Dr. Manuele Giuseppe Muraro

De Luise, Monica, Kurelac, Ivana, Coluccelli, Sara, De Leo, Antonio, Bartoszek, Ewelina M., Iorio, Maria, Grillini, Marco, Coadă, Camelia Alexandra, de Biase, Dario, Marchio, Lorena, López, Mónica Núñez, Rimmer, Natalie, Perrone, Anna Myriam, De Iaco, Pierandrea, Porcelli, Anna Maria, Heinzelmann, Viola, Martin, Ivan, Jacob, Francis, Muraro, Manuele Giuseppe, & Gasparre, Giuseppe. (2025). Perfusion-based ex vivo culture of frozen ovarian cancer tissues with preserved tumor microenvironment. Npj Precision Oncology, 9. https://doi.org/10.1038/s41698-025-00941-6

Guagnini, Benedetta, Mazzoleni, Andrea, Moya, Adrien, Scherberich, Arnaud, Medagli, Barbara, Martin, Ivan, Porrelli, Davide, Muraro, Manuele G., & Turco, Gianluca. (2025). Fibronectin- and Bioactive Glass-Modified Alginate Scaffolds Support Limited Primary Cell Proliferation In Vitro yet Demonstrate Effective Host Integration In Vivo. Journal of Functional Biomaterials, 16(10). https://doi.org/10.3390/jfb16100386

Bonaiti, Elena, Muraro, Manuele G., Robert, Philippe A., Jakscha, Jens, Dirnhofer, Stefan, Martin, Ivan, & Berger, Christoph T. (2024). Tonsil explants as a human in vitro model to study vaccine responses [Journal-article]. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1425455

Saggioro, M., D’Agostino, S., Veltri, G., Bacchiega, M., Tombolan, L., Zanon, C., Gamba, P., Serafin, V., Muraro, M. G., Martin, I., & Pozzobon, M. (2023). A perfusion-based three-dimensional cell culture system to model alveolar rhabdomyosarcoma pathological features. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-36210-4

Born, Gordian, Plantier, Evelia, Nannini, Guido, Caimi, Alessandro, Mazzoleni, Andrea, Asnaghi, M. Adelaide, Muraro, Manuele G., Scherberich, Arnaud, Martin, Ivan, & García-García, Andrés. (2023). Mini- and macro-scale direct perfusion bioreactors with optimized flow for engineering 3D tissues. Biotechnology Journal, 18(2). https://doi.org/10.1002/biot.202200405

Shekarian, Tala, Zinner, Carl P., Bartoszek, Ewelina M., Duchemin, Wandrille, Wachnowicz, Anna T., Hogan, Sabrina, Etter, Manina M., Flammer, Julia, Paganetti, Chiara, Martins, Tomas A., Schmassmann, Philip, Zanganeh, Steven, Le Goff, Francois, Muraro, Manuele G., Ritz, Marie-Françoise, Phillips, Darci, Bhate, Salil S., Barlow, Graham L., Nolan, Garry P., et al. (2022). Immunotherapy of glioblastoma explants induces interferon-γ responses and spatial immune cell rearrangements in tumor center, but not periphery. Science Advances, 8(26). https://doi.org/10.1126/sciadv.abn9440

Huo, Zihe, Bilang, Remo, Supuran, Claudiu T., von der Weid, Nicolas, Bruder, Elisabeth, Holland-Cunz, Stefan, Martin, Ivan, Muraro, Manuele G., & Gros, Stephanie J. (2022). Perfusion-Based Bioreactor Culture and Isothermal Microcalorimetry for Preclinical Drug Testing with the Carbonic Anhydrase Inhibitor SLC-0111 in Patient-Derived Neuroblastoma. International Journal of Molecular Sciences, 23(6). https://doi.org/10.3390/ijms23063128

Manfredonia C, Muraro MG, Hirt C, Mele V, Governa V, Papadimitropoulos A, Däster S, Soysal SD, Droeser RA, Mechera R, Oertli D, Rosso R, Bolli M, Zettl A, Terracciano LM, Spagnoli GC, Martin I, & Iezzi G. (2019). Maintenance of Primary Human Colorectal Cancer Microenvironment Using a Perfusion Bioreactor-Based 3D Culture System. Advanced Biosystems, 3(4), e1800300. https://doi.org/10.1002/adbi.201800300

Cremonesi, Eleonora, Governa, Valeria, Garzon, Jesus Francisco Glaus, Mele, Valentina, Amicarella, Francesca, Muraro, Manuele Giuseppe, Trella, Emanuele, Galati-Fournier, Virginie, Oertli, Daniel, Däster, Silvio Raffael, Droeser, Raoul A, Weixler, Benjamin, Bolli, Martin, Rosso, Raffaele, Nitsche, Ulrich, Khanna, Nina, Egli, Adrian, Keck, Simone, Slotta-Huspenina, Julia, et al. (2018). Gut microbiota modulate T cell trafficking into human colorectal cancer. Gut, 67(11), 1984–1994. https://doi.org/10.1136/gutjnl-2016-313498

Mengus, Chantal, Muraro, Manuele G., Mele, Valentina, Arnicarella, Francesca, Manfredonia, Celeste, Foglietta, Federica, Muenst, Simone, Soysal, Savas D., Iezzi, Giandomenica, & Spagnoli, Giulio C. (2018). In Vitro Modeling of Tumor-Immune System Interaction. ACS Biomaterials Science and Engineering, 4(2), 314–323. https://doi.org/10.1021/acsbiomaterials.7b00077

Foglietta, F., Spagnoli, G. C., Muraro, M. G., Ballestri, M., Guerrini, A., Ferroni, C., Aluigi, A., Sotgiu, G., & Varchi, G. (2018). Anticancer activity of paclitaxel-loaded keratin nanoparticles in two-dimensional and perfused three-dimensional breast cancer models. International Journal of Nanomedicine, 13, 4847–4867. https://doi.org/10.2147/ijn.s159942

Cerino G, Gaudiello E, Muraro MG, Eckstein F, Martin I, Scherberich A, & Marsano A. (2017). Engineering of an angiogenic niche by perfusion culture of adipose-derived stromal vascular fraction cells. Scientific Reports, 7(1), 14252. https://doi.org/10.1038/s41598-017-13882-3

Muraro, Manuele G, Muenst, Simone, Mele, Valentina, Quagliata, Luca, Iezzi, Giandomenica, Tzankov, Alexandar, Weber, Walter P, Spagnoli, Giulio C, & Soysal, Savas D. (2017). Ex-vivo assessment of drug response on breast cancer primary tissue with preserved microenvironments. OncoImmunology, 6(7), e1331798. https://doi.org/10.1080/2162402X.2017.1331798

Mele, Valentina, Sokol, Lena, Koelzer, Viktor Hendrik, Pfaff, Dennis, Muraro, Manuele Giuseppe, Keller, Irene, Stefan, Zahnd, Centeno, Irene, Terracciano, Luigi Maria, Dawson, Heather, Zlobec, Inti, Iezzi, Giandomenica, & Lugli, Alessandro. (2017). The hyaluronan-mediated motility receptor RHAMM promotes growth, invasiveness and dissemination of colorectal cancer. Oncotarget, 8(41), 70617–70629. https://doi.org/10.18632/oncotarget.19904

Xue G, Kohler R, Tang F, Hynx D, Wang Y, Orso F, Prêtre V, Ritschard R, Hirschmann P, Cron P, Roloff T, Dummer R, Mandalà M, Bichet S, Genoud C, Meyer AG, Muraro MG, Spagnoli GC, Taverna D, et al. (2017). mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition. Oncotarget, 8(41), 69204–69218. https://doi.org/10.18632/oncotarget.18213

Pippenger BE, Duhr R, Muraro MG, Pagenstert GI, Hügle T, & Geurts J. (2015). Multicolor flow cytometry-based cellular phenotyping identifies osteoprogenitors and inflammatory cells in the osteoarthritic subchondral bone marrow compartment. Osteoarthritis and Cartilage, 23(11), 1865–1869. https://doi.org/10.1016/j.joca.2015.07.021

Tatari, N., Muraro, M. G., Hedad, H. M. S., & Hutter, G. (2025). Patient-Derived Glioblastoma Explants Empower Rapid and Personalized Drug Assessment: Harnessing the Potential of 3D Perfusion Bioreactors in Glioblastoma Drug Discovery. In Methods in Molecular Biology (Vol. 2944, pp. 149–161). Humana Press Inc. https://doi.org/10.1007/978-1-0716-4654-0_12

Parejo, S., Tschan, M. P., Muraro, M. G., Garattini, E., Spagnoli, G. C., & Schläfli, A. M. (2019). Assessing Autophagy During Retinoid Treatment of Breast Cancer Cells. In Methods in Molecular Biology (Vol. 2019, pp. 237–256). Humana Press Inc.humana@humanapr.com. https://doi.org/10.1007/978-1-4939-9585-1_17

Guagnini, Benedetta, Mazzoleni, Andrea, Moya, Adrien, Scherberich, Arnaud, Medagli, Barbara, Martin, Ivan, Porrelli, Davide, Muraro, Manuele G., & Turco, Gianluca. (2025). Fibronectin- and Bioactive Glass-Modified Alginate Scaffolds Support Limited Primary Cell Proliferation In Vitro yet Demonstrate Effective Host Integration In Vivo [Posted-content]. In Preprints.org. MDPI AG. https://doi.org/10.20944/preprints202508.2185.v1

Berger, C., Bonaiti, E., Muraro, M., Robert, P., Jakscha, J., Dirnhofer, S., & Martin, I. (2023, October 20). Tonsil explants as a human in vitro model to study immune responses to vaccines [Posted-content]. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-3426839/v1

Mele, Valentina, Basso, Camilla, Governa, Valeria, Glaus Garzon, Jesus F., Muraro, Manuele G., Däster, Silvio, Nebiker, Christian A., Mechera, Robert, Bolli, Martin, Schmidt, Alexander, Geiger, Roger, Spagnoli, Giulio C., Christoforidis, Dimitri, Majno, Pietro E., Borsig, Lubor, & Iezzi, Giandomenica. (2022). Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells. Cancers, 14(8), 1–12. https://doi.org/10.3390/cancers14082024

Forget, Aurelien, Gianni-Barrera, Roberto, Uccelli, Andrea, Sarem, Melika, Kohler, Esther, Fogli, Barbara, Muraro, Manuele Giuseppe, Bichet, Sandrine, Aumann, Konrad, Banfi, Andrea, & Shastri, Vera Prasad. (2019). Mechanically defined microenvironment promotes stabilization of microvasculature, which correlates with the enrichment of a novel Piezo-1+ population of circulating CD11b+/CD115+ monocytes. Advanced materials, 31(21), e1808050. https://doi.org/10.1002/adma.201808050

Turrini, E., Catanzaro, E., Muraro, M. G., Governa, V., Trella, E., Mele, V., Calcabrini, C., Morroni, F., Sita, G., Hrelia, P., Tacchini, M., & Fimognari, C. (2018). <i>Hemidesmus indicus</i> induces immunogenic death in human colorectal cancer cells [Journal-article]. Oncotarget, 9(36), 24443–24456. https://doi.org/10.18632/oncotarget.25325

Groppa, Elena, Brkic, Sime, Uccelli, Andrea, Wirth, Galina, Korpisalo-Pirinen, Petra, Filippova, Maria, Dasen, Boris, Sacchi, Veronica, Muraro, Manuele Giuseppe, Trani, Marianna, Reginato, Silvia, Gianni-Barrera, Roberto, Ylä-Herttuala, Seppo, & Banfi, Andrea. (2018). EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF. EMBO reports, 19(5), e45054. https://doi.org/10.15252/embr.201745054

Däster, Silvio, Amatruda, Nunzia, Calabrese, Diego, Ivanek, Robert, Turrini, Eleonora, Droeser, Raoul A., Zajac, Paul, Fimognari, Carmela, Spagnoli, Giulio C., Iezzi, Giandomenica, Mele, Valentina, & Muraro, Manuele G. (2017). Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment. Oncotarget, 8(1), 1725–1736. https://doi.org/10.18632/oncotarget.13857

Governa, Valeria, Trella, Emanuele, Mele, Valentina, Tornillo, Luigi, Amicarella, Francesca, Cremonesi, Eleonora, Muraro, Manuele G., Xu, Hui, Droeser, Raoul, Däster, Silvio R., Bolli, Martin, Rosso, Raffaele, Oertli, Daniel, Eppenberger-Castori, Serenella, Terracciano, Luigi M., Iezzi, Giandomenica, & Spagnoli, Giulio C. (2017). The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer. Clinical Cancer Research, 23(14), 3847–3858. https://doi.org/10.1158/1078-0432.ccr-16-2047

Hirt, Christian, Papadimitropoulos, Adam, Mele, Valentina, Muraro, Manuele G., Mengus, Chantal, Iezzi, Giandomenica, Terracciano, Luigi, Martin, Ivan, & Spagnoli, Giulio C. (2014). “In vitro” 3D models of tumor-immune system interaction. Advanced Drug Delivery Reviews, 79-80, 145–154. https://doi.org/10.1016/j.addr.2014.05.003