Prof. Dr. Maria Hondele

Overwijn, Daan, Dörner, Kerstin, de Almeida, Caroline, Müller, Martin, Mironov, Aleksei, Ivanek, Robert, Skrinjar, Peter, Gut, Michelle Jennifer, Solheim, Isabel, Beuret, Nicole, Bock, Thomas, Zeug, Matthias, Smialek, Maciej, Brandkamp, Sina, Maier, Timm, Zavolan, Mihaela, Keller Valsecchi, Claudia Isabelle, & Hondele, Maria. (2026). PAIP1 couples mRNA export to cytoplasmic mRNP remodeling and poly(A) homeostasis [Posted-content]. In bioRxiv (Cold Spring Harbor Laboratory). Cold Spring Harbor Laboratory. https://doi.org/10.64898/2026.07.31.742013

Naduthodi, Mihris I.S., Barrett, James, Pritchard, Jessica, Van der Stappen, Philippe, Demulder, Manon, Garfagnini, Tommaso, Dowle, Adam, Hondele, Maria, Engel, Benjamin D., McCormick, Alistair, & Mackinder, Luke C.M. (2026). Molecular organization of the Chlorella sorokiniana pyrenoid. In BioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.64898/2026.07.17.739135

Mookherjee, Debdatto, Rommel, Madeleine, Weidner, Ferdinand, Siketanc, Matej, Hondele, Maria, & Spang, Anne. (2026). Non-translated mRNA levels determine P-body properties [Posted-content]. In bioRxiv . Cold Spring Harbor Laboratory. https://doi.org/10.64898/2026.03.18.712576

Dörner, Kerstin, Gut, Michelle Jennifer, Overwijn, Daan, Cao, Fan, Siketanc, Matej, Heinrich, Stephanie, Beuret, Nicole, Meyer, Justin, Sharpe, Timothy, Lindorff-Larsen, Kresten, & Hondele, Maria. (2026). Fluorescent protein and peptide tags alter condensate formation and dynamics in vivo and in vitro. EMBO Reports, 27(1), 89–121. https://doi.org/10.1038/s44319-025-00626-y

Kuwayama, Naohiro, Powers, Emily Nicole, Siketanc, Matej, Sousa, Camila Ines, Reynaud, Kendra, Jovanovic, Marko, Hondele, Maria, Ingolia, Nicholas Thomas, & Brar, Gloria Ann. (2024). Analyses of translation factors Dbp1 and Ded1 reveal the cellular response to heat stress to be separable from stress granule formation. Cell Reports, 43(12). https://doi.org/10.1016/j.celrep.2024.115059

Szentgyörgyi, Viktória, Lueck, Leon, Overwijn, Daan, Ritz, Danilo, Zoeller, Nadja, Schmidt, Alexander, Hondele, Maria, Anne Spang, Anne, & Bakhtiar, Shahrzad. (2024). Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis. Journal of Cell Biology, 223(11). https://doi.org/10.1083/jcb.202401167

Szentgyörgyi, Viktória, Lueck, Leon Maximilian, Overwijn, Daan, Zoeller, Nadia, Hondele, Maria, Spang, Anne, & Bakhtiar, Shahrzad. (2024). Endosomal LRBA regulates the endo-lysosomal pathway [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.02.07.579084

Heinrich, Stephanie, Hondele, Maria, Marchand, Désirée, Derrer, Carina Patrizia, Zedan, Mostafa, Oswald, Alexandra, Malinovska, Liliana, Uliana, Federico, Khawaja, Sarah, Mancini, Roberta, Grunwald, David, & Weis, Karsten. (2024). Glucose stress causes mRNA retention in nuclear Nab2 condensates. Cell Reports, 43(1). https://doi.org/10.1016/j.celrep.2023.113593

Dörner, Kerstin, & Hondele, Maria. (2024). The Story of RNA Unfolded: The Molecular Function of DEAD- and DExH-Box ATPases and Their Complex Relationship with Membraneless Organelles. Annual Review of Biochemistry, 93(1), 79–108. https://doi.org/10.1146/annurev-biochem-052521-121259

Heinrich, Stephanie, & Hondele, Maria. (2022). Probing Liquid-Liquid Phase Separation of RNA-Binding Proteins In Vitro and In Vivo. In Scheiffele, Peter;Mauger, Oriane (Ed.), Alternative Splicing: Methods and Protocols (pp. 307–333). Springer. https://doi.org/10.1007/978-1-0716-2521-7_18

Linsenmeier, Miriam, Hondele, Maria, Grigolato, Fulvio, Secchi, Eleonora, Weis, Karsten, & Arosio, Paolo. (2022). Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity. Nature Communications, 13(1), 3030. https://doi.org/10.1038/s41467-022-30521-2

Overwijn, Daan, & Hondele, Maria. (2022). DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles. Trends in Biochemical Sciences, 48(3), 244–258. https://doi.org/10.1016/j.tibs.2022.10.001

Weis, Karsten, & Hondele, Maria. (2022). The Role of DEAD-Box ATPases in Gene Expression and the Regulation of RNA-Protein Condensates. Annual Review of Biochemistry, 91, 197–219. https://doi.org/10.1146/annurev-biochem-032620-105429

Wollny, Damian, Vernot, Benjamin, Wang, Jie, Hondele, Maria, Safrastyan, Aram, Aron, Franziska, Micheel, Julia, He, Zhisong, Hyman, Anthony, Weis, Karsten, Camp, J. Gray, Tang, T.-Y Dora, & Treutlein, Barbara. (2022). Characterization of RNA content in individual phase-separated coacervate microdroplets. Nature Communications, 13(1), 2626. https://doi.org/10.1038/s41467-022-30158-1

Linsenmeier, Miriam, Hondele, Maria, Grigolato, Fulvio, Secchi, Eleonora, Weis, Karsten, & Arosio, Paolo. (2021). Dynamic arrest and aging of biomolecular condensates are regulated by low-complexity domains, RNA and biochemical activity. bioRxiv. https://doi.org/10.1101/2021.02.26.433003

Pérez-Schindler, Joaquín, Kohl, Bastian, Schneider-Heieck, Konstantin, Leuchtmann, Aurel B., Henríquez-Olguín, Carlos, Adak, Volkan, Maier, Geraldine, Delezie, Julien, Sakoparnig, Thomas, Vargas-Fernández, Elyzabeth, Karrer-Cardel, Bettina, Ritz, Danilo, Schmidt, Alexander, Hondele, Maria, Jensen, Thomas E., Hiller, Sebastian, & Handschin, Christoph. (2021). RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates. Proceedings of the National Academy of Sciences of the United States of America, 118(36), e2105951118. https://doi.org/10.1073/pnas.2105951118

Wollny, Damian, Vernot, Benjamin, Wang, Jie, Hondele, Maria, Hyman, Anthony, Weis, Karsten, Camp, J. Gray, Dora Tang, T. -Y., & Treutlein, Barbara. (2021). Characterization of RNA content in individual phase-separated coacervate microdroplets. bioRxiv. https://doi.org/10.1101/2021.03.08.434405

Hondele, Maria, Heinrich, Stephanie, De Los Rios, Paolo, & Weis, Karsten. (2020). Membraneless organelles: phasing out of equilibrium. Emerging topics in life sciences, 4(3), 331–342. https://doi.org/10.1042/etls20190190

Hondele, Maria, Sachdev, Ruchika, Heinrich, Stephanie, Wang, Juan, Vallotton, Pascal, Fontoura, Beatriz M. A., & Weis, Karsten. (2019). DEAD-box ATPases are global regulators of phase-separated organelles. Nature, 573(7772), 144–148. https://doi.org/10.1038/s41586-019-1502-y

Linsenmeier, Miriam, Kopp, Marie R. G., Grigolato, Fulvio, Emmanouilidis, Leonidas, Liu, Dany, Zürcher, Dominik, Hondele, Maria, Weis, Karsten, Capasso Palmiero, Umberto, & Arosio, Paolo. (2019). Corrigendum: Dynamics of Synthetic Membraneless Organelles in Microfluidic Droplets. Angewandte Chemie International Edition, 58(50), 17902. https://doi.org/10.1002/anie.201913379

Linsenmeier, Miriam, Kopp, Marie R. G., Grigolato, Fulvio, Emmanoulidis, Leonidas, Liu, Dany, Zürcher, Dominik, Hondele, Maria, Weis, Karsten, Capasso Palmiero, Umberto, & Arosio, Paolo. (2019). Dynamics of Synthetic Membraneless Organelles in Microfluidic Droplets. Angewandte Chemie International Edition, 58(41), 14489–14494. https://doi.org/10.1002/anie.201907278

Sachdev, Ruchika, Hondele, Maria, Linsenmeier, Miriam, Vallotton, Pascal, Mugler, Christopher F., Arosio, Paolo, & Weis, Karsten. (2019). Pat1 promotes processing body assembly by enhancing the phase separation of the DEAD-box ATPase Dhh1 and RNA. eLife, 8, e41415. https://doi.org/10.7554/elife.41415

Faltova, Lenka, Küffner, Andreas M., Hondele, Maria, Weis, Karsten, & Arosio, Paolo. (2018). Multifunctional Protein Materials and Microreactors using Low Complexity Domains as Molecular Adhesives. ACS nano, 12(10), 9991–9999. https://doi.org/10.1021/acsnano.8b04304

Mugler, Christopher Frederick, Hondele, Maria, Heinrich, Stephanie, Sachdev, Ruchika, Vallotton, Pascal, Koek, Adriana Y., Chan, Leon Y., & Weis, Karsten. (2016). ATPase activity of the DEAD-box protein Dhh1 controls processing body formation. eLife, 5, e18746. https://doi.org/10.7554/elife.18746

Hondele, Maria, & Ladurner, Andreas G. (2013). Catch me if you can: how the histone chaperone FACT capitalizes on nucleosome breathing. Nucleus, 4(6), 443–449. https://doi.org/10.4161/nucl.27235

Hondele, Maria, Stuwe, Tobias, Hassler, Markus, Halbach, Felix, Bowman, Andrew, Zhang, Elisa T., Nijmeijer, Bianca, Kotthoff, Christiane, Rybin, Vladimir, Amlacher, Stefan, Hurt, Ed, & Ladurner, Andreas G. (2013). Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. Nature, 499(7456), 111–114. https://doi.org/10.1038/nature12242

Hondele, Maria, & Ladurner, Andreas G. (2011). The chaperone-histone partnership: for the greater good of histone traffic and chromatin plasticity. Current Opinion in Structural Biology, 21(6), 698–708. https://doi.org/10.1016/j.sbi.2011.10.003

Goetze, Hannah, Wittner, Manuel, Hamperl, Stephan, Hondele, Maria, Merz, Katharina, Stoeckl, Ulrike, & Griesenbeck, Joachim. (2010). Alternative chromatin structures of the 35S rRNA Genes in Saccharomyces cerevisiae provide a molecular basis for the selective recruitment of RNA polymerases I and II. Molecular and cellular biology, 30(8), 2028–2045. https://doi.org/10.1128/mcb.01512-09

Hondele, Maria, & Ladurner, Andreas. (2010). A mitotic beacon reveals its nucleosome anchor. Molecular cell, 39(6), 829–830. https://doi.org/10.1016/j.molcel.2010.09.001

Merz, Katharina, Hondele, Maria, Goetze, Hannah, Gmelch, Katharina, Stoeckl, Ulrike, & Griesenbeck, Joachim. (2008). Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules. Genes & development, 22(9), 1190–1204. https://doi.org/10.1101/gad.466908