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Prof. Dr.
Florian Peter Seebeck
Department of Chemistry
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Publications
47 found
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Peng, Jiaming, Hughes, Gregory R., Müller, Manuel M., & Seebeck, Florian P. (2023). Enzymatic Fluoromethylation as a Tool for ATP‐Independent Ligation [Journal-article]. Angewandte Chemie International Edition, 63(1). https://doi.org/10.1002/anie.202312104
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Reed, John H., & Seebeck, Florian P. (2023). Reagent Engineering for Group Transfer Biocatalysis [Journal-article]. Angewandte Chemie International Edition, 63(7). https://doi.org/10.1002/anie.202311159
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Gericke, Lukas, Mhaindarkar, Dipali, Karst, Lukas C., Jahn, Sören, Kuge, Marco, Mohr, Michael K. F., Gagsteiger, Jana, Cornelissen, Nicolas V., Wen, Xiaojin, Mordhorst, Silja, Jessen, Henning J., Rentmeister, Andrea, Seebeck, Florian P., Layer, Gunhild, Loenarz, Christoph, & Andexer, Jennifer N. (2023). Biomimetic S-Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes [Journal-article]. ChemBioChem, 24(9). https://doi.org/10.1002/cbic.202300133
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Hartmann, Lea, Seebeck, Florian P., Schmalz, Hans-Günther, & Gründemann, Dirk. (2023). Isotope-labeled ergothioneine clarifies the mechanism of reaction with singlet oxygen [Journal-article]. Free Radical Biology and Medicine, 198, 12–26. https://doi.org/10.1016/j.freeradbiomed.2023.01.023
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Beliaeva, Mariia A., Atac, Reyhan, & Seebeck, Florian P. (2022). Bacterial Degradation of Nτ-Methylhistidine. ACS Chemical Biology, 17(7), 1989–1995. https://doi.org/10.1021/acschembio.2c00437
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Beliaeva, Mariia A., & Seebeck, Florian P. (2022). Discovery and Characterization of the Metallopterin-Dependent Ergothioneine Synthase from Caldithrix abyssi. JACS Au, 2(9), 2098–2107. https://doi.org/10.1021/jacsau.2c00365
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Wen, Xiaojin, Leisinger, Florian, Leopold, Viviane, & Seebeck, Florian P. (2022). Synthetic Reagents for Enzyme-Catalyzed Methylation. Angewandte Chemie International Edition, 61(41), e202208746. https://doi.org/10.1002/anie.202208746
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Beliaeva, Mariia A., Burn, Reto, Lim, David, & Seebeck , Florian P. (2021). In Vitro Production of Ergothioneine Isotopologues. Angewandte Chemie International Edition, 60(10), 5209–5212. https://doi.org/10.1002/anie.202011096
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Beliaeva, Mariia A., Leisinger, Florian, & Seebeck, Florian P. (2021). In Vitro Reconstitution of a Five-Step Pathway for Bacterial Ergothioneine Catabolism. ACS Chemical Biology, 16(2), 397–403. https://doi.org/10.1021/acschembio.0c00968
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Duncombe, Todd, Ponti, Aron, Seebeck, Florian Peter, & Dittrich, Petra. (2021). UV-Vis Spectra-Activated Droplet Sorting for Label-Free Chemical Identification and Collection of Drople. Analytical Chemistry, 93(38), 13008–13013. https://doi.org/10.1021/acs.analchem.1c02822
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Leisinger, Florian, Miarzlou , Dzmitry A., & Seebeck, Florian P. (2021). Non-Coordinative Binding of O2 at the Active Center of a Copper-Dependent Enzyme. Angewandte Chemie International Edition, 60(11), 6154–6159. https://doi.org/10.1002/anie.202014981
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Peng, Jiaming, Liao, Cangsong, Bauer, Carste, & Seebeck, Florian Peter. (2021). Fluorinated S-Adenosylmethionine as a Reagent for Enzyme-Catalyzed Fluoromethylation. Angewandte Chemie International Edition, 60(52), 27178–27183. https://doi.org/10.1002/anie.202108802
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Schneider, Peter, Henßen, Birgit, Paschold, Beatrix, Chapple, Benjamin P., Schatton, Marcel, Seebeck, Florian Peter, Classen , Thomas, & Pietruszka, Jörg. (2021). Biocatalytic C3-Indole Methylation-A Useful Tool for the Natural-Product-Inspired Stereoselective Synthesis of Pyrroloindoles. Angewandte Chemie International Edition, 60(43), 23412–23418. https://doi.org/10.1002/anie.202107619
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Flückger, Sebastian, Igareta, Nico V., & Seebeck, Florian P. (2020). Convergent Evolution of Fungal Cysteine Dioxygenases. ChemBioChem, 21(21), 3082–3086. https://doi.org/10.1002/cbic.202000317
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Goncharenko, Kristina V., Flückiger, Sebastian, Liao, Cangsong, Lim, David, Stampfli, Anja R., & Seebeck, Florian P. (2020). Selenocysteine as a Substrate, an Inhibitor and a Mechanistic Probe for Bacterial and Fungal Iron-Dependent Sulfoxide Synthases. Chemistry - A European Journal, 26(6), 1328–1334. https://doi.org/10.1002/chem.201903898
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Liao, Cangsong, & Seebeck, Florian P. (2020). Asymmetric β-Methylation of l- and d-α-Amino Acids by a Self-Contained Enzyme Cascade. Angewandte Chemie International Edition, 59(18), 7184–7187. https://doi.org/10.1002/anie.201916025
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Lim, David, Wen, Xiaojin, & Seebeck, Florian P. (2020). Selenoimidazolium Salts as Supramolecular Reagents for Protein Alkylation. Chembiochem : A European Journal of Chemical Biology, 21(24), 3515–3520. https://doi.org/10.1002/cbic.202000557
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Maurer, Alice, & Seebeck, Florian P. (2020). Reexamination of the Ergothioneine Biosynthetic Methyltransferase EgtD from Mycobacterium tuberculosis as a Protein Kinase Substrate. ChemBioChem, 21(20), 2908–2911. https://doi.org/10.1002/cbic.202000232
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Milito, Alfonsina, Castellano, Immacolata, Burn, Reto, Seebeck, Florian P., Brunet, Christophe, & Palumbo, Anna. (2020). First evidence of ovothiol biosynthesis in marine diatoms. Free Radical Biology and Medicine, 152, 680–688. https://doi.org/10.1016/j.freeradbiomed.2020.01.010
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Stampfli, Anja R., Blankenfeldt, Wulf, & Seebeck, Florian P. (2020). Structural basis of ergothioneine biosynthesis. Current Opinion in Structural Biology, 65, 1–8. https://doi.org/10.1016/j.sbi.2020.04.002
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Stampfli, Anja R., & Seebeck, Florian P. (2020). The catalytic mechanism of sulfoxide synthases. Current Opinion in Chemical Biology, 59, 111–118. https://doi.org/10.1016/j.cbpa.2020.06.007
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Leisinger, Florian, Burn, Reto, Meury, Marcel, Lukat, Peer, & Seebeck, Florian P. (2019). Structural and Mechanistic Basis for Anaerobic Ergothioneine Biosynthesis. Journal of the American Chemical Society, 141(17), 6906–6914. https://doi.org/10.1021/jacs.8b12596
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Liao, Cangsong, & Seebeck, Florian P. (2019). S-adenosylhomocysteine as a methyl transfer catalyst in biocatalytic methylation reactions. Nature Catalysis, 2(8), 696–701. https://doi.org/10.1038/s41929-019-0300-0
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Liao, Cangsong, & Seebeck, Florian Peter. (2019). In vitro reconstitution of bacterial DMSP biosynthesis. Angew. Chemie Int. Ed, 58(11), 3553–3556. https://doi.org/10.1002/anie.201814662
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Lim, David, Gründemann, Dirk, & Seebeck, Florian P. (2019). Total Synthesis and Functional Characterization of Selenoneine. Angewandte Chemie International Edition, 58(42), 15026–15030. https://doi.org/10.1002/anie.201908967
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Maurer, Alice, Leisinger, Florian, Lim, David, & Seebeck, Florian P. (2019). Structure and Mechanism of Ergothionase from Treponema denticola. Chemistry - A European Journal, 25(44), 10298–10303. https://doi.org/10.1002/chem.201901866
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Miarzlou, Dzmitry A., Leisinger, Florian, Joss, Daniel, Häussinger, Daniel, & Seebeck, Florian P. (2019). Structure of formylglycine-generating enzyme in complex with copper and a substrate reveals an acidic pocket for binding and activation of molecular oxygen. Chemical Science, 10(29), 7049–7058. https://doi.org/10.1039/c9sc01723b
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Stampfli, Anja R., Goncharenko, Kristina V., Meury, Marcel, Dubey, Badri N., Schirmer, Tilman, & Seebeck, Florian P. (2019). An Alternative Active Site Architecture for O2 Activation in the Ergothioneine Biosynthetic EgtB from Chloracidobacterium thermophilum. Journal of American Chemical Society, 141(13), 5275–5285. https://doi.org/10.1021/jacs.8b13023
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Castellano, Immacolata, & Seebeck, Florian P. (2018). On ovothiol biosynthesis and biological roles: from life in the ocean to therapeutic potential. Natural Product Reports, 35(12), 1241–1250. https://doi.org/10.1039/c8np00045j
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Gamage, Akshamal M., Liao, Cangsong, Cheah, Irwin K., Chen, Yahua, Lim, Daniel R. X., Ku, Joanne W. K., Chee, Rhonda Sin Ling, Gengenbacher, Martin, Seebeck, Florian P., Halliwell, Barry, & Gan, Yunn-Hwen. (2018). The proteobacterial species Burkholderia pseudomallei produces ergothioneine, which enhances virulence in mammalian infection. FASEB Journal, 32(12), 6395–6409. https://doi.org/10.1096/fj.201800716
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Misson, Laëtitia, Burn, Reto, Vit, Allegra, Hildesheim, Julia, Beliaeva, Mariia A., Blankenfeldt, Wulf, & Seebeck, Florian P. (2018). Inhibition and Regulation of the Ergothioneine Biosynthetic Methyltransferase EgtD. ACS Chemical Biology, 13(5), 1333–1342. https://doi.org/10.1021/acschembio.8b00127
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Burn, Reto, Misson, Laëtitia, Meury, Marcel, & Seebeck, Florian P. (2017). Anaerobic Origin of Ergothioneine. Angewandte Chemie International Edition, 56(41), 12508–12511. https://doi.org/10.1002/anie.201705932
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Faponle, Abayomi S., Seebeck, Florian P., & de Visser, Sam P. (2017). Sulfoxide Synthase versus Cysteine Dioxygenase Reactivity in a Nonheme Iron Enzyme. Journal of the American Chemical Society, 139(27), 9259–9270. https://doi.org/10.1021/jacs.7b04251
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Knop, Matthias, Dang, Thanh Quy, Jeschke, Gunnar, & Seebeck, Florian P. (2017). Copper is a Cofactor of the Formylglycine-Generating Enzyme. ChemBioChem, 18(2), 161–165. https://doi.org/10.1002/cbic.201600359
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Knop, Matthias, Lemnaru, Roxana, & Seebeck, Florian P. (2017). Mutation of Conserved Residues Increases in Vitro Activity of the Formylglycine-Generating Enzyme. ChemBioChem, 18(17), 1755–1761. https://doi.org/10.1002/cbic.201700174
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Liao, Cangsong, & Seebeck, Florian P. (2017). Convergent Evolution of Ergothioneine Biosynthesis in Cyanobacteria. ChemBioChem, 18(21), 2115–2118. https://doi.org/10.1002/cbic.201700354
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Meury, Marcel, Knop, Matthias, & Seebeck, Florian P. (2017). Structural Basis for Copper-Oxygen Mediated C-H Bond Activation by the Formylglycine-Generating Enzyme. Angewandte Chemie International Edition, 56(28), 8115–8119. https://doi.org/10.1002/anie.201702901
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Goncharenko, Kristina V, & Seebeck, Florian P. (2016). Conversion of a non-heme iron-dependent sulfoxide synthase into a thiol dioxygenase by a single point mutation. Chemical Communications, 52(9), 1945–1948. https://doi.org/10.1039/c5cc07772a
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Goncharenko, Kristina V., Vit, Allegra, Blankenfeldt, Wulf, & Seebeck, Florian P. (2015). Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway. Angewandte Chemie International Edition, 54(9), 2821–2824. https://doi.org/10.1002/anie.201410045
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Knop, Matthias, Engi, Pascal, Lemnaru, Roxana, & Seebeck, Florian P. (2015). In Vitro Reconstitution of Formylglycine-Generating Enzymes Requires Copper(I). ChemBioChem, 16(15), 2147–2150. https://doi.org/10.1002/cbic.201500322
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Vit, Allegra, Mashabela, Gabriel, Blankenfeldt, Wulf, & Seebeck, Florian P. (2015). Structure of the Ergothioneine-Biosynthesis Amidohydrolase EgtC. ChemBioChem, 16(10), 1490–1496. https://doi.org/10.1002/cbic.201500168
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Vit, Allegra, Misson, L., Blankenfeldt, W., & Seebeck, Florian P. (2015). Ergothioneine Biosynthetic Methyltransferase EgtD Reveals the Structural Basis of Aromatic Amino Acid Betaine Biosynthesis. ChemBioChem, 16(1), 119–125. https://doi.org/10.1002/cbic.201402522
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Vit, Allegra, Misson, Laetitia, Blankenfeldt, W., & Seebeck, Florian. (2014). Crystallization and preliminary X-ray analysis of the ergothioneine-biosynthetic methyltransferase EgtD. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 70(Pt 5), 676–680. https://doi.org/10.1107/s2053230x1400805x
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Mashabela, Gabriel T M, & Seebeck, Florian P. (2013). Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis. Chemical Communications, 49(70), 7714–7716. https://doi.org/10.1039/c3cc42594k
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Seebeck, Florian. (2013). Thiohistidine biosynthesis. Chimia, 67(5), 333–336. https://doi.org/10.2533/chimia.2013.333
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Amrein, Beat, Schmid, Maurus, Collet, Guillaume, Cuniasse, Philippe, Gilardoni, Francois, Seebeck, Florian P., & Ward, Thomas R. (2012). Identification of two-histidines one-carboxylate binding motifs in proteins amenable to facial coordination to metals. Metallomics, 4(4), 379–388. https://doi.org/10.1039/c2mt20010d
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Hofmann, Frank T., Szostak, Jack W., & Seebeck, Florian P. (2012). In vitro selection of functional lantipeptides. Journal of the American Chemical Society, 134(19), 8038–8041. https://doi.org/10.1021/ja302082d
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