Prof. Dr. Fiona Doetsch

Doetsch, Fiona, & Matsas, Rebecca. (2025). The rise of neural stem cells: From development to disease. Stem Cell Reports, 20. https://doi.org/10.1016/j.stemcr.2025.102638

Madsen, Sofia, Delgado, Ana C., Cadilhac, Christelle, Maillard, Vanille, Battiston, Fabrice, Igelbüscher, Carla Marie, De Neck, Simon, Magrinelli, Elia, Jabaudon, Denis, Telley, Ludovic, Doetsch, Fiona, & Knobloch, Marlen. (2024). A fluorescent perilipin 2 knock-in mouse model reveals a high abundance of lipid droplets in the developing and adult brain. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49449-w

Chaker, Zayna, Makarouni, Eleni, & Doetsch, Fiona. (2024). The Organism as the Niche: Physiological States Crack the Code of Adult Neural Stem Cell Heterogeneity. Annual Review of Cell and Developmental Biology, 40(1), 381–406. https://doi.org/10.1146/annurev-cellbio-120320-040213

Chaker, Zayna, Segalada, Corina, Kretz, Jonas A., Acar, Ilhan E., Delgado, Ana C., Crotet, Valerie, Moor, Andreas E., & Doetsch, Fiona. (2023). Pregnancy-responsive pools of adult neural stem cells for transient neurogenesis in mothers. Science, 382(6673), 958–964. https://doi.org/10.1126/science.abo5199

Favaloro, Fabrizio, DeLeo, Annina M., Delgado, Ana C., & Doetsch, Fiona. (2022). miR-17∼92 exerts stage-specific effects in adult V-SVZ neural stem cell lineages. Cell reports, 41(10), 111773. https://doi.org/10.1016/j.celrep.2022.111773

Madsen, S., Delgado, A. C., Cadilhac, C., Battison, F., Maillard, V., Magrinelli, E., Jabaudon, D., Telley, T., Doetsch, F., & Knobloch, M. (2022). A fluorescent perilipin 2 knock-in mouse model visualizes lipid droplets in the developing and adult brain. bioRxiv. https://doi.org/10.1101/2022.06.21.496932

Chaker, Zayna, Segalada, Corina, & Doetsch, Fiona. (2021). Spatio-Temporal Recruitment of Adult Neural Stem Cells for Transient Neurogenesis During Pregnancy. bioRxiv. https://doi.org/10.1101/2021.07.11.451957

Delgado, Ana C., Maldonado-Soto, Angel R., Silva-Vargas, Violeta, Mizrak, Dogukan, von Känel, Thomas, Tan, Kelly R., Paul, Alex, Madar, Aviv, Cuervo, Henar, Kitajewski, Jan, Lin, Chyuan-Sheng, & Doetsch, Fiona. (2021). Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain. Science (New York, N.Y.), 372(6547), 1205–1209. https://doi.org/10.1126/science.abg8467

Silva-Vargas, Violeta, & Doetsch, Fiona. (2020). Exploring the source of human brain fluids. Science, 369(6500), 143–144. https://doi.org/10.1126/science.abd0269

Mizrak, Dogukan, Levitin, Hanna Mendes, Delgado, Ana C., Crotet, Valerie, Yuan, Jinzhou, Chaker, Zayna, Silva-Vargas, Violeta, Sims, Peter A., & Doetsch, Fiona. (2019). Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages. Cell Reports, 26(2), 394–406. https://doi.org/10.1016/j.celrep.2018.12.044

Crouch, Elizabeth E., & Doetsch, Fiona. (2018). FACS isolation of endothelial cells and pericytes from mouse brain microregions. Nature Protocols, 13(4), 738–751. https://doi.org/10.1038/nprot.2017.158

Ghersi-Egea, Jean-François, Strazielle, Nathalie, Catala, Martin, Silva-Vargas, Violeta, Doetsch, Fiona, & Engelhardt, Britta. (2018). Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease. Acta Neuropathologica, 135(3), 337–361. https://doi.org/10.1007/s00401-018-1807-1

Silva-Vargas, Violeta, Delgado, Ana C., & Doetsch, Fiona. (2018). Symmetric Stem Cell Division at the Heart of Adult Neurogenesis. Neuron, 98(2), 246–248. https://doi.org/10.1016/j.neuron.2018.04.005

Paul, Alex, Chaker, Zayna, & Doetsch, Fiona. (2017). Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis. Science, 356(6345), 1383–1386. https://doi.org/10.1126/science.aal3839

Tome-Garcia, Jessica, Doetsch, Fiona, & Tsankova, Nadejda M. (2017). FACS-based Isolation of Neural and Glioma Stem Cell Populations from Fresh Human Tissues Utilizing EGF Ligand. Bio-Protocol, 7(24), 23. https://doi.org/10.21769/bioprotoc.2659

Tome-Garcia, Jessica, Tejero, Rut, Nudelman, German, Yong, Raymund L., Sebra, Robert, Wang, Huaien, Fowkes, Mary, Magid, Margret, Walsh, Martin, Silva-Vargas, Violeta, Zaslavsky, Elena, Friedel, Roland H., Doetsch, Fiona, & Tsankova, Nadejda M. (2017). Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR(+) Populations with Stem Cell Properties. Stem Cell Reports, 8(5), 1421–1429. https://doi.org/10.1016/j.stemcr.2017.03.019

Chaker, Zayna, Codega, Paolo, & Doetsch, Fiona. (2016). A mosaic world: puzzles revealed by adult neural stem cell heterogeneity [Review of A mosaic world: puzzles revealed by adult neural stem cell heterogeneity]. WIREs Developmental Biology, 5, Article 6. https://doi.org/10.1002/wdev.248

Silva-Vargas, Violeta, Maldonado-Soto, Angel R, Mizrak, Dogukan, Codega, Paolo, & Doetsch, Fiona. (2016). Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells. Cell Stem Cell, 19(5), 643–652. https://doi.org/10.1016/j.stem.2016.06.013

Crouch, Elizabeth E., Liu, Chang, Silva-Vargas, Violeta, & Doetsch, Fiona. (2015). Regional and Stage-Specific Effects of Prospectively Purified Vascular Cells on the Adult V-SVZ Neural Stem Cell Lineage. Journal of Neuroscience, 35(11), 39–4528. https://doi.org/10.1523/jneurosci.1188-14.2015

Erfani, Parsa, Tome-Garcia, Jessica, Canoll, Peter, Doetsch, Fiona, & Tsankova, Nadejda M. (2015). EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas. Epigenetics, 10(6), 496–507. https://doi.org/10.1080/15592294.2015.1042645

Codega, Paolo, Silva-Vargas, Violeta, Paul, Alex, Maldonado-Soto, Angel R., Deleo, Annina M., Pastrana, Erika, & Doetsch, Fiona. (2014). Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche. Neuron, 82(3), 59–545. https://doi.org/10.1016/j.neuron.2014.02.039

Maldonado-Soto, Angel R., Oakley, Derek H., Wichterle, Hynek, Stein, Joel, Doetsch, Fiona K., & Henderson, Christopher E. (2014). Stem Cells in the Nervous System. American Journal of Physical Medicine and Rehabilitation, 93(11 Suppl 3), S132–44. https://doi.org/10.1097/phm.0000000000000111

Silva-Vargas, Violeta, & Doetsch, Fiona. (2014). A new twist for neurotrophins : endothelial-derived NT-3 mediates adult neural stem cell quiescence [Review of A new twist for neurotrophins : endothelial-derived NT-3 mediates adult neural stem cell quiescence]. Neuron, 83, Article 3. https://doi.org/10.1016/j.neuron.2014.07.029

Silva-Vargas, Violeta, Crouch, Elizabeth E., & Doetsch, Fiona. (2013). Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging. Current Opinion in Neurobiology, 23(6), 42–935. https://doi.org/10.1016/j.conb.2013.09.004

Pastrana, Erika, Silva-Vargas, Violeta, & Doetsch, Fiona. (2011). Eyes wide open: a critical review of sphere-formation as an assay for stem cells. Cell Stem Cell, 8(5), 98–486. https://doi.org/10.1016/j.stem.2011.04.007

Carro, Maria Stella, Lim, Wei Keat, Alvarez, Mariano Javier, Bollo, Robert J., Zhao, Xudong, Snyder, Evan Y., Sulman, Erik P., Anne, Sandrine L., Doetsch, Fiona, Colman, Howard, Lasorella, Anna, Aldape, Ken, Califano, Andrea, & Iavarone, Antonio. (2010). The transcriptional network for mesenchymal transformation of brain tumours. Nature, 463(7279), 318–325. https://doi.org/10.1038/nature08712

Kim, Yongsoo, Wang, Wei-Zhi, Comte, Isabelle, Pastrana, Erika, Tran, Phuong B., Brown, Jennifer, Miller, Richard J., Doetsch, Fiona, Molnár, Zoltán, & Szele, Francis G. (2010). Dopamine stimulation of postnatal murine subventricular zone neurogenesis via the D3 receptor. Journal of Neurochemistry, 114(3), 60–750. https://doi.org/10.1111/j.1471-4159.2010.06799.x

Mirzadeh, Zaman, Doetsch, Fiona, Sawamoto, Kazunobu, Wichterle, Hynek, & Alvarez-Buylla, Arturo. (2010). The subventricular zone en-face: wholemount staining and ependymal flow. Journal of Visualized Experiments, 39, 1938. https://doi.org/10.3791/1938

Cheng, Li-Chun, Pastrana, Erika, Tavazoie, Masoud, & Doetsch, Fiona. (2009). miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nature Neuroscience, 12(4), 399–408. https://doi.org/10.1038/nn.2294

Pastrana, Erika, Cheng, Li-Chun, & Doetsch, Fiona. (2009). Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny. Proceedings of the National Academy of Sciences, 106(15), 92–6387. https://doi.org/10.1073/pnas.0810407106

Riquelme, Patricio A., Drapeau, Elodie, & Doetsch, Fiona. (2008). Brain micro-ecologies: neural stem cell niches in the adult mammalian brain. Philosophical Transactions B: Biological Sciences, 363(1489), 37–123. https://doi.org/10.1098/rstb.2006.2016

Tavazoie, Masoud, Van der Veken, Lieven, Silva-Vargas, Violeta, Louissaint, Marjorie, Colonna, Lucrezia, Zaidi, Bushra, Garcia-Verdugo, Jose Manuel, & Doetsch, Fiona. (2008). A specialized vascular niche for adult neural stem cells. Cell Stem Cell, 3(3), 279–288. https://doi.org/10.1016/j.stem.2008.07.025

Galan-Caridad, Jose M., Harel, Sivan, Arenzana, Teresita L., Hou, Z. Esther, Doetsch, Fiona K., Mirny, Leonid A., & Reizis, Boris. (2007). Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell, 129(2), 57–345. https://doi.org/10.1016/j.cell.2007.03.014

Cheng, Li-Chun, Tavazoie, Masoud, & Doetsch, Fiona. (2005). Stem cells: from epigenetics to microRNAs. Neuron, 46(3), 7–363. https://doi.org/10.1016/j.neuron.2005.04.027

Doetsch, Fiona, & Hen, Rene. (2005). Young and excitable: the function of new neurons in the adult mammalian brain. Current Opinion in Neurobiology, 15(1), 8–121. https://doi.org/10.1016/j.conb.2005.01.018

Doetsch, Fiona. (2003). A niche for adult neural stem cells. Current Opinion in Genetics & Development, 13(5), 543–550. https://doi.org/10.1016/j.gde.2003.08.012

Doetsch, Fiona. (2003). The glial identity of neural stem cells. Nature Neuroscience, 6(11), 1127–1134. https://doi.org/10.1038/nn1144

Alvarez-Buylla, Arturo, Seri, Bettina, & Doetsch, Fiona. (2002). Identification of neural stem cells in the adult vertebrate brain. Brain Research Bulletin, 57(6), 8–751. https://doi.org/10.1016/s0361-9230(01)00770-5

Doetsch, Fiona. (2002). Genetics of childhood disorders: XXXVIII. Stem cell research, part 2: reconstructing the brain. Journal of the American Academy of Child and Adolescent Psychiatry, 41(5), 4–622. https://doi.org/10.1097/00004583-200205000-00021

Doetsch, Fiona, Petreanu, Leopoldo, Caille, Isabelle, Garcia-Verdugo, Jose Manuel, & Alvarez-Buylla, Arturo. (2002). EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron, 36(6), 34–1021. https://doi.org/10.1016/s0896-6273(02)01133-9

Doetsch, Fiona, Verdugo, Jose Manuel-Garcia, Caille, Isabelle, Alvarez-Buylla, Arturo, Chao, Moses V., & Casaccia-Bonnefil, Patrizia. (2002). Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis. Journal of Neuroscience, 22(6), 64–2255.

Gritti, Angela, Bonfanti, Luca, Doetsch, Fiona, Caille, Isabelle, Alvarez-Buylla, Arturo, Lim, Daniel A., Galli, Rossella, Verdugo, Jose Manuel Garcia, Herrera, Daniel G., & Vescovi, Angelo L. (2002). Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents. Journal of Neuroscience, 22(2), 45–437.

Doetsch, F., & Scharff, C. (2001). Challenges for brain repair: insights from adult neurogenesis in birds and mammals. Brain, Behavior and Evolution, 58(5), 22–306. https://doi.org/10.1159/000057572

Conover, J. C., Doetsch, F., Garcia-Verdugo, J. M., Gale, N. W., Yancopoulos, G. D., & Alvarez-Buylla, A. (2000). Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone. Nature Neuroscience, 3(11), 7–1091. https://doi.org/10.1038/80606

Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999). Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell, 97(6), 16–703. https://doi.org/10.1016/s0092-8674(00)80783-7

Doetsch, F., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999). Regeneration of a germinal layer in the adult mammalian brain. Proceedings of the National Academy of Sciences, 96(20), 24–11619. https://doi.org/10.1073/pnas.96.20.11619

Kirschenbaum, B., Doetsch, F., Lois, C., & Alvarez-Buylla, A. (1999). Adult subventricular zone neuronal precursors continue to proliferate and migrate in the absence of the olfactory bulb. Journal of Neuroscience, 19(6), 80–2171. http://www.jneurosci.org/content/jneuro/19/6/2171.full.pdf

García-Verdugo, J. M., Doetsch, Fiona, Wichterle, H., Lim, D. A., & Alvarez-Buylla, A. (1998). Architecture and cell types of the adult subventricular zone: in search of the stem cells. Journal of Neurobiology, 36(2), 48–234. https://doi.org/10.1002/(sici)1097-4695(199808)36:23.0.co;2-e

Doetsch, Fiona, García-Verdugo, J. M., & Alvarez-Buylla, A. (1997). Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. Journal of Neuroscience, 17(13), 61–5046.

Doetsch, Fiona, & Alvarez-Buylla, A. (1996). Network of tangential pathways for neuronal migration in adult mammalian brain. Proceedings of the National Academy of Sciences of the United States of America, 93(25), 900–14895. https://doi.org/10.1073/pnas.93.25.14895