Dr. Kapil Dev Singh

Fricke, K., Baur, D. M., Singh, K. D., Schmidt, F., Müsch, K., Sievi, N. A., Di Donato, M., Schmick, A., Herth, J., Ulrich, S., Sinues, P., Galovic, M., & Kohler, M. (2026). Non‐Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof‐of‐Concept Study [Journal-article]. Clinical Pharmacology &Amp; Therapeutics. https://doi.org/10.1002/cpt.70437

Yin, Zhihong, Singh, Kapil Dev, Tang, Zhifeng, Richard, Mélina, Zeng, Jiafa, Frey, Urs, Sinues, Pablo, & Li, Xue. (2026). In Vivo Real-Time Metabolic Isotopic Tracing via Breath Analysis upon Deuterated Water Ingestion: A Proof-of-Concept Study [Journal-article]. ACS Central Science. https://doi.org/10.1021/acscentsci.6c00078

Richard, Mélina, Singh, Kapil Dev, Sezer, Dilan, Buergler, Sarah, Palermo, Luana, Schulz, Yannick, Tang, Zhifeng, Luo, Xin, Frey, Urs, Cattin, Philippe C., Li, Xue, Gaab, Jens, & Sinues, Pablo. (2026). Cold induced pain elicits reproducible breath metabolomic responses across geographically distinct populations. iScience, 29(6). https://doi.org/10.1016/j.isci.2026.115857

Schmidt, Felix, Baur, Diego M., Baumgartner, Patrick, Herth, Jonas, Fricke, Kai, Sievi, Noriane A., Singh, Kapil Dev, Gaisl, Thomas, Huang, Alice, Franzen, Daniel, Ulrich, Silvia, Sinues, Pablo, & Kohler, Malcolm. (2026). Real-time breath metabolomics as catalyst for personalized lung cancer diagnostics: prospective matched case-control trial (LUCAbreath). Translational Lung Cancer Research, 15(3), 57. https://doi.org/10.21037/tlcr-2025-aw-1187

Yin, Zhihong, Xiong, Wei, Zhang, Keda, Luo, Xin, Wei, Ming, Singh, Kapil Dev, Frey, Urs, Li, Xue, Feng, Xia, & Sinues, Pablo. (2025). Real-time breath drug metabolic monitoring under stellate ganglion block with lidocaine: a proof-of-concept study. Discover Medicine, 2(1). https://doi.org/10.1007/s44337-025-00498-0

Zeng, Jiafa, Stankovic, Nikola, Singh, Kapil Dev, Steiner, Regula, Frey, Urs, Erb, Thomas, & Sinues, Pablo. (2025). Breath Analysis of Propofol and Associated Metabolic Signatures: A Pilot Study Using Secondary Electrospray Ionization-High-resolution Mass Spectrometry [Journal-article]. Anesthesiology, 143(2), 345–356. https://doi.org/10.1097/aln.0000000000005531

Richard, Mélina, Singh, Kapil Singh, Sezer, Dilan, Buergler, Sarah, Palermo, Luana, Schulz, Yannick, Tang, Zhifeng, Luo, Xin, Frey, Urs, Cattin, Philippe, Li, Xue, Gaab, Jens, & Sinues, Pablo. (2025). Pain induces a rapid characteristic metabolic signature detectable in breath. In Research Square (Research Square). Research Square (United States). https://doi.org/10.21203/rs.3.rs-6048423/v1

Gisler, Amanda, Singh, Kapil Dev, Marten, Andrea, Decrue, Fabienne, Frey, Urs, Sinues, Pablo, & Usemann, Jakob. (2025). Urinary marker of oxidative stress in children correlates with molecules in exhaled breath. Frontiers in Molecular Biosciences, 12. https://doi.org/10.3389/fmolb.2025.1511119

Zeng, Jiafa, Usemann, Jakob, Singh, Kapil Dev, Jochmann, Anja, Trachsel, Daniel, Frey, Urs, & Sinues, Pablo. (2024). Pharmacometabolomics via real-time breath analysis captures metabotypes of asthmatic children associated with salbutamol responsiveness. iScience, 27(12). https://doi.org/10.1016/j.isci.2024.111446

Arnold, Kim, Gómez-Mejia, Alejandro, de Figueiredo, Miguel, Boccard, Julien, Singh, Kapil Dev, Rudaz, Serge, Sinues, Pablo, & Zinkernagel, Annelies S. (2024). Early detection of bacterial pneumonia by characteristic induced odor signatures. BMC Infectious Diseases, 24. https://doi.org/10.1186/s12879-024-10371-7

Awchi, Mo, Singh, Kapil Dev, Brenner, Sara Bachmann, Burckhardt, Marie-Anne, Hess, Melanie, Zeng, Jiafa, Datta, Alexandre N., Frey, Urs, Zumsteg, Urs, Szinnai, Gabor, & Sinues, Pablo. (2024). Metabolic trajectories of diabetic ketoacidosis onset described by breath analysis. Frontiers in Endocrinology, 15. https://doi.org/10.3389/fendo.2024.1360989

Sola-Martínez, R. A., Zeng, J., Awchi, M., Gisler, A., Arnold, K., Singh, K. D., Frey, U., Díaz, M. C., de Diego Puente, T., & Sinues, P. (2024). Preservation of exhaled breath samples for analysis by off-line SESI-HRMS: proof-of-concept study [Journal-article]. Journal of Breath Research, 18(1). https://doi.org/10.1088/1752-7163/ad10e1

Awchi, M., Singh, K. D., Dill, P. E., Frey, U., Datta, A. N., & Sinues, P. (2023). Prediction of systemic free and total valproic acid by off-line analysis of exhaled breath in epileptic children and adolescents. Journal of Breath Research, 17(4). https://doi.org/10.1088/1752-7163/acf782

Arnold, Kim, Dehio, Philippe, Lötscher, Jonas, Singh, Kapil Dev, García-Gómez, Diego, Hess, Christoph, Sinues, Pablo, & Balmer, Maria L. (2023). Real-Time Volatile Metabolomics Analysis of Dendritic Cells. Analytical Chemistry, 95(25), 9415–9421. https://doi.org/10.1021/acs.analchem.3c00516

Awchi M, Sinues P, Datta AN, García-Gómez D, & Singh KD. (2023). UHPLC-MS/MS-Based Identity Confirmation of Amino Acids Involved in Response to and Side Effects from Antiseizure Medications. Journal of Proteome Research, 22(3), 990–995. https://doi.org/10.1021/acs.jproteome.2c00835

Gisler, Amanda, Singh, Kapil Dev, Zeng, Jiafa, Osswald, Martin, Awchi, Mo, Decrue, Fabienne, Schmidt, Felix, Sievi, Noriane A., Chen, Xing, Usemann, Jakob, Frey, Urs, Kohler, Malcolm, Li, Xue, & Sinues, Pablo. (2022). An interoperability framework for multicentric breath metabolomic studies. iScience, 25(12). https://doi.org/10.1016/j.isci.2022.105557

Gomez-Mejia A., Arnold K., Bar J., Singh K.D., Scheier T.C., Brugger S.D., Zinkernagel A.S., & Sinues P. (2022). Rapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites. iScience, 25(10). https://doi.org/10.1016/j.isci.2022.105080

Arnold K., Chen X., Zhang H., Singh K.D., Yin Z., Yao Y., Luan T., Sinues P., & Li X. (2022). In vivo detection of metabolic 2H-incorporation upon ingestion of 2H2O. Journal of Bio-X Research, 5(2), 81–89. https://doi.org/10.1097/jbr.0000000000000121

Zeng, Jiafa, Christen, Alexandra, Singh, Kapil Dev, Frey, Urs, & Sinues, Pablo. (2022). Comparison of Plasma Ionization- and Secondary Electrospray IonizationHigh-resolution Mass Spectrometry for Real-time Breath Analysis. Chimia, 76(1-2), 127–132. https://doi.org/10.2533/chimia.2022.127

Singh KD, Osswald M, Ziesenitz VC, Awchi M, Usemann J, Imbach LL, Kohler M, García-Gómez D, van den Anker J, Frey U, Datta AN, & Sinues P. (2021). Personalised therapeutic management of epileptic patients guided by pathway-driven breath metabolomics. Communications Medicine, 1(1), 21. https://doi.org/10.1038/s43856-021-00021-3

Decrue, Fabienne, Singh, Kapil Dev, Gisler, Amanda, Awchi, Mo, Zeng, Jiafa, Usemann, Jakob, Frey, Urs, & Sinues. Pablo. (2021). Combination of Exhaled Breath Analysis with Parallel Lung Function and FeNO Measurements in Infants. Analytical Chemistry, 93(47), 15579–15583. https://doi.org/10.1021/acs.analchem.1c02036

Yin Z , Huang W , Singh KD , Chen Z , Chen X , Zhou Z , Yang Z , Sinues P , & Li X . (2021). In vivomonitoring of volatile metabolic trajectories enables rapid diagnosis of influenza A infection. Chemical Communications, 57(39), 4791–4794. https://doi.org/10.1039/d1cc01061a

Gisler, Amanda, Lan, Jiayi, Singh, Kapil Dev, Usemann, Jakob, Frey, Urs, Zenobi, Renato, & Sinues, Pablo. (2020). Real-time breath analysis of exhaled compounds upon peppermint oil ingestion by secondary electrospray ionization-high resolution mass spectrometry: technical aspects. Journal of Breath Research, 14(4). https://doi.org/10.1088/1752-7163/ab9f8b

Sendoel, Ataman, Subasic, Deni, Ducoli, Luca, Keller, Martin, Michel, Erich, Kohler, Ines, Singh, Kapil Dev, Zheng, Xue, Brümmer, Anneke, Imig, Jochen, Kishore, Shivendra, Wu, Yibo, Kanitz, Alexander, Kaech, Andres, Mittal, Nitish, Matia-González, Ana M., Gerber, André P., Zavolan, Mihaela, Aebersold, Ruedi, et al. (2019). MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans. Cell Death & Differentiation Subscription, 26(10), 2157–2178. https://doi.org/10.1038/s41418-019-0291-z

Singh, Kapil Dev, Tancev, Georgi, Decrue, Fabienne, Usemann, Jakob, Appenzeller, Rhea, Barreiro, Pedro, Jaumà, Gabriel, Macia Santiago, Miriam, Vidal de Miguel, Guillermo, Frey, Urs, & Sinues, Pablo. (2019). Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry. Analytical and Bioanalytical Chemistry, 411(19), 4883–4898. https://doi.org/10.1007/s00216-019-01764-8

Singh, Kapil Dev, Del Miguel, Guillermo Vidal, Gaugg, Martin Thomas, Ibañez, Alfredo J., Zenobi, Renato, Kohler, Malcolm, Frey, Urs, & Sinues, Pablo M.-L. (2018). Translating secondary electrospray ionization-high-resolution mass spectrometry to the clinical environment. Journal of Breath Research, 12(2), 27113. https://doi.org/10.1088/1752-7163/aa9ee3

Tejero Rioseras, Alberto, Singh, Kapil Dev, Nowak, Nora, Gaugg, Martin T., Bruderer, Tobias, Zenobi, Renato, & Sinues, Pablo M.-L. (2018). Real-Time Monitoring of Tricarboxylic Acid Metabolites in Exhaled Breath. Analytical Chemistry, 90(11), 6453–6460. https://doi.org/10.1021/acs.analchem.7b04600

Singh KD, Zheng X, Milstein S, Keller M, Roschitzki B, Grossmann J, & Hengartner MO. (2017). Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans. PLoS ONE, 12(7), e0182270. https://doi.org/10.1371/journal.pone.0182270

Singh KD, Roschitzki B, Snoek LB, Grossmann J, Zheng X, Elvin M, Kamkina P, Schrimpf SP, Poulin GB, Kammenga JE, & Hengartner MO. (2016). Natural genetic variation influences protein abundances in C. elegans developmental signalling pathways. PLoS ONE, 11(3), e0149418. https://doi.org/10.1371/journal.pone.0149418