Area of Research
The aim of our research is to provide optimal care for patients with mast cell-associated diseases such as mastocytosis, urticaria and atopic dermatitis. Mast cells are important effector cells in allergies and regulate immunological processes in inflammatory diseases, autoimmune diseases and tumors. Pathologic mast cell proliferation is seen in diverse conditions including mastocytosis, urticaria and atopic dermatitis. We investigate their pathogenesis and develop new diagnostic and therapeutic options for these diseases.
Selected Publications
Niedoszytko, M., Gorska, A., Brockow, K., Bonadonna, P., Lange, M., Kluin-Nelemans, H., Oude-Elberink, H., Sabato, V., Shoumariyeh, K., von Bubnoff, D., Müller, S., Illerhaus, A., Doubek, M., Angelova-Fischer, I., Hermine, O., Arock, M., Elena, C., Malcovati, L., Yavuz, A. S., et al. (2024). Prevalence of hypersensitivity reactions in various forms of mastocytosis: A pilot study of 2485 adult patients with mastocytosis collected in the ECNM registry. Allergy: European Journal of Allergy and Clinical Immunology, 79(9), 2470–2481. https://doi.org/10.1111/all.16132
Niedoszytko, M., Gorska, A., Brockow, K., Bonadonna, P., Lange, M., Kluin-Nelemans, H., Oude-Elberink, H., Sabato, V., Shoumariyeh, K., von Bubnoff, D., Müller, S., Illerhaus, A., Doubek, M., Angelova-Fischer, I., Hermine, O., Arock, M., Elena, C., Malcovati, L., Yavuz, A. S., et al. (2024). Prevalence of hypersensitivity reactions in various forms of mastocytosis: A pilot study of 2485 adult patients with mastocytosis collected in the ECNM registry. Allergy: European Journal of Allergy and Clinical Immunology, 79(9), 2470–2481. https://doi.org/10.1111/all.16132
Höfer, V., Dölle-Bierke, S., Francuzik, W., Ruëff, F., Sabouraud-Leclerc, D., Treudler, R., Moeser, A., Hartmann, K., Pföhler, C., Wagner, N., Ensina, L. F., Wedi, B., Cardona, V., & Worm, M. (2024). Fatal and Near-Fatal Anaphylaxis: Data From the European Anaphylaxis Registry and National Health Statistics. Journal of Allergy and Clinical Immunology: In Practice, 12(1), 96–105. https://doi.org/10.1016/j.jaip.2023.09.044
Höfer, V., Dölle-Bierke, S., Francuzik, W., Ruëff, F., Sabouraud-Leclerc, D., Treudler, R., Moeser, A., Hartmann, K., Pföhler, C., Wagner, N., Ensina, L. F., Wedi, B., Cardona, V., & Worm, M. (2024). Fatal and Near-Fatal Anaphylaxis: Data From the European Anaphylaxis Registry and National Health Statistics. Journal of Allergy and Clinical Immunology: In Practice, 12(1), 96–105. https://doi.org/10.1016/j.jaip.2023.09.044
Konantz M, Williams M, Merkel T, Reiss A, Dirnhofer S, Meyer SC, Valent P, George TI, Tzankov A, & . (2023). Increased TIM-3 and galectin-9 serum levels in patients with advanced systemic mastocytosis. Journal of Allergy and Clinical Immunology, 152(4), 1019–1024. https://doi.org/10.1016/j.jaci.2023.07.001
Konantz M, Williams M, Merkel T, Reiss A, Dirnhofer S, Meyer SC, Valent P, George TI, Tzankov A, & . (2023). Increased TIM-3 and galectin-9 serum levels in patients with advanced systemic mastocytosis. Journal of Allergy and Clinical Immunology, 152(4), 1019–1024. https://doi.org/10.1016/j.jaci.2023.07.001
Kirsch M, Stehle GT, Konantz M, Passweg J, Dirnhofer S, Meyer SC, & . (2022). Presence of neoplastic mast cells in ascites in advanced systemic mastocytosis. Journal of Allergy and Clinical Immunology: In Practice, 10(11), 3035–3038. https://doi.org/10.1016/j.jaip.2022.07.014
Kirsch M, Stehle GT, Konantz M, Passweg J, Dirnhofer S, Meyer SC, & . (2022). Presence of neoplastic mast cells in ascites in advanced systemic mastocytosis. Journal of Allergy and Clinical Immunology: In Practice, 10(11), 3035–3038. https://doi.org/10.1016/j.jaip.2022.07.014
Peters, Franziska, Fiebig, Britta, Lundberg, Pontus, Jaspers, Natalie-Isabel, Holzapfel, Bianca, Ghadimi, Markus P.H, Drebber, Uta, Tuchscherer, Armin, Ullrich, Roland, , & Tantcheva-Poór, Iliana. (2021). Detection of the Germline KIT S476I Mutation in a Kindred with Familial Mastocytosis associated with Gastrointestinal Stromal Tumors. The Journal of Allergy and Clinical Immunology. In Practice, 9(5), 2123–2125. https://doi.org/10.1016/j.jaip.2020.12.049
Peters, Franziska, Fiebig, Britta, Lundberg, Pontus, Jaspers, Natalie-Isabel, Holzapfel, Bianca, Ghadimi, Markus P.H, Drebber, Uta, Tuchscherer, Armin, Ullrich, Roland, , & Tantcheva-Poór, Iliana. (2021). Detection of the Germline KIT S476I Mutation in a Kindred with Familial Mastocytosis associated with Gastrointestinal Stromal Tumors. The Journal of Allergy and Clinical Immunology. In Practice, 9(5), 2123–2125. https://doi.org/10.1016/j.jaip.2020.12.049
