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Gasser, P., Liechti, M. E., & Holze, F. (2025). Treatment of neuropathic pain with repeated low-dose MDMA: a case report. Frontiers in Psychiatry, 16. https://doi.org/10.3389/fpsyt.2025.1513022
Atila, Cihan, Straumann, Isabelle, Vizeli, Patrick, Beck, Julia, Monnerat, Sophie, JAMA network open, 7(11). https://doi.org/10.1001/jamanetworkopen.2024.45278
, Liechti, Matthias E., & Christ-Crain, Mirjam. (2024). Oxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia: A Secondary Analysis of 4 Randomized Clinical Trials. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(5), 472–489. https://doi.org/10.1016/j.bpsc.2024.01.007
, Singh, Nirmal, Liechti, Matthias E., & D’Souza, Deepak Cyril. (2024). Serotonergic Psychedelics: A Comparative Review of Efficacy, Safety, Pharmacokinetics, and Binding Profile. Avram, Mihai, Fortea, Lydia, Wollner, Lea, Coenen, Ricarda, Korda, Alexandra, Rogg, Helena, Molecular Psychiatry. https://doi.org/10.1038/s41380-024-02734-y
, Vizeli, Patrick, Ley, Laura, Radua, Joaquim, Müller, Felix, Liechti, Matthias E., & Borgwardt, Stefan. (2024). Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine [Journal-article]. Avram, Mihai, Müller, Felix, Preller, Katrin H., Razi, Adeel, Rogg, Helena, Korda, Alexandra, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9, 522–532. https://doi.org/10.1016/j.bpsc.2023.07.010
, Vizeli, Patrick, Ley, Laura, Liechti, Matthias E., & Borgwardt, Stefan. (2024). Effective Connectivity of Thalamocortical Interactions Following d-Amphetamine, LSD, and MDMA Administration. British Journal of Clinical Pharmacology, 90(1), 200–208. https://doi.org/10.1111/bcp.15887
, Erne, Livio, Duthaler, Urs, & Liechti, Matthias E. (2024). Pharmacokinetics, pharmacodynamics and urinary recovery of oral lysergic acid diethylamide administration in healthy participants. Stocker, Kurt, Hartmann, Matthias, Ley, Laura, Becker, Anna M, Journal of Psychopharmacology, 38(1), 80–100. https://doi.org/10.1177/02698811231199112
, & Liechti, Matthias E. (2024). The revival of the psychedelic experience scale: Revealing its extended-mystical, visual, and distressing experiential spectrum with LSD and psilocybin studies. Straumann, Isabelle, Ley, Laura, Neuropsychopharmacology, 48(13), 1840–1848. https://doi.org/10.1038/s41386-023-01609-0
, Becker, Anna M., Klaiber, Aaron, Wey, Kathrin, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants. Vogt, Severin B., Ley, Laura, Erne, Livio, Straumann, Isabelle, Becker, Anna M., Klaiber, Aaron, Translational Psychiatry, 13(1). https://doi.org/10.1038/s41398-023-02477-4
, Vandersmissen, Anja, Mueller, Lorenz, Duthaler, Urs, Rudin, Deborah, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants. Ley, Laura, Neuropsychopharmacology, 48(11), 1659–1667. https://doi.org/10.1038/s41386-023-01607-2
, Arikci, Denis, Becker, Anna M., Straumann, Isabelle, Klaiber, Aaron, Coviello, Fabio, Dierbach, Sophie, Thomann, Jan, Duthaler, Urs, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants. Ley, Laura, Neuropsychopharmacology, 48(11), 1659–1667. https://doi.org/10.1038/s41386-023-01607-2
, Arikci, Denis, Becker, Anna M., Straumann, Isabelle, Klaiber, Aaron, Coviello, Fabio, Dierbach, Sophie, Thomann, Jan, Duthaler, Urs, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants [Journal-article]. Clinical Pharmacology and Therapeutics, 113(4), 822–831. https://doi.org/10.1002/cpt.2821
, Becker, Anna M., Kolaczynska, Karolina E., Duthaler, Urs, & Liechti, Matthias E. (2023). Pharmacokinetics and Pharmacodynamics of Oral Psilocybin Administration in Healthy Participants. Becker, Anna M., Klaiber, Aaron, International Journal of Neuropsychopharmacology, 26(2), 97–106. https://doi.org/10.1093/ijnp/pyac075
, Istampoulouoglou, Ioanna, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Ketanserin Reverses the Acute Response to LSD in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Participants. Biological Psychiatry, 93(3), 215–223. https://doi.org/10.1016/j.biopsych.2022.08.025
, Gasser, Peter, Müller, Felix, Dolder, Patrick C., & Liechti, Matthias E. (2023). Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study. Atila, Cihan, The Lancet Diabetes and Endocrinology, 11, 454–464. https://doi.org/10.1016/S2213-8587(23)00120-1
, Murugesu, Rakithan, Rommers, Nikki, Hutter, Nina, Varghese, Nimmy, Sailer, Clara O, Eckert, Anne, Heinrichs, Markus, Liechti, Matthias E, & Christ-Crain, Mirjam. (2023). Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial. Bedford, Peter, Hauke, Daniel J., Wang, Zheng, Roth, Volker, Nagy-Huber, Monika, Neuropsychopharmacology, 48, 1175–1183. https://doi.org/10.1038/s41386-023-01574-8
, Ley, Laura, Vizeli, Patrick, Liechti, Matthias E., Borgwardt, Stefan, Müller, Felix, & Diaconescu, Andreea O. (2023). The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity. Avram, Mihai, Müller, Felix, Rogg, Helena, Korda, Alexandra, Andreou, Christina, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(9), 885–894. https://doi.org/10.1016/j.bpsc.2022.04.003
, Vizeli, Patrick, Ley, Laura, Liechti, Matthias E., & Borgwardt, Stefan. (2022). Characterizing Thalamocortical (Dys)connectivity Following D-Amphetamine, LSD, and MDMA Administration. Neuropsychopharmacology, 47(6), 1180–1187. https://doi.org/10.1038/s41386-022-01297-2
, Ley, Laura, Müller, Felix, Becker, Anna M., Straumann, Isabelle, Vizeli, Patrick, Kuehne, Sebastian Silva, Roder, Marc A., Duthaler, Urs, Kolaczynska, Karolina E., Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2022). Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects [Journal-article]. Clinical Pharmacology and Therapeutics, 109(3), 658–666. https://doi.org/10.1002/cpt.2057
, Liechti, Matthias E, Hutten, Nadia R P W, Mason, Natasha L, Dolder, Patrick C, Theunissen, Eef L, Duthaler, Urs, Feilding, Amanda, Ramaekers, Johannes G, & Kuypers, Kim P C. (2021). Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants. Clinical Pharmacology and Therapeutics, 109(3), 658–666. https://doi.org/10.1002/cpt.2057
, Liechti, Matthias E., Hutten, Nadia R.P.W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., Duthaler, Urs, Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P.C. (2021). Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants. Neuropsychopharmacology, 46(3), 537–544. https://doi.org/10.1038/s41386-020-00883-6
, Vizeli, Patrick, Ley, Laura, Müller, Felix, Dolder, Patrick, Stocker, Melanie, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2021). Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 46(3), 537–544. https://doi.org/10.1038/s41386-020-00883-6
, Vizeli, Patrick, Ley, Laura, Müller, Felix, Dolder, Patrick, Stocker, Melanie, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2021). Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects. Müller, Felix, Neuropsychopharmacology, 46(3), 545–553. https://doi.org/10.1038/s41386-020-00906-2
, Dolder, Patrick, Ley, Laura, Vizeli, Patrick, Soltermann, Alain, Liechti, Matthias E, & Borgwardt, Stefan. (2021). MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens. Müller, Felix, Neuropsychopharmacology, 46(3), 545–553. https://doi.org/10.1038/s41386-020-00906-2
, Dolder, Patrick, Ley, Laura, Vizeli, Patrick, Soltermann, Alain, Liechti, Matthias E., & Borgwardt, Stefan. (2021). MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens. Liechti, Matthias E., & Current Topics in Behavioral Neurosciences, in press. https://doi.org/10.1007/7854_2021_270
. (2021). Dosing Psychedelics and MDMA. Hutten, Nadia R P W, Mason, Natasha L, Dolder, Patrick C, Theunissen, Eef L, European Neuropsychopharmacology, 41, 81–91. https://doi.org/10.1016/j.euroneuro.2020.10.002
, Liechti, Matthias E, Feilding, Amanda, Ramaekers, Johannes G, & Kuypers, Kim P C. (2020). Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study. Hutten, Nadia R.P.W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., European Neuropsychopharmacology, 41, 81–91. https://doi.org/10.1016/j.euroneuro.2020.10.002
, Liechti, Matthias E., Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P.C. (2020). Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study. Müller, Felix, Mühlhauser, Markus, Frontiers in Psychiatry, 11, 573953. https://doi.org/10.3389/fpsyt.2020.573953
, Lang, Undine E, Walter, Marc, Liechti, Matthias E, & Borgwardt, Stefan. (2020). Treatment of a Complex Personality Disorder Using Repeated Doses of LSD—A Case Report on Significant Improvements in the Absence of Acute Drug Effects. Müller, Felix, Mühlhauser, Markus, Frontiers in Psychiatry, 11. https://doi.org/10.3389/fpsyt.2020.573953
, Lang, Undine E., Walter, Marc, Liechti, Matthias E., & Borgwardt, Stefan. (2020). Treatment of a Complex Personality Disorder Using Repeated Doses of LSD—A Case Report on Significant Improvements in the Absence of Acute Drug Effects. Steuer, Andrea E., Kaelin, Daria, Boxler, Martina I., Eisenbeiss, Lisa, Metabolites, 10(8), 1–20. https://doi.org/10.3390/metabo10080306
, Vizeli, Patrick, Czerwinska, Joanna, Dargan, Paul I., Abbate, Vincenzo, Liechti, Matthias E., & Kraemer, Thomas. (2020). Comparative untargeted metabolomics analysis of the psychostimulants 3,4-methylenedioxy-methamphetamine (MDMA), amphetamine, and the novel psychoactive substance mephedrone after controlled drug administration to humans. Steuer, Andrea E, Kaelin, Daria, Boxler, Martina I, Eisenbeiss, Lisa, Metabolites, 10(8), 1–20. https://doi.org/10.3390/metabo10080306
, Vizeli, Patrick, Czerwinska, Joanna, Dargan, Paul I, Abbate, Vincenzo, Liechti, Matthias E, & Kraemer, Thomas. (2020). Comparative untargeted metabolomics analysis of the psychostimulants 3,4-methylenedioxy-methamphetamine (MDMA), amphetamine, and the novel psychoactive substance mephedrone after controlled drug administration to humans. British Journal of Clinical Pharmacology, 85(7), 1474–1483. https://doi.org/10.1111/bcp.13918
, Duthaler, Urs, Vizeli, Patrick, Müller, Felix, Borgwardt, Stefan, & Liechti, Matthias E. (2019). Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects. British Journal of Clinical Pharmacology, 85, 1474–1483. https://doi.org/10.1111/bcp.13918
, Duthaler, Urs, Vizeli, Patrick, Müller, Felix, Borgwardt, Stefan, & Liechti, Matthias E. (2019). Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects. Books
Liechti, Matthias E., & Dosing Psychedelics and MDMA (Vol. 56, pp. 3–21). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/7854_2021_270
. (2022). Other Publications
Ley, L., Liechti, M. E., Becker, A. M., Straumann, I., Klaiber, A., Holze, F., Vogt, S. B., Arikci, D., & Schmid, Y. (2025). Motivation and retrospective appraisal of psychedelic study participation: a qualitative study in healthy volunteers [Journal-article]. Psychopharmacology. https://doi.org/10.1007/s00213-025-06772-4
Holze, F., Madsen, M. K., Svarer, C., Gillings, N., Stenbaek, D. S., Rudin, D., Duthaler, U., Liechti, M. E., Fisher, P. M., & Knudsen, G. M. (2024). Ketanserin exhibits dose- and concentration-proportional serotonin 2A receptor occupancy in healthy individuals: Relevance for psychedelic research [Journal-article]. European Neuropsychopharmacology, 88, 43–48. https://doi.org/10.1016/j.euroneuro.2024.07.003
Calder, A. E., Rausch, B., Liechti, M. E., Holze, F., & Hasler, G. (2024). Naturalistic psychedelic therapy: The role of relaxation and subjective drug effects in antidepressant response [Journal-article]. Journal of Psychopharmacology, 38(10), 873–886. https://doi.org/10.1177/02698811241278873
Holze, F., Gasser, P., Müller, F., Strebel, M., & Liechti, M. E. (2024). LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up [Journal-article]. British Journal of Psychiatry, 225(3), 362–370. https://doi.org/10.1192/bjp.2024.99
Straumann, I., Holze, F., Becker, A. M., Ley, L., Halter, N., & Liechti, M. E. (2024). Safety pharmacology of acute psilocybin administration in healthy participants [Journal-article]. Neuroscience Applied, 3, 104060. https://doi.org/10.1016/j.nsa.2024.104060
Bedford, P., Hauke, D. J., Wang, Z., Roth, V., Nagy-Huber, M., Holze, F., Ley, L., Vizeli, P., Liechti, M. E., Borgwardt, S., Müller, F., & Diaconescu, A. O. (2022). The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.11.01.514687
Becker, Anna M., Clinical Pharmacology & Therapeutics, 111(4), 886–895. https://doi.org/10.1002/cpt.2487
, Grandinetti, Tanja, Klaiber, Aaron, Toedtli, Vanja E., Kolaczynska, Karolina E., Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Grünblatt, Edna, & Liechti, Matthias E. (2022). Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects. Psychopharmacology, 239(6), 1893–1905. https://doi.org/10.1007/s00213-021-05978-6
, Caluori, Toya V., Vizeli, Patrick, & Liechti, Matthias E. (2022). Safety pharmacology of acute LSD administration in healthy subjects. Psychopharmacology, 239(2), 661. https://doi.org/10.1007/s00213-021-05988-4
, Caluori, Toya V., Vizeli, Patrick, & Liechti, Matthias E. (2022). Correction to: Safety pharmacology of acute LSD administration in healthy subjects. Neuropsychopharmacology, 47(6), 1180–1187. https://doi.org/10.1038/s41386-022-01297-2
, Ley, Laura, Müller, Felix, Becker, Anna M., Straumann, Isabelle, Vizeli, Patrick, Kuehne, Sebastian Silva, Roder, Marc A., Duthaler, Urs, Kolaczynska, Karolina E., Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2022). Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects. Müller, Felix, Kraus, Elias, Psychopharmacology, 239(6), 1933–1943. https://doi.org/10.1007/s00213-022-06066-z
, Becker, Anna, Ley, Laura, Schmid, Yasmin, Vizeli, Patrick, Liechti, Matthias E., & Borgwardt, Stefan. (2022). Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants. Frontiers in Pharmacology, 12, 711255. https://doi.org/10.3389/fphar.2021.711255
, Avedisian, Isidora, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2021). Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin. Hutten, Nadia R. P. W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., ACS Pharmacology & Translational Science, 4(2), 461–466. https://doi.org/10.1021/acsptsci.0c00099
, Liechti, Matthias E., Varghese, Nimmy, Eckert, Anne, Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P. C. (2021). Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers. Ramaekers, Johannes G., Hutten, Nadia, Mason, Natasha L., Dolder, Patrick, Theunissen, Eef L., Journal of Psychopharmacology, 35(4), 398–405. https://doi.org/10.1177/0269881120940937
, Liechti, Matthias E., Feilding, Amanda, & Kuypers, Kim P. C. (2021). A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers. Vizeli, Patrick, Straumann, Isabelle, Scientific Reports, 11(1), 10851. https://doi.org/10.1038/s41598-021-90343-y
, Schmid, Yasmin, Dolder, Patrick C., & Liechti, Matthias E. (2021). Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis. Neuropsychopharmacology, 45(3), 462–471. https://doi.org/10.1038/s41386-019-0569-3
, Vizeli, Patrick, Müller, Felix, Ley, Laura, Duerig, Raoul, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2020). Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects. Dolder, Patrick C., Psychopharmacology, 234(1), 41–51. https://doi.org/10.1007/s00213-016-4431-6
, Liakoni, Evangelia, Harder, Samuel, Schmid, Yasmin, & Liechti, Matthias E. (2017). Alcohol acutely enhances decoding of positive emotions and emotional concern for positive stimuli and facilitates the viewing of sexual images. Supplemental Publications
de Wit, Harriet, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(5), 460–461. https://doi.org/10.1016/j.bpsc.2024.02.010
, & Preller, Katrin H. (2024). Psychedelics in Medicine: Can Evidence Keep Up With Enthusiasm?