Prof. Dr. Jörg Huwyler

Cavegn, Alessandra, Waldner, Samuel, Wang, David, Sedzicki, Jaroslaw, Kuzucu, Evrim Ümit, Zogg, Michael, Lotter, Claudia, & Huwyler, Jörg. (2025). Intracellular processing of DNA-lipid nanoparticles: A quantitative assessment by image segmentation. Journal of Controlled Release, 382. https://doi.org/10.1016/j.jconrel.2025.113709

Puligilla, Ramya Deepthi, Roos, Noëmi Johanna, Bolten, Jan Stephan, Hopf, Nancy B., Zurich, Marie-Gabrielle, Barulin, Nikolai, & Huwyler, Jörg. (2025). Zebrafish as a model to assess the neurotoxic potential of propylene glycol ethers. Environmental Toxicology and Pharmacology, 116. https://doi.org/10.1016/j.etap.2025.104678

Lotter, Claudia, Stierli, Megan Anna, Puligilla, Ramya Deepthi, & Huwyler, Jörg. (2025). Dual targeted lipid nanoparticles for enhanced DNA delivery and transfection of breast cancer cells. European Journal of Pharmaceutics and Biopharmaceutics, 209. https://doi.org/10.1016/j.ejpb.2025.114674

Alter, Claudio Luca, Lotter, Claudia, Puligilla, Ramya Deepthi, Bolten, Jan Stephan, Sedzicki, Jaroslaw, Marchese, Jason, Schittny, Valentin, Rucci, Francesca, Beverly, Michael, Palivan, Cornelia G., Detampel, Pascal, Einfalt, Tomaž, & Huwyler, Jörg. (2025). Nano Plasma Membrane Vesicle-Lipid Nanoparticle Hybrids for Enhanced Gene Delivery and Expression. Advanced Healthcare Materials, 14(1). https://doi.org/10.1002/adhm.202401888

Lotter, Claudia, Kuzucu, Evrim Ümit, Casper, Jens, Alter, Claudio Luca, Puligilla, Ramya Deepthi, Detampel, Pascal, Lopez, Juana Serrano, Ham, Alexander Sebastian, & Huwyler, Jörg. (2025). Corrigendum to “Comparison of ionizable lipids for lipid nanoparticle mediated DNA delivery” [European Journal of Pharmaceutical Sciences 203 (2024), 106898] (European Journal of Pharmaceutical Sciences (2024) 203, (S0928098724002100), (10.1016/j.ejps.2024.106898)). European Journal of Pharmaceutical Sciences, 204. https://doi.org/10.1016/j.ejps.2024.106965

Lotter, Claudia, Kuzucu, Evrim Ümit, Casper, Jens, Alter, Claudio Luca, Puligilla, Ramya Deepthi, Detampel, Pascal, Lopez, Juana Serrano, Ham, Alexander Sebastian, & Huwyler, Jörg. (2024). Comparison of ionizable lipids for lipid nanoparticle mediated DNA delivery. European Journal of Pharmaceutical Sciences, 203. https://doi.org/10.1016/j.ejps.2024.106898

Munk, Anna, Philippi, Vanessa, Buchecker, Verena, Bankstahl, Marion, Glasenapp, Aylina, Blutke, Andreas, Michelakaki, Effrosyni, Talbot, Steven Roger, Huwyler, Jörg, Jirkof, Paulin, Kopaczka, Marcin, Merhof, Dorit, Palme, Rupert, & Potschka, Heidrun. (2024). Refining pain management in mice by comparing multimodal analgesia and NSAID monotherapy for neurosurgical procedures. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-69075-2

Peláez, S., Mahler, H.-C., Huwyler, J., & Allmendinger, A. (2024). Optimization of Methodologies to Study Freeze/Thaw Processes in Drug Substance Bottles [Journal-article]. Methods and Protocols, 7(5), 68. https://doi.org/10.3390/mps7050068

Peláez, Sarah S., Mahler, Hanns-Christian, Huwyler, Jörg, & Allmendinger, Andrea. (2024). Directional freezing and thawing of biologics in drug substance bottles. European Journal of Pharmaceutics and Biopharmaceutics, 203. https://doi.org/10.1016/j.ejpb.2024.114427

Golhen, Klervi, Buettcher, Michael, Huwyler, Jörg, van den Anker, John, Gotta, Verena, Dao, Kim, Rothuizen, Laura E., Kobylinski, Kevin, & Pfister, Marc. (2024). Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg [Journal-article]. Pharmaceutics, 16(9), 1186. https://doi.org/10.3390/pharmaceutics16091186

Waldner, Samuel, Huwyler, Jörg, & Puchkov, Maxim. (2024). A deep-learning-based workflow for reconstructing and segmenting challenging sets of time-resolved X-ray micro-computed tomography data. SoftwareX, 27. https://doi.org/10.1016/j.softx.2024.101796

van Os, Winant L., Wielaert, Laura, Alter, Claudio, Davidović, David, Šachl, Radek, Kock, Thomas, González, Urimare Ugueto, Arias-Alpizar, Gabriela, Vigario, Fernando Lozano, Knol, Renzo A., Kuster, Rick, Romeijn, Stefan, Mora, Nestor Lopez, Detampel, Pascal, Hof, Martin, Huwyler, Jörg, & Kros, Alexander. (2024). Lipid conjugate dissociation analysis improves the in vivo understanding of lipid-based nanomedicine. Journal of Controlled Release, 371, 85–100. https://doi.org/10.1016/j.jconrel.2024.05.034

Oezen, Goezde, Kraus, Lisa, Schentarra, Eva-Maria, Bolten, Jan Stephan, Huwyler, Joerg, & Fricker, Gert. (2024). Aluminum and ABC transporter activity. Environmental Toxicology and Pharmacology, 108. https://doi.org/10.1016/j.etap.2024.104451

Peláez, Sarah S., Mahler, Hanns-Christian, Vila, Pau Rubirola, Huwyler, Jörg, & Allmendinger, Andrea. (2024). Characterization of Freezing Processes in Drug Substance Bottles by Ice Core Sampling. AAPS PharmSciTech, 25(5). https://doi.org/10.1208/s12249-024-02818-6

Dao, Kim, Buettcher, Michael, Golhen, Klervi, Kost, Jonas, Schittny, Andreas, Duthaler, Urs, Atkinson, Andrew, Haefliger, David, Guidi, Monia, Bardinet, Carine, Chtioui, Haithem, Boulekbache, Abdelwahab, Buclin, Thierry, Huwyler, Jörg, Pfister, Marc, & Rothuizen, Laura E. (2024). Novel Patient‐Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced Palatability, Controlled Absorption, and Less Variability: High Potential for Pediatric Use [Journal-article]. The Journal of Clinical Pharmacology, 64(10), 1295–1303. https://doi.org/10.1002/jcph.2462

Wozniewski, Maximilian, Besheer, Ahmed, Huwyler, Jörg, Mahler, Hanns-Christian, Sediq, Ahmad S., & Levet, Vincent. (2024). Impact of the Design of Different Infusion Containers on the Dosing Accuracy of a Therapeutic Drug Product. Journal of Pharmaceutical Sciences, 113(4), 990–998. https://doi.org/10.1016/j.xphs.2023.10.010

Wozniewski, Maximilian, Besheer, Ahmed, Huwyler, Jörg, Mahler, Hanns-Christian, Levet, Vincent, & Sediq, Ahmad S. (2024). A Survey on Handling and Administration of Therapeutic Protein Products in German and Swiss Hospitals. Journal of Pharmaceutical Sciences, 113(3), 735–743. https://doi.org/10.1016/j.xphs.2023.09.010

Waldner, Samuel, Wendelspiess, Erwin, Detampel, Pascal, Schlepütz, Christian M., Huwyler, Jörg, & Puchkov, Maxim. (2024). Advanced analysis of disintegrating pharmaceutical compacts using deep learning-based segmentation of time-resolved micro-tomography images. Heliyon, 10(4). https://doi.org/10.1016/j.heliyon.2024.e26025

Wozniewski, Maximilian, Besheer, Ahmed, Sediq, Ahmad S., Huwyler, Jörg, Mahler, Hanns-Christian, & Levet, Vincent. (2024). Characterization of Silicone from Closed System Transfer Devices and its Migration into Pharmaceutical Drug Products. Journal of Pharmaceutical Sciences, 113(2), 419–426. https://doi.org/10.1016/j.xphs.2023.11.012

Batista, João V. C., Melo, Michelle Nonato de Oliveira, Holandino, Carla, Maier, Jakob, Huwyler, Jörg, Baumgartner, Stephan, & Boylan, Fabio. (2024). Characterization of Larix decidua Mill. (Pinaceae) oleoresin’s essential oils composition using GC-MS. Frontiers in Plant Science. https://www.frontiersin.org/articles/10.3389/fpls.2023.1331894

Hopf, Nancy B., Suter-Dick, Laura, Huwyler, Jörg, Borgatta, Myriam, Hegg, Lucie, Pamies, David, Paschoud, Hélène, Puligilla, Ramya Deepthi, Reale, Elena, Werner, Sophie, & Zurich, Marie-Gabrielle. (2024). Novel Strategy to Assess the Neurotoxicity of Organic Solvents Such as Glycol Ethers: Protocol for Combining In Vitro and In Silico Methods With Human-Controlled Exposure Experiments [Journal-article]. JMIR Research Protocols, 13(1), e50300. https://doi.org/10.2196/50300

Linares, Vicente, Casas, Marta, Huwyler, Jörg, & Caraballo, Isidoro. (2023). Stereolithographic 3D printing: Formulation design based on percolation thresholds. Journal of Drug Delivery Science and Technology, 90. https://doi.org/10.1016/j.jddst.2023.105099

Wolter, Angelique, Bucher, Christian H, Kurmies, Sebastian, Schreiner, Viktoria, Konietschke, Frank, Hohlbaum, Katharina, Klopfleisch, Robert, Löhning, Max, Thöne-Reineke, Christa, Buttgereit, Frank, Huwyler, Jörg, Jirkof, Paulin, Rapp, Anna E, & Lang, Annemarie. (2023). A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models. Scientific Reports, 13(1), 3824. https://doi.org/10.1038/s41598-023-30641-9

Kardorff, M., Mahler, H.-C., Huwyler, J., & Sorret, L. (2023). Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress [Journal-article]. Journal of Pharmacological and Toxicological Methods, 124, 107474. https://doi.org/10.1016/j.vascn.2023.107474

Casper, Jens, Schenk, Susanne H, Parhizkar, Elahehnaz, Detampel, Pascal, Dehshahri, Ali, & Huwyler, Jörg. (2023). Polyethylenimine (PEI) in gene therapy: Current status and clinical applications. Journal of Controlled Release, 362, 667–691. https://doi.org/10.1016/j.jconrel.2023.09.001

Kost, Jonas, & Huwyler, Jörg, Puchkov, Maxim. (2023). Calcium Phosphate Microcapsules as Multifunctional Drug Delivery Devices. Advanced Functional Materials, 33(38), 2303333. https://doi.org/10.1002/adfm.202303333

Farzan, Maryam, Roth, Roger, Schoelkopf, Joachim, Huwyler, Jörg, & Puchkov, Maxim. (2023). The processes behind drug loading and release in porous drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics, 189, 133–151. https://doi.org/10.1016/j.ejpb.2023.05.019

Kardorff, Markus, Mahler, Hanns-Christian, Huwyler, Jörg, Jere, Dhananjay, & Sorret, Léa. (2023). Cryoprotection in Human Mesenchymal Stromal/Stem Cells: Synergistic Impact of Urea and Glucose. Journal of Pharmaceutical Sciences, 112(6), 1681–1686. https://doi.org/10.1016/j.xphs.2023.02.001

Bolten, Jan Stephan, Mancuso, Riccardo Vincenzo, Roos, Noëmi Johanna, Mayr, Aline, Puligilla, Ramya Deepthi, Kraus, Lisa, Odermatt, Alex, Fricker, Gert, & Huwyler, Jörg. (2023). Nephrotoxicity of iopamidol is associated with mitochondrial impairment in human cell and teleost models. Toxicology and Applied Pharmacology, 466(446), 116493. https://doi.org/10.1016/j.taap.2023.116493

Bolten, Jan Stephan, Tanner, Christine, Rodgers, Griffin, Schulz, Georg, Levano, Soledad, Weitkamp, Timm, Waldner, Samuel, Puligilla, Ramya Deepthi, Bodmer, Daniel, Müller, Bert, & Huwyler, Jörg. (2023). Zebrafish (Danio rerio) larvae as a predictive model to study gentamicin-induced structural alterations of the kidney. PLoS ONE, 18(4 APRIL). https://doi.org/10.1371/journal.pone.0284562

Golhen K, Buettcher M, Kost J, Huwyler J, & Pfister M. (2023). Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children. Pharmaceutics, 15(4). https://doi.org/10.3390/pharmaceutics15041033

Golhen, Klervi, Buettcher, Michael, Kost, Jonas, Huwyler, Jörg, & Pfister, Marc. (2023). Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children. Pharmaceutics, 15(4), 1033. https://doi.org/10.3390/pharmaceutics15041033

Kullmann, Daniel, Lema Martinez, Carmen, Lümkemann, Jörg, & Huwyler, Jörg. (2023). Part I: Significant reduction of lyophilization process times by using novel matrix based scaffolds. European Journal of Pharmaceutics and Biopharmaceutics, 184, 248–261. https://doi.org/10.1016/j.ejpb.2022.12.008

Kullmann, Daniel, Lema Martinez, Carmen, Lümkemann, Jörg, & Huwyler, Jörg. (2023). Part II: Matrix based scaffold lyophilization facilitates processing as a prerequisite for an innovative packaging system. European Journal of Pharmaceutics and Biopharmaceutics, 184, 262–273. https://doi.org/10.1016/j.ejpb.2022.12.007

Alter, Claudio L., Detampel, Pascal, Schefer, Roman B., Lotter, Claudia, Hauswirth, Patrick, Puligilla, Ramya D., Weibel, Vera J., Schenk, Susanne H., Heusermann, Wolf, Schürz, Melanie, Meisner-Kober, Nicole, Palivan, Cornelia, Einfalt, Tomaž, & Huwyler, Jörg. (2023). High efficiency preparation of monodisperse plasma membrane derived extracellular vesicles for therapeutic applications. Communications biology, 6(1), 478. https://doi.org/10.1038/s42003-023-04859-2

Batista, João V. C., Melo, Michelle Nonato de Oliveira, Holandino, Carla, Maier, Jakob, Huwyler, Jörg, Baumgartner, Stephan, & Boylan, Fabio. (2023). Characterization of Larix decidua Mill. (Pinaceae) oleoresin’s essential oils composition using GC-MS. Frontiers in Plant Science, 14. https://doi.org/10.3389/fpls.2023.1331894

Casper J, Nicolle L, Willimann M, Kuzucu EÜ, Tran A, Robin P, Detampel P, Grisch-Chan HM, Thöny B, Huwyler J, & Gerber-Lemaire S. (2023). Core–Shell Structured Chitosan-Polyethylenimine Nanoparticles for Gene Delivery: Improved Stability, Cellular Uptake, and Transfection Efficiency. Macromolecular Bioscience, 23(1), e2200314. https://doi.org/10.1002/mabi.202200314

Hauswirth, Patrick, Buck, Jonas, Puligilla, Ramya, Alter, Claudio, Sieber, Sandro, Claudi, Beatrice, Fanous, Joseph, Bumann, Dirk, & Huwyler, Jörg. (2023). Zebrafish Larvae as an in vivo Model for Antimicrobial Activity Tests against Intracellular Salmonella. IMR Press, FBL, 28(5), 99. https://doi.org/10.31083/j.fbl2805099

Hauswirth, Patrick, Graber, Philipp, Buczak, Katarzyna, Mancuso, Riccardo Vincenzo, Schenk, Susanne Heidi, Nüesch, Jürg P. F., & Huwyler, Jörg. (2023). Design and Characterization of Mutated Variants of the Oncotoxic Parvoviral Protein NS1. Viruses, 15(1), 1–19. https://doi.org/10.3390/v15010209

Waldner, S., Wendelspiess, E., Detampel, P., Schlepütz, C. M., Huwyler, J., & Puchkov, M. (2023). Advanced Analysis of Disintegrating Pharmaceutical Compacts Using Deep Learning-Based Segmentation of Time-Resolved Micro-Tomography Images [Posted-content]. Elsevier BV. https://doi.org/10.2139/ssrn.4541286

Oezen G., Schentarra E.-M., Bolten J.S., Huwyler J., & Fricker G. (2022). Sodium arsenite but not aluminum chloride stimulates ABC transporter activity in renal proximal tubules of killifish (Fundulus heteroclitus). Aquatic Toxicology, 252. https://doi.org/10.1016/j.aquatox.2022.106314

Wolter, A., Bucher, C. H., Kurmies, S., Schreiner, V., Konietschke, F., Hohlbaum, K., Klopfleisch, R., Löhning, M., Thöne-Reineke, C., Buttgereit, F., Huwyler, J., Jirkof, P., Rapp, A. E., & Lang, A. (2022). A Buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72h in mouse femoral fracture models [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.07.05.498859

Bolten J.S., Pratsinis A., Alter C.L., Fricker G., & Huwyler J. (2022). Zebrafish (Danio rerio) larva as an in vivo vertebrate model to study renal function. American Journal of Physiology - Renal Physiology, 322(3), F280–F294. https://doi.org/10.1152/ajprenal.00375.2021

Jooss V.M., Bolten J.S., Bolten J.S., Huwyler J., & Ahmed D. (2022). In vivo acoustic manipulation of microparticles in zebrafish embryos. Science Advances, 8(12). https://doi.org/10.1126/sciadv.abm2785

Batista, João V. C., Uecker, Annekathrin, Holandino, Carla, Boylan, Fabio, Maier, Jakob, Huwyler, Jörg, & Baumgartner, Stephan. (2022). A Scoping Review on the Therapeutic Potential of Resin From the Species Larix decidua Mill. [Pinaceae] to Treat Ulcerating Wounds. Frontiers in Pharmacology, 13, 895838. https://doi.org/10.3389/fphar.2022.895838

Jooss, Viktor M., Bolten, Jan Stephan, Huwyler, Jörg, & Ahmed, Daniel. (2022). In Vivo Acoustic Patterning in Zebrafish Embryos. MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, null, 392–393.

Lötscher, Jonas, Marti Lindez, Adria-Arnau, Kirchhammer, Nicole, Cribioli, Elisabetta, Giordano, Greta, Trefny, Marcel P., Lenz, Markus, Rothschild, Sacha I., Strati, Paolo, Künzli, Marco, Lotter, Claudia, Schenk, Susanne H., Dehio, Philippe, Löliger, Jordan, Litzler, Ludivine, Schreiner, David, Koch, Victoria, Page, Nicolas, Lee, Dahye, et al. (2022). Magnesium sensing via LFA-1 regulates CD8+ T cell effector function. Cell, 185, 1–18. https://doi.org/10.1016/j.cell.2021.12.039

Lotter, Claudia, Alter, Claudio Luca, Bolten, Jan Stephan, Detampel, Pascal, Palivan, Cornelia G., Einfalt, Tomaž, & Huwyler, Jörg. (2022). Incorporation of phosphatidylserine improves efficiency of lipid based gene delivery systems. European Journal of Pharmaceutics and Biopharmaceutics, 172, 134–143. https://doi.org/10.1016/j.ejpb.2022.02.007

Migga, Alexandra, Schulz, Georg, Rodgers, Griffin, Osterwalder, Melissa, Tanner, Christine, Blank, Holger, Jerjen, Iwan, Salmon, Phil, Twengström, William, Scheel, Mario, Weitkamp, Timm, Schlepütz, Christian M., Bolten, Jan S., Huwyler, Jörg, Hotz, Gerhard, Madduri, Srinivas, & Müller, Bert. (2022). Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve. Journal of Medical Imaging, 9(3), 31507. https://doi.org/10.1117/1.jmi.9.3.031507

Schroter A., Peter S., Mahler H.-C., Zerr A., Danton O., Chalus P., Koulov A.V., Huwyler J., & Jahn M. (2021). Identification of an Oxidizing Leachable from a Clinical Syringe Rubber Stopper. Journal of Pharmaceutical Sciences, 110(10), 3410–3417. https://doi.org/10.1016/j.xphs.2021.05.017

Schröter A, Mahler HC, Sayed NB, Koulov AV, Huwyler J, & Jahn M. (2021). 4-Hydroxynonenal – A Toxic Leachable from Clinically Used Administration Materials. Journal of Pharmaceutical Sciences, 110(9), 3268–3275. https://doi.org/10.1016/j.xphs.2021.05.014

Schröter, Ariane, Mahler, Hanns-Christian, Sayed, Nadia Ben, Koulov, Atanas V, Huwyler, Jörg, & Jahn, Michael. (2021). 4-Hydroxynonenal – A Toxic Leachable from Clinically Used Administration Materials. Journal of Pharmaceutical Sciences, 110(9), 3268–3275. https://doi.org/10.1016/j.xphs.2021.05.014

Schuster J, Mahler HC, Joerg S, Huwyler J, & Mathaes R. (2021). Analytical Challenges Assessing Protein Aggregation and Fragmentation Under Physiologic Conditions. Journal of Pharmaceutical Sciences, 110(9), 3103–3110. https://doi.org/10.1016/j.xphs.2021.04.014

Schuster, Joachim, Mahler, Hanns-Christian, Joerg, Susanne, Huwyler, Joerg, & Mathaes, Roman. (2021). Analytical Challenges Assessing Protein Aggregation and Fragmentation Under Physiologic Conditions. Journal of Pharmaceutical Sciences, 110(9), 3103–3110. https://doi.org/10.1016/j.xphs.2021.04.014

Schreiner, Viktoria, Detampel, Pascal, Jirkof, Paulin, Puchkov, Maxim, & Huwyler, Jörg. (2021). Buprenorphine loaded PLGA microparticles: Characterization of a sustained-release formulation. Journal of Drug Delivery Science and Technology, 63(102558). https://doi.org/10.1016/j.jddst.2021.102558

Schröter A, Koulov AV, Huwyler J, Mahler HC, & Jahn M. (2021). 4-Hydroxynonenal is An Oxidative Degradation Product of Polysorbate 80. Journal of Pharmaceutical Sciences, 110(6), 2524–2530. https://doi.org/10.1016/j.xphs.2021.01.027

Schröter, Ariane, Koulov, Atanas V., Huwyler, Jörg, Mahler, Hanns-Christian, & Jahn, Michael. (2021). 4-Hydroxynonenal is An Oxidative Degradation Product of Polysorbate 80. Journal of Pharmaceutical Sciences, 110(6), 2524–2530. https://doi.org/10.1016/j.xphs.2021.01.027

Pratsinis, Anna, Uhl, Philipp, Bolten, Jan Stephan, Hauswirth, Patrick, Schenk, Susanne Heidi, Urban, Stephan, Mier, Walter, Witzigmann, Dominik, & Huwyler, Jörg. (2021). Virus-Derived Peptides for Hepatic Enzyme Delivery. Molecular Pharmaceutics, 18(5), 2004–2014. https://doi.org/10.1021/acs.molpharmaceut.0c01222

Pratsinis A, Uhl P, Bolten JS, Hauswirth P, Schenk SH, Urban S, Mier W, Witzigmann D, & Huwyler J. (2021). Virus-Derived Peptides for Hepatic Enzyme Delivery. Molecular Pharmaceutics, 18(5), 2004–2014. https://doi.org/10.1021/acs.molpharmaceut.0c01222

Dreckmann, Tim, Ludwig, Imke Sonja, Luemkemann, Joerg, & Huwyler, Joerg. (2021). Low-Volume Aseptic Filling Using a Linear Peristaltic Pump. PDA Journal of Pharmaceutical Science and Technology, 75(3), 245–257. https://doi.org/10.5731/pdajpst.2020.011858

Dreckmann T, Ludwig IS, Luemkemann J, & Huwyler J. (2021). Low-Volume Aseptic Filling Using a Linear Peristaltic Pump. PDA Journal of Pharmaceutical Science and Technology, 75(3), 245–257. https://doi.org/10.5731/pdajpst.2020.011858

Nicolle, Laura, Casper, Jens, Willimann, Melanie, Journot, Céline M.A., Detampel, Pascal, Einfalt, Tomaz, Grisch-Chan, Hiu Man, Thöny, Beat, Gerber-Lemaire, Sandrine, & Huwyler, Jörg. (2021). Development of covalent chitosan-polyethylenimine derivatives as gene delivery vehicle: Synthesis, characterization, and evaluation. International Journal of Molecular Sciences, 22(8), 3828. https://doi.org/10.3390/ijms22083828

Nicolle L, Casper J, Willimann M, Journot CMA, Detampel P, Einfalt T, Grisch-Chan HM, Thöny B, Gerber-Lemaire S, & Huwyler J. (2021). Development of covalent chitosan-polyethylenimine derivatives as gene delivery vehicle: Synthesis, characterization, and evaluation. International Journal of Molecular Sciences, 22(8). https://doi.org/10.3390/ijms22083828

Schuster, Joachim, Probst, Christine E, Mahler, Hanns-Christian, Joerg, Susanne, Huwyler, Joerg, & Mathaes, Roman. (2021). Assessing Particle Formation of Biotherapeutics in Biological Fluids. Journal of Pharmaceutical Sciences, 110(4), 1527–1532. https://doi.org/10.1016/j.xphs.2020.12.038

Schuster J, Probst CE, Mahler HC, Joerg S, Huwyler J, & Mathaes R. (2021). Assessing Particle Formation of Biotherapeutics in Biological Fluids. Journal of Pharmaceutical Sciences, 110(4), 1527–1532. https://doi.org/10.1016/j.xphs.2020.12.038

Schittny, Andreas, Waldner, Samuel, Duthaler, Urs, Vorobyev, Alexander, Abramovich, Rimma, Krähenbühl, Stephan, Puchkov, Maxim, & Huwyler, Jörg. (2021). Particle forming amorphous solid dispersions: A mechanistic randomized pharmacokinetic study in humans. Pharmaceutics, 13(3), 1–17. https://doi.org/10.3390/pharmaceutics13030401

Schittny A, Waldner S, Duthaler U, Vorobyev A, Abramovich R, Krähenbühl S, Puchkov M, & Huwyler J. (2021). Particle forming amorphous solid dispersions: A mechanistic randomized pharmacokinetic study in humans. Pharmaceutics, 13(3). https://doi.org/10.3390/pharmaceutics13030401

Bachmann, Fabio, Duthaler, Urs, Meyer Zu Schwabedissen, Henriette E., Puchkov, Maxim, Huwyler, Jörg, Haschke, Manuel, & Krähenbühl, Stephan. (2021). Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2. Clinical Pharmacology and Therapeutics, 109(6), 1505–1516. https://doi.org/10.1002/cpt.2141

Einfalt, Tomaz, Detampel, Pascal, Häussinger, Daniel, Casper, Jens, Meier, Christoph, Puchkov, Maxim, & Huwyler, Jörg. (2021). Hydroxychloroquine immediate release tablets: Formulation and evaluation of a solid dosage form. ChemRxiv Preprint. https://doi.org/10.26434/chemrxiv.14170508.v1

Jere, Dhananjay, Sediq, Ahmad S., Huwyler, Jörg, Vollrath, Ilona, Kardorff, Markus, & Mahler, Hanns-Christian. (2021). Challenges for cell-based medicinal products from a pharmaceutical product perspective. Journal of Pharmaceutical Sciences, 110(5), 1900–1908. https://doi.org/10.1016/j.xphs.2020.11.040

Migga, Alexandra, Schulz, Georg, Schulz G., Griffin, Osterwalder, Melissa, Tanner, Christine, Blank, Holger, Blank H., Jerjen I., Twengström, William, Twengstrom W., Scheel M., Schlepütz, Christian M., Bolten, Jan S., Huwyler, Jörg, Huwyler J., Hotz G., Madduri S., & Muller B. (2021). Laboratory-based phase and absorption tomography for microimaging of annual layers in human tooth cementum, paraffinembedded nerve and zebrafish embryo. Proceedings of SPIE - the International Society for Optical Engineering, 11840. https://doi.org/10.1117/12.2597926

Osterwalder, Melissa, Bolten, Jan Stephan, Rodgers, Griffin, Schulz, Georg, Tanner, Christine, Cörek, Emre, Huwyler, Jörg, & Müller, Bert. (2021). Three-dimensional X-ray microscopy of zebra sh larvae. Bioinspiration, Biomimetics, and Bioreplication XI, 11586, 115860J. https://doi.org/10.1117/12.2583639

Preisig, Daniel, Varum, Felipe, Bravo, Roberto, Hartig, Claudia, Spleiss, Johannes, Abbes, Sonia, Caobelli, Federico, Wild, Damian, Puchkov, Maxim, Huwyler, Jörg, & Haschke, Manuel. (2021). Colonic delivery of metronidazole-loaded capsules for local treatment of bacterial infections: a clinical pharmacoscintigraphy study. European Journal of Pharmaceutics and Biopharmaceutics, 165, 22–30. https://doi.org/10.1016/j.ejpb.2021.05.002

Sanad, Mahmoud Tarek, Alter, Claudio, Detampel, Pascal, Einfalt, Tomaz, & Huwyler, Jörg. (2021). Manufacturing of Liposomes: A Direct Comparison of Extrusion and Microfluidics Protocols. American Chemical Society. https://doi.org/10.26434/chemrxiv.14604921.v1

Schreiner, Viktoria, Detampel, Pascal, Jirkof, Paulin, Puchkov, Maxim, & Huwyler, Jörg. (2021). Buprenorphine loaded PLGA microparticles: Characterization of a sustained-release formulation. Journal of Drug Delivery Science and Technology, 63, 102558. https://doi.org/10.1016/j.jddst.2021.102558

Schuster, Joachim, Mahler, Hanns-Christian, Joerg, Susanne, Kamuju, Vinay, Huwyler, Joerg, & Mathaes, Roman. (2021). Stability of Monoclonal Antibodies after Simulated Subcutaneous Administration. Journal of Pharmaceutical Sciences, 110(6), 2386–2394. https://doi.org/10.1016/j.xphs.2021.03.007

Wagner-Hattler, Leonie, Kiene, Klara, Bielicki, Julia, Pfister, Marc, Puchkov, Maxim, & Huwyler, Jörg. (2021). High Acceptability of an Orally Dispersible Tablet Formulation by Children. Children, 8(3), 194. https://doi.org/10.3390/children8030194

Witzigmann, Dominik, Grossen, Philip, Quintavalle, Cristina, Lanzafame, Manuela, Schenk, Susanne H., Tran, Xue-Ting, Englinger, Bernhard, Hauswirth, Patrick, Grünig, David, van Schoonhoven, Sushilla, Krähenbühl, Stephan, Terracciano, Luigi M., Berger, Walter, Piscuoglio, Salvatore, Quagliata, Luca, Rommelaere, Jean, Nüesch, Jürg P. F., & Huwyler, Jörg. (2021). Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma. Journal of Controlled Release, 334, 138–152. https://doi.org/10.1016/j.jconrel.2021.04.023

Mahsa Sedighi, Fereshteh Rahimi, Mohammad-Ali Shahbazi, Ali Hossein, Rezayan, Helene Kettiger, Tomaz Einfalt, Jörg Huwyler, & Dominik Witzigmann. (2020). Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles. ACS Applied Bio Materials, 3, 239–251. https://pubs.acs.org/doi/10.1021/acsabm.9b00772

Nikolaev YA, Tutel’yan AV, Loiko NG, Buck J, Sidorenko SV, Lazareva I, Gostev V, Manzen’yuk OY, Shemyakin IG, Abramovich RA, Huwyler J, & El’-Registan GI. (2020). The use of 4-Hexylresorcinol as antibiotic adjuvant. PLoS ONE, 15(9 September), e0239147. https://doi.org/10.1371/journal.pone.0239147

Nikolaev, Y.A., Tutel’yan, A.V., Loiko, N.G., Buck, J., Sidorenko, S.V., Lazareva, I., Gostev, V., Manzen’yuk, O.Y., Shemyakin, I.G., Abramovich, R.A., Huwyler, J., & El’-Registan, G.I. (2020). The use of 4-Hexylresorcinol as antibiotic adjuvant. PLoS ONE, 15(9 September), e0239147. https://doi.org/10.1371/journal.pone.0239147

Grapentin, Christoph, Müller, Claudia, Kishore, Ravuri S K, Adler, Michael, ElBialy, Inas, Friess, Wolfgang, Huwyler, Jörg, & Khan, Tarik A. (2020). Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188. Journal of Pharmaceutical Sciences, 109(8), 2393–2404. https://doi.org/10.1016/j.xphs.2020.03.010

Grapentin C, Müller C, Kishore RSK, Adler M, ElBialy I, Friess W, Huwyler J, & Khan TA. (2020). Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188. Journal of Pharmaceutical Sciences, 109(8), 2393–2404. https://doi.org/10.1016/j.xphs.2020.03.010

Schuster, Joachim, Koulov, Atanas, Mahler, Hanns-Christian, Detampel, Pascal, Huwyler, Joerg, Singh, Satish, & Mathaes, Roman. (2020). Correction to: In Vivo Stability of Therapeutic Proteins (Pharmaceutical Research, (2020), 37, 2, (23), 10.1007/s11095-019-2689-1). Pharmaceutical Research, 37(3), 68. https://doi.org/10.1007/s11095-020-2780-7

Dreckmann, Tim, Boeuf, Julien, Ludwig, Imke-Sonja, Lümkemann, Jörg, & Huwyler, Jörg. (2020). Low volume aseptic filling: Impact of pump systems on shear stress. European Journal of Pharmaceutics and Biopharmaceutics, 147, 10–18. https://doi.org/10.1016/j.ejpb.2019.12.006

Buck, Jonas, Müller, Dennis, Mettal, Ute, Ackermann, Miriam, Grisch-Chan, Hiu Man, Thöny, Beat, Zumbuehl, Andreas, Huwyler, Jörg, & Witzigmann, Dominik. (2020). Improvement of DNA Vector Delivery of DOTAP Lipoplexes by Short-Chain Aminolipids. ACS Omega, 5(38), 24724–24732. https://doi.org/10.1021/acsomega.0c03303

Cörek, Emre, Rodgers, Griffin, Siegrist, Stefan, Einfalt, Tomaz, Detampel, Pascal, Schlepütz, Christian M., Sieber, Sandro, Fluder, Pascal, Schulz, Georg, Unterweger, Harald, Alexiou, Christoph, Müller, Bert, Puchkov, Maxim, & Huwyler, Jörg. (2020). Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution. Small, 16(31), e2000746. https://doi.org/10.1002/smll.202000746

Dreckmann, Tim, Aipperspach, Wolfgang, Pfleghar, Kevin, Tröndle, Julien, Ernst, Andreas, Huwyler, Joerg, Ludwig, Imke-Sonja, & Luemkemann, Joerg. (2020). Assessment of Sensor Concepts for 100% In-Process Control of Low-Volume Aseptic Fill-Finish Processes. PDA Journal of Pharmaceutical Science and Technology, 74(6), 660–673. https://doi.org/10.5731/pdajpst.2019.011270

Dreckmann, Tim, Ludwig, Imke-Sonja, Boeuf, Julien, Lümkemann, Jörg, & Huwyler, Jörg. (2020). Low Volume Aseptic Filling: Impact of Pump Systems on Shear Stress. European Journal of Pharmaceutics and Biopharmaceutics, 147, 10–18. https://doi.org/10.1016/j.ejpb.2019.12.006

Ehrsam, Daniel, Sieber, Sandro, Oufir, Mouhssin, Porta, Fabiola, Hamburger, Matthias, Huwyler, Jörg, & Meyer zu Schwabedissen, Henriette E. (2020). Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9. Bioconjugate Chemistry, 31(3), 781–793. https://doi.org/10.1021/acs.bioconjchem.9b00865

Einfalt, Tomaz, Garni, Martina, Witzigmann, Dominik, Sieber, Sandro, Baltisberger, Niklaus, Huwyler, Jörg, Meier, Wolfgang, & Palivan, Cornelia. (2020). Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics. Advanced Science, 7(4), 1901923. https://doi.org/10.1002/advs.201901923

Farzan, Maryam, Québatte, Gabriela, Strittmatter, Katrin, Hilty, Florentine Marianne, Schoelkopf, Joachim, Huwyler, Jörg, & Puchkov, Maxim. (2020). Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery. Pharmaceutics, 12(8), 777. https://doi.org/10.3390/pharmaceutics12080777

Häuser, Christina, Goldbach, Pierre, Huwyler, Jörg, Friess, Wolfgang, & Allmendinger, Andrea. (2020). Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations. Journal of Pharmaceutical Sciences, 109(1), 807–817. https://doi.org/10.1016/j.xphs.2019.10.016

Keller, Ladina, Palmeirim, Marta S., Ame, Shaali M., Ali, Said M., Puchkov, Maxim, Huwyler, Jörg, Hattendorf, Jan, & Keiser, Jennifer. (2020). Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against Trichuris trichiura in adolescents: a randomized controlled trial. Clinical Infectious Diseases, 70(6), 1193–1201. https://doi.org/10.1093/cid/ciz326

Liu, Juan, Craciun, Ioana, Belluati, Andrea, Wu, Dalin, Sieber, Sandro, Einfalt, Tomaz, Witzigmann, Dominik, Chami, Mohamed, Huwyler, Jörg, & Palivan, Cornelia G. (2020). DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo. Nanoscale, 12(17), 9786–9799. https://doi.org/10.1039/d0nr00361a

Matter, Madlaina, Mühlebach, Stefan, Puchkov, Maxim, & Huwyler, Jörg. (2020). Missbrauch von Opioiden und mögliche Auswege aus der Opioid-Krise. Therapeutische Umschau, 77(1), 24–28. https://doi.org/10.1024/0040-5930/a001147

Matter, Madlaina, Mühlebach, Stefan, Puchkov, Maxim, & Huwyler, Jörg. (2020). Abuse deterrent drug formulations for opioids. Therapeutische Umschau, 77, 24–28. https://doi.org/10.24/0040-5930/a001147

Osterwalder, Melissa, Bolten, Jan Stephan, Rodgers, Griffin, Humbel, Mattia, Schulz, Georg, Tanner, Christine, Huwyler, Jörg, & Müller, Bert. (2020). Hard X-ray microtomography of Zebrafish larvae. Spiedigitallibrary, Conference Proceedings of SPIE, 11886, 118864. https://doi.org/10.1117/12.2593119

Schittny, Andreas, Huwyler, Jörg, & Puchkov, Maxim. (2020). Mechanisms of increased bioavailability through amorphous solid dispersions: a review. Drug Delivery, 27(1), 110–127. https://doi.org/10.1080/10717544.2019.1704940

Schittny, Andreas, Philipp-Bauer, Selina, Detampel, Pascal, Huwyler, Jörg, & Puchkov, Maxim. (2020). Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions. Journal of Controlled Release, 320, 214–225. https://doi.org/10.1016/j.jconrel.2020.01.031