Prof. Dr. Christoph Dehio

Fromm, Katja, Ortelli, Monica, Boegli, Alexandra, & Dehio, Christoph. (2024). Translocation of YopJ family effector proteins through the VirB/VirD4 T4SS of Bartonella [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.03.23.586424

Ketterer, Maren, Chiquet, Petra, Sedzicki, Jaroslaw, Québatte, Maxime, & Dehio, Christoph. (2024). The putative Type 4 secretion system effector BspD is involved in maintaining envelope integrity of the pathogen Brucella [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.03.18.585630

Sedzicki, Jaroslaw, Ni, Dongchun, Lehmann, Frank, Stahlberg, Henning, & Dehio, Christoph. (2024). Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens. Nature Communications, 15. https://doi.org/10.1038/s41467-024-45415-8

Sollier, Julie, Basler, Marek, Broz, Petr, Dittrich, Petra S., Drescher, Knut, Egli, Adrian, Harms, Alexander, Hierlemann, Andreas, Hiller, Sebastian, King, Carolyn G., McKinney, John D., Moran-Gilad, Jacob, Neher, Richard A., Page, Malcolm G. P., Panke, Sven, Persat, Alexandre, Picotti, Paola, Rentsch, Katharina M., Rivera-Fuentes, Pablo, et al. (2024). Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions. Nature Microbiology, 9(1), 1–3. https://doi.org/10.1038/s41564-023-01566-w

Ma, Fengjiao, Kaufmann, Rainer, Sedzicki, Jaroslaw, Cseresnyés, Zoltán, Dehio, Christoph, Hoeppener, Stephanie, Figge, Marc Thilo, & Heintzmann, Rainer. (2023). Guided-deconvolution for correlative light and electron microscopy. PLoS ONE, 18. https://doi.org/10.1371/journal.pone.0282803

Verbeke, Jérémy, Fayt, Youri, Martin, Lisa, Yilmaz, Oya, Sedzicki, Jaroslaw, Reboul, Angéline, Jadot, Michel, Renard, Patricia, Dehio, Christoph, Renard, Henri-François, Letesson, Jean-Jacques, De Bolle, Xavier, & Arnould, Thierry. (2023). Host cell egress of Brucella abortus requires BNIP3L-mediated mitophagy. EMBO Journal, 42. https://doi.org/10.15252/embj.2022112817

Alt, Silke, Haggstrom, Douglas, Kessmann, Helmut, Kloss, Florian, Schneider, Christian Elias, Jäger, Timo, Schwede, Torsten, Brakhage, Axel, & Dehio, Christoph. (2022). INCATE: a partnership to boost the antibiotic pipeline. Nature Reviews. Drug Discovery, 21(9), 621–622. https://doi.org/10.1038/d41573-022-00138-7

Fromm, Katja, Boegli, Alexandra, Ortelli, Monica, Wagner, Alexander, Bohn, Erwin, Malmsheimer, Silke, Wagner, Samuel, & Dehio, Christoph. (2022). Bartonella taylorii; : A Model Organism for Studying; Bartonella; Infection; in vitro; and; in vivo; Frontiers in Microbiology, 13, 913434. https://doi.org/10.3389/fmicb.2022.913434

Mode, Selma, Ketterer, Maren, Québatte, Maxime, & Dehio, Christoph. (2022). Antibiotic persistence of intracellular Brucella abortus. PLoS Neglected Tropical Diseases, 16(7), e0010635. https://doi.org/10.1371/journal.pntd.0010635

Sedzicki, Jaroslaw, Ni, Dongchun, Lehmann, Frank, Wu, Na, Zenobi, Renato, Jung, Seunho, Stahlberg, Henning, & Dehio, Christoph. (2022). Mechanism of cyclic β-glucan export by ABC transporter Cgt of Brucella. Nature Structural and Molecular Biology, 29(12), 1170–1177. https://doi.org/10.1038/s41594-022-00868-7

Siewert, Lena K., Dehio, Christoph, & Pinschewer, Daniel D. (2022). Adaptive immune defense prevents Bartonella persistence upon trans-placental transmission. PLoS Pathogens, 18(5), e1010489. https://doi.org/10.1371/journal.ppat.1010489

Siewert, Lena K., Korotaev, Aleksandr, Sedzicki, Jaroslaw, Fromm, Katja, Pinschewer, Daniel D., & Dehio, Christoph. (2022). Identification of the; Bartonella; autotransporter CFA as a protective antigen and hypervariable target of neutralizing antibodies in mice. Proceedings of the National Academy of Sciences of the United States of America, 119(25), e2202059119. https://doi.org/10.1073/pnas.2202059119

Dietz, Nikolaus, Huber, Markus, Sorg, Isabel, Goepfert, Arnaud, Harms, Alexander, Schirmer, Tilman, & Dehio, Christoph. (2021). Structural basis for selective AMPylation of Rac-subfamily GTPases by Bartonella effector protein 1 (Bep1). Proceedings of the National Academy of Sciences, 118(12), e2023245118. https://doi.org/10.1073/pnas.2023245118

Fromm, Katja, & Dehio, Christoph. (2021). The Impact of; Bartonella; VirB/VirD4 Type IV Secretion System Effectors on Eukaryotic Host Cells. Frontiers in Microbiology, 12, 762582. https://doi.org/10.3389/fmicb.2021.762582

Marlaire, Simon, & Dehio, Christoph. (2021). Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1. PLoS pathogens, 17(1), e1008548. https://doi.org/10.1371/journal.ppat.1008548

Schirmer, Tilman, de Beer, Tjaart A. P., Tamegger, Stefanie, Harms, Alexander, Dietz, Nikolaus, Dranow, David M., Edwards, Thomas E., Myler, Peter J., Phan, Isabelle, & Dehio, Christoph. (2021). Evolutionary Diversification of Host-Targeted; Bartonella; Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module. Microorganisms, 9(8), 23. https://doi.org/10.3390/microorganisms9081645

Dietz, Nikolaus Balthasar, Huber, Markus, Sorg, Isabel, Goepfert, Arnaud, Harms, Alexander, Schirmer, Tilman, & Dehio, Christoph. (2020). Structural basis for selective targeting of Rac subfamily GTPases by a bacterial effector protein. bioRxiv. https://doi.org/10.1101/2020.06.29.167221

Sorg, Isabel, Schmutz, Christoph, Lu, Yun-Yueh, Fromm, Katja, Siewert, Lena K., Bögli, Alexandra, Strack, Kathrin, Harms, Alexander, & Dehio, Christoph. (2020). A Bartonella effector acts as signaling hub for intrinsic STAT3 activation to trigger anti-inflammatory responses. Cell host & microbe, 27(3), 476–485. https://doi.org/10.1016/j.chom.2020.01.015

Balaban, Nathalie Q., Helaine, Sophie, Lewis, Kim, Ackermann, Martin, Aldridge, Bree, Andersson, Dan I., Brynildsen, Mark P., Bumann, Dirk, Camilli, Andrew, Collins, James J., Dehio, Christoph, Fortune, Sarah M., Ghigo, Jean-Marc, Hardt, Wolf-Dietrich, Harms, Alexander, Heinemann, Matthias, Hung, Deborah T., Jenal, Urs, Levin, Bruce R., et al. (2019). Definitions and guidelines for research on antibiotic persistence. Nature Reviews Microbiology, 17(7), 441–448. https://doi.org/10.1038/s41579-019-0196-3

Casanova, Alain, Low, Shyan Huey, Québatte, Maxime, Sedzicki, Jaroslaw, Tschon, Therese, Ketterer, Maren, Smith, Kevin, Emmenlauer, Mario, Ben-Tekaya, Houchaima, & Dehio, Christoph. (2019). A Role for the VPS Retromer in Brucella Intracellular Replication Revealed by Genomewide siRNA Screening. mSphere, 4(3), e00380–19. https://doi.org/10.1128/msphere.00380-19

Cunrath, Olivier, Meinel, Dominik M., Maturana, Pauline, Fanous, Joseph, Buyck, Julien M., Saint Auguste, Pamela, Seth-Smith, Helena M. B., Körner, Jonas, Dehio, Christoph, Trebosc, Vincent, Kemmer, Christian, Neher, Richard, Egli, Adrian, & Bumann, Dirk. (2019). Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains. EBioMedicine, 41, 479–487. https://doi.org/10.1016/j.ebiom.2019.02.061

Dirmeier, Simon, Emmenlauer, Mario, Dehio, Christoph, & Beerenwinkel, Niko. (2019). PyBDA: a command line tool for automated analysis of big biological data sets. BMC Bioinformatics, 20(1), 564. https://doi.org/10.1186/s12859-019-3087-8

Liu, Yansheng, Mi, Yang, Müller, Torsten, Kreibich, Saskia, Williams, Evan G., Van Drogen, Audry, Borel, Christelle, Frank, Max, Germain, Pierre-Luc, Bludau, Isabell, Mehnert, Martin, Seifert, Michael, Emmenlauer, Mario, Sorg, Isabel, Bezrukov, Fedor, Sloan Bena, Frederique, Zhou, Hu, Dehio, Christoph, Testa, Giuseppe, et al. (2019). Multi-omic measurements of heterogeneity in HeLa cells across laboratories. Nature Biotechnology, 37(3), 314–322. https://doi.org/10.1038/s41587-019-0037-y

Québatte, Maxime, & Dehio, Christoph. (2019). Bartonella gene transfer agent: Evolution, function, and proposed role in host adaptation. Cellular Microbiology, 21(11), e13068. https://doi.org/10.1111/cmi.13068

Wagner, Alexander, & Dehio, Christoph. (2019). Role of distinct type-IV-secretion systems and secreted effector sets in host adaptation by pathogenic Bartonella species. Cellular microbiology, 21(3), e13004. https://doi.org/10.1111/cmi.13004

Wagner, Alexander, Tittes, Colin, & Dehio, Christoph. (2019). Versatility of the BID Domain: Conserved Function as Type-IV-Secretion-Signal and Secondarily Evolved Effector Functions Within; Bartonella; -Infected Host Cells. Frontiers in Microbiology, 10, 921. https://doi.org/10.3389/fmicb.2019.00921

Daga, Neha, Eicher, Simone, Kannan, Abhilash, Casanova, Alain, Low, Shyan H., Kreibich, Saskia, Andritschke, Daniel, Emmenlauer, Mario, Jenkins, Jeremy L., Hardt, Wolf-Dietrich, Greber, Urs F., Dehio, Christoph, & von Mering, Christian. (2018). Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition. Nucleic Acids Research, 46(18), 9309–9320. https://doi.org/10.1093/nar/gky798

Lobet, Elodie, Willemart, Kevin, Ninane, Noëlle, Demazy, Catherine, Sedzicki, Jaroslaw, Lelubre, Christophe, De Bolle, Xavier, Renard, Patricia, Raes, Martine, Dehio, Christoph, Letesson, Jean-Jacques, & Arnould, Thierry. (2018). Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria. Scientific Reports, 8(1), 5173. https://doi.org/10.1038/s41598-018-23483-3

Sedzicki, Jaroslaw, Tschon, Therese, Low, Shyan Huey, Willemart, Kevin, Goldie, Kenneth N., Letesson, Jean-Jacques, Stahlberg, Henning, & Dehio, Christoph. (2018). 3D correlative electron microscopy reveals continuity of Brucella -containing vacuoles with the endoplasmic reticulum. Journal of Cell Science, 131(4), jcs. https://doi.org/10.1242/jcs.210799

Srivatsa, Sumana, Kuipers, Jack, Schmich, Fabian, Eicher, Simone, Emmenlauer, Mario, Dehio, Christoph, & Beerenwinkel, Niko. (2018). Improved pathway reconstruction from RNA interference screens by exploiting off-target effects. Bioinformatics, 34(13), i519–i527. https://doi.org/10.1093/bioinformatics/bty240

Dehio, Christoph, & Bumann, Dirk. (2017). Editorial overview: Bacterial systems biology. Current Opinion in Microbiology, 39, viii–vixi. https://doi.org/10.1016/j.mib.2017.11.024

Dehio, C., & Tsolis, R. M. (2017). Type IV effector secretion and subversion of host functions by bartonella and brucella species (Vol. 413, pp. 269–295). Springer Verlagservice@springer.de. https://doi.org/10.1007/978-3-319-75241-9_11

González-Prieto, Coral, Gabriel, Richard, Dehio, Christoph, Schmidt, Manfred, & Llosa, Matxalen. (2017). The Conjugative Relaxase TrwC Promotes Integration of Foreign DNA in the Human Genome. Applied and Environmental Microbiology, 83(12), e00207–17. https://doi.org/10.1128/aem.00207-17

Harms, Alexander, Liesch, Marius, Körner, Jonas, Québatte, Maxime, Engel, Philipp, & Dehio, Christoph. (2017). A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella. PLoS Genetics, 13(10), e1007077. https://doi.org/10.1371/journal.pgen.1007077

Harms, Alexander, Segers, Francisca H. I. D., Quebatte, Maxime, Mistl, Claudia, Manfredi, Pablo, Körner, Jonas, Chomel, Bruno B., Kosoy, Michael, Maruyama, Soichi, Engel, Philipp, & Dehio, Christoph. (2017). Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella. Genome biology and evolution, 9(3), 761–776. https://doi.org/10.1093/gbe/evx042

Omasits, Ulrich, Varadarajan, Adithi R., Schmid, Michael, Goetze, Sandra, Melidis, Damianos, Bourqui, Marc, Nikolayeva, Olga, Québatte, Maxime, Patrignani, Andrea, Dehio, Christoph, Frey, Juerg E., Robinson, Mark D., Wollscheid, Bernd, & Ahrens, Christian H. (2017). An integrative strategy to identify the entire protein coding potential of prokaryotic genomes by proteogenomics. Genome Research, 27(12), 2083–2095. https://doi.org/10.1101/gr.218255.116

Québatte, Maxime, Christen, Matthias, Harms, Alexander, Körner, Jonas, Christen, Beat, & Dehio, Christoph. (2017). Gene Transfer Agent Promotes Evolvability within the Fittest Subpopulation of a Bacterial Pathogen. Cell Systems, 4(6), 611–621. https://doi.org/10.1016/j.cels.2017.05.011

Québatte, Maxime, & Dehio, Christoph. (2017). Systems-level interference strategies to decipher host factors involved in bacterial pathogen interaction: from RNAi to CRISPRi. Current Opinion in Microbiology, 39, 34–41. https://doi.org/10.1016/j.mib.2017.08.002

Riba, Andrea, Emmenlauer, Mario, Chen, Amy, Sigoillot, Frederic, Cong, Feng, Dehio, Christoph, Jenkins, Jeremy, & Zavolan, Mihaela. (2017). Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results. Cell Systems, 4(2), 182–193. https://doi.org/10.1016/j.cels.2017.01.011

Stanger, Frédéric V., de Beer, Tjaart A. P., Dranow, David M., Schirmer, Tilman, Phan, Isabelle, & Dehio, Christoph. (2017). The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook. Structure, 25(1), 203–211. https://doi.org/10.1016/j.str.2016.10.010

Andritschke, Daniel, Dilling, Sabrina, Emmenlauer, Mario, Welz, Tobias, Schmich, Fabian, Misselwitz, Benjamin, Rämö, Pauli, Rottner, Klemens, Kerkhoff, Eugen, Wada, Teiji, Penninger, Josef M., Beerenwinkel, Niko, Horvath, Peter, Dehio, Christoph, & Hardt, Wolf-Dietrich. (2016). A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion. PLoS ONE, 11(9), e0161965. https://doi.org/10.1371/journal.pone.0161965

Casanova, Alain, Low, Shyan H., Emmenlauer, Mario, Conde-Alvarez, Raquel, Salcedo, Suzana P., Gorvel, Jean-Pierre, & Dehio, Christoph. (2016). Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells. Journal of Visualized Experiments, 114, e54263. https://doi.org/10.3791/54263

Harms, Alexander, Stanger, Frédéric Valentin, & Dehio, Christoph. (2016). Biological Diversity and Molecular Plasticity of FIC Domain Proteins [Review of Biological Diversity and Molecular Plasticity of FIC Domain Proteins]. Annual Reviews of Microbiology, 70, 341–360. https://doi.org/10.1146/annurev-micro-102215-095245

Stanger, Frédéric V., Burmann, Björn M., Harms, Alexander, Aragão, Hugo, Mazur, Adam, Sharpe, Timothy, Dehio, Christoph, Hiller, Sebastian, & Schirmer, Tilman. (2016). Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proceedings of the National Academy of Sciences of the United States of America, 113(5), E529–37. https://doi.org/10.1073/pnas.1516930113

Stanger, Frédéric V., Harms, Alexander, Dehio, Christoph, & Schirmer, Tilman. (2016). Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin. PLoS ONE, 11(9), e0163654. https://doi.org/10.1371/journal.pone.0163654

Harms, Alexander, Stanger, Frédéric Valentin, Scheu, Patrick Daniel, de Jong, Imke Greet, Goepfert, Arnaud, Glatter, Timo, Gerdes, Kenn, Schirmer, Tilman, & Dehio, Christoph. (2015). Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology. Cell Reports, 12(9), 1497–1507. https://doi.org/10.1016/j.celrep.2015.07.056

Kreibich, Saskia, Emmenlauer, Mario, Fredlund, Jennifer, Rämö, Pauli, Münz, Christian, Dehio, Christoph, Enninga, Jost, & Hardt, Wolf-Dietrich. (2015). Autophagy Proteins Promote Repair of Endosomal Membranes Damaged by the Salmonella Type Three Secretion System 1. Cell Host & Microbe, 18(5), 527–537. https://doi.org/10.1016/j.chom.2015.10.015

Kühbacher, Andreas, Emmenlauer, Mario, Rämö, Pauli, Kafai, Natasha, Dehio, Christoph, Cossart, Pascale, & Pizarro-Cerdá, Javier. (2015). Genome-Wide siRNA Screen Identifies Complementary Signaling Pathways Involved in Listeria Infection and Reveals Different Actin Nucleation Mechanisms during Listeria Cell Invasion and Actin Comet Tail Formation. mBio, 6(3), e00598–15. https://doi.org/10.1128/mbio.00598-15

Schmich, Fabian, Szczurek, Ewa, Kreibich, Saskia, Dilling, Sabrina, Andritschke, Daniel, Casanova, Alain, Low, Shyan Huey, Eicher, Simone, Muntwiler, Simone, Emmenlauer, Mario, Rämo, Pauli, Conde-Alvarez, Raquel, von Mering, Christian, Hardt, Wolf-Dietrich, Dehio, Christoph, & Beerenwinkel, Niko. (2015). Erratum to: gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens. [Review of Erratum to: gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens.]. Genome Biology, 16, Article 233. https://doi.org/10.1186/s13059-015-0807-x

Schmich, Fabian, Szczurek, Ewa, Kreibich, Saskia, Dilling, Sabrina, Andritschke, Daniel, Casanova, Alain, Low, Shyan Huey, Eicher, Simone, Muntwiler, Simone, Emmenlauer, Mario, Rämö, Pauli, Conde-Alvarez, Raquel, von Mering, Christian, Hardt, Wolf-Dietrich, Dehio, Christoph, & Beerenwinkel, Niko. (2015). gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens. Genome Biology, 16(220), 220. https://doi.org/10.1186/s13059-015-0783-1

Siebourg-Polster, Juliane, Mudrak, Daria, Emmenlauer, Mario, Rämö, Pauli, Dehio, Christoph, Greber, Urs, Fröhlich, Holger, & Beerenwinkel, Niko. (2015). NEMix: single-cell nested effects models for probabilistic pathway stimulation. PLoS Computational Biology, 11(4), e1004078. https://doi.org/10.1371/journal.pcbi.1004078

Franceschini, Andrea, Meier, Roger, Casanova, Alain, Kreibich, Saskia, Daga, Neha, Andritschke, Daniel, Dilling, Sabrina, Rämö, Pauli, Emmenlauer, Mario, Kaufmann, Andreas, Conde-Álvarez, Raquel, Low, Shyan Huey, Pelkmans, Lucas, Helenius, Ari, Hardt, Wolf-Dietrich, Dehio, Christoph, & von Mering, Christian. (2014). Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens. Proceedings of the National Academy of Sciences, 111(12), 4548–4553. https://doi.org/10.1073/pnas.1402353111

Okujava, Rusudan, Guye, Patrick, Lu, Yun-Yueh, Mistl, Claudia, Polus, Florine, Vayssier-Taussat, Muriel, Halin, Cornelia, Rolink, Antonius G., & Dehio, Christoph. (2014). A translocated effector required for bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectors. PLoS Pathogens, 10(6). https://doi.org/10.1371/journal.ppat.1004187

Pieles, Kathrin, Glatter, Timo, Harms, Alexander, Schmidt, Alexander, & Dehio, Christoph. (2014). An experimental strategy for the identification of AMPylation targets from complex protein samples. Proteomics, 14(9), 1048–1052. https://doi.org/10.1002/pmic.201300470

Rämö, Pauli, Drewek, Anna, Arrieumerlou, Cécile, Beerenwinkel, Niko, Ben-Tekaya, Houchaïma, Cardel, Bettina, Casanova, Alain, Conde-Alvarez, Raquel, Cossart, Pascale, Csúcs, Gábor, Eicher, Simone, Emmenlauer, Mario, Greber, Urs, Hardt, Wolf-Dietrich, Helenius, Ari, Kasper, Christoph, Kaufmann, Andreas, Kreibich, Saskia, Kühbacher, Andreas, et al. (2014). Simultaneous analysis of large-scale RNAi screens for pathogen entry. BMC Genomics, 15(1), 1162. https://doi.org/10.1186/1471-2164-15-1162

Siamer, Sabrina, & Dehio, Christoph. (2014). New insights into the role of Bartonella effector proteins in pathogenesis [Review of New insights into the role of Bartonella effector proteins in pathogenesis]. Current Opinion in Microbiology, 23, 80–85. https://doi.org/10.1016/j.mib.2014.11.007

Stanger, Frédéric V., Dehio, Christoph, & Schirmer, Tilman. (2014). Structure of the N-terminal gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis. PLoS ONE, 9(9), e107289. https://doi.org/10.1371/journal.pone.0107289

Stekhoven, Daniel J., Omasits, Ulrich, Quebatte, Maxime, Dehio, Christoph, & Ahrens, Christian H. (2014). Proteome-wide identification of predominant subcellular protein localizations in a bacterial model organism. Journal of Proteomics, 99, 123–137. https://doi.org/10.1016/j.jprot.2014.01.015

Stekhoven, Daniel J., Omasits, Ulrich, Quebatte, Maxime, Dehio, Christoph, & Ahrens, Christian H. (2014). Proteome-wide identification of predominant subcellular protein localizations in a bacterial model organism. Journal of Proteomics, 99, 123–137. https://doi.org/10.1016/j.jprot.2014.01.015

Alperi, A., Larrea, D., Fernández-González, E., Dehio, C., Zechner, E. L., & Llosa, M. (2013). A translocation motif in relaxase TrwC specifically affects recruitment by its conjugative Type IV Secretion System. Journal of Bacteriology, 195(22), 4999–5006. https://doi.org/10.1128/jb.00367-13

Ben-Tekaya, H., Gorvel, J. P., & Dehio, C. (2013). Bartonella and Brucella - weapons and strategies for stealth attack. Cold Spring Harbor Perspectives in Medicine, 3(8), a010231. https://doi.org/10.1101/cshperspect.a010231

Eicher, Simone C, & Dehio, Christoph. (2013). Systems-level analysis of host-pathogen interaction using RNA interference. New Biotechnology, 30(3), 308–313. https://doi.org/10.1016/j.nbt.2013.01.008

Farhan, M., Ruusuvuori, P., Emmenlauer, M., Rämö, P., Dehio, C., & Yli-Harja, O. (2013). Multi-scale Gaussian representation and outline-learning based cell image segmentation. BMC Bioinformatics, 14 Suppl 10(S10 S6), S6. https://doi.org/10.1186/1471-2105-14-s10-s6

Goepfert, Arnaud, Stanger, Frédéric V., Dehio, Christoph, & Schirmer, Tilman. (2013). Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with fic fold. PLoS ONE, 8(5), e64901. https://doi.org/10.1371/journal.pone.0064901

Kühbacher, Andreas, Gouin, Edith, Mercer, Jason, Emmenlauer, Mario, Dehio, Christoph, Cossart, Pascale, & Pizarro-Cerdá, Javier. (2013). Imaging InlC secretion to investigate cellular infection by the bacterial pathogen Listeria monocytogenes. Journal of Visualized Experiments, 79(79), e51043. https://doi.org/10.3791/51043

Omasits, U., Quebatte, M., Stekhoven, D. J., Fortes, C., Roschitzki, B., Robinson, M. D., Dehio, C., & Ahrens, C. H. (2013). Directed shotgun proteomics guided by saturated RNA-seq identifies a complete expressed prokaryotic proteome. Genome Research, 23(11), 1916–1927. https://doi.org/10.1101/gr.151035.112

Québatte, Maxime, Dick, Mathias S., Kaever, Volkhard, Schmidt, Alexander, & Dehio, Christoph. (2013). Dual input control : activation of the Bartonella henselae VirB/D4 type IV secretion system by the stringent sigma factor RpoH1 and the BatR/BatS two-component system. Molecular Microbiology, 90(4), 756–775. https://doi.org/10.1111/mmi.12396

Rolain, J. M., Vayssier-Taussat, M., Saisongkorh, W., Merhej, V., Gimenez, G., Robert, C., Le Rhun, D., Dehio, C., & Raoult, D. (2013). Partial disruption of translational and posttranslational machinery reshapes growth rates of Bartonella birtlesii. mBio, 4(2), e00115–13. https://doi.org/10.1128/mbio.00115-13

Goepfert, Arnaud, Harms, Alexander, Schirmer, Tilman, & Dehio, Christoph. (2013). Type II Toxin-Antitoxin Loci: The fic Family. In Gerdes, Kenn (ed.), Prokaryotic Toxin-Antitoxins (pp. 177–187). Springer Verlag. https://doi.org/10.1007/978-3-642-33253-1_10

Dehio, C., Berry, C., & Bartenschlager, R. (2012). Persistent intracellular pathogens. FEMS Microbiology Reviews, 36(3), 513. https://doi.org/10.1111/j.1574-6976.2012.00336.x

Eicher, S. C., & Dehio, C. (2012). Bartonella entry mechanisms into mammalian host cells. Cellular Microbiology, 14(8), 1166–1173. https://doi.org/10.1111/j.1462-5822.2012.01806.x

Engel, Philipp, Goepfert, Arnaud, Stanger, Frédéric V., Harms, Alexander, Schmidt, Alexander, Schirmer, Tilman, & Dehio, Christoph. (2012). Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. Nature, 482(7383), 107–110. https://doi.org/10.1038/nature10729

Harms, Alexander, & Dehio, Christoph. (2012). Intruders below the Radar : Molecular Pathogenesis of Bartonella spp. Clinical Microbiology Reviews, 25(1), 42–78. https://doi.org/10.1128/cmr.05009-11

Harms, Alexander, & Dehio, Christoph. (2012). Intruders below the radar: molecular pathogenesis of Bartonella spp. Clinical Microbiology Reviews, 25(1), 42–78. https://doi.org/10.1128/cmr.05009-11

Llosa, M., Schröder, G., & Dehio, C. (2012). New perspectives into bacterial DNA transfer to human cells. Trends in Microbiology, 20(8), 355–359. https://doi.org/10.1016/j.tim.2012.05.008

Lu, Y. Y., Franz, B., Truttmann, M. C., Riess, T., Gay-Fraret, J., Faustmann, M., Kempf, V. A., & Dehio, C. (2012). Bartonella henselae trimeric autotransporter adhesin BadA expression interferes with effector translocation by the VirB/D4 type IV secretion system. Cellular Microbiology, 15(5), 759–778. https://doi.org/10.1111/cmi.12070

Pulliainen, Arto Tapio, & Dehio, Christoph. (2012). Persistence of Bartonella spp. stealth pathogens : from subclinical infections to vasoproliferative tumor formation. FEMS Microbiology Reviews, 36(3), 563–599. https://doi.org/10.1111/j.1574-6976.2012.00324.x

Pulliainen, A. T., Pieles, K., Brand, C. S., Hauert, B., Böhm, A., Quebatte, M., Wepf, A., Gstaiger, M., Aebersold, R., Dessauer, C. W., & Dehio, C. (2012). Bacterial effector binds host cell adenylyl cyclase to potentiate Gαs-dependent cAMP production. Proceedings of the National Academy of Sciences of the United States of America, 109(24), 9581–9586. https://doi.org/10.1073/pnas.1117651109

Engel, Philipp, Salzburger, Walter, Liesch, Marius, Chang, Chao-Chin, Maruyama, Soichi, Lanz, Christa, Calteau, Alexandra, Lajus, Aurélie, Médigue, Claudine, Schuster, Stephan C., & Dehio, Christoph. (2011). Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella. PLoS Genetics, 7(2), e1001296. https://doi.org/10.1371/journal.pgen.1001296

Fernández-González, Esther, de Paz, Héctor D, Alperi, Anabel, Agúndez, Leticia, Faustmann, Marco, Sangari, Félix J, Dehio, Christoph, & Llosa, Matxalen. (2011). Transfer of R388 derivatives by a pathogenesis-associated type IV secretion system into both bacteria and human cells. Journal of Bacteriology, 193(22), 6257–6265. https://doi.org/10.1128/jb.05905-11

Mietze, A., Morick, D., Kohler, H., Harrus, S., Dehio, C., Nolte, I., & Goethe, R. (2011). Combined MLST and AFLP typing of Bartonella henselae isolated from cats reveals new sequence types and suggests clonal evolution. Veterinary Microbiology, 148(2-4), 238–245. https://doi.org/10.1016/j.vetmic.2010.08.012

Palanivelu, D. V., Goepfert, A., Meury, M., Guye, P., Dehio, C., & Schirmer, T. (2011). Fic domain catalyzed adenylylation: Insight provided by the structural analysis of the type IV secretion system effector BepA. Protein Science, 20(3), 492–499. https://doi.org/10.1002/pro.581

Schroeder, Gunnar, Schuelein, Ralf, Quebatte, Maxime, & Dehio, Christoph. (2011). Conjugative DNA transfer into human cells by the VirB/VirD4 type IV secretion system of the bacterial pathogen Bartonella henselae. Proceedings of the National Academy of Sciences of the United States of America, 108(35), 14643–14648. https://doi.org/10.1073/pnas.1019074108

Truttmann, Matthias C., Guye, Patrick, & Dehio, Christoph. (2011). BID-F1 and BID-F2 domains of Bartonella henselae effector protein BepF trigger together with BepC the formation of invasome structures. PLoS ONE, 6(10), e25106. https://doi.org/10.1371/journal.pone.0025106

Truttmann, Matthias C., Misselwitz, Benjamin, Huser, Sonja, Hardt, Wolf-Dietrich, Critchley, David R., & Dehio, Christoph. (2011). Bartonella henselae engages inside-out and outside-in signaling by integrin β1 and talin1 during invasome-mediated bacterial uptake. Journal of Cell Science, 124(Pt 21), 3591–3602. https://doi.org/10.1242/jcs.084459

Truttmann, M. C., Rhomberg, T. A., & Dehio, C. (2011). Combined action of the type IV secretion effector proteins BepC and BepF promotes invasome formation of Bartonella henselae on endothelial and epithelial cells. Cellular Microbiology, 13(2), 284–299. https://doi.org/10.1111/j.1462-5822.2010.01535.x

de Paz, Héctor D., Larrea, Delfina, Zunzunegui, Sandra, Dehio, Christoph, de la Cruz, Fernando, & Llosa, Matxalen. (2010). Functional dissection of the conjugative coupling protein TrwB. Journal of bacteriology, 192(11), 2655–2669. https://doi.org/10.1128/jb.01692-09

Quebatte, Maxime, Dehio, Michaela, Tropel, David, Basler, Andrea, Toller, Isabella, Raddatz, Guenter, Engel, Philipp, Huser, Sonja, Schein, Hermine, Lindroos, Hillevi L., Andersson, Siv G. E., & Dehio, Christoph. (2010). The BatR/BatS two-component regulatory system controls the adaptive response of Bartonella henselae during human endothelial cell infection. Journal of bacteriology, 192(13), 3352–3367. https://doi.org/10.1128/jb.01676-09

Scheidegger, F., Quebatte, M., Mistl, C., & Dehio, C. (2010). The Bartonella henselae VirB/Bep system interferes with vascular endothelial growth factor (VEGF) signalling in human vascular endothelial cells. Cellular Microbiology, 13(3), 419–431. https://doi.org/10.1111/j.1462-5822.2010.01545.x

Vayssier-Taussat, Muriel, Le Rhun, Danielle, Deng, Hong Kuan, Biville, Francis, Cescau, Sandra, Danchin, Antoine, Marignac, Geneviève, Lenaour, Evelyne, Boulouis, Henri Jean, Mavris, Maria, Arnaud, Lionel, Yang, Huanming, Wang, Jing, Quebatte, Maxime, Engel, Philipp, Saenz, Henri, & Dehio, Christoph. (2010). The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes. PLoS Pathogens, 6(6), e1000946. https://doi.org/10.1371/journal.ppat.1000946

Chomel, B. B., Boulouis, H. -J., Breitschwerdt, E. B., Kasten, R. W., Vayssier-Taussat, M., Birtles, R. J., Koehler, J. E., & Dehio, C. (2009). Ecological fitness and strategies of adaptation of Bartonella species to their hosts and vectors. Veterinary Research, 40(2), 29. https://doi.org/10.1051/vetres/2009011

Engel, P., & Dehio, C. (2009). Genomics of Host-Restricted Pathogens of the Genus Bartonella. Genome dynamics, 6, 158–169. https://doi.org/10.1159/000235769

Llosa, Matxalen, Roy, Craig, & Dehio, Christoph. (2009). Bacterial type IV secretion systems in human disease. Molecular Microbiology, 73(2), 141–151. https://doi.org/10.1111/j.1365-2958.2009.06751.x

Pulliainen, Arto Tapio, & Dehio, Christoph. (2009). Bartonella henselae : subversion of vascular endothelial cell functions by translocated bacterial effector proteins. The International Journal of Biochemistry & Cell Biology, 41(3), 507–510. https://doi.org/10.1016/j.biocel.2008.10.018

Rhomberg, Thomas A, Truttmann, Matthias C, Guye, Patrick, Ellner, Yvonne, & Dehio, Christoph. (2009). A translocated protein of Bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome. Cellular Microbiology, 11(6), 927–945. https://doi.org/10.1111/j.1462-5822.2009.01302.x

Scheidegger, F, Ellner, Y, Guye, P, Rhomberg, T A, Weber, H, Augustin, H G, & Dehio, C. (2009). Distinct activities of Bartonella henselae type IV secretion effector proteins modulate capillary-like sprout formation. Cellular Microbiology, 11(7), 1088–1101. https://doi.org/10.1111/j.1462-5822.2009.01313.x

Selbach, Matthias, Paul, Florian Ernst, Brandt, Sabine, Guye, Patrick, Daumke, Oliver, Backert, Steffen, Dehio, Christoph, & Mann, Matthias. (2009). Host cell interactome of tyrosine-phosphorylated bacterial proteins. Cell Host & Microbe, 5(4), 397–403. https://doi.org/10.1016/j.chom.2009.03.004

Dehio, Christoph. (2008). Infection-associated type IV secretion systems of Bartonella and their diverse roles in host cell interaction. Cellular Microbiology, 10(8), 1591–1598. https://doi.org/10.1111/j.1462-5822.2008.01171.x

Saenz, Henri L, Engel, Philipp, Stoeckli, Michèle C, Lanz, Christa, Raddatz, Günter, Vayssier-Taussat, Muriel, Birtles, Richard, Schuster, Stephan C, & Dehio, Christoph. (2007). Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors. Nature Genetics, 39(12), 1469–1476. https://doi.org/10.1038/ng.2007.38

Schmid, M. C., Scheidegger, F., Dehio, M., Balmelle-Devaux, N., Schulein, R., Guye, P., Chennakesava, C. S., Biedermann, B., & Dehio, C. (2006). A translocated bacterial protein protects vascular endothelial cells from apoptosis. PLoS Pathogens, 2(11), 1083–1097. https://doi.org/10.1371/journal.ppat.0020115