Prof. Dr. Matthias Emanuel Liechti

Müller, Felix, Zaczek, Hannes, Becker, Anna M., Ley, Laura, Borgwardt, Stefan, Santos de Jesus, Joyce, Loh, Nico, Kohut, Jan, Auernig, Mathias, Boehlke, Christopher, & Liechti, Matthias E. (2025). Efficacy and safety of low- versus high-dose-LSD-assisted therapy in patients with major depression: A randomized trial. Med, 6, 100725. https://doi.org/10.1016/j.medj.2025.100725

Arikci, D., Holze, F., Mueller, L., Vizeli, P., Rudin, D., Luethi, D., Hysek, C. M., & Liechti, M. E. (2025). Absolute Oral Bioavailability and Bioequivalence of LSD Base and Tartrate in a Double-Blind, Placebo-Controlled, Crossover Study [Journal-article]. Clinical Pharmacology &Amp; Therapeutics, 118. https://doi.org/10.1002/cpt.3726

Guessoum, Adrian, Vogt, Severin B., Meyer, Maximilian, Westenberg, Jean Nicolas, Klemperer, Benjamin, Dürsteler, Kenneth M., Liechti, Matthias E., Thomann, Jan, Luethi, Dino, Duthaler, Urs, & Vogel, Marc. (2025). Pharmacokinetics and Pharmacodynamics of Intranasal Diacetylmorphine in Heroin-Assisted Treatment for Severe Opioid Use Disorder. CNS Drugs, 39(8), 807–817. https://doi.org/10.1007/s40263-025-01189-1

Atila, C., Camerin, S.-J., Liechti, M. E., & Christ-Crain, M. (2025). The effect of MDMA on anterior pituitary hormones: a secondary analysis of a randomized placebo-controlled trial [Journal-article]. Endocrine Connections, 14(6). https://doi.org/10.1530/EC-25-0254

Kraus, E., Suter, S., Proescholdt, M., Müller, F., Liechti, M. E., Heim, M., Lang, U., & Vogel, M. (2025). Case report: Well-tolerated MDMA-assisted therapy in a 32-year old female patient with advanced alcohol-induced liver cirrhosis [Journal-article]. Psychiatry Research Case Reports, 4(1), 100252. https://doi.org/10.1016/j.psycr.2025.100252

Atila, C., Nikaj, A., Leibnitz, S., Liechti, M. E., & Christ-Crain, M. (2025). Neurophysin I: a reliable, novel, and robust biomarker for oxytocin [Journal-article]. European Journal of Endocrinology, 192(4), 502–510. https://doi.org/10.1093/ejendo/lvaf078

Avram, Mihai, Fortea, Lydia, Wollner, Lea, Coenen, Ricarda, Korda, Alexandra, Rogg, Helena, Holze, Friederike, Vizeli, Patrick, Ley, Laura, Radua, Joaquim, Müller, Felix, Liechti, Matthias E., & Borgwardt, Stefan. (2025). Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine. Molecular Psychiatry, 30(4), 1297–1307. https://doi.org/10.1038/s41380-024-02734-y

Liechti, Matthias E., Gasser, Peter, Aicher, Helena D., Mueller, Felix, Hawrot, Tadeusz, & Schmid, Yasmin. (2025). Implementing psychedelic-assisted therapy: History and characteristics of the Swiss limited medical use program [Journal-article]. Neuroscience Applied, 4. https://doi.org/10.1016/j.nsa.2025.105525

Mueller, L., Klaiber, A., Ley, L., Becker, A. M., Thomann, J., Luethi, D., Schmid, Y., & Liechti, M. E. (2025). Pharmacokinetics, Pharmacodynamics, and Urinary Recovery of Oral Mescaline Hydrochloride in Healthy Participants [Journal-article]. Clinical Pharmacokinetics. https://doi.org/10.1007/s40262-025-01544-x

Hutten, N. R. P. W., Quaedflieg, C. W. E. M., Mason, N. L., Theunissen, E. L., Liechti, M. E., Duthaler, U., Kuypers, K. P. C., Bonnelle, V., Feilding, A., & Ramaekers, J. G. (2024). Inter-individual variability in neural response to low doses of LSD [Journal-article]. Translational Psychiatry, 14(1). https://doi.org/10.1038/s41398-024-03013-8

Klaiber, A., Schmid, Y., Becker, A. M., Straumann, I., Erne, L., Jelusic, A., Thomann, J., Luethi, D., & Liechti, M. E. (2024). Acute dose-dependent effects of mescaline in a double-blind placebo-controlled study in healthy subjects [Journal-article]. Translational Psychiatry, 14(1). https://doi.org/10.1038/s41398-024-03116-2

Straumann, I., Avedisian, I., Klaiber, A., Varghese, N., Eckert, A., Rudin, D., Luethi, D., & Liechti, M. E. (2024). Acute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants [Journal-article]. Neuropsychopharmacology, 50(2), 362–371. https://doi.org/10.1038/s41386-024-01972-6

Vizeli, Patrick, Studerus, Erich, Holze, Friederike, Schmid, Yasmin, Dolder, Patrick C., Ley, Laura, Straumann, Isabelle, Becker, Anna M., Müller, Felix, Arikci, Denis, & Liechti, Matthias E. (2024). Pharmacological and non-pharmacological predictors of the LSD experience in healthy participants. Translational Psychiatry, 14(1). https://doi.org/10.1038/s41398-024-03074-9

Atila, Cihan, Straumann, Isabelle, Vizeli, Patrick, Beck, Julia, Monnerat, Sophie, Holze, Friederike, Liechti, Matthias E., & Christ-Crain, Mirjam. (2024). Oxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA network open, 7(11). https://doi.org/10.1001/jamanetworkopen.2024.45278

Holze, F., Madsen, M. K., Svarer, C., Gillings, N., Stenbaek, D. S., Rudin, D., Duthaler, U., Liechti, M. E., Fisher, P. M., & Knudsen, G. M. (2024). Ketanserin exhibits dose- and concentration-proportional serotonin 2A receptor occupancy in healthy individuals: Relevance for psychedelic research [Journal-article]. European Neuropsychopharmacology, 88, 43–48. https://doi.org/10.1016/j.euroneuro.2024.07.003

Calder, A. E., Rausch, B., Liechti, M. E., Holze, F., & Hasler, G. (2024). Naturalistic psychedelic therapy: The role of relaxation and subjective drug effects in antidepressant response [Journal-article]. Journal of Psychopharmacology, 38(10), 873–886. https://doi.org/10.1177/02698811241278873

Angerer, Verena, Schmid, Yasmin, Franz, Florian, Gnann, Heike, Speer, Jan Manuel, Gnann, Anke, Helmecke, Stephan, Buchwald, Armin, Brandt, Simon D., Passie, Torsten, Liechti, Matthias E., & Auwärter, Volker. (2024). Acute psychotropic, autonomic, and endocrine effects of 5,6-methylenedioxy-2-aminoindane (MDAI) compared with 3,4-methylenedioxymethamphetamine (MDMA) in human volunteers: A self-administration study. Drug Testing and Analysis, 16(9), 1002–1011. https://doi.org/10.1002/dta.3622

Holze, F., Gasser, P., Müller, F., Strebel, M., & Liechti, M. E. (2024). LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up [Journal-article]. British Journal of Psychiatry, 225(3), 362–370. https://doi.org/10.1192/bjp.2024.99

Arias, H. R., Micheli, L., Rudin, D., Bento, O., Borsdorf, S., Ciampi, C., Marin, P., Ponimaskin, E., Manetti, D., Romanelli, M. N., Ghelardini, C., Liechti, M. E., & Di Cesare Mannelli, L. (2024). Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation. Biomedicine and Pharmacotherapy, 177. https://doi.org/10.1016/j.biopha.2024.116867

Stocker, K., & Liechti, M. E. (2024). Methylenedioxymethamphetamine is a connectogen with empathogenic, entactogenic, and still further connective properties: It is time to reconcile “the great entactogen—empathogen debate”. Journal of Psychopharmacology, 38(8), 685–689. https://doi.org/10.1177/02698811241265352

Atila, Cihan, Beck, Julia, Refardt, Julie, Erlic, Zoran, Drummond, Juliana B., Sailer, Clara O., Liechti, Matthias E., Rocha, Beatriz Santana Soares, Beuschlein, Felix, Winzeler, Bettina, & Christ-Crain, Mirjam. (2024). Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia compared to healthy controls. European Journal of Endocrinology, 190(5), 354–362. https://doi.org/10.1093/ejendo/lvae040

Avram, Mihai, Müller, Felix, Preller, Katrin H., Razi, Adeel, Rogg, Helena, Korda, Alexandra, Holze, Friederike, Vizeli, Patrick, Ley, Laura, Liechti, Matthias E., & Borgwardt, Stefan. (2024). Effective Connectivity of Thalamocortical Interactions Following d-Amphetamine, LSD, and MDMA Administration. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(5), 522–532. https://doi.org/10.1016/j.bpsc.2023.07.010

Holze, Friederike, Singh, Nirmal, Liechti, Matthias E., & D’Souza, Deepak Cyril. (2024). Serotonergic Psychedelics: A Comparative Review of Efficacy, Safety, Pharmacokinetics, and Binding Profile. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(5), 472–489. https://doi.org/10.1016/j.bpsc.2024.01.007

Luethi, Dino, Rudin, Deborah, Straumann, Isabelle, Thomann, Jan, Avedisian, Isidora, Liechti, Matthias E., & Duthaler, Urs. (2024). Derivatization-free determination of chiral plasma pharmacokinetics of MDMA and its enantiomers. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1238. https://doi.org/10.1016/j.jchromb.2024.124123

Thomann, Jan, Vogt, Severin B., Guessoum, Adrian, Meyer, Maximilian, Vogel, Marc, Liechti, Matthias E., Luethi, Dino, & Duthaler, Urs. (2024). Development and validation of an LC-MS/MS method for quantifying diamorphine and its major metabolites 6-monoacetylmorphine, morphine, morphine-3-glucuronide, and morphine-6-glucuronide in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1237. https://doi.org/10.1016/j.jchromb.2024.124104

Arias, Hugo R., Rudin, Deborah, Hines, Dustin J., Contreras, April, Gulsevin, Alican, Manetti, Dina, Anouar, Youssef, De Deurwaerdere, Philippe, Meiler, Jens, Romanelli, Maria Novella, Liechti, Matthias E., & Chagraoui, Abdeslam. (2024). The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation. European Journal of Pharmacology, 966. https://doi.org/10.1016/j.ejphar.2024.176329

Atila, C., Straumann, I., Vizeli, P., Beck, J., Monnerat, S., Holze, F., Liechti, M. E., & Christ-Crain, M. (2024). Oxytocin, Not Vasopressin, Mediates High Incidence of MDMA-Induced Hyponatremia - A Complication Preventable by Fluid Restriction [Posted-content]. Elsevier BV. https://doi.org/10.2139/ssrn.4819307

Holze, Friederike, Erne, Livio, Duthaler, Urs, & Liechti, Matthias E. (2024). Pharmacokinetics, pharmacodynamics and urinary recovery of oral lysergic acid diethylamide administration in healthy participants. British Journal of Clinical Pharmacology, 90(1), 200–208. https://doi.org/10.1111/bcp.15887

Holze, F., Liechti, M. E., & Müller, F. (2024). Pharmacological Properties of Psychedelics with a Special Focus on Potential Harms. In Current Topics in Behavioral Neurosciences. Springer Berlin Heidelberg. https://doi.org/10.1007/7854_2024_510

Klaiber, Aaron, Humbert-Droz, Mélusine, Ley, Laura, Schmid, Yasmin, & Liechti, Matthias E. (2024). Safety pharmacology of acute mescaline administration in healthy participants. British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.16349

E-Wen McCulloch, D., Liechti, M. E., Kuypers, K. PC., Nutt, D., Lundberg, J., Stenbæk, D. S., Goodwin, G. M., Gründer, G., Butlen-Ducuing, F., Haberkamp, M., Thirstrup, S., & Knudsen, G. M. (2024). Knowledge gaps in psychedelic medicalisation: Clinical studies and regulatory aspects [Journal-article]. Neuroscience Applied, 3, 103938. https://doi.org/10.1016/j.nsa.2024.103938

Liechti, Matthias E. (2024). Psychedelics as medication? Revue Medicale Suisse, 20, 118–119. https://doi.org/10.53738/revmed.2024.20.858.118

Stocker, Kurt, Hartmann, Matthias, Ley, Laura, Becker, Anna M, Holze, Friederike, & Liechti, Matthias E. (2024). The revival of the psychedelic experience scale: Revealing its extended-mystical, visual, and distressing experiential spectrum with LSD and psilocybin studies. Journal of Psychopharmacology, 38(1), 80–100. https://doi.org/10.1177/02698811231199112

Straumann, I., Holze, F., Becker, A. M., Ley, L., Halter, N., & Liechti, M. E. (2024). Safety pharmacology of acute psilocybin administration in healthy participants [Journal-article]. Neuroscience Applied, 3, 104060. https://doi.org/10.1016/j.nsa.2024.104060

Thomann, Jan, Kolaczynska, Karolina E., Stoeckmann, Oliver V., Rudin, Deborah, Vizeli, Patrick, Hoener, Marius C., Pryce, Christopher R., Vollenweider, Franz X., Liechti, Matthias E., & Duthaler, Urs. (2024). In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin. Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1391689

Thomann, Jan, Kolaczynska, Karolina E., Stoeckmann, Oliver V., Rudin, Deborah, Vizeli, Patrick, Hoener, Marius C., Pryce, Christopher R., Vollenweider, Franz X., Liechti, Matthias E., & Duthaler, Urs. (2024). In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin [Journal-article]. Frontiers in Pharmacology, 15. https://doi.org/10.3389/fphar.2024.1391689

Waters, M. L., Dargan, P. I., Yates, C., Dines, A. M., Eyer, F., Giraudon, I., Heyerdahl, F., Hovda, K. E., Liechti, M. E., Miró, Ò., Vallersnes, O. M., Anseeuw, K., Badaras, R., Bitel, M., Bonnici, J., Brvar, M., Caganova, B., Calýskan, F., Ceschi, A., et al. (2024). Clinical effects of cannabis compared to synthetic cannabinoid receptor agonists (SCRAs): a retrospective cohort study of presentations with acute toxicity to European hospitals between 2013 and 2020. Clinical Toxicology, 62(6), 378–384. https://doi.org/10.1080/15563650.2024.2346125

Straumann, Isabelle, Ley, Laura, Holze, Friederike, Becker, Anna M., Klaiber, Aaron, Wey, Kathrin, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants. Neuropsychopharmacology, 48(13), 1840–1848. https://doi.org/10.1038/s41386-023-01609-0

Vallersnes, O. M., Dines, A. M., Wood, D. M., Heyerdahl, F., Hovda, K. E., Yates, C., Giraudon, I., Caganova, B., Ceschi, A., Galicia, M., Liakoni, E., Liechti, M. E., Miró, Ò., Noseda, R., Persett, P. S., Põld, K., Schmid, Y., Scholz, I., Vigorita, F., & Dargan, P. I. (2023). Self-discharge during treatment for acute recreational drug toxicity: an observational study from emergency departments in seven European countries. International Journal of Emergency Medicine, 16(1). https://doi.org/10.1186/s12245-023-00566-1

Vogt, Severin B., Ley, Laura, Erne, Livio, Straumann, Isabelle, Becker, Anna M., Klaiber, Aaron, Holze, Friederike, Vandersmissen, Anja, Mueller, Lorenz, Duthaler, Urs, Rudin, Deborah, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants. Translational Psychiatry, 13(1). https://doi.org/10.1038/s41398-023-02477-4

Ley, Laura, Holze, Friederike, Arikci, Denis, Becker, Anna M., Straumann, Isabelle, Klaiber, Aaron, Coviello, Fabio, Dierbach, Sophie, Thomann, Jan, Duthaler, Urs, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants. Neuropsychopharmacology, 48(11), 1659–1667. https://doi.org/10.1038/s41386-023-01607-2

Ley, Laura, Holze, Friederike, Arikci, Denis, Becker, Anna M., Straumann, Isabelle, Klaiber, Aaron, Coviello, Fabio, Dierbach, Sophie, Thomann, Jan, Duthaler, Urs, Luethi, Dino, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants [Journal-article]. Neuropsychopharmacology, 48(11), 1659–1667. https://doi.org/10.1038/s41386-023-01607-2

Noseda, Roberta, Franchi, Matteo, Pagnamenta, Alberto, Müller, Laura, Dines, Alison M., Giraudon, Isabelle, Heyerdahl, Fridtjof, Eyer, Florian, Hovda, Knut Erik, Liechti, Matthias E., Miró, Òscar, Vallersnes, Odd Martin, Yates, Christopher, Dargan, Paul I., Wood, David M., & Ceschi, Alessandro. (2023). Determinants of Admission to Critical Care Following Acute Recreational Drug Toxicity: A Euro-DEN Plus Study. Journal of Clinical Medicine, 12(18). https://doi.org/10.3390/jcm12185970

Atila, Cihan, Holze, Friederike, Murugesu, Rakithan, Rommers, Nikki, Hutter, Nina, Varghese, Nimmy, Sailer, Clara O, Eckert, Anne, Heinrichs, Markus, Liechti, Matthias E, & Christ-Crain, Mirjam. (2023). Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial. The Lancet Diabetes and Endocrinology, 11(7), 454–464. https://doi.org/10.1016/s2213-8587(23)00120-1

Bedford, Peter, Hauke, Daniel J., Wang, Zheng, Roth, Volker, Nagy-Huber, Monika, Holze, Friederike, Ley, Laura, Vizeli, Patrick, Liechti, Matthias E., Borgwardt, Stefan, Müller, Felix, & Diaconescu, Andreea O. (2023). The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity. Neuropsychopharmacology, 48(8), 1175–1183. https://doi.org/10.1038/s41386-023-01574-8

Anderson, C. E., Kozomara, M., Birkhäuser, V., Bywater, M., Gross, O., Kiss, S., Knüpfer, S. C., Koschorke, M., Leitner, L., Mehnert, U., Sadri, H., Sammer, U., Stächele, L., Tornic, J., Liechti, M. D., Brinkhof, M. W. G., & Kessler, T. M. (2023). Temporal development of unfavourable urodynamic parameters during the first year after spinal cord injury. BJU International, 131(4), 503–512. https://doi.org/10.1111/bju.15918

Holze, Friederike, Becker, Anna M., Kolaczynska, Karolina E., Duthaler, Urs, & Liechti, Matthias E. (2023). Pharmacokinetics and Pharmacodynamics of Oral Psilocybin Administration in Healthy Participants. Clinical Pharmacology and Therapeutics, 113(4), 822–831. https://doi.org/10.1002/cpt.2821

Becker, Anna M., Klaiber, Aaron, Holze, Friederike, Istampoulouoglou, Ioanna, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2023). Ketanserin Reverses the Acute Response to LSD in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Participants. International Journal of Neuropsychopharmacology, 26(2), 97–106. https://doi.org/10.1093/ijnp/pyac075

Holze, Friederike, Gasser, Peter, Müller, Felix, Dolder, Patrick C., & Liechti, Matthias E. (2023). Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study. Biological Psychiatry, 93(3), 215–223. https://doi.org/10.1016/j.biopsych.2022.08.025

Miró, Òscar, Burillo-Putze, Guillermo, Schmid, Yasmin, Salgado, Emilio, Liechti, Matthias E., Dines, Alison M., Giraudon, Isabelle, Heyerdahl, Fridtjof, Hovda, Knut Erik, Vallersne, Odd Martin, Eyer, Florian, Wood, David M., Yates, Christopher, Dargan, Paul I., Galicia, Miguel, & Euro-DEN Plus Research Group. (2023). Severity of emergency department presentations due to acute drug toxicity in Europe: A longitudinal analysis over a 6-year period (2014-2019) stratified by sex. European Journal of Emergency Medicine, 30(1), 21–31. https://doi.org/10.1097/MEJ.0000000000000978

Felix Müller, H. Zaczek, Anna M. Becker, Laura Ley, Stefan Borgwardt, J. Santos de Jesus, N. Loh, J. Kohut, M. Auernig, Christopher Boehlke, & Matthias E Liechti. (2023, January 1). Lysergic acid diethylamide for depression — a randomized, double-blind, low dose-controlled phase ii trial. 36th ECNP Congress. https://doi.org/10.1016/j.nsa.2023.103912

Halberstadt, Adam L., Luethi, Dino, Hoener, Marius C., Trachsel, Daniel, Brandt, Simon D., & Liechti, Matthias E. (2023). Use of the head-twitch response to investigate the structure–activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines. Psychopharmacology, 240(1), 115–126. https://doi.org/10.1007/s00213-022-06279-2

Kern, C., Müller, P., Chaccour, C., Liechti, M. E., Hammann, F., & Duthaler, U. (2023). Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes. Malar J, 22(1), 194. https://doi.org/10.1186/s12936-023-04624-0

Reissmann, Steffen, Hartmann, Matthias, Kist, Andreas, Liechti, Matthias E., & Stocker, Kurt. (2023). Case report: Maintaining altered states of consciousness over repeated ketamine infusions may be key to facilitate long-lasting antidepressant effects: some initial lessons from a personalized-dosing single-case study. Frontiers in Psychiatry, 14. https://doi.org/10.3389/fpsyt.2023.1197697

Rudin, Deborah, Areesanan, Alexander, Liechti, Matthias E., & Gründemann, Carsten. (2023). Classic psychedelics do not affect T cell and monocyte immune responses. Frontiers in Psychiatry, 14, 1042440. https://doi.org/10.3389/fpsyt.2023.1042440

Luethi, Dino, Kolaczynska, Karolina E., Vogt, Severin B., Ley, Laura, Erne, Livio, Liechti, Matthias E., & Duthaler, Urs. (2022). Liquid chromatography–tandem mass spectrometry method for the bioanalysis of N,N-dimethyltryptamine (DMT) and its metabolites DMT-N-oxide and indole-3-acetic acid in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1213. https://doi.org/10.1016/j.jchromb.2022.123534

Bedford, P., Hauke, D. J., Wang, Z., Roth, V., Nagy-Huber, M., Holze, F., Ley, L., Vizeli, P., Liechti, M. E., Borgwardt, S., Müller, F., & Diaconescu, A. O. (2022). The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.11.01.514687

Thomann J, Ley L, Klaiber A, Liechti ME, & Duthaler U. (2022). Development and validation of an LC-MS/MS method for the quantification of mescaline and major metabolites in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 220, 114980. https://doi.org/10.1016/j.jpba.2022.114980

Avram, Mihai, Müller, Felix, Rogg, Helena, Korda, Alexandra, Andreou, Christina, Holze, Friederike, Vizeli, Patrick, Ley, Laura, Liechti, Matthias E., & Borgwardt, Stefan. (2022). Characterizing Thalamocortical (Dys)connectivity Following D-Amphetamine, LSD, and MDMA Administration. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(9), 885–894. https://doi.org/10.1016/j.bpsc.2022.04.003

Heier, Eva-Carina, Eyer, Florian, Rabe, Christian, Geith, Stefanie, Dargan, Paul I., Wood, David M., Heyerdahl, Fridtjof, Dines, Alison M., Giraudon, Isabelle, Erik Hovda, Knut, Yates, Chris, Vallersnes, Odd Martin, Miró, Òscar, Liechti, Matthias E., Zellner, Tobias, Anand, Lukasz, Waldman, Wojciech, Anseeuw, Kurt, Gillebeert, Johan, et al. (2022). Clinical effect of ethanol co-use in patients with acute drug toxicity involving the use of central nervous system depressant recreational drugs. European Journal of Emergency Medicine, 29(4), 291–300. https://doi.org/10.1097/MEJ.0000000000000932

Stocker K., Hartmann M., Reissmann S., Kist A., & Liechti M.E. (2022). Buddhist-like opposite diminishing and non-judging during ketamine infusion are associated with antidepressant response: an open-label personalized-dosing study. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.916641

Vizeli P, Straumann I, Duthaler U, Varghese N, Eckert A, Paulus MP, Risbrough V, & Liechti ME. (2022). Effects of 3,4-Methylenedioxymethamphetamine on Conditioned Fear Extinction and Retention in a Crossover Study in Healthy Subjects. Frontiers in Pharmacology, 13, 906639. https://doi.org/10.3389/fphar.2022.906639

Kolaczynska K.E., Ducret P., Trachsel D., Hoener M.C., Liechti M.E., & Luethi D. (2022). Pharmacological characterization of 3,4-methylenedioxamphetamine (MDA) analogs and two amphetamine-based compounds: N,α-DEPEA and DPIA. European Neuropsychopharmacology, 59, 9–22. https://doi.org/10.1016/j.euroneuro.2022.03.006

Holze, Friederike, Ley, Laura, Müller, Felix, Becker, Anna M., Straumann, Isabelle, Vizeli, Patrick, Kuehne, Sebastian Silva, Roder, Marc A., Duthaler, Urs, Kolaczynska, Karolina E., Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2022). Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects [Journal-article]. Neuropsychopharmacology, 47(6), 1180–1187. https://doi.org/10.1038/s41386-022-01297-2

Luethi D., & Liechti M.E. (2022). Correction to: Designer drugs: mechanism of action and adverse effects (Archives of Toxicology, (2020), 94, 4, (1085-1133), 10.1007/s00204-020-02693-7). Archives of Toxicology, 96(5), 1489. https://doi.org/10.1007/s00204-022-03244-y

Ilic M., Maier J., Holy M., Jaentsch K., Liechti M.E., Lubec G., Baumann M.H., Sitte H.H., & Luethi D. (2022). Corrigendum: Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters(Front. Pharmacol., (2020), 11, (673), 10.3389/fphar.2020.00673). Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.878641

Becker, Anna M., Holze, Friederike, Grandinetti, Tanja, Klaiber, Aaron, Toedtli, Vanja E., Kolaczynska, Karolina E., Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Grünblatt, Edna, & Liechti, Matthias E. (2022). Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects. Clinical Pharmacology & Therapeutics, 111(4), 886–895. https://doi.org/10.1002/cpt.2487

Crulli, B., Dines, A. M., Blanco, G., Giraudon, I., Eyer, F., Liechti, M. E., Miró, Ò., Hovda, K. E., Heyerdahl, F., Yates, C., Vallersnes, O. M., Wood, D. M., & Dargan, P. I. (2022). Novel psychoactive substances-related presentations to the emergency departments of the European drug emergencies network plus (Euro-DEN plus) over the six-year period 2014–2019. Clinical Toxicology, 60(12), 1318–1327. https://doi.org/10.1080/15563650.2022.2137524

Holze, Friederike, Caluori, Toya V., Vizeli, Patrick, & Liechti, Matthias E. (2022). Safety pharmacology of acute LSD administration in healthy subjects. Psychopharmacology, 239(6), 1893–1905. https://doi.org/10.1007/s00213-021-05978-6

Holze, Friederike, Caluori, Toya V., Vizeli, Patrick, & Liechti, Matthias E. (2022). Correction to: Safety pharmacology of acute LSD administration in healthy subjects. Psychopharmacology, 239(2), 661. https://doi.org/10.1007/s00213-021-05988-4

Holze, Friederike, Ley, Laura, Müller, Felix, Becker, Anna M., Straumann, Isabelle, Vizeli, Patrick, Kuehne, Sebastian Silva, Roder, Marc A., Duthaler, Urs, Kolaczynska, Karolina E., Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2022). Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 47(6), 1180–1187. https://doi.org/10.1038/s41386-022-01297-2

Kolaczynska, Karolina E., Luethi, Dino, Trachsel, Daniel, Hoener, Marius C., & Liechti, Matthias E. (2022). Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines. Frontiers in Pharmacology, 12, 794254. https://doi.org/10.3389/fphar.2021.794254

Liechti, Matthias E., & Holze, Friederike. (2022). Dosing Psychedelics and MDMA. In Current Topics in Behavioral Neurosciences (Vol. 56, pp. 3–21). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/7854_2021_270

Müller, Felix, Kraus, Elias, Holze, Friederike, Becker, Anna, Ley, Laura, Schmid, Yasmin, Vizeli, Patrick, Liechti, Matthias E., & Borgwardt, Stefan. (2022). Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants. Psychopharmacology, 239(6), 1933–1943. https://doi.org/10.1007/s00213-022-06066-z

Preveden N, Liechti M.E., Oettl T, & Erb S. (2022). Metamizole as a Rare Cause of Drug-Induced Liver Injury. European Journal of Case Reports in Internal Medicine, 9(5). https://doi.org/10.12890/2022_003349

Schmid Y, Galicia M, Vogt SB, Liechti ME, Burillo-Putze G, Dargan PI, Dines AM, Giraudon I, Heyerdahl F, Hovda KE, Wood DM, Yates C, Miró Ò, & (on behalf of the Euro-DEN Plus Research Group). (2022). Differences in clinical features associated with cannabis intoxication in presentations to European emergency departments according to patient age and sex. Clinical Toxicology, 60(8), 912–919. https://doi.org/10.1080/15563650.2022.2060116

Schmid, Yasmin, Gasser, Peter, Oehen, Peter, & Liechti, Matthias E. (2021). Acute subjective effects in LSD- and MDMA-assisted psychotherapy. Journal of Psychopharmacology, 35(4), 362–374. https://doi.org/10.1177/0269881120959604

Holze, Friederike, Liechti, Matthias E, Hutten, Nadia R P W, Mason, Natasha L, Dolder, Patrick C, Theunissen, Eef L, Duthaler, Urs, Feilding, Amanda, Ramaekers, Johannes G, & Kuypers, Kim P C. (2021). Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants. Clinical Pharmacology and Therapeutics, 109(3), 658–666. https://doi.org/10.1002/cpt.2057

Holze, Friederike, Liechti, Matthias E., Hutten, Nadia R.P.W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., Duthaler, Urs, Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P.C. (2021). Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants. Clinical Pharmacology and Therapeutics, 109(3), 658–666. https://doi.org/10.1002/cpt.2057

Leitner, L., Ujmajuridze, A., Chanishvili, N., Goderdzishvili, M., Chkonia, I., Rigvava, S., Chkhotua, A., Changashvili, G., McCallin, S., Schneider, M. P., Liechti, M. D., Mehnert, U., Bachmann, L. M., Sybesma, W., & Kessler, T. M. (2021). Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double-blind clinical trial. The Lancet Infectious Diseases, 21(3), 427–436. https://doi.org/10.1016/s1473-3099(20)30330-3

Holze, Friederike, Vizeli, Patrick, Ley, Laura, Müller, Felix, Dolder, Patrick, Stocker, Melanie, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2021). Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 46(3), 537–544. https://doi.org/10.1038/s41386-020-00883-6

Holze, Friederike, Vizeli, Patrick, Ley, Laura, Müller, Felix, Dolder, Patrick, Stocker, Melanie, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, & Liechti, Matthias E. (2021). Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology, 46(3), 537–544. https://doi.org/10.1038/s41386-020-00883-6

Kolaczynska, Karolina E, Liechti, Matthias E, & Duthaler, Urs. (2021). Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin’s main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1164, 122486. https://doi.org/10.1016/j.jchromb.2020.122486

Kolaczynska KE, Liechti ME, & Duthaler U. (2021). Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin’s main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1164, 122486. https://doi.org/10.1016/j.jchromb.2020.122486

Müller, Felix, Holze, Friederike, Dolder, Patrick, Ley, Laura, Vizeli, Patrick, Soltermann, Alain, Liechti, Matthias E, & Borgwardt, Stefan. (2021). MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens. Neuropsychopharmacology, 46(3), 545–553. https://doi.org/10.1038/s41386-020-00906-2

Müller, Felix, Holze, Friederike, Dolder, Patrick, Ley, Laura, Vizeli, Patrick, Soltermann, Alain, Liechti, Matthias E., & Borgwardt, Stefan. (2021). MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens. Neuropsychopharmacology, 46(3), 545–553. https://doi.org/10.1038/s41386-020-00906-2

Noseda, Roberta, Schmid, Yasmin, Scholz, Irene, Liakoni, Evangelia, Liechti, Matthias E, Dargan, Paul I, Wood, David M, Dines, Alison M, Yates, Christopher, Heyerdahl, Fridtjof, Hovda, Knut E, Giraudon, Isabelle, Ceschi, Alessandro, & Euro-DEN Research Group. (2021). MDMA-related presentations to the emergency departments of the European Drug Emergencies Network plus (Euro-DEN Plus) over the four-year period 2014-2017. Clinical Toxicology (Philadelphia, Pa.), 59(2), 131–137. https://doi.org/10.1080/15563650.2020.1784914

Noseda R, Schmid Y, Scholz I, Liakoni E, Liechti ME, Dargan PI, Wood DM, Dines AM, Yates C, Heyerdahl F, Hovda KE, Giraudon I, Ceschi A, & Euro-DEN Research Group. (2021). MDMA-related presentations to the emergency departments of the European Drug Emergencies Network plus (Euro-DEN Plus) over the four-year period 2014-2017. Clinical Toxicology (Philadelphia, Pa.), 59(2), 131–137. https://doi.org/10.1080/15563650.2020.1784914

Dolder, Patrick C., Liechti, Matthias E., & Rentsch, Katharina M. (2021). Development and validation of a rapid turboflow LC-MS/MS method for the quantification of LSD and 2-oxo-3-hydroxy LSD in serum and urine samples of emergency toxicological cases. Analytical and Bioanalytical Chemistry, 407(6), 1577–1584. https://doi.org/10.1007/s00216-014-8388-1

Holze, Friederike, Avedisian, Isidora, Varghese, Nimmy, Eckert, Anne, & Liechti, Matthias E. (2021). Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin. Frontiers in Pharmacology, 12, 711255. https://doi.org/10.3389/fphar.2021.711255

Hutten, Nadia R. P. W., Mason, Natasha L., Dolder, Patrick C., Theunissen, Eef L., Holze, Friederike, Liechti, Matthias E., Varghese, Nimmy, Eckert, Anne, Feilding, Amanda, Ramaekers, Johannes G., & Kuypers, Kim P. C. (2021). Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers. ACS Pharmacology & Translational Science, 4(2), 461–466. https://doi.org/10.1021/acsptsci.0c00099

Kolaczynska, Karolina E., Thomann, Jan, Hoener, Marius C., & Liechti, Matthias E. (2021). The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative. International journal of molecular sciences, 22(15), 8277. https://doi.org/10.3390/ijms22158277

Liechti, Matthias E., & Holze, Friederike. (2021). Dosing Psychedelics and MDMA. Current Topics in Behavioral Neurosciences, in press. https://doi.org/10.1007/7854_2021_270

Liechti M.E., Simmler L.D., Sitte H.H., & Luethi D. (2021). Pharmacological profiling of novel psychoactive substances. In Novel Psychoactive Substances: Classification, Pharmacology and Toxicology (pp. 109–130). Elsevier. https://doi.org/10.1016/b978-0-12-818788-3.00003-6

Luethi D., & Liechti M.E. (2021). Drugs of Abuse Affecting 5-HT2B Receptors. In Receptors (Vol. 35, pp. 277–289). Humana Press Inc. https://doi.org/10.1007/978-3-030-55920-5_16

Miro O., Waring W.S., Dargan P.I., Wood D.M., Dines A.M., Yates C., Giraudon I., Moughty A., O’Connor N., Heyerdahl F., Hovda K.E., Vallersnes O.M., Paasma R., Pold K., Jurgens G., Megarbane B., Anand J.S., Liakoni E., Liechti M., et al. (2021). Variation of drugs involved in acute drug toxicity presentations based on age and sex: an epidemiological approach based on European emergency departments. Clinical Toxicology, 59(10), 896–904. https://doi.org/10.1080/15563650.2021.1884693

Ramaekers, Johannes G., Hutten, Nadia, Mason, Natasha L., Dolder, Patrick, Theunissen, Eef L., Holze, Friederike, Liechti, Matthias E., Feilding, Amanda, & Kuypers, Kim P. C. (2021). A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers. Journal of Psychopharmacology, 35(4), 398–405. https://doi.org/10.1177/0269881120940937

Rudin, Deborah, Liechti, Matthias E., & Luethi, Dino. (2021). Molecular and clinical aspects of potential neurotoxicity induced by new psychoactive stimulants and psychedelics. Experimental Neurology, 343, 113778. https://doi.org/10.1016/j.expneurol.2021.113778

Studerus, Erich, Vizeli, Patrick, Harder, Samuel, Ley, Laura, & Liechti, Matthias E. (2021). Prediction of MDMA response in healthy humans: a pooled analysis of placebo-controlled studies. Journal of Psychopharmacology, 35(5), 556–565. https://doi.org/10.1177/0269881121998322

Vizeli, Patrick, Straumann, Isabelle, Holze, Friederike, Schmid, Yasmin, Dolder, Patrick C., & Liechti, Matthias E. (2021). Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis. Scientific Reports, 11(1), 10851. https://doi.org/10.1038/s41598-021-90343-y