Prof. Dr. med. Christopher Böhlke

Mueller, Evelyn, Gahr, Susanne, Schnell, Annette, Schildmann, Eva, Boehlke, Christopher, & Roch, Carmen. (2025). Challenges in opioid therapy implementation: national survey of palliative care consultation services. BMC Palliative Care, 24. https://doi.org/10.1186/s12904-025-01921-0

Golla, Heidrun, Nettekoven, Charlotte, Hellmich, Martin, Appelmann, Iris, Bausewein, Claudia, Becker, Gerhild, Boehlke, Christopher, Brumbarova, Tzvetina, Civello, Daniele, Clusmann, Hans, Haberland, Birgit, Henrik Heiland, Dieter, Herrlinger, Ulrich, Jaspers, Birgit, Joshi, Melanie, Mülller, Dirk, Müller, Wiebke, Na, Chuh-Hyoun, Neukirchen, Martin, et al. (2025). Early Palliative Care for Patients with Glioblastoma: A randomized phase lll clinical trial (EPCOG). Neuro-Oncology. https://doi.org/10.1093/neuonc/noaf230

Müller, Felix, Zaczek, Hannes, Becker, Anna M., Ley, Laura, Borgwardt, Stefan, Santos de Jesus, Joyce, Loh, Nico, Kohut, Jan, Auernig, Mathias, Boehlke, Christopher, & Liechti, Matthias E. (2025). Efficacy and safety of low- versus high-dose-LSD-assisted therapy in patients with major depression: A randomized trial. Med, 6, 100725. https://doi.org/10.1016/j.medj.2025.100725

Schuldt, Anna, Clark, Ian C., Schmid, Yasmin, Ljuslin, Michael, Boehlke, Christopher, Schipper, Sivan, Sands, Megan B., & Blum, David. (2025). Psychedelic-Assisted Therapy in Palliative Care—Insights from an International Workshop. Healthcare, 13(18), 2275. https://doi.org/10.3390/healthcare13182275

Gaertner, Jan, Appenzeller-Herzog, Christian, Piechotta, Vanessa, Schwarzer, Guido, Rémi, Constanze, Suter, Katja, & Boehlke, Christopher. (2025). Pharmacological antiemetic prophylaxis and treatment for opioid-induced nausea and vomiting (OINV) in patients treated for cancer pain and cancer-related breathlessness [Journal-article]. Cochrane Database of Systematic Reviews, 8(8). https://doi.org/10.1002/14651858.cd016207

Seibel, Katharina, Rios, Claudia Lorena Orellana, Sparna, Titus, Becker, Carola, Gaertner, Jan, Becker, Gerhild, & Boehlke, Christopher. (2024). Implementation of a digital distress detection system in palliative care: qualitative data on perspectives of a multiprofessional palliative care team [Journal-article]. BMC Palliative Care, 23(1). https://doi.org/10.1186/s12904-024-01530-3

Schipper, Sivan, Nigam, Kabir, Schmid, Yasmin, Piechotta, Vanessa, Ljuslin, Michael, Beaussant, Yvan, Schwarzer, Guido, & Boehlke, Christopher. (2024). Psychedelic-assisted therapy for treating anxiety, depression, and existential distress in people with life-threatening diseases. Cochrane Database of Systematic Reviews, 2024(9). https://doi.org/10.1002/14651858.cd015383.pub2

Boehlke, C., Joos, L., Coune, B., Becker, C., Meerpohl, J. J., Buroh, S., Hercz, D., Schwarzer, G., & Becker, G. (2024). Pharmacological interventions for pruritus in adult palliative care patients [Journal-article]. Cochrane Database of Systematic Reviews, 2024(8). https://doi.org/10.1002/14651858.CD008320.pub4

Gaertner, Jan, Boehlke, Christopher, Kreye, Gudrun, Fusi-Schmidhauser, Tanja, Mueller, Evelyn, & Roch, Carmen. (2024). Pharmacological treatment of cancer pain and opioid induced nausea and vomiting: online survey and comparison with current guidelines [Journal-article]. Supportive Care in Cancer, 32(7). https://doi.org/10.1007/s00520-024-08628-7

Müller, E., Müller, M. J., Boehlke, C., Schäfer, H., Quante, M., & Becker, G. (2024). Screening for Palliative Care Need in Oncology: Validation of Patient-Reported Outcome Measures. Journal of Pain and Symptom Management, 67(4), 279–289. https://doi.org/10.1016/j.jpainsymman.2023.12.013

Gärtner, Jan, Jaroslawski, Karin, Thuss-Patience, Peter, Rosenbruch, Johannes, Böhlke, Christopher, & Becker, Gerhild. (2024). Erratum to: SOP – Aufnahmekriterien auf die Palliativstation (Die Onkologie, (2024), 30, S2, (67-69), 10.1007/s00761-022-01170-3). Onkologie, 30, 113. https://doi.org/10.1007/s00761-022-01225-5

Gärtner, Jan, Jaroslawski, Karin, Thuss-Patience, Peter, Rosenbruch, Johannes, Böhlke, Christopher, & Becker, Gerhild. (2024). SOP – Admission criteria for the palliative ward [Journal-article]. Onkologie, 30, 67–69. https://doi.org/10.1007/s00761-022-01170-3

Jan Gärtner, Christopher Boehlke, Gudrun Kreye, Tanja Fusi-Schmidhauser, & Carmen Roch. (2024, January 1). Inconsistencies in the pharmacological management of common symptoms in palliative care: A physician survey. 13th World Research Congress of the European Association for Palliative Care. https://doi.org/10.1177/02692163241242338

Sivan Schipper, Kabir Nigam, Yasmin Schmid, Vanessa Piechotta, Yvan Beaussant, Guido Schwarzer, & Christopher Boehlke. (2024, January 1). Psychedelic-assisted therapy for treatment of anxiety, depression and existential distress in life-threatening disease. 13th World Research Congress of the European Association for Palliative Care. https://doi.org/10.1177/02692163241242338

Müller, E., Müller, M. J., Seibel, K., Boehlke, C., Schäfer, H., Klein, C., Heckel, M., Simon, S. T., & Becker, G. (2023). Interrater agreement of multi-professional case review as reference standard for specialist palliative care need: a mixed-methods study [Journal-article]. BMC Palliative Care, 22(1). https://doi.org/10.1186/s12904-023-01281-7

Trittler, R., Abotaleb, A., Böhlke, C., Offner, K., Hug, M., & Becker, G. (2023). 3PC-014 Metamorphine instead of polysubstance use? [Proceedings-article]. Section 3: Production and Compounding. https://doi.org/10.1136/ejhpharm-2023-eahp.37

Felix Müller, H. Zaczek, Anna M. Becker, Laura Ley, Stefan Borgwardt, J. Santos de Jesus, N. Loh, J. Kohut, M. Auernig, Christopher Boehlke, & Matthias E Liechti. (2023, January 1). Lysergic acid diethylamide for depression — a randomized, double-blind, low dose-controlled phase ii trial. 36th ECNP Congress. https://doi.org/10.1016/j.nsa.2023.103912

Bausewein, C., Hodiamont, F., Berges, N., Ullrich, A., Gerlach, C., Oechsle, K., Pauli, B., Weber, J., Stiel, S., Schneider, N., Krumm, N., Rolke, R., Gebel, C., Jansky, M., Nauck, F., Wedding, U., van Oorschot, B., Roch, C., Werner, L., et al. (2022). National strategy for palliative care of severely ill and dying people and their relatives in pandemics (PallPan) in Germany - study protocol of a mixed-methods project [Journal-article]. BMC Palliative Care, 21(1). https://doi.org/10.1186/s12904-021-00898-w

Schipper, S., Nigam, K., Piechotta, V., Ljuslin, M., Beaussant, Y., Schwarzer, G., & Boehlke, C. (2022). Psychedelic/entactogen-assisted therapy for treatment of anxiety, depression and existential distress in adult palliative care [Journal-article]. Cochrane Database of Systematic Reviews, 2022(11). https://doi.org/10.1002/14651858.CD015383

Müller, E., Müller, M. J., Boehlke, C., Ramsenthaler, C., Jäger, H., Schäfer, H., Ostgathe, C., Klein, C., Simon, S., & Becker, G. (2022). Development of a screening tool for the need of specialist palliative care in oncologic inpatients: Study protocol for the ScreeningPALL Study [Journal-article]. BMJ Open, 12(9), e059598. https://doi.org/10.1136/bmjopen-2021-059598

Seibel, K., Couné, B., Mueller, M., Boehlke, C., Simon, S. T., Bausewein, C., & Becker, G. (2022). Implementation of an acute palliative care unit for COVID-19 patients in a tertiary hospital: Qualitative data on clinician perspectives [Journal-article]. Palliative Medicine, 36(2), 332–341. https://doi.org/10.1177/02692163211059690

Böhlke, C, Joos, L, Becker, C, Meerpohl, J, Buroh, S, Schwarzer, G, Hercz, D, & Becker, G. (2022, January 1). Pharmakologische Interventionen gegen Pruritus (Juckreiz) bei Palliativpatienten. Deutsche Gesellschaft Für Palliativmedizin.

Müller, EA, Müller, MJ, Opitz, S, Schütte-Nütgen, K, Klein, C, Simon, ST, Schäfer, H, Böhlke, C, Ostgathe, C, Bausewein, C, & Becker, G. (2022, January 1). Sensitivität und Spezifität der Integrated Palliative Care Outcome Scale als Screening auf Bedarf an spezialisierter Palliativversorgung bei onkologischen Patient*innen: preliminary results. Deutsche Gesellschaft Für Palliativmedizin. https://doi.org/10.1055/s-0042-1754023

Müller, MJ, Müller, E, Jäger, H, Klein, C, Ostgathe, C, Simon, ST, Schäfer, H, Böhlke, C, & Becker, G. (2022, January 1). Multiprofessionelle Fallbesprechungen als Referenzkriterium zur Ermittlung des Bedarfs an spezialisierter palliativmedizinischer Versorgung: Beurteiler-Übereinstimmung und Argumentationslinien. Deutsche Gesellschaft Für Palliativmedizin. https://doi.org/10.1055/s-0042-1754035

Kotsis, F., Janusch, H., Li, Y., Viau, A., Epting, D., Kramer-Zucker, A., Walz, G., Nitschke, R., Lorentzen, E., Ganner, A., Neumann-Haefelin, E., Kuehn, E. W., & Boehlke, C. (2021). Ift88, but not Kif3a, is required for establishment of the periciliary membrane compartment [Journal-article]. Biochemical and Biophysical Research Communications, 584, 19–25. https://doi.org/10.1016/j.bbrc.2021.10.075

Andreas, M., Piechotta, V., Skoetz, N., Grummich, K., Becker, M., Joos, L., Becker, G., Meissner, W., & Boehlke, C. (2021). Interventions for palliative symptom control in COVID-19 patients [Journal-article]. Cochrane Database of Systematic Reviews, 2021(8). https://doi.org/10.1002/14651858.CD015061

Mueller, E., Bollig, G., Becker, G., & Boehlke, C. (2021). Lessons learned from introducing last aid courses at a university hospital in Germany [Journal-article]. Healthcare (Switzerland), 9(7), 906. https://doi.org/10.3390/healthcare9070906

Seibel, K., Couné, B., Mueller, M., Boehlke, C., Ramsenthaler, C., & Becker, G.. (2021, January 1). The Ad Hoc Establishment of an Acute Palliative Care (PC) Ward for Covid-19 Patients in a Tertiary University Hospital in Germany – The Perspective of the Staff and Stakeholders Involved. EAPC World Congress.

Siemens Waldemar, Boehlke Christopher, Bennett Michael I., Offner Klaus, Becker Gerhild, & Gaertner Jan. (2020). Transcutaneous electrical nerve stimulation for advanced cancer pain inpatients in specialist palliative care—a blinded, randomized, sham-controlled pilot cross-over trial. Supportive Care in Cancer, 28(11), 5323–5333. https://doi.org/10.1007/s00520-020-05370-8

Viau, A., Kotsis, F., Boehlke, C., Braeg, S., Klein, M., Nitschke, R., Walz, G., & Kuehn, E. W. (2020). Divergent function of polycystin 1 and polycystin 2 in cell size regulation [Journal-article]. Biochemical and Biophysical Research Communications, 521(2), 290–295. https://doi.org/10.1016/j.bbrc.2019.10.074

Golla, H., Nettekoven, C., Bausewein, C., Tonn, J.-C., Thon, N., Feddersen, B., Schnell, O., Böhlke, C., Becker, G., Rolke, R., Clusmann, H., Herrlinger, U., Radbruch, L., Vatter, H., Güresir, E., Stock, S., Müller, D., Civello, D., Papachristou, I., et al. (2020). Effect of early palliative care for patients with glioblastoma (EPCOG): A randomised phase III clinical trial protocol [Journal-article]. BMJ Open, 10(1), e034378. https://doi.org/10.1136/bmjopen-2019-034378

Katharina Seibel, Claudia Lorena Orellana-Rios, Gerhild Becker, & Christopher Boehlke. (2020, January 1). Distresserfassung bei nicht äußerungsfähigen Palliativpatienten durch ein neues Sensorsystem? – Die Perspektive des Palliative Care Teams am Universitätsklinikum Freiburg im Rahmen der Quickstart Evaluation-Studie (QE-Studie) [296]. 13. Kongress Der Deutschen Gesellschaft Für Palliativmedizin. https://doi.org/DOI: 10.1055/s-0040-1715002

Gaertner Jan, Boehlke Christopher, Simone Charles B., & Hui David. (2019). Early palliative care and the opioid crisis: Ten pragmatic steps towards a more rational use of opioids. Annals of Palliative Medicine, 8(4), 420–427. https://doi.org/10.21037/apm.2019.08.01

Boehlke, C., Janusch, H., Hamann, C., Powelske, C., Mergen, M., Herbst, H., Kotsis, F., Nitschke, R., & Kuehn, E. W. (2015). A cilia independent role of Ift88/polaris during cell migration [Journal-article]. PLoS ONE, 10(10), e0140378. https://doi.org/10.1371/journal.pone.0140378

Thien, A., Prentzell, M. T., Holzwarth, B., Kläsener, K., Kuper, I., Boehlke, C., Sonntag, A. G., Ruf, S., Maerz, L., Nitschke, R., Grellscheid, S.-N., Reth, M., Walz, G., Baumeister, R., Neumann-Haefelin, E., & Thedieck, K. (2015). Correction to TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition [Developmental Cell, 32, (2015) 617-630]. Developmental Cell, 33(3), 366. https://doi.org/10.1016/j.devcel.2015.04.002

Thien, A., Prentzell, M., Holzwarth, B., Kläsener, K., Kuper, I., Boehlke, C., Sonntag, Annika G., Ruf, S., Maerz, L., Nitschke, R., Grellscheid, S.-N., Reth, M., Walz, G., Baumeister, R., Neumann-Haefelin, E., & Thedieck, K. (2015). TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition [Journal-article]. Developmental Cell, 32(5), 617–630. https://doi.org/10.1016/j.devcel.2015.01.026

Epting, D., Slanchev, K., Boehlke, C., Hoff, S., Loges, N. T., Yasunaga, T., Indorf, L., Nestel, S., Lienkamp, S. S., Omran, H., Kuehn, E. W., Ronneberger, O., Walz, G., & Kramer-Zucker, A. (2015). The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin [Journal-article]. Development (Cambridge), 142(1), 174–184. https://doi.org/10.1242/dev.112250

Boehlke Christopher, Hartleben Björn, Huber Tobias B., Hopfer Helmut, Walz Gerd, & Neumann-Haefelin Elke. (2014). Hantavirus infection with severe proteinuria and podocyte foot-process effacement. American Journal of Kidney Diseases, 64(3), 452–456. https://doi.org/10.1053/j.ajkd.2014.04.030

Boehlke, C., Kotsis, F., Buchholz, B., Powelske, C., Eckardt, K.-U., Walz, G., Nitschke, R., & Kuehn, E. W. (2013). Kif3a Guides Microtubular Dynamics, Migration and Lumen Formation of MDCK Cells [Journal-article]. PLoS ONE, 8(5), e62165. https://doi.org/10.1371/journal.pone.0062165

Idzko, M., K. Ayata, C., Müller, T., Dürk, T., Grimm, M., Baudiß, K., Vieira, R. P., Cicko, S., Boehlke, C., Zech, A., Sorichter, S., Pelletier, J., Sévigny, J., & Robson, S. C. (2013). Attenuated allergic airway inflammation in Cd39 null mice [Journal-article]. Allergy: European Journal of Allergy and Clinical Immunology, 68(4), 472–480. https://doi.org/10.1111/all.12119

Kotsis, F., Boehlke, C., & Kuehn, E. W. (2013). The ciliary flow sensor and polycystic kidney disease [Journal-article]. Nephrology Dialysis Transplantation, 28(3), 518–526. https://doi.org/10.1093/ndt/gfs524

Hoff, S., Halbritter, J., Epting, D., Frank, V., Nguyen, T.-M. T., van Reeuwijk, J., Boehlke, C., Schell, C., Yasunaga, T., Helmstädter, M., Mergen, M., Filhol, E., Boldt, K., Horn, N., Ueffing, M., Otto, E. A., Eisenberger, T., Elting, M. W., van Wijk, J. A. E., et al. (2013). ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3 [Journal-article]. Nature Genetics, 45(8), 951–956. https://doi.org/10.1038/ng.2681

Thedieck, K., Holzwarth, B., Prentzell, M. T., Boehlke, C., Kläsener, K., Ruf, S., Sonntag, A. G., Maerz, L., Grellscheid, S. N., Kremmer, E., Nitschke, R., Kuehn, E. W., Jonker, J. W., Groen, A. K., Reth, M., Hall, M. N., & Baumeister, R. (2013). Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells. Cell, 154(4), 859–874. https://doi.org/10.1016/j.cell.2013.07.031

Lienkamp, S., Ganner, A., Boehlke, C., Schmidt, T., Arnold, S. J., Schäfer, T., Romaker, D., Schuler, J., Hoff, S., Powelske, C., Eifler, A., Krönig, C., Bullerkotte, A., Nitschke, R., Kuehn, E. W., Kim, E., Burkhardt, H., Brox, T., Ronneberger, O., et al. (2010). Inversin relays Frizzled-8 signals to promote proximal pronephros development [Journal-article]. Proceedings of the National Academy of Sciences of the United States of America, 107(47), 20388–20393. https://doi.org/10.1073/pnas.1013070107

Boehlke, C., Kotsis, F., Patel, V., Braeg, S., Voelker, H., Bredt, S., Beyer, T., Janusch, H., Hamann, C., Gödel, M., Müller, K., Herbst, M., Hornung, M., Doerken, M., Köttgen, M., Nitschke, R., Igarashi, P., Walz, G., & Kuehn, E. W. (2010). Primary cilia regulate mTORC1 activity and cell size through Lkb1 [Journal-article]. Nature Cell Biology, 12(11), 1115–1122. https://doi.org/10.1038/ncb2117

Boehlke, C., Bashkurov, M., Buescher, A., Krick, T., John, A.-K., Nitschke, R., Walz, G., & Kuehn, E. W. (2010). Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels [Journal-article]. Journal of Cell Science, 123(9), 1460–1467. https://doi.org/10.1242/jcs.058883

Gao, H., Wang, Y., Wegierski, T., Skouloudaki, K., Pütz, M., Fu, X., Engel, C., Boehlke, C., Peng, H., Kuehn, E. W., Kim, E., Kramer-Zucker, A., & Walz, G. (2009). PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation [Journal-article]. Human Molecular Genetics, 19(1), 16–24. https://doi.org/10.1093/hmg/ddp463

Skouloudaki, K., Puetz, M., Simons, M., Courbard, J.-R., Boehlke, C., Hartleben, B., Engel, C., Moeller, M. J., Englert, C., Bollig, F., Schäfer, T., Ramachandran, H., Mlodzik, M., Huber, T. B., Kuehn, E. W., Kim, E., Kramer-Zucker, A., & Walz, G. (2009). Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development [Journal-article]. Proceedings of the National Academy of Sciences of the United States of America, 106(21), 8579–8584. https://doi.org/10.1073/pnas.0811691106

Köttgen, M., Buchholz, B., Garcia-Gonzalez, M. A., Kotsis, F., Fu, X., Doerken, M., Boehlke, C., Steffl, D., Tauber, R., Wegierski, T., Nitschke, R., Suzuki, M., Kramer-Zucker, A., Germino, G. G., Watnick, T., Prenen, J., Nilius, B., Kuehn, E. W., & Walz, G. (2008). TRPP2 and TRPV4 form a polymodal sensory channel complex [Journal-article]. The Journal of General Physiology, 132(3), i2–i2. https://doi.org/10.1085/jgp1323oia2

Köttgen, M., Buchholz, B., Garcia-Gonzalez, M. A., Kotsis, F., Fu, X., Doerken, M., Boehlke, C., Steffl, D., Tauber, R., Wegierski, T., Nitschke, R., Suzuki, M., Kramer-Zucker, A., Germino, G. G., Watnick, T., Prenen, J., Nilius, B., Kuehn, E. W., & Walz, G. (2008). TRPP2 and TRPV4 form a polymodal sensory channel complex. Journal of Cell Biology, 182(3), 437–447. https://doi.org/10.1083/jcb.200805124

Kuehn, E. W., Hirt, M. N., John, A.-K., Muehlenhardt, P., Boehlke, C., Pütz, M., Kramer-Zucker, A. G., Bashkurov, M., van de Weyer, P. S., Kotsis, F., & Walz, G. (2007). Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2 [Journal-article]. Biochemical and Biophysical Research Communications, 364(4), 861–866. https://doi.org/10.1016/j.bbrc.2007.10.103

Kotsis, F., Nitschke, R., Boehlke, C., Bashkurov, M., Walz, G., & Kuehn, E. W. (2007). Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1) [Journal-article]. Pflugers Archiv European Journal of Physiology, 453(6), 819–829. https://doi.org/10.1007/s00424-006-0168-0

Christopher Boehlke, Hans-Joerg Busch, Michael Müller, & Gerhild Becker. (2021). Integration von Palliativmanagement im Krisenmanagement. In DIVI Jahrbuch 2021/2022.

Constanze Rémi, Claudia Bausewein, Christopher Böhlke, Bernd Alt-Epping, Steffen Eychmüller, Beatrix Gerhard, hristina Gerlach, Katja Goudinoudis, Ulrich Grabenhorst, Farina Hodiamont, Helmut Hofmann-Menzel, Carsten Klein, Alina Hermann, Eva Masel, Andreas Müller, Wolf-Dieter Ludwig, Susanne Preuß, Achim Rieger, Roman Rolke, et al. (2020). Zum Umgang mit Off-Label-Use in der Palliativmedizin. Deutschen Gesellschaft für Palliativmedizin e. V.

Sivan Schipper, Jan Gärtner, & Christopher Boehlke. (2024). Psychedelika-assistierte Therapie bei Total Pain am Lebensende: Eine therapeutische Perspektive für die Zukunft? [Journal-article]. palliative.ch, 22(3), 1–80. https://doi.org/10.1024/1660-6426/a000009

Gärtner J, Jaroslawski K, Becker G, & Boehlke C. (2019). Improvement of restless legs syndrome under treatment of cancer pain with morphine and fentanyl (Patent No. MAY). Frontiers in Neurology, 10(MAY), Article MAY. https://doi.org/10.3389/fneur.2019.00457