Prof. Dr. Marek Basler

Stubbusch, Astrid K.M., Peaudecerf, François J., Lee, Kang Soo, Paoli, Lucas, Schwartzman, Julia, Stocker, Roman, Basler, Marek, Schubert, Olga T., Ackermann, Martin, Magnabosco, Cara, & D’Souza, Glen G. (2025). Antagonism as a foraging strategy in microbial communities. Science, 388( 6752), 1214–1217. https://doi.org/10.1126/science.adr8286

Brüderlin, Mitchell, Kolesnikov, Maxim, Röthlin, Florian, Lim, Roderick Y. H., & Basler, Marek. (2025). Pseudomonas aeruginosa assembles H1-T6SS in response to physical and chemical damage of the outer membrane. Science Advances , 11(10). https://doi.org/10.1126/sciadv.adr1713

Tejada-Arranz, Alejandro, Plack, Annika, Antelo-Varela, Minia, Kaczmarczyk, Andreas, Klotz, Alexander, Jenal, Urs, & Basler, Marek. (2025). Mechanisms of Pseudomonas aeruginosa resistance to Type VI Secretion System attacks [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.10.26.620397

Smith, William P. J., Armstrong-Bond, Ewan, Coyte, Katharine Z., Knight, Christopher G., Basler, Marek, & Brockhurst, Michael A. (2025). Multiplicity of type 6 secretion system toxins limits the evolution of resistance [Journal-article]. Proceedings of the National Academy of Sciences, 122(2). https://doi.org/10.1073/pnas.2416700122

Stubbusch, Astrid K.M., Peaudecerf, Francois J., Soo Lee, Kang, Paoli, Lucas, Schwartzman, Julia, Stocker, Roman, Basler, Marek, Schubert, Olga T., Ackermann, Martin, Magnabosco, Cara, & D’Souza, Glen G. (2024). Antagonism as a foraging strategy in microbial communities [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.11.04.621785

Smith, William P. J., Armstrong-Bond, Ewan, Coyte, Katharine Z., Knight, Christopher G., Basler, Marek, & Brockhurst, Michael A. (2024). Multiplicity of Type 6 Secretion System toxins limits the evolution of resistance [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.07.30.605577

George, M., Narayanan, S., Tejada-Arranz, A., Plack, A., & Basler, M. (2024). Initiation of H1-T6SS dueling between Pseudomonas aeruginosa [Journal-article]. mBio, 15(8). https://doi.org/10.1128/mbio.00355-24

Plum, Miro Thorsten Wilhelm, Cheung, Hoi Ching, Iscar, Patricia Reist, Iscar, Patricia Reist, Chen, Yahua, Gan, Yunn-Hwen, & Basler, Marek. (2024). Burkholderia thailandensis uses a type VI secretion system to lyse protrusions without triggering host cell responses [Journal-article]. Cell Host & Microbe, 32(5), 676–692. https://doi.org/10.1016/j.chom.2024.03.013

Sollier, Julie, Basler, Marek, Broz, Petr, Dittrich, Petra S., Drescher, Knut, Egli, Adrian, Harms, Alexander, Hierlemann, Andreas, Hiller, Sebastian, King, Carolyn G., McKinney, John D., Moran-Gilad, Jacob, Neher, Richard A., Page, Malcolm G. P., Panke, Sven, Persat, Alexandre, Picotti, Paola, Rentsch, Katharina M., Rivera-Fuentes, Pablo, et al. (2024). Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions. Nature Microbiology, 9(1), 1–3. https://doi.org/10.1038/s41564-023-01566-w

Trotta, Kristine L., Hayes, Beth M., Schneider, Johannes P., Wang, Jing, Todor, Horia, Rockefeller Grimes, Patrick, Zhao, Ziyi, Hatleberg, William L., Silvis, Melanie R., Kim, Rachel, Koo, Byoung Mo, Basler, Marek, & Chou, Seemay. (2023). Lipopolysaccharide transport regulates bacterial sensitivity to a cell wall-degrading intermicrobial toxin. PLoS Pathogens, 19(6), e1011454. https://doi.org/10.1371/journal.ppat.1011454

Trotta, Kristine L., Hayes, Beth M., Schneider, Johannes P., Wang, Jing, Todor, Horia, Rockefeller Grimes, Patrick, Zhao, Ziyi, Hatleberg, William L., Silvis, Melanie R., Kim, Rachel, Koo, Byoung Mo, Basler, Marek, & Chou, Seemay. (2023). Lipopolysaccharide integrity primes bacterial sensitivity to a cell wall-degrading intermicrobial toxin. bioRxiv. https://doi.org/10.1101/2023.01.20.524922

Adamer, Michael F., Brüningk, Sarah C., Tejada-Arranz, Alejandro, Estermann, Fabienne, Basler, Marek, & Borgwardt, Karsten. (2022). reComBat: batch-effect removal in large-scale multi-source gene-expression data integration. Bioinformatics Advances, 2(1), vbac071. https://doi.org/10.1093/bioadv/vbac071

Lin, Lin, Capozzoli, Raffaella, Ferrand, Alexia, Plum, Miro, Vettiger, Andrea, & Basler, Marek. (2022). Subcellular localization of Type VI secretion system assembly in response to cell-cell contact. The EMBO Journal, 41(13), e108595. https://doi.org/10.15252/embj.2021108595

Adamer, Michael R., Brüningk, Sarah C., Tejada-Arranz, Alejandro, Estermann, Fabienne, Basler, Marek, & Borgwardt, Karsten. (2021). reComBat: Batch effect removal in large-scale, multi-source omics data integration. biorxiv.org. https://doi.org/10.1101/2021.11.22.469488

Brodmann, Maj, Schnider, Sophie T., & Basler, Marek. (2021). Type VI Secretion System and Its Effectors PdpC, PdpD, and OpiA Contribute to; Francisella; Virulence in Galleria mellonella Larvae. Infection and immunity, 89(7), e0057920. https://doi.org/10.1128/iai.00579-20

García-Bayona, Leonor, Coyne, Michael J., Hantman, Noam, Montero-Llopis, Paula, Von, Salena S., Ito, Takeshi, Malamy, Michael H., Basler, Marek, Barquera, Blanca, & Comstock, Laurie E. (2020). Nanaerobic growth enables direct visualization of dynamic cellular processes in human gut symbionts. Proceedings of the National Academy of Sciences of the United States of America, 117(39), 24484–24493. https://doi.org/10.1073/pnas.2009556117

Smith, William P. J., Brodmann, Maj, Unterweger, Daniel, Davit, Yohan, Comstock, Laurie E., Basler, Marek, & Foster, Kevin R. (2020). The evolution of tit-for-tat in bacteria via the type VI secretion system. Nature Communications, 11(1), 5395. https://doi.org/10.1038/s41467-020-19017-z

Smith, William P. J., Vettiger, Andrea, Winter, Julius, Ryser, Till, Comstock, Laurie E., Basler, Marek, & Foster, Kevin R. (2020). The evolution of the type VI secretion system as a disintegration weapon. PLoS biology, 18(5), e3000720. https://doi.org/10.1371/journal.pbio.3000720

Basler, M. (2019). Cellular microbiology interview—Dr Marek Basler. Cellular Microbiology, 21(4). https://doi.org/10.1111/cmi.12991

Agnetti, Jessica, Seth-Smith, Helena M. B., Ursich, Sebastian, Reist, Josiane, Basler, Marek, Nickel, Christian, Bassetti, Stefano, Ritz, Nicole, Tschudin-Sutter, Sarah, & Egli, Adrian. (2019). Clinical impact of the type VI secretion system on virulence of Campylobacter species during infection. BMC Infectious Diseases, 19(1), 237. https://doi.org/10.1186/s12879-019-3858-x

Lin, Lin, Lezan, Emmanuelle, Schmidt, Alexander, & Basler, Marek. (2019). Abundance of bacterial Type VI secretion system components measured by targeted proteomics. Nature Communications, 10(1), 2584. https://doi.org/10.1038/s41467-019-10466-9

Lin, Lin, Ringel, Peter David, Vettiger, Andrea, Dürr, Lara, & Basler, Marek. (2019). DNA Uptake upon T6SS-Dependent Prey Cell Lysis Induces SOS Response and Reduces Fitness of Acinetobacter baylyi. Cell Reports, 29(6), 1633–1644. https://doi.org/10.1016/j.celrep.2019.09.083

Schneider, Johannes Paul, Nazarov, Sergey, Adaixo, Ricardo, Liuzzo, Martina, Ringel, Peter David, Stahlberg, Henning, & Basler, Marek. (2019). Diverse roles of TssA-like proteins in the assembly of bacterial type VI secretion systems. The EMBO journal, 38(18), e100825. https://doi.org/10.15252/embj.2018100825

Wang, Jing, Brodmann, Maj, & Basler, Marek. (2019). Assembly and Subcellular Localization of Bacterial Type VI Secretion Systems. Annual Review of Microbiology, 73, 621–638. https://doi.org/10.1146/annurev-micro-020518-115420

Basler, M., & Shao, F. (2018). Bacterial infection and symbiosis. Molecular Biology of the Cell, 29, 683–684. https://doi.org/10.1091/mbc.e17-11-0668

Brackmann, Maximilian, Wang, Jing, & Basler, Marek. (2018). Type VI secretion system sheath inter-subunit interactions modulate its contraction. EMBO Reports, 19(2), 225–233. https://doi.org/10.15252/embr.201744416

Brodmann, Maj, Heilig, Rosalie, Broz, Petr, & Basler, Marek. (2018). Mobilizable Plasmids for Tunable Gene Expression in Francisella novicida. Frontiers in Cellular and Infection Microbiology, 8, 284. https://doi.org/10.3389/fcimb.2018.00284

Nazarov, Sergey, Schneider, Johannes P., Brackmann, Maximilian, Goldie, Kenneth N., Stahlberg, Henning, & Basler, Marek. (2018). Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end. The EMBO Journal, 37(4), e97103. https://doi.org/10.15252/embj.201797103

Brackmann, Maximilian, Wang, Jing, & Basler, Marek. (2017). VipA N-terminal linker and VipB-VipB interaction modulate the contraction of Type VI secretion system sheath [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/152785

Brackmann, Maximilian, Nazarov, Sergey, Wang, Jing, & Basler, Marek. (2017). Using Force to Punch Holes: Mechanics of Contractile Nanomachines. Trends in Cell Biology, 27(9), 623–632. https://doi.org/10.1016/j.tcb.2017.05.003

Brodmann, Maj, Dreier, Roland F., Broz, Petr, & Basler, Marek. (2017). Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape. Nature Communications, 8, 15853. https://doi.org/10.1038/ncomms15853

Ringel, Peter David, Hu, Di, & Basler, Marek. (2017). The Role of Type VI Secretion System Effectors in Target Cell Lysis and Subsequent Horizontal Gene Transfer. Cell Reports, 21(13), 3927–3940. https://doi.org/10.1016/j.celrep.2017.12.020

Vettiger, Andrea, Winter, Julius, Lin, Lin, & Basler, Marek. (2017). The type VI secretion system sheath assembles at the end distal from the membrane anchor. Nature Communications, 8, 16088. https://doi.org/10.1038/ncomms16088

Wang, Jing, Brackmann, Maximilian, Castaño-Díez, Daniel, Kudryashev, Mikhail, Goldie, Kenneth N., Maier, Timm, Stahlberg, Henning, & Basler, Marek. (2017). Cryo-EM structure of the extended type VI secretion system sheath-tube complex. Nature Microbiology, 2(11), 1507–1512. https://doi.org/10.1038/s41564-017-0020-7

Nelson, Michaeline B., Chase, Alexander B., Martiny, Jennifer B. H., Stocker, Roman, Nguyen, Jen, Lloyd, Karen, Oshiro, Reid T., Kearns, Daniel B., Schneider, Johannes P., Ringel, Peter D., Basler, Marek, Olson, Christine A., Vuong, Helen E., Hsiao, Elaine Y., Roller, Benjamin R. K., Ackermann, Martin, Smillie, Chris, Chien, Diana, Alm, Eric, & Jermy, Andrew J. (2016). The Microbial Olympics 2016. Nature Microbiology, 1(8), 16122. https://doi.org/10.1038/nmicrobiol.2016.122

Schneider, Johannes P., & Basler, Marek. (2016). Shedding light on biology of bacterial cells. Philosophical Transactions of the Royal Society of London, Series B : Biological Sciences, 371(1707), 20150499. https://doi.org/10.1098/rstb.2015.0499

Vettiger, Andrea, & Basler, Marek. (2016). Type VI Secretion System Substrates Are Transferred and Reused among Sister Cells. Cell, 167(1), 99–110. https://doi.org/10.1016/j.cell.2016.08.023

Basler, Marek. (2015). Type VI secretion system : secretion by a contractile nanomachine. Philosophical Transactions : the Royal Society of London, 370(1679), 20150021. https://doi.org/10.1098/rstb.2015.0021

Borenstein, David Bruce, Ringel, Peter, Basler, Marek, & Wingreen, Ned S. (2015). Established microbial colonies can survive type VI secretion assault. PLoS Computational Biology, 11(10), e1004520. https://doi.org/10.1371/journal.pcbi.1004520

Kudryashev, Mikhail, Wang, Ray Yu-Ruei, Brackmann, Maximilian, Scherer, Sebastian, Maier, Timm, Baker, David, DiMaio, Frank, Stahlberg, Henning, Egelman, Edward H, & Basler, Marek. (2015). Structure of the Type VI Secretion System Contractile Sheath. Cell, 160(5), 62–952. https://doi.org/10.1016/j.cell.2015.01.037

Wang, Ray Yu-Ruei, Kudryashev, Mikhail, Li, Xueming, Egelman, Edward H, Basler, Marek, Cheng, Yifan, Baker, David, & DiMaio, Frank. (2015). De novo protein structure determination from near-atomic-resolution cryo-EM maps. Nature Methods, 12(4), 8–335. https://doi.org/10.1038/nmeth.3287

Basler, Marek, Ho, Brian T., & Mekalanos, John J. (2013). Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell, 152(4), 94–884. https://doi.org/10.1016/j.cell.2013.01.042

Ho, Brian T., Basler, Marek, & Mekalanos, John J. (2013). Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer. Science, 342(6155), 3–250. https://doi.org/10.1126/science.1243745

Shneider, Mikhail M., Buth, Sergey A., Ho, Brian T., Basler, Marek, Mekalanos, John J., & Leiman, Petr G. (2013). PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature, 500(7462), 350–353. https://doi.org/10.1038/nature12453

Basler, M., & Mekalanos, J. J. (2012). Type 6 secretion dynamics within and between bacterial cells. Science, 337(6096), 815. https://doi.org/10.1126/science.1222901

Basler, M., Pilhofer, M., Henderson, G. P., Jensen, G. J., & Mekalanos, J. J. (2012). Type VI secretion requires a dynamic contractile phage tail-like structure. Nature, 483(7388), 6–182. https://doi.org/10.1038/nature10846

Fiser, Radovan, Masin, Jiri, Bumba, Ladislav, Pospisilova, Eva, Fayolle, Catherine, Basler, Marek, Sadilkova, Lenka, Adkins, Irena, Kamanova, Jana, Cerny, Jan, Konopasek, Ivo, Osicka, Radim, Leclerc, Claude, & Sebo, Peter. (2012). Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores. PLoS Pathogens, 8(4), e1002580. https://doi.org/10.1371/journal.ppat.1002580

Horváthová, Lenka, Safaríková, Lucie, Basler, Marek, Hrdy, Ivan, Campo, Neritza B., Shin, Jyh-Wei, Huang, Kuo-Yang, Huang, Po-Jung, Lin, Rose, Tang, Petrus, & Tachezy, Jan. (2012). Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome. Genome Biology and Evolution, 4(10), 29–1017. https://doi.org/10.1093/gbe/evs078

Rao, Jayasimha, Damron, F. Heath, Basler, Marek, Digiandomenico, Antonio, Sherman, Nicholas E., Fox, Jay W., Mekalanos, John J., & Goldberg, Joanna B. (2011). Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient. Frontiers in Microbiology, 2, 162. https://doi.org/10.3389/fmicb.2011.00162

Linhartová, Irena, Bumba, Ladislav, Mašín, Jiří, Basler, Marek, Osička, Radim, Kamanová, Jana, Procházková, Kateřina, Adkins, Irena, Hejnová-Holubová, Jana, Sadílková, Lenka, Morová, Jana, & Sebo, Peter. (2010). RTX proteins: a highly diverse family secreted by a common mechanism. FEMS Microbiology Reviews, 34(6), 112–1076. https://doi.org/10.1111/j.1574-6976.2010.00231.x

Osickova, Adriana, Masin, Jiri, Fayolle, Catherine, Krusek, Jan, Basler, Marek, Pospisilova, Eva, Leclerc, Claude, Osicka, Radim, & Sebo, Peter. (2010). Adenylate cyclase toxin translocates across target cell membrane without forming a pore. Molecular Microbiology, 75(6), 62–1550. https://doi.org/10.1111/j.1365-2958.2010.07077.x

Leiman, Petr G., Basler, Marek, Ramagopal, Udupi A., Bonanno, Jeffrey B., Sauder, J. Michael, Pukatzki, Stefan, Burley, Stephen K., Almo, Steven C., & Mekalanos, John J. (2009). Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin. Proceedings of the National Academy of Sciences, 106(11), 9–4154. https://doi.org/10.1073/pnas.0813360106

Vojtova-Vodolanova, Jana, Basler, Marek, Osicka, Radim, Knapp, Oliver, Maier, Elke, Cerny, Jan, Benada, Oldrich, Benz, Roland, & Sebo, Peter. (2009). Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin. FASEB Journal, 23(9), 43–2831. https://doi.org/10.1096/fj.09-131250

Pánek, Josef, Bobek, Jan, Mikulík, Karel, Basler, Marek, & Vohradský, Jirí. (2008). Biocomputational prediction of small non-coding RNAs in Streptomyces. BMC Genomics, 9, 217. https://doi.org/10.1186/1471-2164-9-217

Basler, Marek, Knapp, Oliver, Masin, Jiri, Fiser, Radovan, Maier, Elke, Benz, Roland, Sebo, Peter, & Osicka, Radim. (2007). Segments crucial for membrane translocation and pore-forming activity of Bordetella adenylate cyclase toxin. Journal of Biological Chemistry, 282(17), 29–12419. https://doi.org/10.1074/jbc.m611226200

Fiser, Radovan, Masín, Jirí, Basler, Marek, Krusek, Jan, Spuláková, Veronika, Konopásek, Ivo, & Sebo, Peter. (2007). Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities. Journal of Biological Chemistry, 282(5), 20–2808. https://doi.org/10.1074/jbc.m609979200

Frýdlová, Ivana, Basler, Marek, Vasicová, Pavla, Malcová, Ivana, & Hasek, Jirí. (2007). Special type of pheromone-induced invasive growth in Saccharomyces cerevisiae. Current Genetics, 52(2), 87–95. https://doi.org/10.1007/s00294-007-0141-2

Sasková, Lenka, Nováková, Linda, Basler, Marek, & Branny, Pavel. (2007). Eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae. Journal of Bacteriology, 189(11), 79–4168. https://doi.org/10.1128/jb.01616-06

Basler, Marek, Linhartová, Irena, Halada, Petr, Novotná, Jana, Bezousková, Silvia, Osicka, Radim, Weiser, Jaroslav, Vohradský, Jirí, & Sebo, Peter. (2006). The iron-regulated transcriptome and proteome of Neisseria meningitidis serogroup C. Proteomics, 6(23), 6194–6206. https://doi.org/10.1002/pmic.200600312

Basler, Marek, Masin, Jiri, Osicka, Radim, & Sebo, Peter. (2006). Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes. Infection and Immunity, 74(4), 14–2207. https://doi.org/10.1128/iai.74.4.2207-2214.2006

Linhartova, Irena, Basler, Marek, Ichikawa, Jeffrey, Pelicic, Vladimir, Osicka, Radim, Lory, Stephen, Nassif, Xavier, & Sebo, Peter. (2006). Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells. FEMS Microbiology Letters, 263(1), 18–109. https://doi.org/10.1111/j.1574-6968.2006.00407.x

Masin, Jiri, Basler, Marek, Knapp, Oliver, El-Azami-El-Idrissi, Mohammed, Maier, Elke, Konopasek, Ivo, Benz, Roland, Leclerc, Claude, & Sebo, Peter. (2005). Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells. Biochemistry, 44(38), 66–12759. https://doi.org/10.1021/bi050459b