Prof. Dr. Giusi Moffa

Bartels, C., Scauda, M., Coello, N., Dumortier, T., Bornkamp, B., & Moffa, G. (2025). Nonlinear mixed-effects modeling as a method for causal inference to predict exposures under desired within-subject dose titration schemes. CPT: Pharmacometrics and Systems Pharmacology, 14(1), 68–81. https://doi.org/10.1002/psp4.13239

Roethlisberger, Michel, Moffa, Giusi, Rychen, Jonathan, Saemann, Attill, Straumann, Sven, Taub, Ethan, Zumofen, Daniel W., Neddersen, Heike, Westermann, Birgit, Bodmer, Daniel, & Mariani, Luigi. (2024). Long-term tumor control in Koos grade IV vestibular schwannomas without the need for gross-total resection [Journal-article]. Journal of Neurosurgery, 140(6), 1591–1604. https://doi.org/10.3171/2023.9.jns231316

Möckli, Nathalie, Wächter, Matthias, Moffa, Giusi, Simon, Michael, Martins, Tania, & Zúñiga, Franziska. (2024). How regulatory frameworks drive differences in home-care agencies: Results from a national multicenter cross-sectional study in Switzerland. International Journal of Health Planning and Management, 39(2), 477–501. https://doi.org/10.1002/hpm.3744

Moffa, G., Kuipers, J., Kuipers, E., McManus, S., & Bebbington, P. (2023). Sexual abuse and psychotic phenomena: A directed acyclic graph analysis of affective symptoms using English national psychiatric survey data. Psychological Medicine, 53(16), 7817–7826. https://doi.org/10.1017/s003329172300185x

Bayer, F., Roncador, M., Moffa, G., Morita, K., Takahashi, K., Beerenwinkel, N., & Kuipers, J. (2023). Network-based clustering unveils interconnected landscapes of genomic and clinical features across myeloid malignancies [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.10.25.563992

Giudice, E., Kuipers, J., & Moffa, G. (2023). The dual PC algorithm and the role of Gaussianity for structure learning of Bayesian networks. International Journal of Approximate Reasoning, 161. https://doi.org/10.1016/j.ijar.2023.108975

Ali, F., Lim, S. K., Moffa, G., Kuipers, J., & Ang, R. (2023, May 8). Uncovering network structure relating academic achievement, motivation, and schooling experience using structure learning of directed acyclic graphs [Posted-content]. Center for Open Science. https://doi.org/10.35542/osf.io/3e7za

Aghlmandi, Soheila, Halbeisen, Florian S., Saccilotto, Ramon, Godet, Pascal, Signorell, Andri, Sigrist, Simon, Glinz, Dominik, Moffa, Giusi, Zeller, Andreas, Widmer, Andreas F., Kronenberg, Andreas, Bielicki, Julia, & Bucher, Heiner C. (2023). Effect of Antibiotic Prescription Audit and Feedback on Antibiotic Prescribing in Primary Care: A Randomized Clinical Trial. JAMA Internal Medicine, 183(3), 213–220. https://doi.org/10.1001/jamainternmed.2022.6529

Moffa Giusi, Kuipers Jack, Carrà Giuseppe, Crocamo Cristina, Kuipers Elizabeth, Angermeyer Matthias, Brugha Traolach, Toumi Mondher, & Bebbington Paul. (2023). Longitudinal symptomatic interactions in long-standing schizophrenia: A novel five-point analysis based on directed acyclic graphs. Psychological Medicine, 53(4), 1371–1378. https://doi.org/10.1017/s0033291721002920

Suter, P., Kuipers, J., Moffa, G., & Beerenwinkel, N. (2023). Bayesian Structure Learning and Sampling of Bayesian Networks with the R Package BiDAG. Journal of Statistical Software, 105(9), 1–31. https://doi.org/10.18637/jss.v105.i09

Haak, Fabian, Soysal, Savas, Deutschmann, Elisabeth, Moffa, Giusi, Bucher, Heiner C., Kaech, Max, Kettelhack, Christoph, Kollmar, Otto, & von Strauss und Torney, Marco. (2022). Incidence of Liver Resection Following the Introduction of Caseload Requirements for Liver Surgery in Switzerland. World Journal of Surgery, 46(6), 1457–1464. https://doi.org/10.1007/s00268-022-06509-w

Haak, Fabian, Soysal, Savas, Deutschmann, Elisabeth, Moffa, Giusi, Bucher, Heiner C, Kaech, Max, Kettelhack, Christoph, Kollmar, Otto, & von Strauss Und Torney, Marco. (2022). Incidence of Liver Resection Following the Introduction of Caseload Requirements for Liver Surgery in Switzerland. World Journal of Surgery, 46(6), 1457–1464. https://doi.org/10.1007/s00268-022-06509-w

Schmitt AM, Walter M, Herbrand AK, Jörger M, Moffa G, Novak U, Hemkens L, & Kasenda B. (2022). Characteristics and survival of patients with cancer with intended off-label use - A cohort study. BMJ Open, 12(5), e060453. https://doi.org/10.1136/bmjopen-2021-060453

Schmitt, Andreas Michael, Walter, Martin, Herbrand, Amanda Katherina, Jörger, Markus, Moffa, Giusi, Novak, Urban, Hemkens, Lars, & Kasenda, Benjamin. (2022). Characteristics and survival of patients with cancer with intended off-label use - A cohort study. BMJ Open, 12(5), e060453. https://doi.org/10.1136/bmjopen-2021-060453

Dillner, Pernilla, Eggenschwiler, Luisa C., Rutjes, Anne W. S., Berg, Lena, Musy, Sarah N., Simon, Michael, Moffa, Giusi, Förberg, Ulrika, & Unbeck, Maria. (2022). Incidence and characteristics of adverse events in paediatric inpatient care: a systematic review and meta-analysis. BMJ Quality & Safety. https://doi.org/10.1136/bmjqs-2022-015298

Giudice, Enrico, Kuipers, Jack, & Moffa, Giusi. (2022). The Dual PC Algorithm for Structure Learning. Proceedings of Machine Learning Research, 186, 301–312.

Gryaznov, D., von Niederhäusern, B., Speich, B., Kasenda, B., Ojeda-Ruiz, E., Blümle, A., Schandelmaier, S., Mertz, D., Odutayo, A., Tomonaga, Y., Amstutz, A., Pauli-Magnus, C., Gloy, V., Lohner, S., Bischoff, K., Wollmann, K., Rehner, L., Meerpohl, J. J., Nordmann, A., et al. (2022). Reporting quality of clinical trial protocols: a repeated cross-sectional study about the Adherence to SPIrit recommendations in Switzerland, CAnada and GErmany (ASPIRE-SCAGE). BMJ Open, 12(5), e053417. https://doi.org/10.1136/bmjopen-2021-053417

Kuipers, Jack, & Moffa, Giusi. (2022). The variance of causal effect estimators for binary v-structures. Journal of Causal Inference, 10(1), 90–105. https://doi.org/10.1515/jci-2021-0025

Kuipers, Jack, Suter, Polina, & Moffa, Giusi. (2022). Efficient Sampling and Structure Learning of Bayesian Networks. Journal of Computational and Graphical Statistics, 31(3), 639–650. https://doi.org/10.1080/10618600.2021.2020127

Sharma, Narayan, Moffa, Giusi, Schwendimann, René, Endrich, Olga, Ausserhofer, Dietmar, & Simon, Michael. (2022). The effect of time-varying capacity utilization on 14-day in-hospital mortality: a retrospective longitudinal study in Swiss general hospitals. BMC Health Services Research, 22(1), 1551. https://doi.org/10.1186/s12913-022-08950-y

Kappos EA, Schulz A, Regan MM, Moffa G, Harder Y, Ribi K, Potter S, Pusic AL, Fehr MK, Hemkens LG, Holzbach T, Farhadi J, Simonson C, Knauer M, Verstappen R, Bucher HC, Zwahlen D, Zimmermann F, Schwenkglenks M, et al. (2021). Prepectoral versus subpectoral implant-based breast reconstruction after skin-sparing mastectomy or nipple-sparing mastectomy (OPBC-02/ PREPEC): A pragmatic, multicentre, randomised, superiority trial. BMJ Open, 11(9), e045239. https://doi.org/10.1136/bmjopen-2020-045239

Kappos, Elisabeth A, Schulz, Alexandra, Regan, Meredith M, Moffa, Giusi, Harder, Yves, Ribi, Karin, Potter, Shelley, Pusic, Andrea L, Fehr, Mathias K, Hemkens, Lars G, Holzbach, Thomas, Farhadi, Jian, Simonson, Colin, Knauer, Michael, Verstappen, Ralph, Bucher, Heiner C, Zwahlen, Daniel, Zimmermann, Frank, Schwenkglenks, Matthias, et al. (2021). Prepectoral versus subpectoral implant-based breast reconstruction after skin-sparing mastectomy or nipple-sparing mastectomy (OPBC-02/ PREPEC): A pragmatic, multicentre, randomised, superiority trial. BMJ Open, 11(9), e045239. https://doi.org/10.1136/bmjopen-2020-045239

Kaech M, Deutschmann E., Moffa G., Haak F., Bucher HC, Kettelhack C, & von Strauss Und Torney M. (2021). Influence of the introduction of caseload requirements on indication for visceral cancer surgery in Switzerland. European Journal of Surgical Oncology, 47(6), 1324–1331. https://doi.org/10.1016/j.ejso.2021.04.006

Glinz D, Mc Cord KA, Moffa G, Aghlmandi S, Saccilotto R, Zeller A, Widmer AF, Bielicki J, Kronenberg A, & Bucher HC. (2021). Antibiotic prescription monitoring and feedback in primary care in Switzerland: Design and rationale of a nationwide pragmatic randomized controlled trial. Contemporary Clinical Trials Communications, 21, 100712. https://doi.org/10.1016/j.conctc.2021.100712

Glinz, Dominik, Mc Cord, Kimberly A, Moffa, Giusi, Aghlmandi, Soheila, Saccilotto, Ramon, Zeller, Andreas, Widmer, Andreas F, Bielicki, Julia, Kronenberg, Andreas, & Bucher, Heiner C. (2021). Antibiotic prescription monitoring and feedback in primary care in Switzerland: Design and rationale of a nationwide pragmatic randomized controlled trial. Contemporary Clinical Trials Communications, 21, 100712. https://doi.org/10.1016/j.conctc.2021.100712

Deutschmann, Elisabeth, Bucher, Heiner C., Jaeckel, Steffen, Gibbons, Sara, McAllister, Katie, Scherrer, Alexandra U., Braun, Dominique L., Cavassini, Matthias, Hachfeld, Anna, Calmy, Alexandra, Battegay, Manuel, Cipriani, Michela, Elzi, Luigia, Young, James, Lopez-Centeno, Beatriz, Berenguer, Juan, Khoo, Saye, Moffa, Giusi, Marzolini, Catia, & Swiss HIV Cohort Study. (2021). Prevalence of Potential Drug-Drug Interactions in Patients of the Swiss HIV Cohort Study in the Era of HIV Integrase Inhibitors. Clinical Infectious Diseases, 73(7), e2145–e2152. https://doi.org/10.1093/cid/ciaa918

Herbrand, Amanda Katherina, Schmitt, Andreas M., Briel, Matthias, Ewald, Hannah, Goldkuhle, Marius, Diem, Stefan, Hoogkamer, Anouk, Joerger, Markus, Moffa, Giusi, Novak, Urban, Hemkens, Lars G., & Kasenda, Benjamin. (2021). Association of Supporting Trial Evidence and Reimbursement for Off-Label Use of Cancer Drugs. Jama Network Open, 4(3), e210380. https://doi.org/10.1001/jamanetworkopen.2021.0380

Lohner, Szimonetta, Gryaznov, Dmitry, von Niederhäusern, Belinda, Speich, Benjamin, Kasenda, Benjamin, Ojeda-Ruiz, Elena, Schandelmaier, Stefan, Mertz, Dominik, Odutayo, Ayodele, Tomonaga, Yuki, Amstutz, Alain, Pauli-Magnus, Christiane, Gloy, Viktoria, Bischoff, Karin, Wollmann, Katharina, Rehner, Laura, Meerpohl, Joerg J., Nordmann, Alain, Klatte, Katharina, et al. (2021). Reporting quality of trial protocols improved for non-regulated interventions but not regulated interventions: A repeated cross-sectional study. Journal of Clinical Epidemiology, 139, 340–349. https://doi.org/10.1016/j.jclinepi.2021.05.011

Luo, Xiang Ge, Moffa, Giusi, & Kuipers, Jack. (2021). Learning Bayesian networks from ordinal data. Journal of Machine Learning Research, 22.

Gryaznov, D., Odutayo, A., von Niederhausern, B., Speich, B., Kasenda, B., Ojeda-Ruiz, E., Blumle, A., Schandelmaier, S., Mertz, D., Tomonaga, Y., Amstutz, A., Pauli-Magnus, C., Gloy, V., Bischoff, K., Wollmann, K., Rehner, L., Lohner, S., Meerpohl, J. J., Nordmann, A., et al. (2020). Rationale and design of repeated cross-sectional studies to evaluate the reporting quality of trial protocols: the Adherence to SPIrit REcommendations (ASPIRE) study and associated projects. Trials, 21(1), 896. https://doi.org/10.1186/s13063-020-04808-y

Kasenda, Benjamin, Liu, Junhao, Jiang, Yu, Gajewski, Byron, Wu, Cen, von Elm, Erik, Schandelmaier, Stefan, Moffa, Giusi, Trelle, Sven, Schmitt, Andreas Michael, Herbrand, Amanda K., Gloy, Viktoria, Speich, Benjamin, Hopewell, Sally, Hemkens, Lars G., Sluka, Constantin, McGill, Kris, Meade, Maureen, Cook, Deborah, et al. (2020). Prediction of RECRUITment In Randomized Clinical Trials (RECRUIT-IT) - Rationale and Design for an International Collaborative Study. Trials, 21(1), 731. https://doi.org/10.1186/s13063-020-04666-8

Livio, Françoise, Deutschmann, Elisabeth, Moffa, Giusi, Rrustemi, Flamur, Stader, Felix, Elzi, Luigia, Braun, Dominique L., Calmy, Alexandra, Hachfeld, Anna, Cavassini, Matthias, Tarr, Philip E., Wissel, Kerstin, Battegay, Manuel, Marzolini, Catia, & Swiss HIV Cohort Study. (2020). Analysis of inappropriate prescribing in elderly patients of the Swiss HIV Cohort Study reveals gender inequity. The Journal of Antimicrobial Chemotherapy, dkaa505. https://doi.org/10.1093/jac/dkaa505

von Strauss und Torney, Marco, Moffa, Giusi, Kaech, Max, Haak, Fabian, Riss, Stefan, Deutschmann, Elisabeth, Bucher, Heiner C., Kettelhack, Christoph, & Paterson, Hugh M. (2020). Risk of Emergency Surgery or Death After Initial Nonoperative Management of Complicated Diverticulitis in Scotland and Switzerland. JAMA Surgery, 155(7), 600–606. https://doi.org/10.1001/jamasurg.2020.0757

Kuipers, J., Moffa, G., Kuipers, E., Freeman, D., & Bebbington, P. (2019). Links between Psychotic and Neurotic Symptoms in the General Population: An Analysis of Longitudinal British National Survey Data Using Directed Acyclic Graphs. Psychological Medicine, 49(3), 388–395. https://doi.org/10.1017/s0033291718000879

Schaefer, Thorsten, Ramadoss, Archana, Leu, Severina, Tintignac, Lionel, Tostado, Cristobal, Bink, Andrea, Schürch, Christoph, Müller, Joëlle, Schärer, Jonas, Moffa, Giusi, Demougin, Philippe, Moes, Suzette, Stippich, Christoph, Falbo, Simona, Neddersen, Heike, Bucher, Heiner, Frank, Stephan, Jenö, Paul, Lengerke, Claudia, et al. (2019). Regulation of Glioma Cell Invasion by 3q26 Gene Products PIK3CA, SOX2 and OPA1. Brain Pathology, 29(3), 336–350. https://doi.org/10.1111/bpa.12670

Speich, Benjamin, Mc Cord, Kimberly A., Agarwal, Arnav, Gloy, Viktoria, Gryaznov, Dmitry, Moffa, Giusi, Hopewell, Sally, & Briel, Matthias. (2019). Reporting Quality of Journal Abstracts for Surgical Randomized Controlled Trials Before and After the Implementation of the CONSORT Extension for Abstracts. World Journal of Surgery, 43(10), 2371–2378. https://doi.org/10.1007/s00268-019-05064-1

Steffen, Lukas, Moffa, Giusi, Müller, Philip C., & Oertli, Daniel. (2019). Secondary Hyperparathyroidism: Recurrence after Total Parathyroidectomy with Autotransplantation. Swiss Medical Weekly, 149, w20160. https://doi.org/10.4414/smw.2019.20160

Kuipers, Jack, Thurnherr, Thomas, Moffa, Giusi, Suter, Polina, Behr, Jonas, Goosen, Ryan, Christofori, Gerhard, & Beerenwinkel, Niko. (2018). Mutational Interactions Define Novel Cancer Subgroups. Nature Communications, 9(1), 4353. https://doi.org/10.1038/s41467-018-06867-x

Roethlisberger, Michel, Moffa, Giusi, Fisch, Urs, Wiggli, Benedikt, Schoen, Stephan, Kelly, Christopher, Leu, Severina, Croci, Davide, Zumofen, Daniel W., Cueni, Nadine, Nogarth, Danica, Schulz, Marianne, Bucher, Heiner C., Weisser-Rohacek, Maja, Wasner, Morten-Goetz, Widmer, Andreas F., & Mariani, Luigi. (2018). Effectiveness of a Chlorhexidine Dressing on Silver-coated External Ventricular Drain-associated Colonization and Infection: A Prospective Single-blinded Randomized Controlled Clinical Trial. Clinical Infectious Diseases, 67(12), 1868–1877. https://doi.org/10.1093/cid/ciy393

Kuipers, J., Thurnherr, T., Moffa, G., Suter, P., Behr, J., Goosen, R., Christofori, G., & Beerenwinkel, N. (2017, September 11). Mutational interactions define novel cancer subgroups [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/187260

Kuipers, Jack, & Moffa, Giusi. (2017). Partition MCMC for Inference on Acyclic Digraphs. Journal of the American Statistical Association, 112(417), 282–299. https://doi.org/10.1080/01621459.2015.1133426

Moffa, Giusi, Catone, Gennaro, Kuipers, Jack, Kuipers, Elizabeth, Freeman, Daniel, Marwaha, Steven, Lennox, Belinda R., Broome, Matthew R., & Bebbington, Paul. (2017). Using Directed Acyclic Graphs in Epidemiological Research in Psychosis: An Analysis of the Role of Bullying in Psychosis. Schizophrenia Bulletin, 43(6), 1273–1279. https://doi.org/10.1093/schbul/sbx013

Moffa, Giusi, Erdmann, Gerrit, Voloshanenko, Oksana, Hundsrucker, Christian, Sadeh, Mohammad J., Boutros, Michael, & Spang, Rainer. (2016). Refining Pathways: A Model Comparison Approach. PLoS ONE, 11(6), e0155999. https://doi.org/10.1371/journal.pone.0155999

Kuipers, Jack, & Moffa, Giusi. (2015). Uniform Random Generation of Large Acyclic Digraphs. Statistics and Computing, 25, 227–242. https://doi.org/10.1007/s11222-013-9428-y

Kuipers, Jack, Moffa, Giusi, & Heckerman, David. (2014). Addendum on the Scoring of Gaussian Directed Acyclic Graphical Models. The Annals of Statistics, 42(4), 1689–1691. https://doi.org/10.1214/14-aos1217

Moffa, Giusi, & Kuipers, Jack. (2014). Sequential Monte Carlo EM for Multivariate Probit Models. Computational Statistics & Data Analysis, 72, 252–272. https://doi.org/10.1016/j.csda.2013.10.019

Voloshanenko, Oksana, Erdmann, Gerrit, Dubash, Taronish D., Augustin, Iris, Metzig, Marie, Moffa, Giusi, Hundsrucker, Christian, Kerr, Grainne, Sandmann, Thomas, Anchang, Benedikt, Demir, Kubilay, Boehm, Christina, Leible, Svenja, Ball, Claudia R., Glimm, Hanno, Spang, Rainer, & Boutros, Michael. (2013). Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nature Communications, 4, 13. https://doi.org/10.1038/ncomms3610

Sadeh, M. J., Moffa, G., & Spang, R. (2013). Considering unknown unknowns - Reconstruction of non-confoundable causal relations in biological networks. Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 7821 LNBI, 234–248. https://doi.org/10.1007/978-3-642-37195-0_20

Sadeh, Mohammad J., Moffa, Giusi, & Spang, Rainer. (2013). Considering Unknown Unknowns: Reconstruction of Nonconfoundable Causal Relations in Biological Networks. Journal of Computational Biology, 20(11), 32–920. https://doi.org/10.1089/cmb.2013.0119