Prof. Dr. Martin F. Wilks Department of Pharmaceutical Sciences Profiles & Affiliations OverviewResearch Publications Projects & Collaborations Projects & Collaborations OverviewResearch Publications Projects & Collaborations Profiles & Affiliations Projects & Collaborations 8 foundShow per page10 10 20 50 ToxOligo2 - Toxicological properties of oligomers present in food contact materials Research Project | 6 Project MembersToxOligo addresses an important knowledge gap by evaluating toxicological properties of oligomers released from polymers as food contact materials (FCM). The formation and presence of oligomers is inevitable in such FCM. Despite known migration into food, these substances are toxicologically poorly characterized, preventing adequate risk assessment. The ongoing project phase allowed essential new insights into available information on oligomers from all polymeric FCM. A pilot study on PET helped to design an optimized strategy and workflow to address this task. Information on physicochemical, ADME and toxicological properties was collected using computational methods. In a second project phase, a collection of oligomers from all other materials will be made based on the obtained information. The focus will be on bioactivity assessment of these substances. Hazard profiles will be established using various in vitro assays to assess general toxicity, cellular stress pathways, macrophage activation and endocrine effects. These studies aim at assessing the level of concern of such substances and providing recommendations for prioritization of future toxicological testing. New Approach Methods (NAMs) im Rahmen von Next Generation Risk Assessment (NGRA): Bedarfsanalyse bezüglich Aufnahme in den regulatorischen Prozess 2022-2025 Research Project | 2 Project MembersNo Description available Nutzung von computer-basierten Methoden für next generation risk assessment (NGRA) 2022-2025 Research Project | 2 Project MembersNo Description available European Partnership for the Assessment of Risks from Chemicals Research Project | 1 Project MembersNo Description available ToxOligo - Toxicological properties of oligomers present in food contact materials Research Project | 6 Project MembersToxOligo addresses an important knowledge gap by characterizing toxicological properties of oligomers released from food contact materials (FCM) such as plastics, adhesives, printing inks and coatings. Despite known high levels in FCM, these substances are toxicologically poorly investigated, preventing adequate risk assessment. A systematic review of the literature and expert interviews will provide insight on available knowledge of types of structures involved, exposure estimates and toxicological information. Physico-chemical and ADME properties, reactivity of building blocks, stability of oligomers, genotoxicity, endocrine disrupting potentials, and chronic and developmental toxicity will be predicted by in silico methods. Hazard profiles will be established for relevant selected oligomers using in vitro assays on general cytotoxicity, cellular stress pathways, neuronal cell toxicity, macrophage activation, and endocrine regulation. Selected FCM extracts will be considered to identify potentially hazardous materials. Levels of concern will be estimated, information gaps identified, and recommendations for follow-on toxicological analyses and an evaluation concept for safety assessment of oligomers will be proposed. "In vitro" Testung des Potentials endokriner Aktivität von Druckfarbstoffen Research Project | 2 Project MembersImported from Grants Tool 4486515 NanoREG II - Development and Implementation of Grouping and Safe-by-Design approaches within regulatory frameworks Research Project | 2 Project MembersOne of the greatest challenges facing regulators in the ever changing landscape of novel nano-materials is how to design and implement a regulatory process which is robust enough to deal with a rapidly diversifying system of manufactured nanomaterials (MNM) over time. The challenge is to build a regulatory system which is flexible enough to be able to deal with new targets and requirements in the future, and this can be helped by the development and introduction of Safe by Design (SbD) principles. The NANoREG II project, built around the challenge of coupling SbD to the regulatory process, will demonstrate and establish new principles and ideas based on data from value chain implementation studies to establish SbD as a fundamental pillar in the validation of a novel MNM. Grouping concepts that will be developed by NanoREG II can be regarded as a major innovation, and in the form of guidance documents will support industries and regulatory agencies as well as supporting commercial launch of new NM. Smart and Designer Drugs: Toxicoepidemiology of non-medical stimulant use in Switzerland Research Project | 5 Project MembersObjectives of this project are to investigate medical problems associated with stimulant drug use (designer and smart drugs) in Switzerland. The project includes an analysis of the database of the Swiss Toxicological Information Center and retro- and prospective studies at emergency departements at Swiss university hospitals. It is a collaborative project under the auspices of the Swiss Center for Applied Human Toxicology. 1 1 OverviewResearch Publications Projects & Collaborations
Projects & Collaborations 8 foundShow per page10 10 20 50 ToxOligo2 - Toxicological properties of oligomers present in food contact materials Research Project | 6 Project MembersToxOligo addresses an important knowledge gap by evaluating toxicological properties of oligomers released from polymers as food contact materials (FCM). The formation and presence of oligomers is inevitable in such FCM. Despite known migration into food, these substances are toxicologically poorly characterized, preventing adequate risk assessment. The ongoing project phase allowed essential new insights into available information on oligomers from all polymeric FCM. A pilot study on PET helped to design an optimized strategy and workflow to address this task. Information on physicochemical, ADME and toxicological properties was collected using computational methods. In a second project phase, a collection of oligomers from all other materials will be made based on the obtained information. The focus will be on bioactivity assessment of these substances. Hazard profiles will be established using various in vitro assays to assess general toxicity, cellular stress pathways, macrophage activation and endocrine effects. These studies aim at assessing the level of concern of such substances and providing recommendations for prioritization of future toxicological testing. New Approach Methods (NAMs) im Rahmen von Next Generation Risk Assessment (NGRA): Bedarfsanalyse bezüglich Aufnahme in den regulatorischen Prozess 2022-2025 Research Project | 2 Project MembersNo Description available Nutzung von computer-basierten Methoden für next generation risk assessment (NGRA) 2022-2025 Research Project | 2 Project MembersNo Description available European Partnership for the Assessment of Risks from Chemicals Research Project | 1 Project MembersNo Description available ToxOligo - Toxicological properties of oligomers present in food contact materials Research Project | 6 Project MembersToxOligo addresses an important knowledge gap by characterizing toxicological properties of oligomers released from food contact materials (FCM) such as plastics, adhesives, printing inks and coatings. Despite known high levels in FCM, these substances are toxicologically poorly investigated, preventing adequate risk assessment. A systematic review of the literature and expert interviews will provide insight on available knowledge of types of structures involved, exposure estimates and toxicological information. Physico-chemical and ADME properties, reactivity of building blocks, stability of oligomers, genotoxicity, endocrine disrupting potentials, and chronic and developmental toxicity will be predicted by in silico methods. Hazard profiles will be established for relevant selected oligomers using in vitro assays on general cytotoxicity, cellular stress pathways, neuronal cell toxicity, macrophage activation, and endocrine regulation. Selected FCM extracts will be considered to identify potentially hazardous materials. Levels of concern will be estimated, information gaps identified, and recommendations for follow-on toxicological analyses and an evaluation concept for safety assessment of oligomers will be proposed. "In vitro" Testung des Potentials endokriner Aktivität von Druckfarbstoffen Research Project | 2 Project MembersImported from Grants Tool 4486515 NanoREG II - Development and Implementation of Grouping and Safe-by-Design approaches within regulatory frameworks Research Project | 2 Project MembersOne of the greatest challenges facing regulators in the ever changing landscape of novel nano-materials is how to design and implement a regulatory process which is robust enough to deal with a rapidly diversifying system of manufactured nanomaterials (MNM) over time. The challenge is to build a regulatory system which is flexible enough to be able to deal with new targets and requirements in the future, and this can be helped by the development and introduction of Safe by Design (SbD) principles. The NANoREG II project, built around the challenge of coupling SbD to the regulatory process, will demonstrate and establish new principles and ideas based on data from value chain implementation studies to establish SbD as a fundamental pillar in the validation of a novel MNM. Grouping concepts that will be developed by NanoREG II can be regarded as a major innovation, and in the form of guidance documents will support industries and regulatory agencies as well as supporting commercial launch of new NM. Smart and Designer Drugs: Toxicoepidemiology of non-medical stimulant use in Switzerland Research Project | 5 Project MembersObjectives of this project are to investigate medical problems associated with stimulant drug use (designer and smart drugs) in Switzerland. The project includes an analysis of the database of the Swiss Toxicological Information Center and retro- and prospective studies at emergency departements at Swiss university hospitals. It is a collaborative project under the auspices of the Swiss Center for Applied Human Toxicology. 1 1
ToxOligo2 - Toxicological properties of oligomers present in food contact materials Research Project | 6 Project MembersToxOligo addresses an important knowledge gap by evaluating toxicological properties of oligomers released from polymers as food contact materials (FCM). The formation and presence of oligomers is inevitable in such FCM. Despite known migration into food, these substances are toxicologically poorly characterized, preventing adequate risk assessment. The ongoing project phase allowed essential new insights into available information on oligomers from all polymeric FCM. A pilot study on PET helped to design an optimized strategy and workflow to address this task. Information on physicochemical, ADME and toxicological properties was collected using computational methods. In a second project phase, a collection of oligomers from all other materials will be made based on the obtained information. The focus will be on bioactivity assessment of these substances. Hazard profiles will be established using various in vitro assays to assess general toxicity, cellular stress pathways, macrophage activation and endocrine effects. These studies aim at assessing the level of concern of such substances and providing recommendations for prioritization of future toxicological testing.
New Approach Methods (NAMs) im Rahmen von Next Generation Risk Assessment (NGRA): Bedarfsanalyse bezüglich Aufnahme in den regulatorischen Prozess 2022-2025 Research Project | 2 Project MembersNo Description available
Nutzung von computer-basierten Methoden für next generation risk assessment (NGRA) 2022-2025 Research Project | 2 Project MembersNo Description available
European Partnership for the Assessment of Risks from Chemicals Research Project | 1 Project MembersNo Description available
ToxOligo - Toxicological properties of oligomers present in food contact materials Research Project | 6 Project MembersToxOligo addresses an important knowledge gap by characterizing toxicological properties of oligomers released from food contact materials (FCM) such as plastics, adhesives, printing inks and coatings. Despite known high levels in FCM, these substances are toxicologically poorly investigated, preventing adequate risk assessment. A systematic review of the literature and expert interviews will provide insight on available knowledge of types of structures involved, exposure estimates and toxicological information. Physico-chemical and ADME properties, reactivity of building blocks, stability of oligomers, genotoxicity, endocrine disrupting potentials, and chronic and developmental toxicity will be predicted by in silico methods. Hazard profiles will be established for relevant selected oligomers using in vitro assays on general cytotoxicity, cellular stress pathways, neuronal cell toxicity, macrophage activation, and endocrine regulation. Selected FCM extracts will be considered to identify potentially hazardous materials. Levels of concern will be estimated, information gaps identified, and recommendations for follow-on toxicological analyses and an evaluation concept for safety assessment of oligomers will be proposed.
"In vitro" Testung des Potentials endokriner Aktivität von Druckfarbstoffen Research Project | 2 Project MembersImported from Grants Tool 4486515
NanoREG II - Development and Implementation of Grouping and Safe-by-Design approaches within regulatory frameworks Research Project | 2 Project MembersOne of the greatest challenges facing regulators in the ever changing landscape of novel nano-materials is how to design and implement a regulatory process which is robust enough to deal with a rapidly diversifying system of manufactured nanomaterials (MNM) over time. The challenge is to build a regulatory system which is flexible enough to be able to deal with new targets and requirements in the future, and this can be helped by the development and introduction of Safe by Design (SbD) principles. The NANoREG II project, built around the challenge of coupling SbD to the regulatory process, will demonstrate and establish new principles and ideas based on data from value chain implementation studies to establish SbD as a fundamental pillar in the validation of a novel MNM. Grouping concepts that will be developed by NanoREG II can be regarded as a major innovation, and in the form of guidance documents will support industries and regulatory agencies as well as supporting commercial launch of new NM.
Smart and Designer Drugs: Toxicoepidemiology of non-medical stimulant use in Switzerland Research Project | 5 Project MembersObjectives of this project are to investigate medical problems associated with stimulant drug use (designer and smart drugs) in Switzerland. The project includes an analysis of the database of the Swiss Toxicological Information Center and retro- and prospective studies at emergency departements at Swiss university hospitals. It is a collaborative project under the auspices of the Swiss Center for Applied Human Toxicology.
