Prof. Dr. Stephanie Gros

Brazzola, S., Guglielmetti, L., Gros, S., Holland-Cunz, S., Vuille-dit-Bille, R., & Muff, J. L. (2025). Level of awareness regarding MIS-C among medical students and surgeons in Switzerland [Journal-article]. World Journal of Pediatric Surgery, 8(2), e000986. https://doi.org/10.1136/wjps-2024-000986

Volkart, Stefanie, Kym, Urs, Braissant, Olivier, Delgado-Eckert, Edgar, Al-Samir, Samer, Angresius, Rebecca, Huo, Zihe, Holland-Cunz, Stefan, & Gros, Stephanie J. (2023). AQP1 in the Gastrointestinal Tract of Mice: Expression Pattern and Impact of AQP1 Knockout on Colonic Function. International Journal of Molecular Sciences, 24(4). https://doi.org/10.3390/ijms24043616

Volkart, Stefanie, Kym, Urs, Braissant, Olivier, Delgado-Eckert, Edgar, Al-Samir, Samer, Angresius, Rebecca, Huo, Zihe, Holland-Cunz, Stefan, & Gros, Stephanie J. (2023). AQP1 in the Gastrointestinal Tract of Mice: Expression Pattern and Impact of AQP1 Knockout on Colonic Function [Journal-article]. International Journal of Molecular Sciences, 24(4), 3616. https://doi.org/10.3390/ijms24043616

Sommer-Joergensen, Vivienne., Sarcevic, Jelena, Haecker, Frank-Martin, Holland-Cunz, Stefan, Gros, Stephanie J., & Frech-Dörfler, Martina. (2022). Dysfunctional Voiding and Incontinence Scoring System for Children and Adolescents: A Tool to Predict Clinical Course and Outcome. European Journal of Pediatric Surgery, 32(5), 429–434. https://doi.org/10.1055/s-0041-1741543

Muff, J.L., Guglielmetti, L.C., Gros, S.J., Buchmüller, L., Frongia, G., Haecker, F.-M., Holland-Cunz, S.G., de Trey, T., & Vuille-dit-Bille, Raphael N. (2022). Correction to: Failed preoperative vacuum bell therapy does not affect outcomes following minimally invasive repair of pectus excavatum (Pediatric Surgery International, (2021), 37, 10, (1429-1435), 10.1007/s00383-021-04963-6). Pediatric Surgery International, 38(5), 779. https://doi.org/10.1007/s00383-022-05087-1

Huo, Zihe, Bilang, Remo, Supuran, Claudiu T., von der Weid, Nicolas, Bruder, Elisabeth, Holland-Cunz, Stefan, Martin, Ivan, Muraro, Manuele G., & Gros, Stephanie J. (2022). Perfusion-Based Bioreactor Culture and Isothermal Microcalorimetry for Preclinical Drug Testing with the Carbonic Anhydrase Inhibitor SLC-0111 in Patient-Derived Neuroblastoma. International Journal of Molecular Sciences, 23(6). https://doi.org/10.3390/ijms23063128

Muff, J.L., Guglielmetti, L.C., Gros, S.J., Buchmüller, L., Frongia, G., Holland-Cunz, S.G., de Trey, T., & Vuille-dit-Bille, Raphael N. (2021). Failed preoperative vacuum bell therapy does not affect outcomes following minimally invasive repair of pectus excavatum. Pediatric Surgery International, 37(10), 1429–1435. https://doi.org/10.1007/s00383-021-04963-6

Pini N, Huo Z, Holland-Cunz S, & Gros S.J. (2021). Increased proliferation of neuroblastoma cells under fructose metabolism can be measured by isothermal microcalorimetry. Children, 8(9). https://doi.org/10.3390/CHILDREN8090784

Manz N, Höfele-Behrendt C, Bielicki J, Schmid H, Matter M.S., Bielicki I, Holland-Cunz S, & Gros S.J. (2021). Mis-c-implications for the pediatric surgeon: An algorithm for differential diagnostic considerations. Children, 8(8). https://doi.org/10.3390/children8080712

Kapp A, Troxler D., Prufer F., Holland-Cunz S, Frech M, & Gros S.J. (2021). Testicular torsion in the absence of severe pain: Considerations for the pediatric surgeon (Patent No. 6). Children, 8(6), Article 6. https://doi.org/10.3390/children8060429

Huo Z., Bilang R., Brantner B., von der Weid N., Holland-Cunz SG, & Gros SJ. (2021). Perspective on similarities and possible overlaps of congenital disease formation—exemplified on a case of congenital diaphragmatic hernia and neuroblastoma in a neonate. Children, 8(2). https://doi.org/10.3390/children8020163

Huo, Zihe, Lomora, Mihai, Kym, Urs, Palivan, Cornelia, Holland-Cunz, Stefan G., & Gros, Stephanie J. (2021). AQP1 Is Up-Regulated by Hypoxia and Leads to Increased Cell Water Permeability, Motility, and Migration in Neuroblastoma. Frontiers in Cell and Developmental Biology, 9, 605272. https://doi.org/10.3389/fcell.2021.605272

Huo, Zihe, Sá Santos, Mariana, Drenckhan, Astrid, Holland-Cunz, Stefan, Izbicki, Jakob R., Nash, Michael A., & Gros, Stephanie J. (2021). Metastatic Esophageal Carcinoma Cells Exhibit Reduced Adhesion Strength and Enhanced Thermogenesis. Cells, 10(5), 1213. https://doi.org/10.3390/cells10051213

Pini N, Huo Z, Kym U, Holland-Cunz S, & Gros SJ. (2021). Aqp1-driven migration is independent of other known adverse factors but requires a hypoxic undifferentiated cell profile in neuroblastoma. Children, 8(1). https://doi.org/10.3390/children8010048

Sommer-Jörgensen, Vivienne, Künzli, Markus, Holland-Cunz, Stefan Gerhard, Gros, Stephanie, & Frech, Martina. (2020). A CARE-compliant article successful salvage of bilateral perinatal testicular torsion after delivery out of breech presentation: A case report and review of the literature. Medicine (United States), 99(36). https://doi.org/10.1097/MD.0000000000021763

Gros, Stephanie J., Holland-Cunz, Stefan G., Supuran, Claudiu T., & Braissant, Olivier. (2019). Personalized Treatment Response Assessment for Rare Childhood Tumors Using Microcalorimetry-Exemplified by Use of Carbonic Anhydrase IX and Aquaporin 1 Inhibitors. International Journal of Molecular Sciences, 20(20), 4984. https://doi.org/10.3390/ijms20204984

Meier C, Camargo SM, Hunziker S, Moehrlen U, Gros SJ, Bode P, Leu S, Meuli M, Holland-Cunz S, Verrey F, & Vuille-Dit-Bille RN. (2018). Intestinal IMINO transporter SIT1 is not expressed in human newborns. American Journal of Physiology - Gastrointestinal and Liver Physiology, 315(5), G887–G895. https://doi.org/10.1152/ajpgi.00318.2017

Gros, S., Lomora, M., Kym, U., & Holland-Cunz, S. (2018). AQP1 INFLUENCES CELL WATER PERMEABILITY AND MOBILITY IN NEUROBLASTOMA CELLS. 148, 2S–2S. E M H SWISS MEDICAL PUBLISHERS LTD.

Sucic, Lucy, Galati-Fournier V, Kym, Urs, Pfeifle, Viktoria A, Gros, Stephanie J, Schäfer KH, Holland-Cunz S, & Keck, Simone. (2018). Increased regulatory T cells in pediatric acute appendicitis (Patent No. 1). Pediatric Allergy and Immunology, 29(1), Article 1. https://doi.org/10.1111/pai.12797

Drenckhan A, Freytag M, Supuran CT, Sauter G, Izbicki JR, & Gros SJ. (2018). CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target. Journal of Enzyme Inhibition and Medicinal Chemistry, 33(1), 1024–1033. https://doi.org/10.1080/14756366.2018.1475369

Pfeifle V.A., Gros, Stephanie J., Holland-Cunz S., & Kampfen A. (2017). Necrotizing fasciitis in children due to minor lesions. Journal of Pediatric Surgery Case Reports, 25, 52–55. https://doi.org/10.1016/j.epsc.2017.08.005

Pfeifle VA, Gros SJ, Frongia G, Schäfer KH, & Holland-Cunz S. (2017). Regenerative Capacity of the Enteric Nervous System after Ileoileal Anastomoses in a Rat Model. European Journal of Pediatric Surgery, 27(2), 200–205. https://doi.org/10.1055/s-0036-1586200

Pini N, Pfeifle VA, Kym U, Keck, Simone, Galati V, Holland-Cunz S, & Gros, Stephanie J. (2017). Water permeability is a measure of severity in acute appendicitis. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 1036–1041. https://doi.org/10.1080/14756366.2017.1347167

Ameis HM, Drenckhan A, Freytag M, Izbicki JR, Supuran CT, Reinshagen K, Holland-Cunz S, & Gros SJ. (2016). Carbonic anhydrase IX correlates with survival and is a potential therapeutic target for neuroblastoma. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(3), 404–409. https://doi.org/10.3109/14756366.2015.1029471

Ameis HM, Drenckhan A, Freytag M, Izbicki JR, Supuran CT, Reinshagen K, Holland-Cunz S, & Gros SJ. (2016). Influence of hypoxia-dependent factors on the progression of neuroblastoma. Pediatric Surgery International, 32(2), 187–192. https://doi.org/10.1007/s00383-015-3831-8

Kebenko M, Drenckhan A, Gros SJ, Jücker M, Grabinski N, Ewald F, Grottke A, Schultze A, Izbicki JR, Bokemeyer C, Wellbrock J, & Fiedler W. (2015). ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts. Cellular Signalling, 27(2), 373–381. https://doi.org/10.1016/j.cellsig.2014.11.022

Drenckhan A, Grob T, Dupree A, Dohrmann T, Mann O, Izbicki JR, & Gros SJ. (2014). Esophageal carcinoma cell line with high EGFR polysomy is responsive to gefitinib. Langenbeck’s Archives of Surgery, 399(7), 879–888. https://doi.org/10.1007/s00423-014-1235-1

Zhao Y, Bao Q, Schwarz B, Zhao L, Mysliwietz J, Ellwart J, Renner A, Hirner H, Niess H, Camaj P, Angele M, Gros S, Izbicki J, Jauch KW, Nelson PJ, & Bruns CJ. (2014). Stem cell-like side populations in esophageal cancer: A source of chemotherapy resistance and metastases. Stem Cells and Development, 23(2), 180–192. https://doi.org/10.1089/scd.2013.0103

Ameis HM, Drenckhan A, von Loga K, Escherich G, Wenke K, Izbicki JR, Reinshagen K, & Gros SJ. (2013). PGK1 as predictor of CXCR4 expression, bone marrow metastases and survival in neuroblastoma. PLoS ONE, 8(12), e83701. https://doi.org/10.1371/journal.pone.0083701

Koenig, Alexandra M., Reeh, Matthias, Dancau, Ana-Maria, Rathjens, Merrit, Gros, Stephanie, Uzunoglu, Faik G., Bockhorn, Maximilian, Simon, Ronald, Sauter, Guido, Marx, Andreas, & Izbicki, Jakob R. (2013). Concordance of HER2 Status in Primary Tumour and Lymph Node Metastases in Patients with Esophageal Carcinoma. ANTICANCER RESEARCH, 33, 4975–4982.

Drenckhan A, Kurschat N, Dohrmann T, Raabe N, Koenig AM, Reichelt U, Kaifi JT, Izbicki JR, & Gros SJ. (2013). Effective inhibition of metastases and primary tumor growth with CTCE-9908 in esophageal cancer. Journal of Surgical Research, 182(2), 250–256. https://doi.org/10.1016/j.jss.2012.09.035

Gros SJ, Kurschat N, Drenckhan A, Dohrmann T, Forberich E, Effenberger K, Reichelt U, Hoffman RM, Pantel K, Kaifi JT, & Izbicki JR. (2012). Involvement of CXCR4 Chemokine Receptor in Metastastic HER2-Positive Esophageal Cancer. PLoS ONE, 7(10), e47287. https://doi.org/10.1371/journal.pone.0047287

Rawnaq T, Quaas A, Zander H, Gros SJ, Reichelt U, Blessmann M, Wilzcak W, Schachner M, Sauter G, Izbicki JR, & Kaifi JT. (2012). L1 is highly expressed in tumors of the nervous system: A study of over 8000 human tissues. Journal of Surgical Research, 173(2), 314–319. https://doi.org/10.1016/j.jss.2010.10.029

Blessmann M, Gröbe A, Quaas A, Kaifi JT, Mistakidis G, Bernreuther C, Sauter G, Gros S, Rawnaq T, Friedrich R, Mautner VF, Smeets R, Heiland M, Schachner M, & Izbicki JR. (2012). Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 113(2), 239–244. https://doi.org/10.1016/j.tripleo.2011.04.019

Gros SJ, Graeff H, Drenckhan A, Kurschat N, Blessmann M, Rawnaq T, & Izbicki JR. (2012). CXCR4/SDF-1α-mediated chemotaxis in an in vivo model of metastatic esophageal carcinoma. In Vivo, 26(4), 711–718.

Gros, Stephanie J., Graeff, Hanna, Drenckhan, Astrid, Kurschat, Nina, Blessmann, Marco, Rawnaq, Tamina, & Izbicki, Jakob R. (2012). CXCR4/SDF-1 alpha-mediated Chemotaxis in an In Vivo Model of Metastatic Esophageal Carcinoma. IN VIVO, 26, 711–718.

Gros SJ. (2011). Orthotopic models of esophageal carcinoma and their use in drug discovery. Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.], Chapter 14, Unit14. https://doi.org/10.1002/0471141755.ph1420s54

Gros SJ, Dohrmann T, Rawnaq T, Kurschat N, Bouvet M, Wessels J, Hoffmann RM, Izbicki JR, & Kaifi JT. (2010). Orthotopic fluorescent peritoneal carcinomatosis model of esophageal cancer. Anticancer Research, 30(10), 3933–3938.

Gros SJ, Dohrmann T, Peldschus K, Schurr PG, Kaifi JT, Kalinina T, Reichelt U, Mann O, Strate TG, Adam G, Hoffman RM, & Izbicki JR. (2010). Complementary use of fluorescence and magnetic resonance imaging of metastatic esophageal cancer in a novel orthotopic mouse model. International Journal of Cancer, 126(11), 2671–2681. https://doi.org/10.1002/ijc.24980

Gros SJ, Kurschat N, Dohrmann T, Reichelt U, Dancau AM, Peldschus K, Adam G, Hoffman RM, Izbicki JR, & Kaifi JT. (2010). Effective therapeutic targeting of the overexpressed HER-2 receptor in a highly metastatic orthotopic model of esophageal carcinoma. Molecular Cancer Therapeutics, 9(7), 2037–2045. https://doi.org/10.1158/1535-7163.MCT-10-0209

Reichelt U, Duesedau P, Tsourlakis MCh, Quaas A, Link BC, Schurr PG, Kaifi JT, Gros SJ, Yekebas EF, Marx A, Simon R, Izbicki JR, & Sauter G. (2007). Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus. Modern Pathology, 20(1), 120–129. https://doi.org/10.1038/modpathol.3800712