The main focus of our research is surgical oncology and neuroblastoma in particular. Pediatric tumor disease is still life threatening and can already occur in neonates. Surgical, oncological and interdisciplinary approaches have improved the outcome in the past. Nevertheless, there is a need for identifying underlying mechanisms of tumor development and tumor cell migration that can lead to the development of novel therapeutic approaches. The research interest of my group is focused on investigating the metastatic process and on understanding which cellular and genetic changes are involved in this process.

The molecular research of my group is driven by clinical questions. Our intention is to generate knowledge that can potentially be translated back to the clinic to have an impact on future treatment.

Selected Publications

Volkart, Stefanie, Kym, Urs, Braissant, Olivier, Delgado-Eckert, Edgar, Al-Samir, Samer, Angresius, Rebecca, Huo, Zihe, Holland-Cunz, Stefan, & Gros, Stephanie J. (2023). AQP1 in the Gastrointestinal Tract of Mice: Expression Pattern and Impact of AQP1 Knockout on Colonic Function. International Journal of Molecular Sciences, 24. https://doi.org/10.3390/ijms24043616

URLs

Huo Z, Bilang R, Supuran CT, von der Weid N, Bruder E, Holland-Cunz S, Martin I, Muraro MG, & Gros SJ. (2022). Perfusion-Based Bioreactor Culture and Isothermal Microcalorimetry for Preclinical Drug Testing with the Carbonic Anhydrase Inhibitor SLC-0111 in Patient-Derived Neuroblastoma. International Journal of Molecular Sciences, 23(6). https://doi.org/10.3390/ijms23063128

URLs

Huo, Zihe, Lomora, Mihai, Kym, Urs, Palivan, Cornelia, Holland-Cunz, Stefan G., & Gros, Stephanie J. (2021). AQP1 Is Up-Regulated by Hypoxia and Leads to Increased Cell Water Permeability, Motility, and Migration in Neuroblastoma. Frontiers in Cell and Developmental Biology, 9, 605272. https://doi.org/10.3389/fcell.2021.605272

URLs

Huo, Zihe, Sá Santos, Mariana, Drenckhan, Astrid, Holland-Cunz, Stefan, Izbicki, Jakob R., Nash, Michael A., & Gros, Stephanie J. (2021). Metastatic Esophageal Carcinoma Cells Exhibit Reduced Adhesion Strength and Enhanced Thermogenesis. Cells, 10(5), 1213. https://doi.org/10.3390/cells10051213

URLs

Gros, Stephanie J., Holland-Cunz, Stefan G., Supuran, Claudiu T., & Braissant, Olivier. (2019). Personalized Treatment Response Assessment for Rare Childhood Tumors Using Microcalorimetry-Exemplified by Use of Carbonic Anhydrase IX and Aquaporin 1 Inhibitors. International Journal of Molecular Sciences, 20(20), 4984. https://doi.org/10.3390/ijms20204984

URLs

Prof. Dr. Stephanie Gros

Selected Publications

Huo, Zihe, Sá Santos, Mariana, Drenckhan, Astrid, Holland-Cunz, Stefan, Izbicki, Jakob R., Nash, Michael A., & Gros, Stephanie J. (2021). Metastatic Esophageal Carcinoma Cells Exhibit Reduced Adhesion Strength and Enhanced Thermogenesis. Cells, 10(5), 1213. https://doi.org/10.3390/cells10051213