Prof. Dr. Markus A. Rüegg

Ham, Daniel J., Semeraro, Michelangelo, Berger, Bianca M., McGowan, Timothy J., Lin, Shuo, Maino, Eleonora, Oliveri, Filippo, & Rüegg, Markus A. (2025). Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis. Nature Communications , 16(1). https://doi.org/10.1038/s41467-025-58542-7

Reinhard, J. R., Lin, S., Maino, E., Ham, D. J., & Rüegg, M. A. (2025). Dual AAV gene therapy using laminin-linking proteins ameliorates muscle and nerve defects in LAMA2-related muscular dystrophy [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2025.09.16.676550

McGowan, Timothy J., Reinhard, Judith R., Lewerenz, Nicolas, Białobrzeska, Marta, Lin, Shuo, Stępniewski, Jacek, Szade, Krzysztof, Dulak, Józef, & Rüegg, Markus A. (2025). Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2025.06.23.660989

McGowan, Timothy J., Lewerenz, Nicolas, Maino, Eleonora, Thürkauf, Marco, Jörin, Lena, & Rüegg, Markus A. (2025). AAV capsids target muscle-resident cells with different efficiencies—A comparative study between AAV8, AAVMYO, and AAVMYO2. Molecular Therapy Methods and Clinical Development, 33(2). https://doi.org/10.1016/j.omtm.2025.101451

Ham, Alexander S., Lin, Shuo, Tse, Alice, Thürkauf, Marco, McGowan, Timothy J., Jörin, Lena, Oliveri, Filippo, & Rüegg, Markus A. (2025). Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance [Journal-article]. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-57487-1

Falcetta, Denis, Quirim, Sandrine, Cocchiararo, Ilaria, Chabry, Florent, Théodore, Marine, Stiefvater, Adeline, Lin, Shuo, Tintignac, Lionel, Ivanek, Robert, Kinter, Jochen, Rüegg, Markus A., Sinnreich, Michael, & Castets, Perrine. (2024). CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I [Journal-article]. Skeletal Muscle, 14(1). https://doi.org/10.1186/s13395-024-00345-3

Mittal, Nitish, Ataman, Meric, Tintignac, Lionel, Ham, Daniel J., Jörin, Lena, Schmidt, Alexander, Sinnreich, Michael, Ruegg, Markus A., & Zavolan, Mihaela. (2024). Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice [Journal-article]. Npj Regenerative Medicine, 9(1). https://doi.org/10.1038/s41536-024-00369-9

Ataman, Meric, Mittal, Nitish, Tintignac, Lionel, Schmidt, Alexander, Ham, Daniel J., González, Asier, Ruegg, Markus A., & Zavolan, Mihaela. (2024). Calorie restriction and rapamycin distinctly mitigate aging-associated protein phosphorylation changes in mouse muscles [Journal-article]. Communications Biology, 7(1). https://doi.org/10.1038/s42003-024-06679-4

Ham, Alexander S, Lin, Shuo, Tse, Alice, Thürkauf, Marco, Oliveri, Filippo, & Ruegg, Markus A. (2024). Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.05.15.594276

Ham, Daniel J, Semeraro, Michelangelo, Berger, Bianca Manuela, Lin, Shuo, Maino, Eleonora, Oliveri, Filippo, & Ruegg, Markus A. (2024). Muscle fiber Myc is dispensable for muscle growth and forced expression severely perturbs homeostasis. bioRxiv. https://doi.org/10.1101/2024.03.13.584777

Blandino-Rosano, Manuel, Louzada, Ruy Andrade, Werneck-De-Castro, Joao Pedro, Lubaczeuski, Camila, Almaça, Joana, Rüegg, Markus A., Hall, Michael N., Leibowitz, Gil, & Bernal-Mizrachi, Ernesto. (2023). Raptor levels are critical for β-cell adaptation to a high-fat diet in male mice. Molecular Metabolism, 75. https://doi.org/10.1016/j.molmet.2023.101769

Reinhard, Judith R., Porrello, Emanuela, Lin, Shuo, Pelczar, Pawel, Previtali, Stefano C., & Rüegg, Markus A. (2023). Nerve pathology is prevented by linker proteins in mouse models for LAMA2-related muscular dystrophy. PNAS Nexus, 2(4), pgad083. https://doi.org/10.1093/pnasnexus/pgad083

Thürkauf, Marco, Lin, Shuo, Oliveri, Filippo, Grimm, Dirk, Platt, Randall J., & Rüegg, Markus A. (2023). Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9. Nature communications, 14(1), 6116. https://doi.org/10.1038/s41467-023-41769-7

Ham DJ, Börsch A, Chojnowska K, Lin S, Leuchtmann AB, Ham AS, Thürkauf M, Delezie J, Furrer R, Burri D, Sinnreich M, Handschin C, Tintignac LA, Zavolan M, Mittal N, & Rüegg MA. (2022). Author Correction: Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. (Patent No. 1). 13(1), Article 1. https://doi.org/10.1038/s41467-022-30189-8

Blandino-Rosano, Manuel, Scheys, Joshua O., Werneck-de-Castro, Joao Pedro, Louzada, Ruy A., Almaça, Joana, Leibowitz, Gil, Rüegg, Markus A., Hall, Michael N., & Bernal-Mizrachi, Ernesto. (2022). Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling. American Journal of Physiology, Endocrinology and Metabolism, 323(2), E133–E144. https://doi.org/10.1152/ajpendo.00076.2022

Ham, Daniel J., Börsch, Anastasiya, Chojnowska, Kathrin, Lin, Shuo, Leuchtmann, Aurel B., Ham, Alexander S., Thürkauf, Marco, Delezie, Julien, Furrer, Regula, Burri, Dominik, Sinnreich, Michael, Handschin, Christoph, Tintignac, Lionel A., Zavolan, Mihaela, Mittal, Nitish, & Rüegg, Markus A. (2022). Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. Nature Communications, 13(1), 2025. https://doi.org/10.1038/s41467-022-29714-6

Kaiser, Marco S., Milan, Giulia, Ham, Daniel J., Lin, Shuo, Oliveri, Filippo, Chojnowska, Kathrin, Tintignac, Lionel A., Mittal, Nitish, Zimmerli, Christian E., Glass, David J., Zavolan, Mihaela, & Rüegg, Markus A. (2022). Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis. Communications Biology, 5(1), 1141. https://doi.org/10.1038/s42003-022-04097-y

Smeets, H. J. M., Verbrugge, B., Springuel, P., Voermans, N. C., Cossu, G., de Coo, R., Diamantidis, C., Dragendorf, E., Durbeej-Hjalt, M., Dziewczapolski, G., Erasmus, C., Foley, R., Girgenrath, S., Herrero, L. Z., Kemaladewi, D., Klein, A., Lemmens, M.-J., van de Loo, L., Previtali, S., et al. (2021). Merosin deficient congenital muscular dystrophy type 1A: An international workshop on the road to therapy 15-17 November 2019, Maastricht, the Netherlands. Neuromuscular Disorders, 31, 673–680. https://doi.org/10.1016/j.nmd.2021.04.003

Börsch, Anastasiya, Ham, Daniel J., Mittal, Nitish, Tintignac, Lionel A., Migliavacca, Eugenia, Feige, Jérôme N., Rüegg, Markus A., & Zavolan, Mihaela. (2021). Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia. Communications Biology, 4(1), 194. https://doi.org/10.1038/s42003-021-01723-z

Ham, Daniel J., Börsch, Anastasyia, Chojnowska, Kathrin, Lin, Shuo, Leuchtmann, Aurel B., Ham, Alexander S., Thürkauf, Marco, Delezie, Julien, Furrer, Regula, Burri, Dominik, Sinnreich, Michael, Handschin, Christoph, Tintignac, Lionel A., Zavolan, Mihaela, Mittal, Nitish, & Rüegg, Markus A. (2021). Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. bioRxiv. https://doi.org/10.1101/2021.05.28.446097

Previtali, Stefano C., Cohn, Ronald D., & Ruegg, Markus A. (2021). Editorial: Current Insights Into LAMA2 Disease. Frontiers in Molecular Neuroscience, 14, 780635. https://doi.org/10.3389/fnmol.2021.780635

Castets, Perrine, Ham, Daniel J., & Rüegg, Markus A. (2020). The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player? Frontiers in Molecular Neuroscience, 13, 162. https://doi.org/10.3389/fnmol.2020.00162

Ding, Xiaolei, Willenborg, Sebastian, Bloch, Wilhelm, Wickström, Sara A., Wagle, Prerana, Brodesser, Susanne, Roers, Axel, Jais, Alexander, Brüning, Jens C., Hall, Michael N., Rüegg, Markus A., & Eming, Sabine A. (2020). Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. Journal of Allergy and Clinical Immunology, 145(1), 283–300. https://doi.org/10.1016/j.jaci.2019.07.033

Ham, Alexander S., Chojnowska, Kathrin, Tintignac, Lionel A., Lin, Shuo, Schmidt, Alexander, Ham, Daniel J., Sinnreich, Michael, & Rüegg, Markus A. (2020). mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice. Journal of Cachexia, Sarcopenia and Muscle, 11(1), 259–273. https://doi.org/10.1002/jcsm.12505

Ham, Daniel J., Börsch, Anastasiya, Lin, Shuo, Thürkauf, Marco, Weihrauch, Martin, Reinhard, Judith R., Delezie, Julien, Battilana, Fabienne, Wang, Xueyong, Kaiser, Marco S., Guridi, Maitea, Sinnreich, Michael, Rich, Mark M., Mittal, Nitish, Tintignac, Lionel A., Handschin, Christoph, Zavolan, Mihaela, & Rüegg, Markus A. (2020). The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia. Nature Communications, 11(1), 4510. https://doi.org/10.1038/s41467-020-18140-1

Pereira, Jorge A., Gerber, Joanne, Ghidinelli, Monica, Gerber, Daniel, Tortola, Luigi, Ommer, Andrea, Bachofner, Sven, Santarella, Francesco, Tinelli, Elisa, Lin, Shuo, Rüegg, Markus A., Kopf, Manfred, Toyka, Klaus V., & Suter, Ueli. (2020). Mice carrying an analogous heterozygous Dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy. Human Molecular Genetics, 29(8), 1253–1273. https://doi.org/10.1093/hmg/ddaa034

Morgan, J., Butler-Browne, G., Muntoni, F., Patel, K., Amthor, H., Birchmeier, C., Bonaldo, P., Bönnemann, C., Browne, G. B., Chaturvedi, D., Davenport, R., Ferreiro, A., Furling, D., Giordani, L., Grounds, M., Jungbluth, H., Canoves, P. M., Mishra, P., Padberg, G., et al. (2019). 240th ENMC workshop: The involvement of skeletal muscle stem cells in the pathology of muscular dystrophies 25–27 January 2019, Hoofddorp, The Netherlands. Neuromuscular Disorders, 29, 704–715. https://doi.org/10.1016/j.nmd.2019.07.003

Ham, Alexander S., Chojnowska, Kathrin, Tintignac, Lionel A., Lin, Shuo, Schmidt, Alexander, Ham, Daniel J., Sinnreich, Michael, & Rüegg, Markus A. (2019). mTORC1 signaling is not essential for the maintenance of muscle mass and function in adult sedentary mice [Posted-content]. bioRxiv. https://doi.org/10.1101/738294

Castets, Perrine, Rion, Nathalie, Théodore, Marine, Falcetta, Denis, Lin, Shuo, Reischl, Markus, Wild, Franziska, Guérard, Laurent, Eickhorst, Christopher, Brockhoff, Marielle, Guridi, Maitea, Ibebunjo, Chikwendu, Cruz, Joseph, Sinnreich, Michael, Rudolf, Rüdiger, Glass, David J., & Rüegg, Markus A. (2019). mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4. Nature Communications, 10(1), 3187. https://doi.org/10.1038/s41467-019-11227-4

Delezie, Julien, Weihrauch, Martin, Maier, Geraldine, Tejero, Rocío, Ham, Daniel J., Gill, Jonathan F., Karrer-Cardel, Bettina, Rüegg, Markus A., Tabares, Lucía, & Handschin, Christoph. (2019). BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. Proceedings of the National Academy of Sciences (PNAS), 116(32), 16111–16120. https://doi.org/10.1073/pnas.1900544116

Donadon, Irving, Bussani, Erica, Riccardi, Federico, Licastro, Danilo, Romano, Giulia, Pianigiani, Giulia, Pinotti, Mirko, Kostantinova, Pavlina, Evers, Melvin, Lin, Shuo, Rüegg, Markus A., & Pagani, Franco. (2019). Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA. Nucleic Acids Research, 47(14), 7618–7632. https://doi.org/10.1093/nar/gkz469

Rion, Nathalie, Castets, Perrine, Lin, Shuo, Enderle, Leonie, Reinhard, Judith R., Eickhorst, Christopher, & Rüegg, Markus A. (2019). mTOR controls embryonic and adult myogenesis via mTORC1. Development, 146(7), 1–15. https://doi.org/10.1242/dev.172460

Rion, Nathalie, Castets, Perrine, Lin, Shuo, Enderle, Leonie, Reinhard, Judith R., & Rüegg, Markus A. (2019). mTORC2 affects the maintenance of the muscle stem cell pool. Skeletal Muscle, 9(1), 30. https://doi.org/10.1186/s13395-019-0217-y

Ham, D. J., & Rüegg, M. A. (2018). Causes and consequences of age-related changes at the neuromuscular junction. Current Opinion in Physiology, 4, 32–39. https://doi.org/10.1016/j.cophys.2018.04.007

van Putten, Maaike, Aartsma-Rus, Annemieke, Grounds, Miranda D., Kornegay, Joe N., Mayhew, Anna, Gillingwater, Thomas H., Takeda, Shin’ichi, Rüegg, Markus A., De Luca, Annamaria, Nagaraju, Kanneboyina, & Willmann, Raffaella. (2018). Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, The Netherlands. Journal of Neuromuscular Diseases, 5(1), 29–34. https://doi.org/10.3233/jnd-170288

Boido, Marina, De Amicis, Elena, Valsecchi, Valeria, Trevisan, Marco, Ala, Ugo, Ruegg, Markus A., Hettwer, Stefan, & Vercelli, Alessandro. (2018). Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy. Frontiers in Cellular Neuroscience, 12, 17. https://doi.org/10.3389/fncel.2018.00017

Martin, Sally K., Fitter, Stephen, El Khawanky, Nadia, Grose, Randall H., Walkley, Carl R., Purton, Louise E., Ruegg, Markus A., Hall, Michael N., Gronthos, Stan, & Zannettino, Andrew C. W. (2018). mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis. Scientific Reports, 8(1), 14501. https://doi.org/10.1038/s41598-018-32858-5

Yurchenco, Peter D., McKee, Karen K., Reinhard, Judith R., & Rüegg, Markus A. (2018). Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies. Matrix biology : journal of the International Society for Matrix Biology, 71-72, 174–187. https://doi.org/10.1016/j.matbio.2017.11.009

Zainul, Zarin, Heikkinen, Anne, Koivisto, Hennariikka, Rautalahti, Iina, Kallio, Mika, Lin, Shuo, Härönen, Heli, Norman, Oula, Rüegg, Markus A., Tanila, Heikki, & Pihlajaniemi, Taina. (2018). Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury. The Journal of neuroscience, 38(17), 4243–4258. https://doi.org/10.1523/jneurosci.3119-17.2018

Willmann R, Gordish-Dressman H, Meinen S, Rüegg MA, Yu Q, Nagaraju K, Kumar A, Girgenrath M, Coffey CBM, Cruz V, Van Ry PM, Bogdanik L, Lutz C, Rutkowski A, & Burkin DJ. (2017). Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy. Journal of Neuromuscular Diseases, 4(2), 115–126. https://doi.org/10.3233/JND-170217

Blandino-Rosano, M., Barbaresso, R., Jimenez-Palomares, M., Bozadjieva, N., Werneck-de-Castro, J. P., Hatanaka, M., Mirmira, R. G., Sonenberg, N., Liu, M., Rüegg, M. A., Hall, M. N., & Bernal-Mizrachi, E. (2017). Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing. Nature Communications, 8, 16014. https://doi.org/10.1038/ncomms16014

Bozadjieva, Nadejda, Blandino-Rosano, Manuel, Chase, Jennifer, Dai, Xiao-Qing, Cummings, Kelsey, Gimeno, Jennifer, Dean, Danielle, Powers, Alvin C., Gittes, George K., Rüegg, Markus A., Hall, Michael N., MacDonald, Patrick E., & Bernal-Mizrachi, Ernesto. (2017). Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion. The Journal of Clinical Investigation, 127(12), 4379–4393. https://doi.org/10.1172/jci90004

Brockhoff, Marielle, Rion, Nathalie, Chojnowska, Kathrin, Wiktorowicz, Tatiana, Eickhorst, Christopher, Erne, Beat, Frank, Stephan, Angelini, Corrado, Furling, Denis, Rüegg, Markus A., Sinnreich, Michael, & Castets, Perrine. (2017). Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I. Journal of Clinical Investigation, 127(2), 549–563. https://doi.org/10.1172/jci89616

Fitter, Stephen, Matthews, Mary P., Martin, Sally K., Xie, Jianling, Ooi, Soo Siang, Walkley, Carl R., Codrington, John D., Ruegg, Markus A., Hall, Michael N., Proud, Christopher G., Gronthos, Stan, & Zannettino, Andrew C. W. (2017). mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Molecular and Cellular Biology, 37(7), e00668–16. https://doi.org/10.1128/mcb.00668-16

Hodson, Nathan, McGlory, Chris, Oikawa, Sara Y., Jeromson, Stewart, Song, Zhe, Ruegg, Markus A., Hamilton, D. Lee, Phillips, Stuart M., & Philp, Andrew. (2017). Differential localisation and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise. American Journal of Physiology - Cell Physiology, 313(6), C604–C611. https://doi.org/10.1152/ajpcell.00176.2017

Karakatsani, Andromachi, Marichal, Nicolás, Urban, Severino, Kalamakis, Georgios, Ghanem, Alexander, Schick, Anna, Zhang, Yina, Conzelmann, Karl-Klaus, Rüegg, Markus A., Berninger, Benedikt, Ruiz de Almodovar, Carmen, Gascón, Sergio, & Kröger, Stephan. (2017). Neuronal LRP4 regulates synapse formation in the developing CNS. Development, 144(24), 4604–4615. https://doi.org/10.1242/dev.150110

Kleinert, Maximilian, Parker, Benjamin L., Fritzen, Andreas M., Knudsen, Jonas R., Jensen, Thomas E., Kjøbsted, Rasmus, Sylow, Lykke, Ruegg, Markus, James, David E., & Richter, Erik A. (2017). Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. Journal of Physiology, 595(14), 4845–4855. https://doi.org/10.1113/jp274203

McKee, Karen K., Crosson, Stephanie C., Meinen, Sarina, Reinhard, Judith R., Rüegg, Markus A., & Yurchenco, Peter D. (2017). Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype. Journal of Clinical Investigation, 127(3), 1075–1089. https://doi.org/10.1172/jci90854

Reinhard, Judith R., Lin, Shuo, McKee, Karen K., Meinen, Sarina, Crosson, Stephanie C., Sury, Maurizio, Hobbs, Samantha, Maier, Geraldine, Yurchenco, Peter D., & Rüegg, Markus A. (2017). Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice. Science Translational Medicine, 9(396), eaal4649. https://doi.org/10.1126/scitranslmed.aal4649

Rion, Nathalie, & Rüegg, Markus A. (2017). LncRNA-encoded peptides: More than translational noise? Cell Research, 27(5), 604–605. https://doi.org/10.1038/cr.2017.35

Willmann, Raffaella, Gordish-Dressman, Heather, Meinen, Sarina, Rüegg, Markus A., Yu, Qing, Nagaraju, Kanneboyina, Kumar, Ayar, Girgenrath, Mahasweta, Coffey, Caroline B. M., Cruz, Vivian, Van Ry, Pam M., Bogdanik, Laurent, Lutz, Cathleen, Rutkowski, Anne, & Burkin, Dean J. (2017). Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy. Journal of Neuromuscular Diseases, 4(2), 115–126. https://doi.org/10.3233/jnd-170217

Castets, Perrine, Frank, Stephan, Sinnreich, Michael, & Rüegg, Markus A. (2016). “Get the Balance Right”: Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders. Journal of Neuromuscular Diseases, 3(2), 127–155. https://doi.org/10.3233/jnd-160153

Ding, X., Bloch, W., Iden, S., Rüegg, M. A., Hall, M. N., Leptin, M., Partridge, L., & Eming, S. A. (2016). mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nature Communications, 7, 13226. https://doi.org/10.1038/ncomms13226

Grahammer, F., Nesterov, V., Ahmed, A., Steinhardt, F., Sandner, L., Arnold, F., Cordts, T., Negrea, S., Bertog, M., Rüegg, M. A., Hall, M. N., Walz, G., Korbmacher, C., Artunc, F., & Huber, T. B. (2016). mTORC2 critically regulates renal potassium handling. Journal of Clinical Investigation, 126(5), 1773–1782. https://doi.org/10.1172/jci80304

Guridi, Maitea, Kupr, Barbara, Romanino, Klaas, Lin, Shuo, Falcetta, Denis, Tintignac, Lionel, & Rüegg, Markus A. (2016). Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism. Skeletal Muscle, 6(13), 13. https://doi.org/10.1186/s13395-016-0084-8

Kleinert, Maximilian, Parker, Benjamin L., Chaudhuri, Rima, Fazakerley, Daniel J., Serup, Annette, Thomas, Kristen C., Krycer, James R., Sylow, Lykke, Fritzen, Andreas M., Hoffman, Nolan J., Jeppesen, Jacob, Schjerling, Peter, Rüegg, Markus A., Kiens, Bente, James, David E., & Richter, Erik A. (2016). mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Molecular Metabolism, 5(8), 55–646. https://doi.org/10.1016/j.molmet.2016.06.007

Reinhard, Judith R., Kriz, Alexander, Galic, Milos, Angliker, Nico, Rajalu, Mathieu, Vogt, Kaspar E., & Rüegg, Markus A. (2016). The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nature Communications, 7, 11613. https://doi.org/10.1038/ncomms11613

Ruegsegger, Céline, Stucki, David M., Steiner, Silvio, Angliker, Nico, Radecke, Julika, Keller, Eva, Zuber, Benoît, Rüegg, Markus A., & Saxena, Smita. (2016). Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. Neuron, 89(1), 46–129. https://doi.org/10.1016/j.neuron.2015.11.033

Schell, Christoph, Kretz, Oliver, Liang, Wei, Kiefer, Betina, Schneider, Simon, Sellung, Dominik, Bork, Tillmann, Leiber, Christian, Rüegg, Markus A., Mallidis, Con, Schlatt, Stefan, Mayerhofer, Artur, Huber, Tobias B., & Grahammer, Florian. (2016). The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility. American Journal of Pathology, 186(2), 324–336. https://doi.org/10.1016/j.ajpath.2015.10.012

Shende, P., Xu, L., Morandi, C., Pentassuglia, L., Heim, P., Lebboukh, S., Berthonneche, C., Pedrazzini, T., Kaufmann, B. A., Hall, M. N., Rüegg, M. A., & Brink, M. (2016). Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy. Cardiovascular Research, 109(1), 103–114. https://doi.org/10.1093/cvr/cvv252

Zhang, L., Tschumi, B. O., Lopez-Mejia, I. C., Oberle, S. G., Meyer, M., Samson, G., Rüegg, M. A., Hall, M. N., Fajas, L., Zehn, D., Mach, J.-P., Donda, A., & Romero, P. (2016). Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner. Cell Reports, 14(5), 1206–1217. https://doi.org/10.1016/j.celrep.2015.12.095

Grahammer, F., Haenisch, N., Steinhardt, F., Sandner, L., Roerden, M., Arnold, F., Cordts, T., Wanner, N., Reichardt, W., Kerjaschki, D., Ruegg, M. A., Hall, M. N., Moulin, P., Busch, H., Boerries, M., Walz, G., Artunc, F., & Huber, T. B. (2015). Erratum: mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress (Proceedings of the National Academy of Sciences of the United States of America (2014)111 (E2817-E2826) DOI: 10.1073/pnas.1402352111). Proceedings of the National Academy of Sciences of the United States of America, 112(49). https://doi.org/10.1073/pnas.1522405112

Aimi, F., Georgiopoulou, S., Kalus, I., Lehner, F., Hegglin, A., Limani, P., Gomes de Lima, V., Rüegg, M. A., Hall, M. N., Lindenblatt, N., Haas, E., Battegay, E. J., & Humar, R. (2015). Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult. Scientific Reports, 5, 17705. https://doi.org/10.1038/srep17705

Angliker, Nico, Burri, Michael, Zaichuk, Mariana, Fritschy, Jean-Marc, & Rüegg, Markus A. (2015). mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. European Journal of Neuroscience, 42(8), 612–2595. https://doi.org/10.1111/ejn.13051

Carr, T. D., Feehan, R. P., Hall, M. N., Rüegg, M. A., & Shantz, L. M. (2015). Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors. Carcinogenesis, 36(4), 487–497. https://doi.org/10.1093/carcin/bgv012

Domi, Teuta, Porrello, Emanuela, Velardo, Daniele, Capotondo, Alessia, Biffi, Alessandra, Tonlorenzi, Rossana, Amadio, Stefano, Ambrosi, Alessandro, Miyagoe-Suzuki, Yuko, Takeda, Shin’ichi, Ruegg, Markus A., & Previtali, Stefano Carlo. (2015). Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A. Skeletal Muscle, 5(30), 30. https://doi.org/10.1186/s13395-015-0055-5

Guridi, Maitea, Tintignac, Lionel A., Lin, Shuo, Kupr, Barbara, Castets, Perrine, & Rüegg, Markus A. (2015). Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. Science Signaling, 8(402), ra113. https://doi.org/10.1126/scisignal.aab3715

Lopez, R. J., Mosca, B., Treves, S., Maj, M., Bergamelli, L., Calderon, J. C., Bentzinger, C. F., Romanino, K., Hall, M. N., Rüegg, M. A., Delbono, O., Caputo, C., & Zorzato, F. (2015). Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochemical Journal, 466(1), 123–135. https://doi.org/10.1042/bj20140935

Martin, Sally K., Fitter, Stephen, Dutta, Ankit K., Matthews, Mary P., Walkley, Carl R., Hall, Michael N., Ruegg, Markus A., Gronthos, Stan, & Zannettino, Andrew C. W. (2015). Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation. Stem Cells, 33(4), 65–1359. https://doi.org/10.1002/stem.1931

Ma, S., Venkatesh, A., Langellotto, F., Le, Y. Z., Hall, M. N., Rüegg, M. A., & Punzo, C. (2015). Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival. Experimental Eye Research, 135, 1–13. https://doi.org/10.1016/j.exer.2015.04.006

Tintignac, Lionel A., Brenner, Hans-Rudolf, & Rüegg, Markus A. (2015). Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting. Physiological Reviews, 95(3), 52–809. https://doi.org/10.1152/physrev.00033.2014

Venkatesh, A., Ma, S., Le, Y. Z., Hall, M. N., Rüegg, M. A., & Punzo, C. (2015). Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. Journal of Clinical Investigation, 125(4), 1446–1458. https://doi.org/10.1172/jci79766

Willmann, Raffaella, De Luca, Annamaria, Nagaraju, Kanneboyina, & Rüegg, Markus A. (2015). Best Practices and Standard Protocols as a Tool to Enhance Translation for Neuromuscular Disorders. Journal of Neuromuscular Diseases, 2(2), 113–117. https://doi.org/10.3233/jnd-140067

Zhang, Yina, Lin, Shuo, Karakatsani, Andromachi, Rüegg, Markus A., & Kröger, Stephan. (2015). Differential regulation of AChR clustering in the polar and equatorial region of murine muscle spindles. European Journal of Neuroscience, 41(1), 69–78. https://doi.org/10.1111/ejn.12768

Chen, J., Tu, X., Esen, E., Joeng, K. S., Lin, C., Arbeit, J. M., Rüegg, M. A., Hall, M. N., Ma, L., & Long, F. (2014). WNT7B promotes bone formation in part through mTORC1. PLoS Genetics, 10(1), e1004145. https://doi.org/10.1371/journal.pgen.1004145

Chou, Po-Chien, Oh, Won Jun, Wu, Chang-Chih, Moloughney, Joseph, Rüegg, Markus A., Hall, Michael N., Jacinto, Estela, & Werlen, Guy. (2014). Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development. Journal of Immunology, 193(3), 70–1162. https://doi.org/10.4049/jimmunol.1303162

Grahammer, F., Haenisch, N., Steinhardt, F., Sander, L., Roerden, M., Arnold, F., Cordts, T., Wanner, N., Reichardt, W., Kerjaschki, D., Ruegg, M. A., Hall, M. N., Moulin, P., Busch, H., Boerries, M., Walz, G., Artunc, F., & Huber, T. B. (2014). mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proceedings of the National Academy of Sciences of the United States of America, 111(27), E2817–26. https://doi.org/10.1073/pnas.1402352111

Hettwer, Stefan, Lin, Shuo, Kucsera, Stefan, Haubitz, Monika, Oliveri, Filippo, Fariello, Ruggero G., Ruegg, Markus A., & Vrijbloed, Jan W. (2014). Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction. PLoS ONE, 9(2), e88739. https://doi.org/10.1371/journal.pone.0088739

Kleinert, Maximilian, Sylow, Lykke, Fazakerley, Daniel J., Krycer, James R., Thomas, Kristen C., Oxbøll, Anne-Julie, Jordy, Andreas B., Jensen, Thomas E., Yang, Guang, Schjerling, Peter, Kiens, Bente, James, David E., Ruegg, Markus A., & Richter, Erik A. (2014). Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Molecular Metabolism, 3(6), 41–630. https://doi.org/10.1016/j.molmet.2014.06.004

Lebrun-Julien, F., Bachmann, L., Norrmén, C., Trötzmüller, M., Köfeler, H., Rüegg, M. A., Hall, M. N., & Suter, U. (2014). Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. Journal of Neuroscience, 34(25), 8432–8448. https://doi.org/10.1523/jneurosci.1105-14.2014

Miloslavski, Rachel, Cohen, Elad, Avraham, Adam, Iluz, Yifat, Hayouka, Zvi, Kasir, Judith, Mudhasani, Rajini, Jones, Stephen N., Cybulski, Nadine, Rüegg, Markus A., Larsson, Ola, Gandin, Valentina, Rajakumar, Arjuna, Topisirovic, Ivan, & Meyuhas, Oded. (2014). Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. Journal of Molecular Cell Biology, 6(3), 66–255. https://doi.org/10.1093/jmcb/mju008

Norrmén, C., Figlia, G., Lebrun-Julien, F., Pereira, J. A., Trötzmüller, M., Köfeler, H. C., Rantanen, V., Wessig, C., van Deijk, A. F., Smit, A. B., Verheijen, M. G., Rüegg, M. A., Hall, M. N., & Suter, U. (2014). mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells. Cell Reports, 9(2), 646–660. https://doi.org/10.1016/j.celrep.2014.09.001

Steiner, Esther, Enzmann, Gaby U., Lyck, Ruth, Lin, Shuo, Rüegg, Markus A., Kröger, Stephan, & Engelhardt, Britta. (2014). The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions. Cell and Tissue Research, 358(2), 465–479. https://doi.org/10.1007/s00441-014-1969-7

Zhang, L., Tschumi, B. O., Corgnac, S., Rüegg, M. A., Hall, M. N., Mach, J.-P., Romero, P., & Donda, A. (2014). Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function. Journal of Immunology, 193(4), 1759–1765. https://doi.org/10.4049/jimmunol.1400769

Angliker, Nico, & Rüegg, Markus A. (2013). In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons. Bioarchitecture, 3(4), 8–113. https://doi.org/10.4161/bioa.26497

Bentzinger, C. Florian, Lin, Shuo, Romanino, Klaas, Castets, Perrine, Guridi, Maitea, Summermatter, Serge, Handschin, Christoph, Tintignac, Lionel A., Hall, Michael N., & Rüegg, Markus A. (2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle, 3(1), 6. https://doi.org/10.1186/2044-5040-3-6

Castets, Perrine, Lin, Shuo, Rion, Nathalie, Di Fulvio, Sabrina, Romanino, Klaas, Guridi, Maitea, Frank, Stephan, Tintignac, Lionel A., Sinnreich, Michael, & Ruegg, Markus A. (2013). Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. Cell metabolism, 17(5), 44–731. https://doi.org/10.1016/j.cmet.2013.03.015

Castets, Perrine, & Rüegg, Markus A. (2013). MTORC1 determines autophagy through ULK1 regulation in skeletal muscle. Autophagy, 9(9), 7–1435. https://doi.org/10.4161/auto.25722

Cloëtta, Dimitri, Thomanetz, Venus, Baranek, Constanze, Lustenberger, Regula M., Lin, Shuo, Oliveri, Filippo, Atanasoski, Suzana, & Rüegg, Markus A. (2013). Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis. Journal of neuroscience, 33(18), 810–7799. https://doi.org/10.1523/jneurosci.3294-12.2013

Rutkowski, A., Bönnemann, C., Brown, S., Thorsteinsdóttir, S., Dominov, J., Ruegg, M. A., Matter, M. L., Guttridge, D., Crosbie-Watson, R. H., Kardon, G., Nagaraju, K., Girgenrath, M., & Burkin, D. J. (2013). Report on the Myomatrix Conference April 22-24, 2012, University of Nevada, Reno, Nevada, USA. Neuromuscular Disorders, 23(2), 188–191. https://doi.org/10.1016/j.nmd.2012.06.353

Song, Jian, Lokmic, Zerina, Lämmermann, Tim, Rolf, Julia, Wu, Chuan, Zhang, Xueli, Hallmann, Rupert, Hannocks, Melanie-Jane, Horn, Nathalie, Ruegg, Markus A., Sonnenberg, Arnoud, Georges-Labouesse, Elisabeth, Winkler, Thomas H., Kearney, John F., Cardell, Susanna, & Sorokin, Lydia. (2013). Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110(31), E2915–24. https://doi.org/10.1073/pnas.1218131110

Thomanetz, Venus, Angliker, Nico, Cloëtta, Dimitri, Lustenberger, Regula M, Schweighauser, Manuel, Oliveri, Filippo, Suzuki, Noboru, & Rüegg, Markus A. (2013). Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology. The journal of cell biology, 201(2), 293–308. https://doi.org/10.1083/jcb.201205030

Blättler, Sharon M., Cunningham, John T., Verdeguer, Francisco, Chim, Helen, Haas, Wilhelm, Liu, Huifei, Romanino, Klaas, Rüegg, Markus A., Gygi, Steven P., Shi, Yang, & Puigserver, Pere. (2012). Yin yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metabolism, 15(4), 17–505. https://doi.org/10.1016/j.cmet.2012.03.008

Blättler, Sharon M., Verdeguer, Francisco, Liesa, Marc, Cunningham, John T., Vogel, Rutger O., Chim, Helen, Liu, Huifei, Romanino, Klaas, Shirihai, Orian S., Vazquez, Francisca, Rüegg, Markus A., Shi, Yang, & Puigserver, Pere. (2012). Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Molecular and cellular biology, 32(16), 46–3333. https://doi.org/10.1128/mcb.00337-12

Hagiwara, Asami, Cornu, Marion, Cybulski, Nadine, Polak, Pazit, Betz, Charles, Trapani, Francesca, Terracciano, Luigi, Heim, Markus H., Rüegg, Markus A., & Hall, Michael N. (2012). Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c. Cell Metabolism, 15(5), 38–725. https://doi.org/10.1016/j.cmet.2012.03.015

Meinen, Sarina, Lin, Shuo, & Ruegg, Markus A. (2012). Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A). Skeletal Muscle, 2(1), 18. https://doi.org/10.1186/2044-5040-2-18

Meinen, Sarina, Lin, Shuo, Rüegg, Markus A., & Punga, Anna Rostedt. (2012). Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS. PLoS ONE, 7(8), e44148. https://doi.org/10.1371/journal.pone.0044148

Punga, Anna Rostedt, & Ruegg, Markus A. (2012). Signaling and aging at the neuromuscular synapse : lessons learnt from neuromuscular diseases. Current Opinion in Pharmacology, 12(3), 6–340. https://doi.org/10.1016/j.coph.2012.02.002

Steiner, Esther, Enzmann, Gaby U., Lin, Shuo, Ghavampour, Sharang, Hannocks, Melanie-Jane, Zuber, Benoît, Rüegg, Markus A., Sorokin, Lydia, & Engelhardt, Britta. (2012). Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia, 60(11), 59–1646. https://doi.org/10.1002/glia.22383

Gödel, M., Hartleben, B., Herbach, N., Liu, S., Zschiedrich, S., Lu, S., Debreczeni-Mor, A., Lindenmeyer, M. T., Rastaldi, M. -P., Hartleben, G., Wiech, T., Fornoni, A., Nelson, R. G., Kretzler, M., Wanke, R., Pavenstadt, H., Kerjaschki, D., Cohen, C. D., Hall, M. N., et al. (2011). Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. Journal of Clinical Investigation, 121(6), 2197–2209. https://doi.org/10.1172/jci44774