Dr. Deborah Rudin

Rudin, D., Luethi, D., Niello, M., Yang, J.-W., Burger, I., Sandtner, W., Birner-Gruenberger, R., Schütz, G. J., & Sitte, H. H. (2025). Cell membrane cholesterol affects serotonin transporter efflux due to altered transporter oligomerization [Journal-article]. Molecular Psychiatry. https://doi.org/10.1038/s41380-025-03201-y

Arikci, D., Holze, F., Mueller, L., Vizeli, P., Rudin, D., Luethi, D., Hysek, C. M., & Liechti, M. E. (2025). Absolute Oral Bioavailability and Bioequivalence of LSD Base and Tartrate in a Double-Blind, Placebo-Controlled, Crossover Study [Journal-article]. Clinical Pharmacology &Amp; Therapeutics, 118. https://doi.org/10.1002/cpt.3726

Straumann, I., Avedisian, I., Klaiber, A., Varghese, N., Eckert, A., Rudin, D., Luethi, D., & Liechti, M. E. (2024). Acute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants [Journal-article]. Neuropsychopharmacology, 50(2), 362–371. https://doi.org/10.1038/s41386-024-01972-6

Holze, F., Madsen, M. K., Svarer, C., Gillings, N., Stenbaek, D. S., Rudin, D., Duthaler, U., Liechti, M. E., Fisher, P. M., & Knudsen, G. M. (2024). Ketanserin exhibits dose- and concentration-proportional serotonin 2A receptor occupancy in healthy individuals: Relevance for psychedelic research [Journal-article]. European Neuropsychopharmacology, 88, 43–48. https://doi.org/10.1016/j.euroneuro.2024.07.003

Arias, H. R., Micheli, L., Rudin, D., Bento, O., Borsdorf, S., Ciampi, C., Marin, P., Ponimaskin, E., Manetti, D., Romanelli, M. N., Ghelardini, C., Liechti, M. E., & Di Cesare Mannelli, L. (2024). Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation. Biomedicine and Pharmacotherapy, 177. https://doi.org/10.1016/j.biopha.2024.116867

Anliker-Ort, Marion, Rodieux, Frédérique, Ziesenitz, Victoria C., Atkinson, Andrew, Bielicki, Julia A., Erb, Thomas O., Gürtler, Nicolas, Holland-Cunz, Stefan, Duthaler, Urs, Rudin, Deborah, Haschke, Manuel, van den Anker, John, Pfister, Marc, & Gotta, Verena. (2024). Pharmacokinetics-Based Pediatric Dose Evaluation and Optimization Using Saliva – A Case Study. Journal of Clinical Pharmacology, 64(7), 810–819. https://doi.org/10.1002/jcph.2428

Anliker‐Ort, Marion, Rodieux, Frédérique, Ziesenitz, Victoria C., Atkinson, Andrew, Bielicki, Julia A., Erb, Thomas O., Gürtler, Nicolas, Holland‐Cunz, Stefan, Duthaler, Urs, Rudin, Deborah, Haschke, Manuel, van den Anker, John, Pfister, Marc, & Gotta, Verena. (2024). Pharmacokinetics-Based Pediatric Dose Evaluation and Optimization Using Saliva – A Case Study [Journal-article]. Journal of Clinical Pharmacology, 64(7), 810–819. https://doi.org/10.1002/jcph.2428

Luethi, Dino, Rudin, Deborah, Straumann, Isabelle, Thomann, Jan, Avedisian, Isidora, Liechti, Matthias E., & Duthaler, Urs. (2024). Derivatization-free determination of chiral plasma pharmacokinetics of MDMA and its enantiomers. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1238. https://doi.org/10.1016/j.jchromb.2024.124123

Arias, Hugo R., Rudin, Deborah, Hines, Dustin J., Contreras, April, Gulsevin, Alican, Manetti, Dina, Anouar, Youssef, De Deurwaerdere, Philippe, Meiler, Jens, Romanelli, Maria Novella, Liechti, Matthias E., & Chagraoui, Abdeslam. (2024). The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation. European Journal of Pharmacology, 966. https://doi.org/10.1016/j.ejphar.2024.176329

Thomann, Jan, Kolaczynska, Karolina E., Stoeckmann, Oliver V., Rudin, Deborah, Vizeli, Patrick, Hoener, Marius C., Pryce, Christopher R., Vollenweider, Franz X., Liechti, Matthias E., & Duthaler, Urs. (2024). In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin. Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1391689

Thomann, Jan, Kolaczynska, Karolina E., Stoeckmann, Oliver V., Rudin, Deborah, Vizeli, Patrick, Hoener, Marius C., Pryce, Christopher R., Vollenweider, Franz X., Liechti, Matthias E., & Duthaler, Urs. (2024). In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin [Journal-article]. Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1391689

Vogt, Severin B., Ley, Laura, Erne, Livio, Straumann, Isabelle, Becker, Anna M., Klaiber, Aaron, Holze, Friederike, Vandersmissen, Anja, Mueller, Lorenz, Duthaler, Urs, Rudin, Deborah, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants. Translational Psychiatry, 13(1). https://doi.org/10.1038/s41398-023-02477-4

Rudin, Deborah, Areesanan, Alexander, Liechti, Matthias E., & Gründemann, Carsten. (2023). Classic psychedelics do not affect T cell and monocyte immune responses. Frontiers in Psychiatry, 14, 1042440. https://doi.org/10.3389/fpsyt.2023.1042440

Luethi, Dino, Maier, Julian, Rudin, Deborah, Szöllősi, Dániel, Angenoorth, Thomas J. F., Stankovic, Stevan, Schittmayer, Matthias, Burger, Isabella, Yang, Jae-Won, Jaentsch, Kathrin, Holy, Marion, Das, Anand Kant, Brameshuber, Mario, Camacho-Hernandez, Gisela Andrea, Casiraghi, Andrea, Newman, Amy Hauck, Kudlacek, Oliver, Birner-Gruenberger, Ruth, Stockner, Thomas, et al. (2022). Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-04210-1

Rudin, Deborah, McCorvy, John D., Glatfelter, Grant C., Luethi, Dino, Szöllősi, Dániel, Ljubišić, Tea, Kavanagh, Pierce V., Dowling, Geraldine, Holy, Marion, Jaentsch, Kathrin, Walther, Donna, Brandt, Simon D., Stockner, Thomas, Baumann, Michael H., Halberstadt, Adam L., & Sitte, Harald H. (2022). (2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice [Journal-article]. Neuropsychopharmacology, 47(4), 914–923. https://doi.org/10.1038/s41386-021-01221-0

Rudin D, McCorvy JD, Glatfelter GC, Luethi D, Szöllősi D, Ljubišić T, Kavanagh PV, Dowling G, Holy M, Jaentsch K, Walther D, Brandt SD, Stockner T, Baumann MH, Halberstadt AL, & Sitte HH. (2022). (2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice. Neuropsychopharmacology, 47(4), 914–923. https://doi.org/10.1038/s41386-021-01221-0

Camacho-Hernandez GA, Casiraghi A, Rudin D, Luethi D, Ku TC, Guthrie DA, Straniero V, Valoti E, Schütz GJ, Sitte HH, & Newman AH. (2021). Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram. RSC Medicinal Chemistry, 12(7), 1174–1186. https://doi.org/10.1039/d1md00072a

Camacho-Hernandez, Gisela Andrea, Casiraghi, Andrea, Rudin, Deborah, Luethi, Dino, Ku, Therese C., Guthrie, Daryl A., Straniero, Valentina, Valoti, Ermanno, Schütz, Gerhard J., Sitte, Harald H., & Newman, Amy Hauck. (2021). Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram [Journal-article]. RSC Medicinal Chemistry, 12(7), 1174–1186. https://doi.org/10.1039/d1md00072a

Maier J, Rauter L, Rudin D, Niello M, Holy M, Schmid D, Wilson J, Blough BE, Gannon BM, Murnane KS, & Sitte HH. (2021). α-PPP and its derivatives are selective partial releasers at the human norepinephrine transporter: A pharmacological characterization of interactions between pyrrolidinopropiophenones and uptake1 and uptake2 monoamine transporters. Neuropharmacology, 190, 108570. https://doi.org/10.1016/j.neuropharm.2021.108570

Maier J, Niello M, Rudin D, Daws LC, & Sitte HH. (2021). The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances. Handbook of Experimental Pharmacology, 266, 199–214. https://doi.org/10.1007/164_2021_469

Rudin, Deborah, Liechti, Matthias E., & Luethi, Dino. (2021). Molecular and clinical aspects of potential neurotoxicity induced by new psychoactive stimulants and psychedelics. Experimental Neurology, 343, 113778. https://doi.org/10.1016/j.expneurol.2021.113778

Cismaru AL, Rudin D, Ibañez L, Liakoni E, Bonadies N, Kreutz R, Carvajal A, Lucena MI, Martin J, Sancho Ponce E, Molokhia M, Eriksson N, EuDAC Collaborators, Krähenbühl S, Largiadèr CR, Haschke M, Hallberg P, Wadelius M, & Amstutz U. (2020). Genome-wide association study of metamizole-induced agranulocytosis in european populations. Genes, 11(11), 1–21. https://doi.org/10.3390/genes11111275

Cismaru, Anca Liliana, Rudin, Deborah, Ibañez, Luisa, Liakoni, Evangelia, Bonadies, Nicolas, Kreutz, Reinhold, Carvajal, Alfonso, Lucena, Maria Isabel, Martin, Javier, Sancho Ponce, Esther, Molokhia, Mariam, Eriksson, Niclas, EuDAC Collaborators, Krähenbühl, Stephan, Largiadèr, Carlo R, Haschke, Manuel, Hallberg, Pär, Wadelius, Mia, & Amstutz, Ursula. (2020). Genome-wide association study of metamizole-induced agranulocytosis in european populations. Genes, 11(11), 1–21. https://doi.org/10.3390/genes11111275

Cismaru AL, Grimm L, Rudin D, Ibañez L, Liakoni E, Bonadies N, Kreutz R, Hallberg P, Wadelius M, EuDAC Collaborators, Haschke M, Largiadèr CR, & Amstutz U. (2020). High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis. Frontiers in Genetics, 11, 951. https://doi.org/10.3389/fgene.2020.00951

Cismaru, Anca Liliana, Grimm, Livia, Rudin, Deborah, Ibañez, Luisa, Liakoni, Evangelia, Bonadies, Nicolas, Kreutz, Reinhold, Hallberg, Pär, Wadelius, Mia, EuDAC Collaborators, Haschke, Manuel, Largiadèr, Carlo R, & Amstutz, Ursula. (2020). High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis. Frontiers in Genetics, 11, 951. https://doi.org/10.3389/fgene.2020.00951

Rudin, Deborah, Schmutz, Maurice, Roos, Noëmi Johanna, Bouitbir, Jamal, & Krähenbühl, Stephan. (2020). Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis. Biomedicines, 8(7), 212. https://doi.org/10.3390/biomedicines8070212

Rudin, Deborah, Spoendlin, Julia, Cismaru, Anca L, Liakoni, Evangelia, Bonadies, Nicolas, Amstutz, Ursula, Meier, Christoph R, Krähenbühl, Stephan, & Haschke, Manuel. (2019). Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients. European Journal of Internal Medicine, 68, 36–43. https://doi.org/10.1016/j.ejim.2019.07.029

Rudin D, Roos NJ, Duthaler U, & Krähenbühl S. (2019). Toxicity of metamizole on differentiating HL60 cells and human neutrophil granulocytes. Toxicology, 426, 152254. https://doi.org/10.1016/j.tox.2019.152254

Krisai P, Rudin D, Grünig D, Scherer K., Pichler W., Terracciano L., & Krähenbühl S. (2019). Acute liver failure in a patient treated with metamizole (Patent No. SEP). Frontiers in Pharmacology, 10(SEP), Article SEP. https://doi.org/10.3389/fphar.2019.00996

Luethi, Dino, Walter, Melanie, Zhou, Xun, Rudin, Deborah, Krähenbühl, Stephan, & Liechti, Matthias E. (2019). Para-halogenation affects monoamine transporter inhibition properties and hepatocellular toxicity of amphetamines and methcathinones. Frontiers in Pharmacology, 10(APR), 438. https://doi.org/10.3389/fphar.2019.00438

Luethi, Dino, Walter, Melanie, Zhou, Xun, Rudin, Deborah, Krähenbühl, Stephan, & Liechti, Matthias E. (2019). Para-halogenation affects monoamine transporter inhibition properties and hepatocellular toxicity of amphetamines and methcathinones [Journal-article]. Frontiers in Pharmacology, 10(APR). https://doi.org/10.3389/fphar.2019.00438

Luethi D, Walter M, Zhou X, Rudin D, Krähenbühl S, & Liechti ME. (2019). Para-halogenation affects monoamine transporter inhibition properties and hepatocellular toxicity of amphetamines and methcathinones. Frontiers in Pharmacology, 10(APR), 438. https://doi.org/10.3389/fphar.2019.00438

Rudin, Deborah, Lanzilotto, Angelo, Bachmann, Fabio, Housecroft, Catherine E., Constable, Edwin C., Drewe, Jürgen, Haschke, Manuel, & Krähenbühl, Stephan. (2019). Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells. Biochemical Pharmacology, 163, 345–356. https://doi.org/10.1016/j.bcp.2019.01.011

Rudin, Deborah, Spoendlin, Julia, Cismaru, Anca L., Liakoni, Evangelia, Bonadies, Nicolas, Amstutz, Ursula, Meier, Christoph R., Krähenbühl, Stephan, & Haschke, Manuel. (2019). Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients. European Journal of Internal Medicine, 68, 36–43. https://doi.org/10.1016/j.ejim.2019.07.029

Bachmann, Fabio, Duthaler, Urs, Rudin, Deborah, Krähenbühl, Stephan, & Haschke, Manuel. (2018). N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 120, 172–180. https://doi.org/10.1016/j.ejps.2018.05.003