Publications by Type
56 found
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Peer-Reviewed Publication Types
Pronovost-Morgan, Chloé, Greenway, Kyle T., Roseman, Leor, Aday, Jacob S., Agin-Liebes, Gabrielle, Ahmad, Kirran, Aicher, Helena, Aixalà, Marc, Amar, Simon, de Araujo, Draulio B., Barrett, Frederick S., Belser, Alexander, Blainey, Marc, Bourne, Michael, Bowman, Ronald, Breeksema, Joost, Carter, Kayla Breelove, Bussey, Jacqueline, Camara, Cesar, et al. (2025). An international Delphi consensus for reporting of setting in psychedelic clinical trials. Nature Medicine, 31. https://doi.org/10.1038/s41591-025-03685-9
Avram, Mihai, Fortea, Lydia, Wollner, Lea, Coenen, Ricarda, Korda, Alexandra, Rogg, Helena, , Vizeli, Patrick, Ley, Laura, Radua, Joaquim, Müller, Felix, Liechti, Matthias E., & Borgwardt, Stefan. (2025). Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine. Molecular Psychiatry, 30(4), 1297–1307. https://doi.org/10.1038/s41380-024-02734-y
Gasser, P., Liechti, M. E., & Holze, F. (2025). Treatment of neuropathic pain with repeated low-dose MDMA: a case report. Frontiers in Psychiatry, 16. https://doi.org/10.3389/fpsyt.2025.1513022
Vizeli, Patrick, Studerus, Erich, , Schmid, Yasmin, Dolder, Patrick C., Ley, Laura, Straumann, Isabelle, Becker, Anna M., Müller, Felix, Arikci, Denis, & Liechti, Matthias E. (2024). Pharmacological and non-pharmacological predictors of the LSD experience in healthy participants. Translational Psychiatry, 14(1). https://doi.org/10.1038/s41398-024-03074-9
Atila, Cihan, Straumann, Isabelle, Vizeli, Patrick, Beck, Julia, Monnerat, Sophie, , Liechti, Matthias E., & Christ-Crain, Mirjam. (2024). Oxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA network open, 7(11). https://doi.org/10.1001/jamanetworkopen.2024.45278
Avram, Mihai, Müller, Felix, Preller, Katrin H., Razi, Adeel, Rogg, Helena, Korda, Alexandra, , Vizeli, Patrick, Ley, Laura, Liechti, Matthias E., & Borgwardt, Stefan. (2024). Effective Connectivity of Thalamocortical Interactions Following d-Amphetamine, LSD, and MDMA Administration. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(5), 522–532. https://doi.org/10.1016/j.bpsc.2023.07.010
, Singh, Nirmal, Liechti, Matthias E., & D’Souza, Deepak Cyril. (2024). Serotonergic Psychedelics: A Comparative Review of Efficacy, Safety, Pharmacokinetics, and Binding Profile. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(5), 472–489. https://doi.org/10.1016/j.bpsc.2024.01.007
, Erne, Livio, Duthaler, Urs, & Liechti, Matthias E. (2024). Pharmacokinetics, pharmacodynamics and urinary recovery of oral lysergic acid diethylamide administration in healthy participants. British Journal of Clinical Pharmacology, 90(1), 200–208. https://doi.org/10.1111/bcp.15887
Stocker, Kurt, Hartmann, Matthias, Ley, Laura, Becker, Anna M, , & Liechti, Matthias E. (2024). The revival of the psychedelic experience scale: Revealing its extended-mystical, visual, and distressing experiential spectrum with LSD and psilocybin studies. Journal of Psychopharmacology, 38(1), 80–100. https://doi.org/10.1177/02698811231199112
Straumann, Isabelle, Ley, Laura, , Becker, Anna M., Klaiber, Aaron, Wey, Kathrin, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants. Neuropsychopharmacology, 48(13), 1840–1848. https://doi.org/10.1038/s41386-023-01609-0
Vogt, Severin B., Ley, Laura, Erne, Livio, Straumann, Isabelle, Becker, Anna M., Klaiber, Aaron, , Vandersmissen, Anja, Mueller, Lorenz, Duthaler, Urs, Rudin, Deborah, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants. Translational Psychiatry, 13(1). https://doi.org/10.1038/s41398-023-02477-4
Ley, Laura, , Arikci, Denis, Becker, Anna M., Straumann, Isabelle, Klaiber, Aaron, Coviello, Fabio, Dierbach, Sophie, Thomann, Jan, Duthaler, Urs, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants. Neuropsychopharmacology, 48(11), 1659–1667. https://doi.org/10.1038/s41386-023-01607-2
Ley, Laura, , Arikci, Denis, Becker, Anna M., Straumann, Isabelle, Klaiber, Aaron, Coviello, Fabio, Dierbach, Sophie, Thomann, Jan, Duthaler, Urs, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants [Journal-article]. Neuropsychopharmacology, 48(11), 1659–1667. https://doi.org/10.1038/s41386-023-01607-2
Atila, Cihan, , Murugesu, Rakithan, Rommers, Nikki, Hutter, Nina, Varghese, Nimmy, Sailer, Clara O, Eckert, Anne, Heinrichs, Markus, Liechti, Matthias E, & Christ-Crain, Mirjam. (2023). Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial. The Lancet Diabetes and Endocrinology, 11(7), 454–464. https://doi.org/10.1016/s2213-8587(23)00120-1
Bedford, Peter, Hauke, Daniel J., Wang, Zheng, Roth, Volker, Nagy-Huber, Monika, , Ley, Laura, Vizeli, Patrick, Liechti, Matthias E., Borgwardt, Stefan, Müller, Felix, & Diaconescu, Andreea O. (2023). The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity. Neuropsychopharmacology, 48(8), 1175–1183. https://doi.org/10.1038/s41386-023-01574-8
, Becker, Anna M., Kolaczynska, Karolina E., Duthaler, Urs, & Liechti, Matthias E. (2023). Pharmacokinetics and Pharmacodynamics of Oral Psilocybin Administration in Healthy Participants. Clinical Pharmacology and Therapeutics, 113(4), 822–831. https://doi.org/10.1002/cpt.2821
Becker, Anna M., Klaiber, Aaron, , Istampoulouoglou, Ioanna, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Ketanserin Reverses the Acute Response to LSD in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Participants. International Journal of Neuropsychopharmacology, 26(2), 97–106. https://doi.org/10.1093/ijnp/pyac075
, Gasser, Peter, Müller, Felix, Dolder, Patrick C., & Liechti, Matthias E. (2023). Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study. Biological Psychiatry, 93(3), 215–223. https://doi.org/10.1016/j.biopsych.2022.08.025
Avram, Mihai, Müller, Felix, Rogg, Helena, Korda, Alexandra, Andreou, Christina, , Vizeli, Patrick, Ley, Laura, Liechti, Matthias E., & Borgwardt, Stefan. (2022). Characterizing Thalamocortical (Dys)connectivity Following D-Amphetamine, LSD, and MDMA Administration. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(9), 885–894. https://doi.org/10.1016/j.bpsc.2022.04.003
, Ley, Laura, Müller, Felix, Becker, Anna M., Straumann, Isabelle, Vizeli, Patrick, Kuehne, Sebastian Silva, Roder, Marc A., Duthaler, Urs, Kolaczynska, Karolina E., Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2022). Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects [Journal-article]. Neuropsychopharmacology, 47(6), 1180–1187. https://doi.org/10.1038/s41386-022-01297-2
, Liechti, Matthias E, Hutten, Nadia R P W, Mason, Natasha L, Dolder, Patrick C, Theunissen, Eef L, Duthaler, Urs, Feilding, Amanda, Ramaekers, Johannes G, & Kuypers, Kim P C. (2021). Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants. Clinical Pharmacology and Therapeutics, 109(3), 658–666. https://doi.org/10.1002/cpt.2057
, Liechti, Matthias E., Hutten, Nadia R.P.W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., Duthaler, Urs, Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P.C. (2021). Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants. Clinical Pharmacology and Therapeutics, 109(3), 658–666. https://doi.org/10.1002/cpt.2057
, Vizeli, Patrick, Ley, Laura, Müller, Felix, Dolder, Patrick, Stocker, Melanie, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2021). Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 46(3), 537–544. https://doi.org/10.1038/s41386-020-00883-6
, Vizeli, Patrick, Ley, Laura, Müller, Felix, Dolder, Patrick, Stocker, Melanie, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2021). Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 46(3), 537–544. https://doi.org/10.1038/s41386-020-00883-6
Müller, Felix, , Dolder, Patrick, Ley, Laura, Vizeli, Patrick, Soltermann, Alain, Liechti, Matthias E, & Borgwardt, Stefan. (2021). MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens. Neuropsychopharmacology, 46(3), 545–553. https://doi.org/10.1038/s41386-020-00906-2
Müller, Felix, , Dolder, Patrick, Ley, Laura, Vizeli, Patrick, Soltermann, Alain, Liechti, Matthias E., & Borgwardt, Stefan. (2021). MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens. Neuropsychopharmacology, 46(3), 545–553. https://doi.org/10.1038/s41386-020-00906-2
Liechti, Matthias E., & . (2021). Dosing Psychedelics and MDMA. Current Topics in Behavioral Neurosciences, in press. https://doi.org/10.1007/7854_2021_270
Hutten, Nadia R P W, Mason, Natasha L, Dolder, Patrick C, Theunissen, Eef L, , Liechti, Matthias E, Feilding, Amanda, Ramaekers, Johannes G, & Kuypers, Kim P C. (2020). Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study. European Neuropsychopharmacology, 41, 81–91. https://doi.org/10.1016/j.euroneuro.2020.10.002
Hutten, Nadia R.P.W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., , Liechti, Matthias E., Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P.C. (2020). Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study. European Neuropsychopharmacology, 41, 81–91. https://doi.org/10.1016/j.euroneuro.2020.10.002
Müller, Felix, Mühlhauser, Markus, , Lang, Undine E, Walter, Marc, Liechti, Matthias E, & Borgwardt, Stefan. (2020). Treatment of a Complex Personality Disorder Using Repeated Doses of LSD—A Case Report on Significant Improvements in the Absence of Acute Drug Effects. Frontiers in Psychiatry, 11, 573953. https://doi.org/10.3389/fpsyt.2020.573953
Müller, Felix, Mühlhauser, Markus, , Lang, Undine E., Walter, Marc, Liechti, Matthias E., & Borgwardt, Stefan. (2020). Treatment of a Complex Personality Disorder Using Repeated Doses of LSD—A Case Report on Significant Improvements in the Absence of Acute Drug Effects. Frontiers in Psychiatry, 11. https://doi.org/10.3389/fpsyt.2020.573953
Steuer, Andrea E., Kaelin, Daria, Boxler, Martina I., Eisenbeiss, Lisa, , Vizeli, Patrick, Czerwinska, Joanna, Dargan, Paul I., Abbate, Vincenzo, Liechti, Matthias E., & Kraemer, Thomas. (2020). Comparative untargeted metabolomics analysis of the psychostimulants 3,4-methylenedioxy-methamphetamine (MDMA), amphetamine, and the novel psychoactive substance mephedrone after controlled drug administration to humans. Metabolites, 10(8), 1–20. https://doi.org/10.3390/metabo10080306
Steuer, Andrea E, Kaelin, Daria, Boxler, Martina I, Eisenbeiss, Lisa, , Vizeli, Patrick, Czerwinska, Joanna, Dargan, Paul I, Abbate, Vincenzo, Liechti, Matthias E, & Kraemer, Thomas. (2020). Comparative untargeted metabolomics analysis of the psychostimulants 3,4-methylenedioxy-methamphetamine (MDMA), amphetamine, and the novel psychoactive substance mephedrone after controlled drug administration to humans. Metabolites, 10(8), 1–20. https://doi.org/10.3390/metabo10080306
, Duthaler, Urs, Vizeli, Patrick, Müller, Felix, Borgwardt, Stefan, & Liechti, Matthias E. (2019). Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects. British Journal of Clinical Pharmacology, 85(7), 1474–1483. https://doi.org/10.1111/bcp.13918
, Duthaler, Urs, Vizeli, Patrick, Müller, Felix, Borgwardt, Stefan, & Liechti, Matthias E. (2019). Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects. British Journal of Clinical Pharmacology, 85(7), 1474–1483. https://doi.org/10.1111/bcp.13918
Books
Liechti, Matthias E., & . (2022). Dosing Psychedelics and MDMA. In Current Topics in Behavioral Neurosciences (Vol. 56, pp. 3–21). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/7854_2021_270
Other Publications
Arikci, D., Holze, F., Mueller, L., Vizeli, P., Rudin, D., Luethi, D., Hysek, C. M., & Liechti, M. E. (2025). Absolute Oral Bioavailability and Bioequivalence of LSD Base and Tartrate in a Double-Blind, Placebo-Controlled, Crossover Study [Journal-article]. Clinical Pharmacology &Amp; Therapeutics, 118. https://doi.org/10.1002/cpt.3726
Ley, Laura, Liechti, Matthias E., Becker, Anna M., Straumann, Isabelle, Klaiber, Aaron, , Vogt, Severin B., Arikci, Denis, & Schmid, Yasmin. (2025). Motivation and retrospective appraisal of psychedelic study participation: a qualitative study in healthy volunteers [Journal-article]. Psychopharmacology, 242, 1875–1892. https://doi.org/10.1007/s00213-025-06772-4
McCulloch, D. E.-W., Larsen, K., Johansen, A., Reveles Jensen, K. H., Nykjaer, C. H., Holze, F., Falck, N., Neufeld, V. A. B., Steenstrup, E., Skov-Andersen, P. M., Spangaard, A., Geisler, M., Randrup, P. P., Jensen, P. S., Shulganov, V., Johansen, S. S., Nielsen, M. K. K., Andersen, T. L., Stenbaek, D. S., et al. (2025). Molecular, haemodynamic and functional effects of LSD in the human brain [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2025.06.17.25329677
Holze, F., Madsen, M. K., Svarer, C., Gillings, N., Stenbaek, D. S., Rudin, D., Duthaler, U., Liechti, M. E., Fisher, P. M., & Knudsen, G. M. (2024). Ketanserin exhibits dose- and concentration-proportional serotonin 2A receptor occupancy in healthy individuals: Relevance for psychedelic research [Journal-article]. European Neuropsychopharmacology, 88, 43–48. https://doi.org/10.1016/j.euroneuro.2024.07.003
Calder, A. E., Rausch, B., Liechti, M. E., Holze, F., & Hasler, G. (2024). Naturalistic psychedelic therapy: The role of relaxation and subjective drug effects in antidepressant response [Journal-article]. Journal of Psychopharmacology, 38(10), 873–886. https://doi.org/10.1177/02698811241278873
Holze, F., Gasser, P., Müller, F., Strebel, M., & Liechti, M. E. (2024). LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up [Journal-article]. British Journal of Psychiatry, 225(3), 362–370. https://doi.org/10.1192/bjp.2024.99
Straumann, I., Holze, F., Becker, A. M., Ley, L., Halter, N., & Liechti, M. E. (2024). Safety pharmacology of acute psilocybin administration in healthy participants [Journal-article]. Neuroscience Applied, 3, 104060. https://doi.org/10.1016/j.nsa.2024.104060
Bedford, P., Hauke, D. J., Wang, Z., Roth, V., Nagy-Huber, M., Holze, F., Ley, L., Vizeli, P., Liechti, M. E., Borgwardt, S., Müller, F., & Diaconescu, A. O. (2022). The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.11.01.514687
Becker, Anna M., , Grandinetti, Tanja, Klaiber, Aaron, Toedtli, Vanja E., Kolaczynska, Karolina E., Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Grünblatt, Edna, & Liechti, Matthias E. (2022). Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects. Clinical Pharmacology & Therapeutics, 111(4), 886–895. https://doi.org/10.1002/cpt.2487
, Caluori, Toya V., Vizeli, Patrick, & Liechti, Matthias E. (2022). Safety pharmacology of acute LSD administration in healthy subjects. Psychopharmacology, 239(6), 1893–1905. https://doi.org/10.1007/s00213-021-05978-6
, Caluori, Toya V., Vizeli, Patrick, & Liechti, Matthias E. (2022). Correction to: Safety pharmacology of acute LSD administration in healthy subjects. Psychopharmacology, 239(2), 661. https://doi.org/10.1007/s00213-021-05988-4
, Ley, Laura, Müller, Felix, Becker, Anna M., Straumann, Isabelle, Vizeli, Patrick, Kuehne, Sebastian Silva, Roder, Marc A., Duthaler, Urs, Kolaczynska, Karolina E., Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2022). Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 47(6), 1180–1187. https://doi.org/10.1038/s41386-022-01297-2
Müller, Felix, Kraus, Elias, , Becker, Anna, Ley, Laura, Schmid, Yasmin, Vizeli, Patrick, Liechti, Matthias E., & Borgwardt, Stefan. (2022). Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants. Psychopharmacology, 239(6), 1933–1943. https://doi.org/10.1007/s00213-022-06066-z
, Avedisian, Isidora, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2021). Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin. Frontiers in Pharmacology, 12, 711255. https://doi.org/10.3389/fphar.2021.711255
Hutten, Nadia R. P. W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., , Liechti, Matthias E., Varghese, Nimmy, Eckert, Anne, Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P. C. (2021). Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers. ACS Pharmacology & Translational Science, 4(2), 461–466. https://doi.org/10.1021/acsptsci.0c00099
Ramaekers, Johannes G., Hutten, Nadia, Mason, Natasha L., Dolder, Patrick, Theunissen, Eef L., , Liechti, Matthias E., Feilding, Amanda, & Kuypers, Kim P. C. (2021). A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers. Journal of Psychopharmacology, 35(4), 398–405. https://doi.org/10.1177/0269881120940937
Vizeli, Patrick, Straumann, Isabelle, , Schmid, Yasmin, Dolder, Patrick C., & Liechti, Matthias E. (2021). Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis. Scientific Reports, 11(1), 10851. https://doi.org/10.1038/s41598-021-90343-y
, Vizeli, Patrick, Müller, Felix, Ley, Laura, Duerig, Raoul, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2020). Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects. Neuropsychopharmacology, 45(3), 462–471. https://doi.org/10.1038/s41386-019-0569-3
Dolder, Patrick C., , Liakoni, Evangelia, Harder, Samuel, Schmid, Yasmin, & Liechti, Matthias E. (2017). Alcohol acutely enhances decoding of positive emotions and emotional concern for positive stimuli and facilitates the viewing of sexual images. Psychopharmacology, 234(1), 41–51. https://doi.org/10.1007/s00213-016-4431-6
Supplemental Publications
de Wit, Harriet, , & Preller, Katrin H. (2024). Psychedelics in Medicine: Can Evidence Keep Up With Enthusiasm? Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(5), 460–461. https://doi.org/10.1016/j.bpsc.2024.02.010