Prof. Dr. Alex Odermatt

De Luca, H. P., Boudon, S., Odermatt, A., Schenk, L., & Hopf, N. B. (2025). Estimates of skin and blood concentrations of UV-filters: Insights from in vitro skin experiments [Journal-article]. Regulatory Toxicology and Pharmacology, 163. https://doi.org/10.1016/j.yrtph.2025.105916

Sakalauskaite, Gabriele, Weingartner, Michael, Ebert, Sophie, Boot, Gina, Bock, Thomas, Birk, Julia, Tsachaki, Maria, Gallon, John W., Piscuoglio, Salvatore, & Odermatt, Alex. (2025). A BioID-based approach uncovers the interactome of hexose-6-phosphate dehydrogenase in breast cancer cells and identifies anterior gradient protein 2 as an interacting partner [Journal-article]. Cell and Bioscience, 15(1). https://doi.org/10.1186/s13578-025-01388-9

Moser, S. O., Moscalu, A., Roberts, C. F., Winter, D. V., Joos, F. L., Gomez, C., Sheu, E. G., & Odermatt, A. (2025). Alterations in glucocorticoid homeostasis following sleeve gastrectomy [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2025.09.01.673462

Karpstein, T., Kalamatianou, A., Keller, S., Späne, P., Häberli, C., Odermatt, A., Blacque, O., Cariou, K., Gasser, G., & Keiser, J. (2025). Synthesis and Multidisciplinary Preclinical Investigations of Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Thiabendazole as New Drug Candidates against Soil-Transmitted Helminth Infections [Journal-article]. ACS Infectious Diseases, 11(7), 2037–2047. https://doi.org/10.1021/acsinfecdis.5c00340

Kȩdzierski, J., van Diest, R. E., Allard, J. A., Odermatt, A., & Smieško, M. (2025). Discovery of non-steroidal aldo-keto reductase 1D1 inhibitors through automated screening and in vitro evaluation. Toxicology Letters, 406, 31–37. https://doi.org/10.1016/j.toxlet.2025.02.009

Rouseti, Georgia M., Fischer, Audrey, Rathfelder, Nicole, Grimes, Karen, Waldt, Annick, Cuttat, Rachel, Schuierer, Sven, Wild, Sophia, Jivkov, Magali, Dubost, Valerie, Schadt, Heiko S., Odermatt, Alex, Vicart, Axel, & Moretti, Francesca. (2025). Disruption of serotonin homeostasis in intestinal organoids provides insights into drug-induced gastrointestinal toxicity [Journal-article]. Toxicology, 511, 154028. https://doi.org/10.1016/j.tox.2024.154028

Bell, Luisa, Simonneau, Claire, Zanini, Chiara, Kassianidou, Elena, Zundel, Christelle, Neff, Rachel, Steinhuber, Bernd, Tecilla, Marco, Odermatt, Alex, Villaseñor, Roberto, & Stokar-Regenscheit, Nadine. (2025). Advanced tissue technologies of blood-brain barrier organoids as high throughput toxicity readouts in drug development [Journal-article]. Heliyon, 11(1), e40813. https://doi.org/10.1016/j.heliyon.2024.e40813

Blum, J., Brüll, M., Hengstler, J. G., Dietrich, D. R., Gruber, A. J., Dipalo, M., Kraushaar, U., Mangas, I., Terron, A., Fritsche, E., Marx-Stoelting, P., Hardy, B., Schepky, A., Escher, S. E., Hartung, T., Landsiedel, R., Odermatt, A., Sachana, M., Koch, K., et al. (2025). The Long Way from Raw Data to NAM-Based Information: Overview on Data Layers and Processing Steps. Altex, 42(1), 167–180. https://doi.org/10.14573/altex.2412171

Looney, C. M., Ducret, A., Steiner, G., Dernick, K., Hartman, K., Siegel, M., Hickling, T., Odermatt, A., & Marban-Doran, C. (2025). Elucidation of B-cell specific drug immunogenicity liabilities via a novel ex vivo assay [Journal-article]. Frontiers in Immunology, 16. https://doi.org/10.3389/fimmu.2025.1589483

Verouti, S., Aeschlimann, G., Wang, Q., Del Olmo, D. A., Peyter, A. C., Menétrey, S., Winter, D. V., Odermatt, A., Pearce, D., Hummler, E., & Vanderriele, P. E. (2025). Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity [Journal-article]. Pflugers Archiv European Journal of Physiology, 477(1), 37–53. https://doi.org/10.1007/s00424-024-03014-y

Kley, Manuel, Stücheli, Simon, Ruffiner, Pamela, Temml, Veronika, Boudon, Stéphanie, Schuster, Daniela, & Odermatt, Alex. (2024). Potential antiandrogenic effects of parabens and benzophenone-type UV-filters by inhibition of 3α-hydroxysteroid dehydrogenases. Toxicology, 509. https://doi.org/10.1016/j.tox.2024.153997

Lazaridis, Ioannis I., Bosch, Angela J.T., Keller, Lena, Low, Andy J.Y., Tamarelle, Jeanne, Moser, Seraina O., Winter, Denise V., Gómez, Cristina, Peterson, Caspar J., Schneider, Romano, Kraljević, Marko, Odermatt, Alex, Vonaesch, Pascale, Peterli, Ralph, Delko, Tarik, & Cavelti-Weder, Claudia. (2024). Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb. American Journal of Physiology - Endocrinology and Metabolism, 326(6), E819–E831. https://doi.org/10.1152/ajpendo.00327.2023

Kędzierski, Jacek, Jäger, Marie-Christin, Naeem, Sadaf, Odermatt, Alex, & Smieško, Martin. (2024). In silico and in vitro assessment of drugs potentially causing adverse effects by inhibiting CYP17A1. Toxicology and Applied Pharmacology, 486. https://doi.org/10.1016/j.taap.2024.116945

Abegg, Vanessa Fabienne, Panajatovic, Miljenko Valentin, Mancuso, Riccardo Vincenzo, Allard, Julien Arthur, Duthaler, Urs, Odermatt, Alex, Krähenbühl, Stephan, & Bouitbir, Jamal. (2024). Mechanisms of hepatocellular toxicity associated with the components of St. John’s Wort extract hypericin and hyperforin in HepG2 and HepaRG cells. Toxicology Letters, 393, 1–13. https://doi.org/10.1016/j.toxlet.2024.01.008

Gómez, C., Alimajstorovic, Z., Othonos, N., Winter, D. V., White, S., Lavery, G. G., Tomlinson, J. W., Sinclair, A. J., & Odermatt, A. (2024). Identification of a human blood biomarker of pharmacological 11β-hydroxysteroid dehydrogenase 1 inhibition. British Journal of Pharmacology, 181(5), 698–711. https://doi.org/10.1111/bph.16251

Jäger, Marie-Christin, González-Ruiz, Víctor, Joos, Friedrich L., Winter, Denise V., Boccard, Julien, Degenhardt, Thorsten, Brand, Steve, Rudaz, Serge, Thompson, George R., & Odermatt, Alex. (2024). Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids. Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1394846

Thomson, Paul, Fragkas, Nik, Kafu, Laila M., Aithal, Guruprasad P., Lucena, M. Isabel, Terracciano, Luigi, Meng, Xiaoli, Pirmohamed, Munir, Brees, Dominique, Kullak-Ublick, Gerd A., Odermatt, Alex, Hammond, Thomas, Kammüller, Michael, & Naisbitt, Dean J. (2024). Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-desmethyl naproxen metabolite but not the acyl glucuronide. Allergy: European Journal of Allergy and Clinical Immunology, 79(1), 200–214. https://doi.org/10.1111/all.15830

Kolesnyk, Serhii, Prodanchuk, Mykola, Zhminko, Petro, Kolianchuk, Yana, Bubalo, Nataliia, Odermatt, Alex, & Smieško, Martin. (2023). A battery of in silico models application for pesticides exerting reproductive health effects: Assessment of performance and prioritization of mechanistic studies [Journal-article]. Toxicology in Vitro, 93, 105706. https://doi.org/10.1016/j.tiv.2023.105706

Jäger, Marie-Christin, Kędzierski, Jacek, Gell, Victoria, Wey, Tim, Kollár, Jakub, Winter, Denise V., Schuster, Daniela, Smieško, Martin, & Odermatt, Alex. (2023). Virtual screening and biological evaluation to identify pharmaceuticals potentially causing hypertension and hypokalemia by inhibiting steroid 11β-hydroxylase [Journal-article]. Toxicology and Applied Pharmacology, 475, 116638. https://doi.org/10.1016/j.taap.2023.116638

Szabo, Leonora, Cummins, Nadia, Paganetti, Paolo, Odermatt, Alex, Papassotiropoulos, Andreas, Karch, Celeste, Götz, Jürgen, Eckert, Anne, & Grimm, Amandine. (2023). ER-mitochondria contacts and cholesterol metabolism are disrupted by disease-associated tau protein. EMBO Reports, 24(8). https://doi.org/10.15252/embr.202357499

Kędzierski, Jacek, Allard, Julien A., Odermatt, Alex, & Smieško, Martin. (2023). Assessment of the inhibitory potential of anabolic steroids towards human AKR1D1 by computational methods and in vitro evaluation [Journal-article]. Toxicology Letters, 384, 1–13. https://doi.org/10.1016/j.toxlet.2023.07.006

Jäger, Marie-Christin, Patt, Melanie, González-Ruiz, Víctor, Boccard, Julien, Wey, Tim, Winter, Denise V, Rudaz, Serge, & Odermatt, Alex. (2023). Extended steroid profiling in H295R cells provides deeper insight into chemical-induced disturbances of steroidogenesis: Exemplified by prochloraz and anabolic steroids. Molecular and Cellular Endocrinology, 570, 111929. https://doi.org/10.1016/j.mce.2023.111929

Bolten, Jan Stephan, Mancuso, Riccardo Vincenzo, Roos, Noëmi Johanna, Mayr, Aline, Puligilla, Ramya Deepthi, Kraus, Lisa, Odermatt, Alex, Fricker, Gert, & Huwyler, Jörg. (2023). Nephrotoxicity of iopamidol is associated with mitochondrial impairment in human cell and teleost models. Toxicology and Applied Pharmacology, 466(446), 116493. https://doi.org/10.1016/j.taap.2023.116493

Bourqui, Laurent, Winter, Denise V, Odermatt, Alex, Loffing-Cueni, Dominique, & Loffing, Johannes. (2023). A novel mouse model for an inducible gene modification in the renal thick ascending limb. American Journal of Physiology - Renal Physiology, 324(5), F446–F460. https://doi.org/10.1152/ajprenal.00250.2022

Ben Rhouma, Bochra, Kley, Manuel, Kallabi, Fakhri, Kacem, Faten Hadj, Kammoun, Thouraya, Safi, Wajdi, Keskes, Leila, Mnif, Mouna, Odermatt, Alex, & Belguith, Neila. (2023). Molecular mechanisms underlying the defects of two novel mutations in the HSD17B3 gene found in the Tunisian population. Journal of Steroid Biochemistry and Molecular Biology, 227, 106235. https://doi.org/10.1016/j.jsbmb.2022.106235

Berber, M., Leng, S., Wengi, A., Winter, D. V., Odermatt, A., Beuschlein, F., Loffing, J., Breault, D. T., & Penton, D. (2023). Calcineurin regulates aldosterone production via dephosphorylation of NFATC4. JCI Insight, 8(14). https://doi.org/10.1172/jci.insight.157027

Geueke, Birgit, Groh, Ksenia J, Maffini, Maricel V, Martin, Olwenn V, Boucher, Justin M, Chiang, Yu-Ting, Gwosdz, Frank, Jieh, Phoenix, Kassotis, Christopher D, Łańska, Paulina, Myers, John Peterson, Odermatt, Alex, Parkinson, Lindsey V, Schreier, Verena N, Srebny, Vanessa, Zimmermann, Lisa, Scheringer, Martin, & Muncke, Jane. (2023). Systematic evidence on migrating and extractable food contact chemicals: Most chemicals detected in food contact materials are not listed for use. Critical Reviews in Food Science and Nutrition, 63(28), 9425–9435. https://doi.org/10.1080/10408398.2022.2067828

Jäger, M.-C., Joos, F. L., Winter, D. V., & Odermatt, A. (2023). Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays. Current Research in Toxicology, 5. https://doi.org/10.1016/j.crtox.2023.100119

Schreier, Verena N., Çörek, Emre, Appenzeller-Herzog, Christian, Brüschweiler, Beat J., Geueke, Birgit, Wilks, Martin F., Schilter, Benoit, Muncke, Jane, Simat, Thomas J., Smie�ko, Martin, Roth, Nicolas, & Odermatt, Alex. (2023). Evaluating the food safety and risk assessment evidence-base of polyethylene terephthalate oligomers: A systematic evidence map. Environment international, 176, 107978. https://doi.org/10.1016/j.envint.2023.107978

Schreier, V. N., Odermatt, A., & Welle, F. (2023). Migration Modeling as a Valuable Tool for Exposure Assessment and Risk Characterization of Polyethylene Terephthalate Oligomers. Molecules, 28(1). https://doi.org/10.3390/molecules28010173

Meier, Daniel T, Rachid, Leila, Wiedemann, Sophia J, Traub, Shuyang, Trimigliozzi, Kelly, Stawiski, Marc, Sauteur, Loïc, Winter, Denise V, Le Foll, Christelle, Brégère, Catherine, Guzman, Raphael, Odermatt, Alex, Böni-Schnetzler, Marianne, & Donath, Marc Y. (2022). Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing. Nature Communications, 13(1), 4761. https://doi.org/10.1038/s41467-022-32509-4

Meier DT, Rachid L, Wiedemann SJ, Traub S, Trimigliozzi K, Stawiski M, Sauteur L, Winter DV, Le Foll C, Brégère C, Guzman R, Odermatt A, Böni-Schnetzler M, & Donath MY. (2022). Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing. Nature Communications, 13(1), 4761. https://doi.org/10.1038/s41467-022-32509-4

Stücheli S, Araya S, Ercan C, Moser SO, Gallon J, Jenö P, Piscuoglio S, Terracciano L, & Odermatt A. (2022). The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples. Cancers, 14(13). https://doi.org/10.3390/cancers14133074

Inderbinen, Silvia G, Kley, Manuel, Zogg, Michael, Sellner, Manuel, Fischer, André, Kędzierski, Jacek, Boudon, Stéphanie, Jetten, Anton M, Smiesko, Martin, & Odermatt, Alex. (2022). Activation of retinoic acid-related orphan receptor γ(t) by parabens and benzophenone UV-filters. Toxicology, 471, 153159. https://doi.org/10.1016/j.tox.2022.153159

Leclercq, Gabrielle, Haegel, Hélène, Toso, Alberto, Zimmermann, Tina, Green, Luke, Steinhoff, Nathalie, Sam, Johannes, Pulko, Vesna, Schneider, Anneliese, Giusti, Anna Maria, Challier, John, Freimoser-Grundschober, Anne, Larivière, Laurent, Odermatt, Alex, Stern, Martin, Umana, Pablo, Bacac, Marina, & Klein, Christian. (2022). JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy. Journal for ImmunoTherapy of Cancer, 10(1), e003766. https://doi.org/10.1136/jitc-2021-003766

Gathercole, Laura L, Nikolaou, Nikolaos, Harris, Shelley E, Arvaniti, Anastasia, Poolman, Toryn M, Hazlehurst, Jonathan M, Kratschmar, Denise V, Todorčević, Marijana, Moolla, Ahmad, Dempster, Niall, Pink, Ryan C, Saikali, Michael F, Bentley, Liz, Penning, Trevor M, Ohlsson, Claes, Cummins, Carolyn L, Poutanen, Matti, Odermatt, Alex, Cox, Roger D, & Tomlinson, Jeremy W. (2022). AKR1D1 knockout mice develop a sex-dependent metabolic phenotype. Journal of Endocrinology, 253(3), 97–113. https://doi.org/10.1530/JOE-21-0280

Keppner, Anna, Correia, Miguel, Santambrogio, Sara, Koay, Teng Wei, Maric, Darko, Osterhof, Carina, Winter, Denise V, Clerc, Angèle, Stumpe, Michael, Chalmel, Frédéric, Dewilde, Sylvia, Odermatt, Alex, Kressler, Dieter, Hankeln, Thomas, Wenger, Roland H, & Hoogewijs, David. (2022). Androglobin, a chimeric mammalian globin, is required for male fertility. eLife, 11, 72374. https://doi.org/10.7554/eLife.72374

Leclercq, Gabrielle, Servera, Llucia Alberti, Danilin, Sabrina, Challier, John, Steinhoff, Nathalie, Bossen, Claudia, Odermatt, Alex, Nicolini, Valeria, Umaña, Pablo, Klein, Christian, Bacac, Marina, Giusti, Anna-Maria, Schneider, Anneliese, & Haegel, Hélène. (2022). Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophils. OncoImmunology, 11(1), 2039432. https://doi.org/10.1080/2162402X.2022.2039432

Schreier, Verena N., Appenzeller-Herzog, Christian, Brüschweiler, Beat J., Geueke, Birgit, Wilks, Martin F., Simat, Thomas J., Schilter, Benoit, Smiesko, Martin, Muncke, Jane, Odermatt, Alex, & Roth, Nicolas. (2022). Evaluating the food safety and risk assessment evidence-base of polyethylene terephthalate oligomers: Protocol for a systematic evidence map. Environment International, 167, 107387. https://doi.org/10.1016/j.envint.2022.107387

Weingartner, Michael, Stücheli, Simon, Jebbawi, Fadi, Gottstein, Bruno, Beldi, Guido, Lundström-Stadelmann, Britta, Wang, Junhua, & Odermatt, Alex. (2022). Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection. PLoS Neglected Tropical Diseases, 16(1), e0009192. https://doi.org/10.1371/journal.pntd.0009192

Lemmens, Myriam, Fischer, Benoit, Zogg, Michael, Rodrigues, Lindsey, Kerr, Grainne, Del Rio-Espinola, Alberto, Schaeffer, Fanny, Maddalo, Danilo, Dubost, Valerie, Piaia, Alessandro, Müller, Arne, Plappert-Helbig, Ulla, Naumann, Ulrike, Haegele, Jasmin, Odermatt, Alex, Martus, Hans-Jörg, & Libertini, Silvana. (2021). Evaluation of two in vitro assays for tumorigenicity assessment of CRISPR-Cas9 genome-edited cells. Molecular Therapy Methods and Clinical Development, 23, 241–253. https://doi.org/10.1016/j.omtm.2021.09.004

Vanderriele, Paul-Emmanuel, Wang, Qing, Mérillat, Anne-Marie, Ino, Frédérique, Aeschlimann, Gilles, Ehret, Xavier, Ancin Del Olmo, David, Ponce de León, Verónica, Scholl, Ute I, Winter, Denise V, Odermatt, Alex, Hummler, Edith, & Verouti, Sophia N. (2021). Salt-sensitive hypertension in gr+/− rats is accompanied with dysregulation in adrenal soluble epoxide hydrolase and polyunsaturated fatty acid pathways. International Journal of Molecular Sciences, 22(24), 13218. https://doi.org/10.3390/ijms222413218

Morris, D. J., Brem, A. S., & Odermatt, A. (2021). Modulation of 11β-hydroxysteroid dehydrogenase functions by the cloud of endogenous metabolites in a local microenvironment: The glycyrrhetinic acid-like factor (GALF) hypothesis. Journal of Steroid Biochemistry and Molecular Biology, 214. https://doi.org/10.1016/j.jsbmb.2021.105988

Banki, Eszter, Fisi, Viktoria, Moser, Sandra, Wengi, Agnieszka, Carrel, Monique, Loffing-Cueni, Dominique, Penton, David, Kratschmar, Denise V, Rizzo, Ludovica, Lienkamp, Soeren, Odermatt, Alex, Rinschen, Markus M, & Loffing, Johannes. (2021). Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis. Kidney International, 100(4), 850–869. https://doi.org/10.1016/j.kint.2021.06.030

Weingartner, Michael, Stücheli, Simon, Kratschmar, Denise V, Birk, Julia, Klusonova, Petra, Chapman, Karen E, Lavery, Gareth G, & Odermatt, Alex. (2021). The ratio of ursodeoxycholyltaurine to 7-oxolithocholyltaurine serves as a biomarker of decreased 11β-hydroxysteroid dehydrogenase 1 activity in mouse. British Journal of Pharmacology, 178(16), 3309–3326. https://doi.org/10.1111/bph.15367

Leclercq, Gabrielle, Haegel, Hélène, Schneider, Anneliese, Giusti, Anna Maria, Marrer-Berger, Estelle, Boetsch, Christophe, Walz, Antje-Christine, Pulko, Vesna, Sam, Johannes, Challier, John, Ferlini, Cristiano, Odermatt, Alex, Umaña, Pablo, Bacac, Marina, & Klein, Christian. (2021). Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies. Journal for ImmunoTherapy of Cancer, 9(7), e002582. https://doi.org/10.1136/jitc-2021-002582

Gómez, Cristina, Jebbawi, Fadi, Weingartner, Michael, Wang, Junhua, Stücheli, Simon, Stieger, Bruno, Gottstein, Bruno, Beldi, Guido, Lundström-Stadelmann, Britta, & Odermatt, Alex. (2021). Impact on bile acid concentrations by alveolar echinococcosis and treatment with albendazole in mice. Metabolites, 11(7), 442. https://doi.org/10.3390/metabo11070442

Bell, Rachel M B, Villalobos, Elisa, Nixon, Mark, Miguelez-Crespo, Allende, Murphy, Lee, Fawkes, Angie, Coutts, Audrey, Sharp, Matthew G F, Koerner, Martha V, Allan, Emma, Meijer, Onno C, Houtman, Renè, Odermatt, Alex, Beck, Katharina R, Denham, Scott G, Lee, Patricia, Homer, Natalie Z M, Walker, Brian R, & Morgan, Ruth A. (2021). Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice. Molecular Metabolism, 48, 101225. https://doi.org/10.1016/j.molmet.2021.101225

Weingartner, M., Jebbawi, F., Wang, J., Stücheli, S., Gottstein, B., Beldi, G., Lundström-Stadelmann, B., & Odermatt, A. (2021). Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.02.03.429530

Baier, Felix Alexander, Sánchez-Taltavull, Daniel, Yarahmadov, Tural, Castellà, Cristina Gómez, Jebbawi, Fadi, Keogh, Adrian, Tombolini, Riccardo, Odriozola, Adolfo, Dias, Mariana Castro, Deutsch, Urban, Furuse, Mikio, Engelhardt, Britta, Zuber, Benoît, Odermatt, Alex, Candinas, Daniel, & Stroka, Deborah. (2021). Loss of Claudin-3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver. Cellular and Molecular Gastroenterology and Hepatology, 12(2), 745–767. https://doi.org/10.1016/j.jcmgh.2021.04.003

Beck, Katharina R., & Odermatt, Alex. (2021). Antifungal therapy with azoles and the syndrome of acquired mineralocorticoid excess. Molecular and Cellular Endocrinology, 524, 111168. https://doi.org/10.1016/j.mce.2021.111168

Birk, Julia, Lizak, Beata, Appenzeller-Herzog, Christian, & Odermatt, Alex. (2021). Monitoring Changes in the Oxidizing Milieu in the Endoplasmic Reticulum of Mammalian Cells Using HyPerER. Bio-Protocol, 11(13), e4076. https://doi.org/10.21769/bioprotoc.4076

Inderbinen, Silvia G., Zogg, Michael, Kley, Manuel, Smieško, Martin, & Odermatt, Alex. (2021). Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole. Toxicology and applied pharmacology, 412, 115387. https://doi.org/10.1016/j.taap.2020.115387

Schnoz, Christina, Moser, Sandra, Kratschmar, Denise V., Odermatt, Alex, Loffing-Cueni, Dominique, & Loffing, Johannes. (2021). Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC. Pflügers Archiv : European Journal of Physiology, 473(1), 79–93. https://doi.org/10.1007/s00424-020-02491-1

Mayr, F., Möller, G., Garscha, U., Fischer, J., Rodríguez Castano, P., Inderbinen, S. G., Temml, V., Waltenberger, B., Schwaiger, S., Hartmann, R. W., Gege, C., Martens, S., Odermatt, A., Pandey, A. V., Werz, O., Adamski, J., Stuppner, H., & Schuster, D. (2020). Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction [Posted-content]. MDPI AG. https://doi.org/10.20944/preprints202007.0495.v1

Odermatt, A., Nguyen, M.-V., & Thompson, G. R. (2020). Reply to DiPippo and Kontoyiannis. Clinical Infectious Diseases, 71(2). https://doi.org/10.1093/cid/ciz945

Beck, Katharina R., Telisman, Lucija, van Koppen, Chris J., Thompson, George R., & Odermatt, Alex. (2020). Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals. The Journal of Steroid Biochemistry and Molecular Biology, 199, 105605. https://doi.org/10.1016/j.jsbmb.2020.105605

Beck, Katharina R., Thompson, George R., & Odermatt, Alex. (2020). Drug-induced endocrine blood pressure elevation. Pharmacological Research, 154, 104311. https://doi.org/10.1016/j.phrs.2019.104311

Davis, Matthew R., Nguyen, Minh-Vu H., Gintjee, Thomas J., Odermatt, Alex, Young, Brian Y., & Thompson, George R. (2020). Management of posaconazole-induced pseudohyperaldosteronism. Journal of Antimicrobial Chemotherapy, 75(12), 3688–3693. https://doi.org/10.1093/jac/dkaa366

Gómez, Cristina, Stücheli, Simon, Kratschmar, Denise V., Bouitbir, Jamal, & Odermatt, Alex. (2020). Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples. Metabolites, 10(7), 282. https://doi.org/10.3390/metabo10070282

Inderbinen, Silvia G., Engeli, Roger T., Rohrer, Simona R., Di Renzo, Erminio, Aengenheister, Leonie, Buerki-Thurnherr, Tina, & Odermatt, Alex. (2020). Tributyltin and triphenyltin induce 11β-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor α. Toxicology Letters, 322, 39–49. https://doi.org/10.1016/j.toxlet.2020.01.001

Lizák, Beáta, Birk, Julia, Zana, Melinda, Kosztyi, Gergely, Kratschmar, Denise V., Odermatt, Alex, Zimmermann, Richard, Geiszt, Miklós, Appenzeller-Herzog, Christian, & Bánhegyi, Gábor. (2020). Ca2+ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione. BMC Biology, 18(1), 19. https://doi.org/10.1186/s12915-020-0749-y

Mayr, Fabian, Möller, Gabriele, Garscha, Ulrike, Fischer, Jana, Rodríguez Castaño, Patricia, Inderbinen, Silvia G., Temml, Veronika, Waltenberger, Birgit, Schwaiger, Stefan, Hartmann, Rolf W., Gege, Christian, Martens, Stefan, Odermatt, Alex, Pandey, Amit V., Werz, Oliver, Adamski, Jerzy, Stuppner, Hermann, & Schuster, Daniela. (2020). Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction. International Journal of Molecular Sciences, 21(19), 7102. https://doi.org/10.3390/ijms21197102

Nguyen, Minh-Vu H., Davis, Matthew R., Wittenberg, Rebecca, McHardy, Ian, Baddley, John W., Young, Brian Y., Odermatt, Alex, & Thompson, George R. (2020). Posaconazole Serum Drug Levels Associated With Pseudohyperaldosteronism. Clinical Infectious Diseases, 70(12), 2593–2598. https://doi.org/10.1093/cid/ciz741

Patt, Melanie, Beck, Katharina R., Di Marco, Tobias, Jäger, Marie-Christin, González-Ruiz, Victor, Boccard, Julien, Rudaz, Serge, Hartmann, Rolf W., Salah, Mohamed, van Koppen, Chris J., Grill, Matthias, & Odermatt, Alex. (2020). Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesis. Biochemical Pharmacology, 172, 113781. https://doi.org/10.1016/j.bcp.2019.113781

Patt, Melanie, Gysi, Joël, Faresse, Nourdine, Cidlowski, John A., & Odermatt, Alex. (2020). Protein phosphatase 1 alpha enhances glucocorticoid receptor activity by a mechanism involving phosphorylation of serine-211. Molecular and cellular endocrinology, 518, 110873. https://doi.org/10.1016/j.mce.2020.110873

Randi, Elisa B., Vervaet, Benjamin, Tsachaki, Maria, Porto, Elena, Vermeylen, Stijn, Lindenmeyer, Maja T., Thuy, Le Thi Thanh, Cohen, Clemens D., Devuyst, Olivier, Kistler, Andreas D., Szabo, Csaba, Kawada, Norifumi, Hankeln, Thomas, Odermatt, Alex, Dewilde, Sylvia, Wenger, Roland H., & Hoogewijs, David. (2020). The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease. Antioxidants & Redox Signaling, 32(16), 1155–1171. https://doi.org/10.1089/ars.2019.7868

Schulze, Friederike, Wehner, Josua, Kratschmar, Denise V., Makshana, Valmir, Meier, Daniel T., Häuselmann, Stéphanie P., Dalmas, Elise, Thienel, Constanze, Dror, Erez, Wiedemann, Sophia J., Traub, Shuyang, Nordmann, Thierry M., Rachid, Leila, De Baat, Axel, Rohm, Theresa V., Zhao, Cheng, Odermatt, Alex, Böni-Schnetzler, Marianne, & Donath, Marc Y. (2020). Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes. Scientific Reports, 10(1), 3035. https://doi.org/10.1038/s41598-020-59701-0

Thompson, George R., Surampudi, Prasanth N., & Odermatt, Alex. (2020). Gynecomastia and hypertension in a patient treated with posaconazole. Clinical case reports, 8(12), 3158–3161. https://doi.org/10.1002/ccr3.3376

Tsachaki, Maria, Strauss, Pirmin, Dunkel, Anja, Navrátilová, Hana, Mladenovic, Natasa, & Odermatt, Alex. (2020). Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration. Cellular and Molecular Life Sciences, 77(6), 1153–1175. https://doi.org/10.1007/s00018-019-03227-w

Grill, M., Patt, M., & Odermatt, A. (2019). Novel Protective Group Synthesis of Androgen Receptor Modulators with Steroidal and Nonsteroidal Scaffolds [Posted-content]. American Chemical Society (ACS). https://doi.org/10.26434/chemrxiv.11346962.v1

Akram, Muhammad, Patt, Melanie, Kaserer, Teresa, Temml, Veronika, Waratchareeyakul, Watcharee, Kratschmar, Denise V., Haupenthal, Joerg, Hartmann, Rolf W., Odermatt, Alex, & Schuster, Daniela. (2019). Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase. Journal of Steroid Biochemistry and Molecular Biology, 192, 105358. https://doi.org/10.1016/j.jsbmb.2019.04.007

Beck, Katharina R., Inderbinen, Silvia G., Kanagaratnam, Sharavan, Kratschmar, Denise V., Jetten, Anton M., Yamaguchi, Hideaki, & Odermatt, Alex. (2019). 11β-Hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor γ. Journal of Lipid Research, 60, 1535–1546. https://doi.org/10.1194/jlr.m092908

Beck, Katharina R., Kanagaratnam, Sharavan, Kratschmar, Denise V., Birk, Julia, Yamaguchi, Hideaki, Sailer, Andreas W., Seuwen, Klaus, & Odermatt, Alex. (2019). Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2. The Journal of Steroid Biochemistry and Molecular Biology, 190, 19–28. https://doi.org/10.1016/j.jsbmb.2019.03.011

Boccard, Julien, Tonoli, David, Strajhar, Petra, Jeanneret, Fabienne, Odermatt, Alex, & Rudaz, Serge. (2019). Removal of batch effects using stratified subsampling of metabolomic data for in vitro endocrine disruptors screening. Talanta, 195, 77–86. https://doi.org/10.1016/j.talanta.2018.11.019

Canonica, Jérémie, Frateschi, Simona, Boscardin, Emilie, Ebering, Anna, Sergi, Chloé, Jäger, Yannick, Peyrollaz, Thibaud, Mérillat, Anne-Marie, Maillard, Marc, Klusonova, Petra, Odermatt, Alex, Koesters, Robert, Debonneville, Anne, Staub, Olivier, Verouti, Sophia N., & Hummler, Edith. (2019). Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl- Cotransporter NCC and Transiently Affects Sodium Handling. Frontiers in Physiology, 10, 989. https://doi.org/10.3389/fphys.2019.00989

Crane, Erika A., Heydenreuter, Wolfgang, Beck, Katharina R., Strajhar, Petra, Vomacka, Jan, Smiesko, Martin, Mons, Elma, Barth, Lydia, Neuburger, Markus, Vedani, Angelo, Odermatt, Alex, Sieber, Stephan A., & Gademann, Karl. (2019). Profiling withanolide A for therapeutic targets in neurodegenerative diseases. Bioorganic & Medicinal Chemistry, 27(12), 2508–2520. https://doi.org/10.1016/j.bmc.2019.03.022

Egli, Jerome, Schlothauer, Tilman, Spick, Christian, Seeber, Stefan, Singer, Thomas, Odermatt, Alex, & Iglesias, Antonio. (2019). The Binding of Human IgG to Minipig FcγRs - Implications for Preclinical Assessment of Therapeutic Antibodies. Pharmaceutical Research, 36(3), 47. https://doi.org/10.1007/s11095-019-2574-y

Egli, Jerome, Schmucki, Roland, Loos, Benjamin, Reichl, Stephan, Grabole, Nils, Roller, Andreas, Ebeling, Martin, Odermatt, Alex, & Iglesias, Antonio. (2019). The genomic organization and expression pattern of the low-affinity Fc gamma receptors (FcγR) in the Göttingen minipig. Immunogenetics, 71(2), 123–136. https://doi.org/10.1007/s00251-018-01099-1

Keppner, Anna, Maric, Darko, Sergi, Chloé, Ansermet, Camille, De Bellis, Damien, Kratschmar, Denise V., Canonica, Jérémie, Klusonova, Petra, Fenton, Robert A., Odermatt, Alex, Crambert, Gilles, Hoogewijs, David, & Hummler, Edith. (2019). Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion. Scientific Reports, 9(1), 19540. https://doi.org/10.1038/s41598-019-55995-x

Sandström, Jenny, Kratschmar, Denise V., Broyer, Alexandra, Poirot, Olivier, Marbet, Philippe, Chantong, Boonrat, Zufferey, Fanny, Dos Santos, Tania, Boccard, Julien, Chrast, Roman, Odermatt, Alex, & Monnet-Tschudi, Florianne. (2019). In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice. Archives of Toxicology, 93, 1649–1664. https://doi.org/10.1007/s00204-019-02455-0

Strajhar, Petra, Vizeli, Patrick, Patt, Melanie, Dolder, Patrick C., Kratschmar, Denise V., Liechti, Matthias E., & Odermatt, Alex. (2019). Effects of lisdexamfetamine on plasma steroid concentrations compared with d-amphetamine in healthy subjects: A randomized, double-blind, placebo-controlled study. Journal of Steroid Biochemistry and Molecular Biology, 186, 212–225. https://doi.org/10.1016/j.jsbmb.2018.10.016

Thompson, George R., Beck, Katharina R., Patt, Melanie, Kratschmar, Denise V., & Odermatt, Alex. (2019). Posaconazole-Induced Hypertension Due to Inhibition of 11β-Hydroxylase and 11β-Hydroxysteroid Dehydrogenase 2. Journal of the Endocrine Society, 3(7), 1361–1366. https://doi.org/10.1210/js.2019-00189

Trinh, Beckey, Hepprich, Matthias, Betz, Matthias J., Burkard, Thilo, Cavelti-Weder, Claudia, Seelig, Eleonora, Meienberg, Fabian, Kratschmar, Denise V., Beuschlein, Felix, Reincke, Martin, Odermatt, Alex, Hall, Michael N., Donath, Marc Y., & Swierczynska, Marta M. (2019). Treatment of Primary Aldosteronism with mTORC1 Inhibitors. The Journal of Clinical Endocrinology and Metabolism, 104(10), 4703–4714. https://doi.org/10.1210/jc.2019-00563

Tsachaki, Maria, & Odermatt, Alex. (2019). Subcellular localization and membrane topology of 17β-hydroxysteroid dehydrogenases. Molecular and Cellular Endocrinology, 489, 98–106. https://doi.org/10.1016/j.mce.2018.07.003

Boudon, Stephanie, Heidl, Marc, Vuorinen, Anna, Wandeler, Eliane, Campiche, Remo, Odermatt, Alex, & Jackson, Eileen. (2018). Design, synthesis, and biological evaluation of novel selective peptide inhibitors of 11β-hydroxysteroid dehydrogenase 1. Bioorganic & Medicinal Chemistry, 26(18), 5128–5139. https://doi.org/10.1016/j.bmc.2018.09.009

Dolder, Patrick C., Strajhar, Petra, Vizeli, Patrick, Odermatt, Alex, & Liechti, Matthias E. (2018). Acute effects of lisdexamfetamine and D-amphetamine on social cognition and cognitive performance in a placebo-controlled study in healthy subjects. Psychopharmacology, 235(5), 1389–1402. https://doi.org/10.1007/s00213-018-4849-0

Emmerich, Juliette, van Koppen, Chris J., Burkhart, Jens L., Engeli, Roger T., Hu, Qingzhong, Odermatt, Alex, & Hartmann, Rolf W. (2018). Accelerated skin wound healing by selective 11β²-Hydroxylase (CYP11B1) inhibitors. European Journal of Medicinal Chemistry, 143, 591–597. https://doi.org/10.1016/j.ejmech.2017.11.018

Engeli, Roger T., Fürstenberger, Cornelia, Kratschmar, Denise V., & Odermatt, Alex. (2018). Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis. Heliyon, 4(2), e00527. https://doi.org/10.1016/j.heliyon.2018.e00527

Liao, Wan-Hui, Suendermann, Claudia, Steuer, Andrea Eva, Pacheco Lopez, Gustavo, Odermatt, Alex, Faresse, Nourdine, Henneberg, Maciej, & Langhans, Wolfgang. (2018). Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity. JCI insight, 3(14), e99015. https://doi.org/10.1172/jci.insight.99015

Lister, Adam, Bourgeois, Soline, Imenez Silva, Pedro H., Rubio-Aliaga, Isabel, Marbet, Philippe, Walsh, Joanne, Shelton, Luke M., Keller, Bettina, Verrey, Francois, Devuyst, Olivier, Giesbertz, Pieter, Daniel, Hannelore, Goldring, Christopher E., Copple, Ian M., Wagner, Carsten A., & Odermatt, Alex. (2018). NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. Scientific reports, 8(1), 5629. https://doi.org/10.1038/s41598-018-24000-2

Marbet, Philippe, Klusonova, Petra, Birk, Julia, Kratschmar, Denise V., & Odermatt, Alex. (2018). Absence of hexose-6-phosphate dehydrogenase results in reduced overall glucose consumption but does not prevent 11β-hydroxysteroid dehydrogenase-1-dependent glucocorticoid activation. The FEBS journal, 285(21), 3993–4004. https://doi.org/10.1111/febs.14642

Tsachaki, Maria, Mladenovic, Natasa, Štambergová, Hana, Birk, Julia, & Odermatt, Alex. (2018). Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance. FASEB journal, 32(5), 2690–2705. https://doi.org/10.1096/fj.201700870rr

Aghagolzadeh, Parisa, Radpour, Ramin, Bachtler, Matthias, van Goor, Harry, Smith, Edward R., Lister, Adam, Odermatt, Alex, Feelisch, Martin, & Pasch, Andreas. (2017). Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation. Atherosclerosis, 265, 78–86. https://doi.org/10.1016/j.atherosclerosis.2017.08.012

Alesutan, Ioana, Voelkl, Jakob, Feger, Martina, Kratschmar, Denise V., Castor, Tatsiana, Mia, Sobuj, Sacherer, Michael, Viereck, Robert, Borst, Oliver, Leibrock, Christina, Gawaz, Meinrad, Kuro-O, Makoto, Pilz, Stefan, Tomaschitz, Andreas, Odermatt, Alex, Pieske, Burkert, Wagner, Carsten A., & Lang, Florian. (2017). Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells. Scientific Reports, 7(1), 2059. https://doi.org/10.1038/s41598-017-01882-2

Araya, Selene, Kratschmar, Denise V., Tsachaki, Maria, Stücheli, Simon, Beck, Katharina R., & Odermatt, Alex. (2017). DHRS7 (SDR34C1) - A new player in the regulation of androgen receptor function by inactivation of 5α-dihydrotestosterone? Journal of Steroid Biochemistry and Molecular Biology, 171, 288–295. https://doi.org/10.1016/j.jsbmb.2017.04.013

Beck, Katharina R., Bächler, Murielle, Vuorinen, Anna, Wagner, Sandra, Akram, Muhammad, Griesser, Ulrich, Temml, Veronika, Klusonova, Petra, Yamaguchi, Hideaki, Schuster, Daniela, & Odermatt, Alex. (2017). Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole. Biochemical Pharmacology, 130, 93–103. https://doi.org/10.1016/j.bcp.2017.01.010

Beck, Katharina R., Kaserer, Teresa, Schuster, Daniela, & Odermatt, Alex. (2017). Virtual screening applications in short-chain dehydrogenase/reductase research. Journal of Steroid Biochemistry and Molecular Biology, 171, 157–177. https://doi.org/10.1016/j.jsbmb.2017.03.008

Ben Rhouma, Bochra, Kallabi, Fakhri, Mahfoudh, Nadia, Ben Mahmoud, Afif, Engeli, Roger T., Kamoun, Hassen, Keskes, Leila, Odermatt, Alex, & Belguith, Neila. (2017). Novel cases of Tunisian patients with mutations in the gene encoding 17β-hydroxysteroid dehydrogenase type 3 and a founder effect. Journal of Steroid Biochemistry and Molecular Biology, 165(Pt A), 86–94. https://doi.org/10.1016/j.jsbmb.2016.03.007

Bonifacio, Annalisa, Sanvee, Gerda M., Brecht, Karin, Kratschmar, Denise V., Odermatt, Alex, Bouitbir, Jamal, & Krähenbühl, Stephan. (2017). IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes. Archives of Toxicology, 91(5), 2223–2234. https://doi.org/10.1007/s00204-016-1871-z