy, Safety, Pharmacokinetics, and Binding Profile. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(5), 472–489. https://doi.org/10.1016/j.bpsc.2024.01.007

Holze, Friederike, Erne, Livio, Duthaler, Urs, & Liechti, Matthias E. (2024). Pharmacokinetics, pharmacodynamics and urinary recovery of oral lysergic acid diethylamide administration in healthy participants. British Journal of Clinical Pharmacology, 90(1), 200–208. https://doi.org/10.1111/bcp.15887

Stocker, Kurt, Hartmann, Matthias, Ley, Laura, Becker, Anna M, Holze, Friederike, & Liechti, Matthias E. (2024). The revival of the psychedelic experience scale: Revealing its extended-mystical, visual, and distressing experiential spectrum with LSD and psilocybin studies. Journal of Psychopharmacology, 38(1), 80–100. https://doi.org/10.1177/02698811231199112

Straumann, Isabelle, Ley, Laura, Holze, Friederike, Becker, Anna M., Klaiber, Aaron, Wey, Kathrin, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants. Neuropsychopharmacology, 48(13), 1840–1848. https://doi.org/10.1038/s41386-023-01609-0

Vogt, Severin B., Ley, Laura, Erne, Livio, Straumann, Isabelle, Becker, Anna M., Klaiber, Aaron, Holze, Friederike, Vandersmissen, Anja, Mueller, Lorenz, Duthaler, Urs, Rudin, Deborah, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants. Translational Psychiatry, 13(1). https://doi.org/10.1038/s41398-023-02477-4

Ley, Laura, Holze, Friederike, Arikci, Denis, Becker, Anna M., Straumann, Isabelle, Klaiber, Aaron, Coviello, Fabio, Dierbach, Sophie, Thomann, Jan, Duthaler, Urs, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants. Neuropsychopharmacology, 48(11), 1659–1667. https://doi.org/10.1038/s41386-023-01607-2

Ley, Laura, Holze, Friederike, Arikci, Denis, Becker, Anna M., Straumann, Isabelle, Klaiber, Aaron, Coviello, Fabio, Dierbach, Sophie, Thomann, Jan, Duthaler, Urs, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants [Journal-article]. Neuropsychopharmacology, 48(11), 1659–1667. https://doi.org/10.1038/s41386-023-01607-2

Atila, Cihan, Holze, Friederike, Murugesu, Rakithan, Rommers, Nikki, Hutter, Nina, Varghese, Nimmy, Sailer, Clara O, Eckert, Anne, Heinrichs, Markus, Liechti, Matthias E, & Christ-Crain, Mirjam. (2023). Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial. The Lancet Diabetes and Endocrinology, 11(7), 454–464. https://doi.org/10.1016/S2213-8587(23)00120-1

Bedford, Peter, Hauke, Daniel J., Wang, Zheng, Roth, Volker, Nagy-Huber, Monika, Holze, Friederike, Ley, Laura, Vizeli, Patrick, Liechti, Matthias E., Borgwardt, Stefan, Müller, Felix, & Diaconescu, Andreea O. (2023). The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity. Neuropsychopharmacology, 48(8), 1175–1183. https://doi.org/10.1038/s41386-023-01574-8

Holze, Friederike, Becker, Anna M., Kolaczynska, Karolina E., Duthaler, Urs, & Liechti, Matthias E. (2023). Pharmacokinetics and Pharmacodynamics of Oral Psilocybin Administration in Healthy Participants. Clinical Pharmacology and Therapeutics, 113(4), 822–831. https://doi.org/10.1002/cpt.2821

Becker, Anna M., Klaiber, Aaron, Holze, Friederike, Istampoulouoglou, Ioanna, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Ketanserin Reverses the Acute Response to LSD in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Participants. International Journal of Neuropsychopharmacology, 26(2), 97–106. https://doi.org/10.1093/ijnp/pyac075

Holze, Friederike, Gasser, Peter, Müller, Felix, Dolder, Patrick C., & Liechti, Matthias E. (2023). Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study. Biological Psychiatry, 93(3), 215–223. https://doi.org/10.1016/j.biopsych.2022.08.025

Avram, Mihai, Müller, Felix, Rogg, Helena, Korda, Alexandra, Andreou, Christina, Holze, Friederike, Vizeli, Patrick, Ley, Laura, Liechti, Matthias E., & Borgwardt, Stefan. (2022). Characterizing Thalamocortical (Dys)connectivity Following D-Amphetamine, LSD, and MDMA Administration. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(9), 885–894. https://doi.org/10.1016/j.bpsc.2022.04.003

Holze, Friederike, Ley, Laura, Müller, Felix, Becker, Anna M., Straumann, Isabelle, Vizeli, Patrick, Kuehne, Sebastian Silva, Roder, Marc A., Duthaler, Urs, Kolaczynska, Karolina E., Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2022). Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects [Journal-article]. Neuropsychopharmacology, 47(6), 1180–1187. https://doi.org/10.1038/s41386-022-01297-2

Holze, Friederike, Liechti, Matthias E, Hutten, Nadia R P W, Mason, Natasha L, Dolder, Patrick C, Theunissen, Eef L, Duthaler, Urs, Feilding, Amanda, Ramaekers, Johannes G, & Kuypers, Kim P C. (2021). Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants. Clinical Pharmacology and Therapeutics, 109(3), 658–666. https://doi.org/10.1002/cpt.2057

Holze, Friederike, Liechti, Matthias E., Hutten, Nadia R.P.W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., Duthaler, Urs, Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P.C. (2021). Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants. Clinical Pharmacology and Therapeutics, 109(3), 658–666. https://doi.org/10.1002/cpt.2057

Holze, Friederike, Vizeli, Patrick, Ley, Laura, Müller, Felix, Dolder, Patrick, Stocker, Melanie, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2021). Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 46(3), 537–544. https://doi.org/10.1038/s41386-020-00883-6

Holze, Friederike, Vizeli, Patrick, Ley, Laura, Müller, Felix, Dolder, Patrick, Stocker, Melanie, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2021). Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 46(3), 537–544. https://doi.org/10.1038/s41386-020-00883-6

Müller, Felix, Holze, Friederike, Dolder, Patrick, Ley, Laura, Vizeli, Patrick, Soltermann, Alain, Liechti, Matthias E, & Borgwardt, Stefan. (2021). MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens. Neuropsychopharmacology, 46(3), 545–553. https://doi.org/10.1038/s41386-020-00906-2

Müller, Felix, Holze, Friederike, Dolder, Patrick, Ley, Laura, Vizeli, Patrick, Soltermann, Alain, Liechti, Matthias E., & Borgwardt, Stefan. (2021). MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens. Neuropsychopharmacology, 46(3), 545–553. https://doi.org/10.1038/s41386-020-00906-2

Liechti, Matthias E., & Holze, Friederike. (2021). Dosing Psychedelics and MDMA. Current Topics in Behavioral Neurosciences, in press. https://doi.org/10.1007/7854_2021_270

Hutten, Nadia R P W, Mason, Natasha L, Dolder, Patrick C, Theunissen, Eef L, Holze, Friederike, Liechti, Matthias E, Feilding, Amanda, Ramaekers, Johannes G, & Kuypers, Kim P C. (2020). Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study. European Neuropsychopharmacology, 41, 81–91. https://doi.org/10.1016/j.euroneuro.2020.10.002

Hutten, Nadia R.P.W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., Holze, Friederike, Liechti, Matthias E., Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P.C. (2020). Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study. European Neuropsychopharmacology, 41, 81–91. https://doi.org/10.1016/j.euroneuro.2020.10.002

Müller, Felix, Mühlhauser, Markus, Holze, Friederike, Lang, Undine E, Walter, Marc, Liechti, Matthias E, & Borgwardt, Stefan. (2020). Treatment of a Complex Personality Disorder Using Repeated Doses of LSD—A Case Report on Significant Improvements in the Absence of Acute Drug Effects. Frontiers in Psychiatry, 11, 573953. https://doi.org/10.3389/fpsyt.2020.573953

Müller, Felix, Mühlhauser, Markus, Holze, Friederike, Lang, Undine E., Walter, Marc, Liechti, Matthias E., & Borgwardt, Stefan. (2020). Treatment of a Complex Personality Disorder Using Repeated Doses of LSD—A Case Report on Significant Improvements in the Absence of Acute Drug Effects. Frontiers in Psychiatry, 11. https://doi.org/10.3389/fpsyt.2020.573953

Steuer, Andrea E., Kaelin, Daria, Boxler, Martina I., Eisenbeiss, Lisa, Holze, Friederike, Vizeli, Patrick, Czerwinska, Joanna, Dargan, Paul I., Abbate, Vincenzo, Liechti, Matthias E., & Kraemer, Thomas. (2020). Comparative untargeted metabolomics analysis of the psychostimulants 3,4-methylenedioxy-methamphetamine (MDMA), amphetamine, and the novel psychoactive substance mephedrone after controlled drug administration to humans. Metabolites, 10(8), 1–20. https://doi.org/10.3390/metabo10080306

Steuer, Andrea E, Kaelin, Daria, Boxler, Martina I, Eisenbeiss, Lisa, Holze, Friederike, Vizeli, Patrick, Czerwinska, Joanna, Dargan, Paul I, Abbate, Vincenzo, Liechti, Matthias E, & Kraemer, Thomas. (2020). Comparative untargeted metabolomics analysis of the psychostimulants 3,4-methylenedioxy-methamphetamine (MDMA), amphetamine, and the novel psychoactive substance mephedrone after controlled drug administration to humans. Metabolites, 10(8), 1–20. https://doi.org/10.3390/metabo10080306

Holze, Friederike, Duthaler, Urs, Vizeli, Patrick, Müller, Felix, Borgwardt, Stefan, & Liechti, Matthias E. (2019). Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects. British Journal of Clinical Pharmacology, 85(7), 1474–1483. https://doi.org/10.1111/bcp.13918

Holze, Friederike, Duthaler, Urs, Vizeli, Patrick, Müller, Felix, Borgwardt, Stefan, & Liechti, Matthias E. (2019). Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects. British Journal of Clinical Pharmacology, 85, 1474–1483. https://doi.org/10.1111/bcp.13918

Liechti, Matthias E., & Holze, Friederike. (2022). Dosing Psychedelics and MDMA. In Current Topics in Behavioral Neurosciences (Vol. 56, pp. 3–21). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/7854_2021_270

Ley, L., Liechti, M. E., Becker, A. M., Straumann, I., Klaiber, A., Holze, F., Vogt, S. B., Arikci, D., & Schmid, Y. (2025). Motivation and retrospective appraisal of psychedelic study participation: a qualitative study in healthy volunteers [Journal-article]. Psychopharmacology. https://doi.org/10.1007/s00213-025-06772-4

Holze, F., Madsen, M. K., Svarer, C., Gillings, N., Stenbaek, D. S., Rudin, D., Duthaler, U., Liechti, M. E., Fisher, P. M., & Knudsen, G. M. (2024). Ketanserin exhibits dose- and concentration-proportional serotonin 2A receptor occupancy in healthy individuals: Relevance for psychedelic research [Journal-article]. European Neuropsychopharmacology, 88, 43–48. https://doi.org/10.1016/j.euroneuro.2024.07.003

Calder, A. E., Rausch, B., Liechti, M. E., Holze, F., & Hasler, G. (2024). Naturalistic psychedelic therapy: The role of relaxation and subjective drug effects in antidepressant response [Journal-article]. Journal of Psychopharmacology, 38(10), 873–886. https://doi.org/10.1177/02698811241278873

Holze, F., Gasser, P., Müller, F., Strebel, M., & Liechti, M. E. (2024). LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up [Journal-article]. British Journal of Psychiatry, 225(3), 362–370. https://doi.org/10.1192/bjp.2024.99

Straumann, I., Holze, F., Becker, A. M., Ley, L., Halter, N., & Liechti, M. E. (2024). Safety pharmacology of acute psilocybin administration in healthy participants [Journal-article]. Neuroscience Applied, 3, 104060. https://doi.org/10.1016/j.nsa.2024.104060

Bedford, P., Hauke, D. J., Wang, Z., Roth, V., Nagy-Huber, M., Holze, F., Ley, L., Vizeli, P., Liechti, M. E., Borgwardt, S., Müller, F., & Diaconescu, A. O. (2022). The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.11.01.514687

Becker, Anna M., Holze, Friederike, Grandinetti, Tanja, Klaiber, Aaron, Toedtli, Vanja E., Kolaczynska, Karolina E., Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Grünblatt, Edna, & Liechti, Matthias E. (2022). Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects. Clinical Pharmacology & Therapeutics, 111(4), 886–895. https://doi.org/10.1002/cpt.2487

Holze, Friederike, Caluori, Toya V., Vizeli, Patrick, & Liechti, Matthias E. (2022). Safety pharmacology of acute LSD administration in healthy subjects. Psychopharmacology, 239(6), 1893–1905. https://doi.org/10.1007/s00213-021-05978-6

Holze, Friederike, Caluori, Toya V., Vizeli, Patrick, & Liechti, Matthias E. (2022). Correction to: Safety pharmacology of acute LSD administration in healthy subjects. Psychopharmacology, 239(2), 661. https://doi.org/10.1007/s00213-021-05988-4

Holze, Friederike, Ley, Laura, Müller, Felix, Becker, Anna M., Straumann, Isabelle, Vizeli, Patrick, Kuehne, Sebastian Silva, Roder, Marc A., Duthaler, Urs, Kolaczynska, Karolina E., Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2022). Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 47(6), 1180–1187. https://doi.org/10.1038/s41386-022-01297-2

Müller, Felix, Kraus, Elias, Holze, Friederike, Becker, Anna, Ley, Laura, Schmid, Yasmin, Vizeli, Patrick, Liechti, Matthias E., & Borgwardt, Stefan. (2022). Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants. Psychopharmacology, 239(6), 1933–1943. https://doi.org/10.1007/s00213-022-06066-z

Holze, Friederike, Avedisian, Isidora, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2021). Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin. Frontiers in Pharmacology, 12, 711255. https://doi.org/10.3389/fphar.2021.711255

Hutten, Nadia R. P. W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., Holze, Friederike, Liechti, Matthias E., Varghese, Nimmy, Eckert, Anne, Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P. C. (2021). Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers. ACS Pharmacology & Translational Science, 4(2), 461–466. https://doi.org/10.1021/acsptsci.0c00099

Ramaekers, Johannes G., Hutten, Nadia, Mason, Natasha L., Dolder, Patrick, Theunissen, Eef L., Holze, Friederike, Liechti, Matthias E., Feilding, Amanda, & Kuypers, Kim P. C. (2021). A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers. Journal of Psychopharmacology, 35(4), 398–405. https://doi.org/10.1177/0269881120940937

Vizeli, Patrick, Straumann, Isabelle, Holze, Friederike, Schmid, Yasmin, Dolder, Patrick C., & Liechti, Matthias E. (2021). Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis. Scientific Reports, 11(1), 10851. https://doi.org/10.1038/s41598-021-90343-y

Holze, Friederike, Vizeli, Patrick, Müller, Felix, Ley, Laura, Duerig, Raoul, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2020). Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects. Neuropsychopharmacology, 45(3), 462–471. https://doi.org/10.1038/s41386-019-0569-3

Dolder, Patrick C., Holze, Friederike, Liakoni, Evangelia, Harder, Samuel, Schmid, Yasmin, & Liechti, Matthias E. (2017). Alcohol acutely enhances decoding of positive emotions and emotional concern for positive stimuli and facilitates the viewing of sexual images. Psychopharmacology, 234(1), 41–51. https://doi.org/10.1007/s00213-016-4431-6

de Wit, Harriet, Holze, Friederike, & Preller, Katrin H. (2024). Psychedelics in Medicine: Can Evidence Keep Up With Enthusiasm? Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(5), 460–461. https://doi.org/10.1016/j.bpsc.2024.02.010