Prof. Dr. Médéric Diard

Berdejo, Daniel, Mortier, Julien, Cambré, Alexander, Sobota, Malgorzata, Van Eyken, Ronald, Kim, Tom Dongmin, Vanoirbeek, Kristof, Gonzalo, Diego García, Pagán, Rafael, Diard, Médéric, & Aertsen, Abram. (2024). Evolutionary trade-off between heat shock resistance, growth at high temperature, and virulence expression in SalmonellaTyphimurium. mBio, 15(3). https://doi.org/10.1128/mbio.03105-23

Gül, Ersin, Bakkeren, Erik, Salazar, Guillem, Steiger, Yves, Younes, Andrew Abi, Clerc, Melanie, Christen, Philipp, Fattinger, Stefan A., Nguyen, Bidong D., Kiefer, Patrick, Slack, Emma, Ackermann, Martin, Vorholt, Julia A., Sunagawa, Shinichi, Diard, Médéric, & Hardt, Wolf-Dietrich. (2023). The microbiota conditions a gut milieu that selects for wild-type Salmonella Typhimurium virulence. PLoS Biology, 21. https://doi.org/10.1371/journal.pbio.3002253

Bakkeren, Erik, Gül, Ersin, Huisman, Jana S., Steiger, Yves, Rocker, Andrea, Hardt, Wolf-Dietrich, & Diard, Médéric. (2022). Impact of horizontal gene transfer on emergence and stability of cooperative virulence in Salmonella Typhimurium. Nature Communications, 13(1), 1939. https://doi.org/10.1038/s41467-022-29597-7

Lentsch, Verena, Woller, Aurore, Moresi, Claudia, Fattinger, Stefan A., Aslani, Selma, Hardt, Wolf-Dietrich, Loverdo, Claude, Diard, Médéric, & Slack, Emma. (2022). Combined oral vaccination with niche competition can generate sterilizing immunity against entero-pathogenic bacteria. biorxiv.org. https://doi.org/10.1101/2022.07.20.498444

Ramirez Garcia, Alejandro, Hurley, Katherine, Marastoni, Giovanni, Diard, Médéric, Hofer, Sophie, Greppi, Anna, Hardt, Wolf-Dietrich, Lacroix, Christophe, Sturla, Shana J., & Schwab, Clarissa. (2022). Pathogenic and Commensal Gut Bacteria Harboring Glycerol/Diol Dehydratase Metabolize Glycerol and Produce DNA-Reactive Acrolein. Chemical Research in Toxicology, 35(10), 1840–1850. https://doi.org/10.1021/acs.chemrestox.2c00137

Slack, Emma, & Diard, Médéric. (2022). Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution. Mucosal Immunology, 15(6), 1188–1198. https://doi.org/10.1038/s41385-022-00574-z

Sobota, Malgorzata, Rodilla Ramirez, Pilar Natalia, Cambré, Alexander, Rocker, Andrea, Mortier, Julien, Gervais, Théo, Haas, Tiphaine, Cornillet, Delphine, Chauvin, Dany, Hug, Isabelle, Julou, Thomas, Aertsen, Abram, & Diard, Médéric. (2022). The expression of virulence genes increases membrane permeability and sensitivity to envelope stress in Salmonella Typhimurium. PLoS Biology, 20(4), e3001608. https://doi.org/10.1371/journal.pbio.3001608

Bakkeren, Erik, Gül, Ersin, Huisman, Jana S., Steiger, Yves, Rocker, Andrea, Hardt, Wolf-Dietrich, & Diard, Médéric. (2021). Cooperative virulence can emerge via horizontal gene transfer but is stabilized by transmission. biorxiv.org. https://doi.org/10.1101/2021.02.11.430745

Bakkeren, Erik, Herter, Joana Anuschka, Huisman, Jana Sanne, Steiger, Yves, Gül, Ersin, Newson, Joshua Patrick Mark, Brachmann, Alexander Oliver, Piel, Jörn, Regoes, Roland, Bonhoeffer, Sebastian, Diard, Médéric, & Hardt, Wolf-Dietrich. (2021). Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut. eLife, 10, e69744. https://doi.org/10.7554/elife.69744

Benz, Fabienne, Huisman, Jana S., Bakkeren, Erik, Herter, Joana A., Stadler, Tanja, Ackermann, Martin, Diard, Médéric, Egli, Adrian, Hall, Alex R., Hardt, Wolf-Dietrich, & Bonhoeffer, Sebastian. (2021). Plasmid- and strain-specific factors drive variation in ESBL-plasmid spread in vitro and in vivo. The ISME Journal, 15(3), 862–878. https://doi.org/10.1038/s41396-020-00819-4

Diard, Médéric, Bakkeren, Erik, Lentsch, Verena, Rocker, Andrea, Bekele, Nahimi Amare, Hoces, Daniel, Aslani, Selma, Arnoldini, Markus, Böhi, Flurina, Schumann-Moor, Kathrin, Adamcik, Jozef, Piccoli, Luca, Lanzavecchia, Antonio, Stadtmueller, Beth M., Donohue, Nicholas, van der Woude, Marjan W., Hockenberry, Alyson, Viollier, Patrick H., Falquet, Laurent, et al. (2021). A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants. Nature Microbiology, 6(7), 830–841. https://doi.org/10.1038/s41564-021-00911-1

Sobota, Malgorzata, Rodilla Ramirez, Pilar Natalia, Cambré, Alexander, Haas, Tiphaine, Cornillet, Delphine, Rocker, Andrea, Aertsen, Abram, & Diard, Médéric. (2021). The expression of virulence increases outer-membrane permeability and sensitivity to envelope stress in Salmonella Typhimurium. biorxiv.org. https://doi.org/10.1101/2021.06.08.447568

Bakkeren, Erik, Diard, Médéric, & Hardt, Wolf-Dietrich. (2020). Evolutionary causes and consequences of bacterial antibiotic persistence. Nature reviews. Microbiology, 18(9), 479–490. https://doi.org/10.1038/s41579-020-0378-z

Hausmann, Annika, Böck, Desirée, Geiser, Petra, Berthold, Dorothée L., Fattinger, Stefan A., Furter, Markus, Bouman, Judith A., Barthel-Scherrer, Manja, Lang, Crispin M., Bakkeren, Erik, Kolinko, Isabel, Diard, Médéric, Bumann, Dirk, Slack, Emma, Regoes, Roland R., Pilhofer, Martin, Sellin, Mikael E., & Hardt, Wolf-Dietrich. (2020). Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression. Mucosal Immunology, 13(3), 530–544. https://doi.org/10.1038/s41385-019-0247-0

Hoces, Daniel, Arnoldini, Markus, Diard, Médéric, Loverdo, Claude, & Slack, Emma. (2020). Growing, evolving and sticking in a flowing environment: understanding IgA interactions with bacteria in the gut. Immunology, 159(1), 52–62. https://doi.org/10.1111/imm.13156

Bakkeren, Erik, Huisman, Jana S., Fattinger, Stefan A., Hausmann, Annika, Furter, Markus, Egli, Adrian, Slack, Emma, Sellin, Mikael E., Bonhoeffer, Sebastian, Regoes, Roland R., Diard, Médéric, & Hardt, Wolf-Dietrich. (2019). Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut. Nature, 573(7773), 276–280. https://doi.org/10.1038/s41586-019-1521-8

Bansept, Florence, Schumann-Moor, Kathrin, Diard, Médéric, Hardt, Wolf-Dietrich, Slack, Emma, & Loverdo, Claude. (2019). Enchained growth and cluster dislocation: A possible mechanism for microbiota homeostasis. PLoS Computational Biology, 15(5), e1006986. https://doi.org/10.1371/journal.pcbi.1006986

Diard, Médéric, Bakkeren, Erik, Hoces, Daniel, Lentsch, Verena, Arnoldini, Markus, Böhi, Flurina, Schumann-Moor, Kathrin, Adamcik, Jozef, Piccoli, Luca, Lanzavecchia, Antonio, Stadtmueller, Beth M., Donohue, Nicholas, van der Woude, Marjan W., Hockenberry, Alyson, Viollier, Patrick H., Falquet, Laurent, Wüthrich, Daniel, Bonfiglio, Ferdinando, Egli, Adrian, et al. (2019). Rationally designed oral vaccines can set an evolutionary trap for Salmonella Typhimurium. bioRxiv. https://doi.org/10.1101/824821

Harms, Alexander, & Diard, Médéric. (2019). Crowd Controlled-Host Quorum Sensing Drives Phage Decision. Cell Host & Microbe, 25(2), 179–181. https://doi.org/10.1016/j.chom.2019.01.016

Wotzka, Sandra Y., Kreuzer, Markus, Maier, Lisa, Arnoldini, Markus, Nguyen, Bidong D., Brachmann, Alexander O., Berthold, Dorothée L., Zünd, Mirjam, Hausmann, Annika, Bakkeren, Erik, Hoces, Daniel, Gül, Ersin, Beutler, Markus, Dolowschiak, Tamas, Zimmermann, Michael, Fuhrer, Tobias, Moor, Kathrin, Sauer, Uwe, Typas, Athanasios, et al. (2019). Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice. Nature Microbiology, 4(12), 2164–2174. https://doi.org/10.1038/s41564-019-0568-5

Diard, Médéric, Bakkeren, Erik, Cornuault, Jeffrey K., Moor, Kathrin, Hausmann, Annika, Sellin, Mikael E., Loverdo, Claude, Aertsen, Abram, Ackermann, Martin, De Paepe, Marianne, Slack, Emma, & Hardt, Wolf-Dietrich. (2017). Inflammation boosts bacteriophage transfer between Salmonella spp. Science, 355(6330), 1211–1215. https://doi.org/10.1126/science.aaf8451

Diard, Médéric, & Hardt, Wolf-Dietrich. (2017). Basic Processes in Salmonella-Host Interactions: Within-Host Evolution and the Transmission of the Virulent Genotype. Microbiology Spectrum, 5(5), epub. https://doi.org/10.1128/microbiolspec.mtbp-0012-2016

Diard, Médéric, & Hardt, Wolf-Dietrich. (2017). Evolution of bacterial virulence. FEMS Microbiology Reviews, 41(5), 679–697. https://doi.org/10.1093/femsre/fux023

Moor, Kathrin, Diard, Médéric, Sellin, Mikael E., Felmy, Boas, Wotzka, Sandra Y., Toska, Albulena, Bakkeren, Erik, Arnoldini, Markus, Bansept, Florence, Co, Alma Dal, Völler, Tom, Minola, Andrea, Fernandez-Rodriguez, Blanca, Agatic, Gloria, Barbieri, Sonia, Piccoli, Luca, Casiraghi, Costanza, Corti, Davide, Lanzavecchia, Antonio, et al. (2017). High-avidity IgA protects the intestine by enchaining growing bacteria. Nature, 544(7651), 498–502. https://doi.org/10.1038/nature22058

Colgan, Aoife M., Kröger, Carsten, Diard, Médéric, Hardt, Wolf-Dietrich, Puente, José L., Sivasankaran, Sathesh K., Hokamp, Karsten, & Hinton, Jay C. D. (2016). The Impact of 18 Ancestral and Horizontally-Acquired Regulatory Proteins upon the Transcriptome and sRNA Landscape of Salmonella enterica serovar Typhimurium. PLoS Genetics, 12(8), e1006258. https://doi.org/10.1371/journal.pgen.1006258

Curkić, Ismeta, Schütz, Monika, Oberhettinger, Philipp, Diard, Médéric, Claassen, Manfred, Linke, Dirk, & Hardt, Wolf-Dietrich. (2016). Epitope-Tagged Autotransporters as Single-Cell Reporters for Gene Expression by a Salmonella Typhimurium wbaP Mutant. PloS One, 11(5), e0154828. https://doi.org/10.1371/journal.pone.0154828

Moor, Kathrin, Wotzka, Sandra Y., Toska, Albulena, Diard, Médéric, Hapfelmeier, Siegfried, & Slack, Emma. (2016). Peracetic Acid Treatment Generates Potent Inactivated Oral Vaccines from a Broad Range of Culturable Bacterial Species. Frontiers in Immunology, 7(34), 34. https://doi.org/10.3389/fimmu.2016.00034

Maier, Lisa, Diard, Médéric, Sellin, Mikael E., Chouffane, Elsa-Sarah, Trautwein-Weidner, Kerstin, Periaswamy, Balamurugan, Slack, Emma, Dolowschiak, Tamas, Stecher, Bärbel, Loverdo, Claude, Regoes, Roland R., & Hardt, Wolf-Dietrich. (2015). Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis. PLoS Pathogens, 11(7), e1005047. https://doi.org/10.1371/journal.ppat.1005047

Arnoldini, Markus, Vizcarra, Ima Avalos, Peña-Miller, Rafael, Stocker, Nicolas, Diard, Médéric, Vogel, Viola, Beardmore, Robert E., Hardt, Wolf-Dietrich, & Ackermann, Martin. (2014). Bistable expression of virulence genes in salmonella leads to the formation of an antibiotic-tolerant subpopulation. PLoS Biology, 12(8), e1001928. https://doi.org/10.1371/journal.pbio.1001928

Diard, Médéric, Sellin, Mikael E., Dolowschiak, Tamas, Arnoldini, Markus, Ackermann, Martin, & Hardt, Wolf-Dietrich. (2014). Antibiotic treatment selects for cooperative virulence of Salmonella typhimurium. Current Biology, 24(17), 2000–2005. https://doi.org/10.1016/j.cub.2014.07.028

Maier, Lisa, Diard, Médéric, Sellin, Mikael E., Chouffane, Elsa-Sarah, Trautwein-Weidner, Kerstin, Periaswamy, Balamurugan, Slack, Emma, Dolowschiak, Tamas, Stecher, Bärbel, Loverdo, Claude, Regoes, Roland R., & Hardt, Wolf-Dietrich. (2014). Granulocytes impose a tight bottleneck upon the gut luminal pathogen population during Salmonella typhimurium colitis. PLoS Pathogens, 10(12), e1004557. https://doi.org/10.1371/journal.ppat.1004557

Sellin, Mikael E., Müller, Anna A., Felmy, Boas, Dolowschiak, Tamas, Diard, Médéric, Tardivel, Aubry, Maslowski, Kendle M., & Hardt, Wolf-Dietrich. (2014). Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. Cell Host & Microbe, 16(2), 237–248. https://doi.org/10.1016/j.chom.2014.07.001

Diard, Médéric, Garcia, Victor, Maier, Lisa, Remus-Emsermann, Mitja N. P., Regoes, Roland R., Ackermann, Martin, & Hardt, Wolf-Dietrich. (2013). Stabilization of cooperative virulence by the expression of an avirulent phenotype. Nature, 494(7437), 353–356. https://doi.org/10.1038/nature11913

Kaiser, Patrick, Diard, Médéric, Stecher, Bärbel, & Hardt, Wolf-Dietrich. (2012). The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen’s virulence factors, and the host’s mucosal immune response. Immunological Reviews, 245(1), 56–83. https://doi.org/10.1111/j.1600-065x.2011.01070.x

Baeriswyl, Simon, Diard, Médéric, Mosser, Thomas, Leroy, Magali, Manière, Xavier, Taddei, François, & Matic, Ivan. (2010). Modulation of aging profiles in isogenic populations of Caenorhabditis elegans by bacteria causing different extrinsic mortality rates. Biogerontology, 11(1), 53–65. https://doi.org/10.1007/s10522-009-9228-0

Diard, Médéric, Garry, Louis, Selva, Marjorie, Mosser, Thomas, Denamur, Erick, & Matic, Ivan. (2010). Pathogenicity-associated islands in extraintestinal pathogenic Escherichia coli are fitness elements involved in intestinal colonization. Journal of Bacteriology, 192(19), 4885–4893. https://doi.org/10.1128/jb.00804-10

Tourret, Jérôme, Diard, Médéric, Garry, Louis, Matic, Ivan, & Denamur, Erick. (2010). Effects of single and multiple pathogenicity island deletions on uropathogenic Escherichia coli strain 536 intrinsic extra-intestinal virulence. International Journal of Medical Microbiology : IJMM, 300(7), 435–439. https://doi.org/10.1016/j.ijmm.2010.04.013

Touchon, Marie, Hoede, Claire, Tenaillon, Olivier, Barbe, Valérie, Baeriswyl, Simon, Bidet, Philippe, Bingen, Edouard, Bonacorsi, Stéphane, Bouchier, Christiane, Bouvet, Odile, Calteau, Alexandra, Chiapello, Hélène, Clermont, Olivier, Cruveiller, Stéphane, Danchin, Antoine, Diard, Médéric, Dossat, Carole, Karoui, Meriem El, Frapy, Eric, et al. (2009). Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths. PLoS Genetics, 5(1), e1000344. https://doi.org/10.1371/journal.pgen.1000344

Diard, Médéric, Baeriswyl, Simon, Clermont, Olivier, Gouriou, Stéphanie, Picard, Bertrand, Taddei, François, Denamur, Erick, & Matic, Ivan. (2007). Caenorhabditis elegans as a simple model to study phenotypic and genetic virulence determinants of extraintestinal pathogenic Escherichia coli. Microbes and Infection, 9(2), 214–223. https://doi.org/10.1016/j.micinf.2006.11.009