Prof. Dr. Susan Elizabeth Mango

Bayer, Emily A, Mango, Susan E, Hobert, Oliver, & Schier, Alexander F. (2025). The mechanosensory DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2025.01.01.631014

Delaney, Colin E., You, Jia Emil, Gasser, Susan, Padeken, Jan, & Mango, Susan E. (2024). H3K9 methylation-independent activity for HPL-2/HP1 in heterochromatin foci, gene repression, and organogenesis [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.09.29.615660

Wan, Yinan, El Kholtei, Jakob, Jenie, Ignatius, Colomer-Rosell, Mariona, Liu, Jialin, Acedo, Joaquin Navajas, Du, Lucia Y., Codina-Tobias, Mireia, Wang, Mengfan, Sawh, Ahilya, Lin, Edward, Chuang, Tzy-Harn, Mango, Susan E., Yu, Guoqiang, Bintu, Bogdan, & Schier, Alexander F. (2024). Whole-embryo Spatial Transcriptomics at Subcellular Resolution from Gastrulation to Organogenesis [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.08.27.609868

Tocchini, C., & Mango, S. E. (2024). An adapted MS2-MCP system to visualize endogenous cytoplasmic mRNA with live imaging in Caenorhabditis elegans [Journal-article]. PLOS Biology, 22(3), e3002526. https://doi.org/10.1371/journal.pbio.3002526

Gutnik, Silvia, You, Jia Emil, Sawh, Ahilya N., Andriollo, Aude, & Mango, Susan E. (2024). Multiplex DNA fluorescence in situ hybridization to analyze maternal vs. paternal C. elegans chromosomes. Genome Biology, 25. https://doi.org/10.1186/s13059-024-03199-6

Tocchini, C., & Mango, S. E. (2023). An adapted MS2-MCP system to visualize endogenous cytoplasmic mRNA with live imaging in<i>Caenorhabditis elegans</i> [Posted-content]. bioRxiv. https://doi.org/10.1101/2023.06.13.544769

Gutnik, Silvia, Sawh, Ahilya, & Mango, Susan E. (2022). Multiplex DNA fluorescence in situ hybridization to analyze maternal vs. paternal C. elegans chromosomes. bioRxiv. https://doi.org/10.1101/2022.11.01.514763

Sawh, Ahilya N., & Mango, Susan E. (2022). Chromosome organization in 4D: insights from C. elegans development. Current Opinion in Genetics & Development, 75, 101939. https://doi.org/10.1016/j.gde.2022.101939

Tocchini, Cristina, Rohner, Michèle, Guerard, Laurent, Ray, Poulomi, Von Stetina, Stephen E., & Mango, Susan E. (2021). Translation-dependent mRNA localization to Caenorhabditis elegans adherens junctions. Development, 148(24), 200027. https://doi.org/10.1242/dev.200027

Tocchini, Cristina, Rohner, Michèle, Von Stetina, Stephen E., & Mango, Susan E. (2021). Translation-dependent mRNA localization to Caenorhabditis elegans adherens junctions. bioRxiv. https://doi.org/10.1101/2021.05.20.444977

Wasson, Jadiel A., Harris, Gareth, Keppler-Ross, Sabine, Brock, Trisha J., Dar, Abdul R., Butcher, Rebecca A., Fischer, Sylvia E. J., Kagias, Konstantinos, Clardy, Jon, Zhang, Yun, & Mango, Susan E. (2021). Neuronal control of maternal provisioning in response to social cues. Science Advances, 7(34), eabf8782. https://doi.org/10.1126/sciadv.abf8782

Choi, Joonhee, Zhou, Hengyun, Landig, Renate, Wu, Hai-Yin, Yu, Xiaofei, Von Stetina, Stephen E., Kucsko, Georg, Mango, Susan E., Needleman, Daniel J., Samuel, Aravinthan D. T., Maurer, Peter C., Park, Hongkun, & Lukin, Mikhail D. (2020). Probing and manipulating embryogenesis via nanoscale thermometry and temperature control. Proceedings of the National Academy of Sciences of the United States of America, 117(26), 14636–14641. https://doi.org/10.1073/pnas.1922730117

Sawh, Ahilya N., & Mango, Susan E. (2020). Multiplexed Sequential DNA FISH in Caenorhabditis elegans Embryos. STAR Protocols, 1(3), 100107. https://doi.org/10.1016/j.xpro.2020.100107

Sawh, Ahilya N., Shafer, Maxwell E. R., Su, Jun-Han, Zhuang, Xiaowei, Wang, Siyuan, & Mango, Susan E. (2020). Lamina-Dependent Stretching and Unconventional Chromosome Compartments in Early C. elegans Embryos. Molecular Cell, 78(1), 96–111. https://doi.org/10.1016/j.molcel.2020.02.006

Mutlu, Beste, Chen, Huei-Mei, Gutnik, Silvia, Hall, David H., Keppler-Ross, Sabine, & Mango, Susan E. (2019). Distinct functions and temporal regulation of methylated histone H3 during early embryogenesis. Development (Cambridge, England), 146(19), dev174516. https://doi.org/10.1242/dev.174516

Mutlu, B., Chen, H.-M., Hall, D. H., & Mango, S. E. (2018, September 28). MET-2, a SETDB1 family methyltransferase, coordinates embryo events through distinct histone H3 methylation states [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/429902

Mutlu, B., Chen, H.-M., Moresco, J. J., Orelo, B. D., Yang, B., Gaspar, J. M., Keppler-Ross, S., Yates, J. R., Hall, D. H., Maine, E. M., & Mango, S. E. (2018, May 18). Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in<i>C. elegans</i>embryos [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/326231

Chen, H. M., Mutlu, B., Sackton, T., Wang, J., Keppler-Ross, S., Levine, E., Liu, T., & Mango, S. E. (2018). A heterochromatic histone methyltransferase lowers nucleosome occupancy at euchromatic promoters. bioRxiv. https://doi.org/10.1101/429191

Mutlu, Beste, Chen, Huei-Mei, Moresco, James J., Orelo, Barbara D., Yang, Bing, Gaspar, John M., Keppler-Ross, Sabine, Yates, John R., Hall, David H., Maine, Eleanor M., & Mango, Susan E. (2018). Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in; C. elegans; embryos. Science Advances, 4(8), eaat6224. https://doi.org/10.1126/sciadv.aat6224

Von Stetina, Stephen E., Liang, Jennifer, Marnellos, Georgios, & Mango, Susan E. (2017). Temporal regulation of epithelium formation mediated by FoxA, MKLP1, MgcRacGAP, and PAR-6. Molecular Biology of the Cell, 28(15), 2042–2065. https://doi.org/10.1091/mbc.e16-09-0644

Von Stetina, S. E., Liang, J., Marnellos, G., & Mango, S. E. (2016, September 21). Temporal regulation of epithelium formation [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/076570

Zaret, Kenneth S., & Mango, Susan E. (2016). Pioneer transcription factors, chromatin dynamics, and cell fate control. Current Opinion in Genetics & Development, 37, 76–81. https://doi.org/10.1016/j.gde.2015.12.003

Hsu, H.T., Chen, H.M., Yang, Z., Wang, J., Lee, N.K., Burger, A., Zaret, K., Liu, T., Levine, E., & Mango, S.E. (2015). Erratum: Recruitment of RNA polymerase II by the pioneer transcription factor PHA4 (Science (2015) 19 (1372-1376)). Science, 350(6258). https://doi.org/10.1126/science.aad5928

Hsu, H.-T., Chen, H.-M., Yang, Z., Wang, J., Lee, N. K., Burger, A., Zaret, K., Liu, T., Levine, E., & Mango, S. E. (2015). Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4. Science, 348(6241), 1372–1376. https://doi.org/10.1126/science.aab1223

Von Stetina, Stephen E., & Mango, Susan E. (2015). PAR-6, but not E-cadherin and β-integrin, is necessary for epithelial polarization in C. elegans. Developmental Biology, 403(1), 5–14. https://doi.org/10.1016/j.ydbio.2015.03.002

Choi, Youngeun, & Mango, Susan E. (2014). Hunting for Darwin’s gemmules and Lamarck’s fluid: transgenerational signaling and histone methylation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1839(12), 1440–1453. https://doi.org/10.1016/j.bbagrm.2014.05.011

Rosains, Jacqueline, & Mango, Susan E. (2012). Genetic characterization of smg-8 mutants reveals no role in C. elegans nonsense mediated decay. PLoS ONE, 7(11), e49490. https://doi.org/10.1371/journal.pone.0049490

Mango, S. E. (2011). Erratum: Ageing: Generations of longevity (Nature (2011) 479 (302-303)). Nature, 480(7376). https://doi.org/10.1038/480191a

Mango, Susan E. (2011). Ageing: generations of longevity. Nature, 479(7373), 302–303. https://doi.org/10.1038/479302a

Meister, Peter, Mango, Susan E., & Gasser, Susan M. (2011). Locking the genome: nuclear organization and cell fate. Current Opinion in Genetics & Development, 21(2), 167–174. https://doi.org/10.1016/j.gde.2011.01.023

Fakhouri, Tala H. I., Stevenson, Jeff, Chisholm, Andrew D., & Mango, Susan E. (2010). Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA. PLoS Genetics, 6(8), e1001060. https://doi.org/10.1371/journal.pgen.1001060

Zhong, Mei, Niu, Wei, Lu, Zhi John, Sarov, Mihail, Murray, John I., Janette, Judith, Raha, Debasish, Sheaffer, Karyn L., Lam, Hugo Y. K., Preston, Elicia, Slightham, Cindie, Hillier, LaDeana W., Brock, Trisha, Agarwal, Ashish, Auerbach, Raymond, Hyman, Anthony A., Gerstein, Mark, Mango, Susan E., Kim, Stuart K., et al. (2010). Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response. PLoS Genetics, 6(2), e1000848. https://doi.org/10.1371/journal.pgen.1000848

Mango, S. (2009). Susan Mango [Journal-article]. Current Biology, 19(7), R276–R277. https://doi.org/10.1016/j.cub.2009.01.035

Mango, Susan E. (2009). The molecular basis of organ formation: insights from the C. elegans foregut. Annual Review of Cell and Developmental Biology, 25, 597–628. https://doi.org/10.1146/annurev.cellbio.24.110707.175411

Yuzyuk, T., Fakhouri, T. H. I., Kiefer, J., & Mango, S. E. (2009). The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos. Developmental Cell, 16(5), 699–710. https://doi.org/10.1016/j.devcel.2009.03.008

Sheaffer, Karyn L., Updike, Dustin L., & Mango, Susan E. (2008). The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Current Biology, 18(18), 1355–1364. https://doi.org/10.1016/j.cub.2008.07.097

Von Stetina, Stephen E., & Mango, Susan E. (2008). Wormnet: a crystal ball for Caenorhabditis elegans. Genome Biology, 9(6), 226. https://doi.org/10.1186/gb-2008-9-6-226

Kiefer, Julie C., Smith, Pliny A., & Mango, Susan E. (2007). PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut. Developmental Biology, 303(2), 611–624. https://doi.org/10.1016/j.ydbio.2006.11.042

Mango, Susan E. (2007). The C. elegans pharynx: a model for organogenesis. WormBook : The Online Review of C. Elegans Biology, 1–26. https://doi.org/10.1895/wormbook.1.129.1

Mango, Susan E. (2007). A green light to expression in time and space. Nature Biotechnology, 25(6), 645–646. https://doi.org/10.1038/nbt0607-645

Smith, Pliny A., & Mango, Susan E. (2007). Role of T-box gene tbx-2 for anterior foregut muscle development in C. elegans. Developmental Biology, 302(1), 25–39. https://doi.org/10.1016/j.ydbio.2006.08.023

Updike, Dustin L., & Mango, Susan E. (2007). Genetic suppressors of Caenorhabditis elegans pha-4/FoxA identify the predicted AAA helicase ruvb-1/RuvB. Genetics, 177(2), 819–833. https://doi.org/10.1534/genetics.107.076653

Deplancke, Bart, Mukhopadhyay, Arnab, Ao, Wanyuan, Elewa, Ahmed M., Grove, Christian A., Martinez, Natalia J., Sequerra, Reynaldo, Doucette-Stamm, Lynn, Reece-Hoyes, John S., Hope, Ian A., Tissenbaum, Heidi A., Mango, Susan E., & Walhout, Albertha J. M. (2006). A gene-centered C. elegans protein-DNA interaction network. Cell, 125(6), 1193–1205. https://doi.org/10.1016/j.cell.2006.04.038

Jenkins, Noah, Saam, Jennifer R., & Mango, Susan E. (2006). CYK-4/GAP provides a localized cue to initiate anteroposterior polarity upon fertilization. Science, 313(5791), 1298–1301. https://doi.org/10.1126/science.1130291

Updike, Dustin L., & Mango, Susan E. (2006). Temporal regulation of foregut development by HTZ-1/H2A.Z and PHA-4/FoxA. PLoS Genetics, 2(9), e161. https://doi.org/10.1371/journal.pgen.0020161

Han, Zhenbo, Riefler, Gary M., Saam, Jennifer R., Mango, Susan E., & Schumacher, Jill M. (2005). The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase. Current Biology, 15(10), 894–904. https://doi.org/10.1016/j.cub.2005.04.019

Kaltenbach, Linda S., Updike, Dustin L., & Mango, Susan E. (2005). Contribution of the amino and carboxyl termini for PHA-4/FoxA function in Caenorhabditis elegans. Developmental Dynamics, 234(2), 346–354. https://doi.org/10.1002/dvdy.20550

Ao, Wanyuan, Gaudet, Jeb, Kent, W. James, Muttumu, Srikanth, & Mango, Susan E. (2004). Environmentally induced foregut remodeling by PHA-4/FoxA and DAF-12/NHR. Science, 305(5691), 1743–1746. https://doi.org/10.1126/science.1102216

Fay, David S., Qiu, Xiaohui, Large, Edward, Smith, Christopher P., Mango, Susan, & Johanson, Bethany L. (2004). The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18. Developmental Biology, 271(1), 11–25. https://doi.org/10.1016/j.ydbio.2004.03.022

Gaudet, Jeb, Muttumu, Srikanth, Horner, Michael, & Mango, Susan E. (2004). Whole-genome analysis of temporal gene expression during foregut development. PLoS Biology, 2(11), e352. https://doi.org/10.1371/journal.pbio.0020352

Li, Siming, Armstrong, Christopher M., Bertin, Nicolas, Ge, Hui, Milstein, Stuart, Boxem, Mike, Vidalain, Pierre-Olivier, Han, Jing-Dong J., Chesneau, Alban, Hao, Tong, Goldberg, Debra S., Li, Ning, Martinez, Monica, Rual, Jean-François, Lamesch, Philippe, Xu, Lai, Tewari, Muneesh, Wong, Sharyl L., Zhang, Lan V., et al. (2004). A map of the interactome network of the metazoan C. elegans. Science, 303(5657), 540–543. https://doi.org/10.1126/science.1091403

Portereiko, Michael F., Saam, Jennifer, & Mango, Susan E. (2004). ZEN-4/MKLP1 is required to polarize the foregut epithelium. Current Biology, 14(11), 932–941. https://doi.org/10.1016/j.cub.2004.05.052

Alder, Matthew N., Dames, Shale, Gaudet, Jeffrey, & Mango, Susan E. (2003). Gene silencing in Caenorhabditis elegans by transitive RNA interference. Rna, 9(1), 25–32. https://doi.org/10.1261/rna.2650903

Han, Zhenbo, Saam, Jennifer R., Adams, Henry P., Mango, Susan E., & Schumacher, Jill M. (2003). The C. elegans Tousled-like kinase (TLK-1) has an essential role in transcription. Current Biology, 13(22), 1921–1929. https://doi.org/10.1016/j.cub.2003.10.035

Gaudet, J., & Mango, S. E. (2002). Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4. Science, 295(5556), 821–825. https://doi.org/10.1126/science.1065175

Jorgensen, Erik M., & Mango, Susan E. (2002). The art and design of genetic screens: caenorhabditis elegans. Nature Reviews. Genetics, 3(5), 356–369. https://doi.org/10.1038/nrg794

Mango, Susan E. (2001). Stop making nonSense: the C. elegans smg genes. Trends in Genetics : TIG, 17(11), 646–653. https://doi.org/10.1016/s0168-9525(01)02479-9

Portereiko, Michael F., & Mango, Susan E. (2001). Early morphogenesis of the Caenorhabditis elegans pharynx. Developmental Biology, 233(2), 482–494. https://doi.org/10.1006/dbio.2001.0235

Domeier, Mary Ellen, Morse, Daniel P., Knight, Scott W., Portereiko, Michael, Bass, Brenda L., & Mango, Susan E. (2000). A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans. Science, 289(5486), 1928–1930. https://doi.org/10.1126/science.289.5486.1928

Kaltenbach, Linda, Horner, Michael A., Rothman, Joel H., & Mango, Susan E. (2000). The TBP-like factor CeTLF is required to activate RNA polymerase II transcription during C. elegans embryogenesis. Molecular Cell, 6(3), 705–713. https://doi.org/10.1016/s1097-2765(00)00068-x

Labouesse, Michel, & Mango, Susan E. (1999). Patterning the C. elegans embryo: moving beyond the cell lineage. Trends in Genetics, 15(8), 307–313. https://doi.org/10.1016/s0168-9525(99)01750-3

Horner, Michael A., Quintin, Sophie, Domeier, Mary Ellen, Kimble, Judith, Labouesse, Michel, & Mango, Susan E. (1998). pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans. Genes and Development, 12(13), 1947–1952. https://doi.org/10.1101/gad.12.13.1947

Goodwin, E. B., Hofstra, K., Hurney, C. A., Mango, S., & Kimble, J. (1997). A genetic pathway for regulation of tra-2 translation. Development, 124(3), 749–758.

Mango, S. E., Lambie, E. J., & Kimble, J. (1994). The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans. Development, 120(10), 3019–3031.

Mango, S. E., Thorpe, C. J., Martin, P. R., Chamberlain, S. H., & Bowerman, B. (1994). Two maternal genes, apx-1 and pie-1, are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo. Development, 120(8), 2305–2315.

Kimble, J., Crittenden, S., Lambie, E., Kodoyianni, V., Mango, S., & Troemel, E. (1992). Regulation of induction by GLP1, and localized cell surface receptor in Caenorhabditis elegans. Cold Spring Harbor Symposia on Quantitative Biology, 57, 401–407. https://doi.org/10.1101/sqb.1992.057.01.045

Mango, Susan E., Maine, Eleanor M., & Kimble, Judith. (1991). Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans. Nature, 352(6338), 811–815. https://doi.org/10.1038/352811a0

Cole, M. D., & Mango, S. E. (1990). cis-acting determinants of c-myc mRNA stability. Enzyme, 44(1-4), 167–180. https://doi.org/10.1159/000468755

Mango, S. E., Schuler, G. D., Steele, M. E., & Cole, M. D. (1989). Germ line c-myc is not down-regulated by loss or exclusion of activating factors in myc-induced macrophage tumors. Molecular and Cellular Biology, 9(8), 3482–3490. https://doi.org/10.1128/mcb.9.8.3482

Postel, E. H., Mango, S. E., & Flint, S. J. (1989). A nuclease-hypersensitive element of the human c-myc promoter interacts with a transcription initiation factor. Molecular and Cellular Biology, 9(11), 5123–5133. https://doi.org/10.1128/mcb.9.11.5123

Ueno-Nishio, Shizue, Mango, Susan, Reitzer, Lawrence J., & Magasanik, Boris. (1984). Identification and regulation of the glnL operator-promoter of the complex glnALG operon of Escherichia coli. Journal of Bacteriology, 160(1), 379–384. https://doi.org/10.1128/jb.160.1.379-384.1984