Prof. Dr. Ivan Martin

Seitz, Sarina, Lehoczky, Gyözö, Wixmerten, Anke, Schuster-Amft, Corina, Miot, Sylvie, Shrestha, Kristin, Schaedelin, Sabine, Martin, Ivan, & Mumme, Marcus. (2025). Treatment of patellofemoral osteoarthritis with nasal chondrocyte-based engineered cartilage implantation in a randomised, controlled, multicentre phase II clinical trial: protocol for a randomised controlled trial [Journal-article]. BMJ Open, 15(8), e106140. https://doi.org/10.1136/bmjopen-2025-106140

Mumme, Marcus, Wixmerten, Anke, Ivkovic, Alan, Peretti Giuseppe M, Yilmaz, Tayfun, Reppenhagen, Stephan, Pullig, Olliver, Miot, Sylvie, Izadpanah, Kaywan, Jakob, Marcel, Mangiavini, Laura, Sosio, Corrado, Vuletić, Filip, Bieri, Oliver, Biguzzi, Stefano, Gahl, Brigitta, Lehoczky, Gyözö, Vukojevic, Rudolf, Häusner, Sebastian, et al. (2025). Clinical relevance of engineered cartilage maturation in a randomized multicenter trial for articular cartilage repair. Science Translational Medicine, 17(788). https://doi.org/10.1126/scitranslmed.ads0848

Kaiser, Benedict, Miot, Sylvie, Wixmerten, Anke, Pullig, Oliver, Eyrich, Matthias, Fulco, Ilario, Vavrina, Josef, Schaefer, Dirk J., Martin, Ivan, Barbero, Andrea, & Haug, Martin D. (2024). Engineered autologous nasal cartilage for repair of nasal septal perforations: a case series [Journal-article]. International journal of surgery (London, England), 110(10), 6573–6580. https://doi.org/10.1097/js9.0000000000001843

Dönges, Laura, Damle, Atharva, Mainardi, Andrea, Bock, Thomas, Schönenberger, Monica, Martin, Ivan, & Barbero, Andrea. (2024). Engineered human osteoarthritic cartilage organoids [Journal-article]. Biomaterials, 308, 122549. https://doi.org/10.1016/j.biomaterials.2024.122549

Majumder, Nilotpal, Roy, Chandrashish, Doenges, Laura, Martin, Ivan, Barbero, Andrea, & Ghosh, Sourabh. (2024). Covalent Conjugation of Small Molecule Inhibitors and Growth Factors to a Silk Fibroin-Derived Bioink to Develop Phenotypically Stable 3D Bioprinted Cartilage [Journal-article]. ACS Applied Materials and Interfaces, 16(8), 9925–9943. https://doi.org/10.1021/acsami.3c18903

Bonaiti, Elena, Muraro, Manuele G., Robert, Philippe A., Jakscha, Jens, Dirnhofer, Stefan, Martin, Ivan, & Berger, Christoph T. (2024). Tonsil explants as a human in vitro model to study vaccine responses [Journal-article]. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1425455

Schaller, Romain, Moya, Adrien, Zhang, Gangyu, Chaaban, Mansoor, Paillaud, Robert, Bartoszek, Ewelina M, Schaefer, Dirk J, Martin, Ivan, Kaempfen, Alexandre, & Scherberich, Arnaud. (2024). Engineered phalangeal grafts for children with symbrachydactyly: A proof of concept [Journal-article]. Journal of Tissue Engineering, 15. https://doi.org/10.1177/20417314241257352

Chaaban, Mansoor, Moya, Adrien, García-García, Andres, Paillaud, Robert, Schaller, Romain, Klein, Thibaut, Power, Laura, Buczak, Katarzyna, Schmidt, Alexander, Kappos, Elisabeth, Ismail, Tarek, Schaefer, Dirk J., Martin, Ivan, & Scherberich, Arnaud. (2023). Harnessing human adipose-derived stromal cell chondrogenesis in vitro for enhanced endochondral ossification [Journal-article]. Biomaterials, 303. https://doi.org/10.1016/j.biomaterials.2023.122387

Viswanathan S, Blanc KL, Ciccocioppo R, Dagher G, Filiano AJ, Galipeau J, Krampera M, Krieger L, Lalu MM, Nolta J, Rodriguez Pardo VM, Shi Y, Tarte K, Weiss DJ, & Martin I. (2023). An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells (MSC) Committee perspectives on International Standards Organization/Technical Committee 276 Biobanking Standards for bone marrow-MSCs and umbilical cord tissue–derived MSCs for research purposes. Cytotherapy, 25(8), 803–807. https://doi.org/10.1016/j.jcyt.2023.04.005

Muthu S, Korpershoek JV, Novais EJ, Tawy GF, Hollander AP, & Martin I. (2023). Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies. Nature Reviews Rheumatology, 19(7), 403–416. https://doi.org/10.1038/s41584-023-00979-5

García-García, Andrés, Pigeot, Sébastien, & Martin, Ivan. (2023). Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity. Bioactive Materials, 24, 174–184. https://doi.org/10.1016/j.bioactmat.2022.12.017

Wixmerten, Anke, Miot, Sylvie, Bittorf, Patrick, Wolf, Francine, Feliciano, Sandra, Hackenberg, Stephan, Häusner, Sebastian, Krenger, Werner, Haug, Martin, Martin, Ivan, Pullig, Oliver, & Barbero, Andrea. (2023). Good Manufacturing Practice–compliant change of raw material in the manufacturing process of a clinically used advanced therapy medicinal product–a comparability study. Cytotherapy, 25(5), 548–558. https://doi.org/10.1016/j.jcyt.2023.01.003

Gu, Yawei, Pigeot, Sebastien, Ahrens, Lucas, Tribukait-Riemenschneider, Fabian, Sarem, Melika, Wolf, Francine, García-García, Andres, Barbero, Andrea, Martin, Ivan, & Shastri, V. Prasad. (2023). Toward 3D Bioprinting of Osseous Tissue of Predefined Shape Using Single-Matrix Cell-Bioink Constructs. Advanced Healthcare Materials, 12(9). https://doi.org/10.1002/adhm.202202550

Dasen, Boris, Pigeot, Sebastien, Born, Gordian Manfred, Verrier, Sophie, Rivero, Olga, Dittrich, Petra S., Martin, Ivan, & Filippova, Maria. (2023). T-cadherin is a novel regulator of pericyte function during angiogenesis. American Journal of Physiology - Cell Physiology, 324(4), C821–C836. https://doi.org/10.1152/ajpcell.00326.2022

Born, Gordian, Plantier, Evelia, Nannini, Guido, Caimi, Alessandro, Mazzoleni, Andrea, Asnaghi, M. Adelaide, Muraro, Manuele G., Scherberich, Arnaud, Martin, Ivan, & García-García, Andrés. (2023). Mini- and macro-scale direct perfusion bioreactors with optimized flow for engineering 3D tissues. Biotechnology Journal, 18(2). https://doi.org/10.1002/biot.202200405

Kasamkattil, Jesil, Gryadunova, Anna, Schmid, Raphael, Gay-Dujak, Max Hans Peter, Dasen, Boris, Hilpert, Morgane, Pelttari, Karoliina, Martin, Ivan, Schären, Stefan, Barbero, Andrea, Krupkova, Olga, & Mehrkens, Arne. (2023). Human 3D nucleus pulposus microtissue model to evaluate the potential of pre-conditioned nasal chondrocytes for the repair of degenerated intervertebral disc. Frontiers in Bioengineering and Biotechnology, 11. https://doi.org/10.3389/fbioe.2023.1119009

Chawla, Shikha, Mainardi, Andrea, Majumder, Nilotpal, Dönges, Laura, Kumar, Bhupendra, Occhetta, Paola, Martin, Ivan, Egloff, Christian, Ghosh, Sourabh, Bandyopadhyay, Amitabha, & Barbero, Andrea. (2022). Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies. Cells, 11(24). https://doi.org/10.3390/cells11244034

Kouba L, Bürgin J, Born G, Perale G, Schaefer DJ, Scherberich A, Pigeot S, & Martin I. (2022). A composite, off-the-shelf osteoinductive material for large, vascularized bone flap prefabrication. Acta Biomaterialia, 154, 641–649. https://doi.org/10.1016/j.actbio.2022.10.023

Weiss D.J., Filiano A., Galipeau J., Khoury M., Krampera M., Lalu M., Blanc K.L., Nolta J., Phinney D.G., Rocco P.R.M., Shi Y., Tarte K., Viswanathan S., & Martin I. (2022). An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells Committee editorial on overcoming limitations in clinical trials of mesenchymal stromal cell therapy for coronavirus disease-19: time for a global registry. Cytotherapy, 24(11), 1071–1073. https://doi.org/10.1016/j.jcyt.2022.07.010

Ding M, Koroma KE, Wendt D, Martin I, Martinetti R, Jespersen S, Schrøder HD, & Overgaard S. (2022). Efficacy of bioreactor-activated bone substitute with bone marrow nuclear cells on fusion rate and fusion mass microarchitecture in sheep. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 110(8), 1862–1875. https://doi.org/10.1002/jbm.b.35044

Lehoczky, Gyözö, Trofin, Raluca Elena, Vallmajo-Martin, Queralt, Chawla, Shikha, Pelttari, Karoliina, Mumme, Marcus, Haug, Martin, Egloff, Christian, Jakob, Marcel, Ehrbar, Martin, Martin, Ivan, & Barbero, Andrea. (2022). In Vitro and Ectopic In Vivo Studies toward the Utilization of Rapidly Isolated Human Nasal Chondrocytes for Single-Stage Arthroscopic Cartilage Regeneration Therapy. International Journal of Molecular Sciences, 23(13). https://doi.org/10.3390/ijms23136900

Scialla S, Gullotta F, Izzo D, Palazzo B, Scalera F, Martin I, Sannino A, & Gervaso F. (2022). Genipin-crosslinked collagen scaffolds inducing chondrogenesis: a mechanical and biological characterization. Journal of Biomedical Materials Research - Part A, 110(7), 1372–1385. https://doi.org/10.1002/jbm.a.37379

Cheng C, Chaaban M, Born G, Martin I, Li Q, Schaefer DJ, Jaquiery C, & Scherberich A. (2022). Repair of a Rat Mandibular Bone Defect by Hypertrophic Cartilage Grafts Engineered From Human Fractionated Adipose Tissue. Frontiers in Bioengineering and Biotechnology, 10, 841690. https://doi.org/10.3389/fbioe.2022.841690

Huo, Zihe, Bilang, Remo, Supuran, Claudiu T., von der Weid, Nicolas, Bruder, Elisabeth, Holland-Cunz, Stefan, Martin, Ivan, Muraro, Manuele G., & Gros, Stephanie J. (2022). Perfusion-Based Bioreactor Culture and Isothermal Microcalorimetry for Preclinical Drug Testing with the Carbonic Anhydrase Inhibitor SLC-0111 in Patient-Derived Neuroblastoma. International Journal of Molecular Sciences, 23(6). https://doi.org/10.3390/ijms23063128

Kasamkattil J, Gryadunova A, Martin I, Barbero A, Schären S, Krupkova O, & Mehrkens A. (2022). Spheroid-Based Tissue Engineering Strategies for Regeneration of the Intervertebral Disc. International Journal of Molecular Sciences, 23(5). https://doi.org/10.3390/ijms23052530

Guerrero, Julien, Dasen, Boris, Frismantiene, Agne, Pigeot, Sebastien, Ismail, Tarek, Schaefer, Dirk J, Philippova, Maria, Resink, Therese J, Martin, Ivan, & Scherberich, Arnaud. (2022). T-cadherin Expressing Cells in the Stromal Vascular Fraction of Human Adipose Tissue: Role in Osteogenesis and Angiogenesis. Stem Cells Translational Medicine, 11(2), 213–229. https://doi.org/10.1093/stcltm/szab021

Mainardi, Andrea, Mainardi, Andrea, Cambria, Elena, Occhetta, Paola, Martin, Ivan, Barbero, Andrea, Schären, Stefan, Mehrkens, Arne, & Krupkova, Olga. (2022). Intervertebral Disc-on-a-Chip as Advanced In Vitro Model for Mechanobiology Research and Drug Testing: A Review and Perspective. Frontiers in Bioengineering and Biotechnology, 9, 826867. https://doi.org/10.3389/fbioe.2021.826867

Baranovskii D, Demner J, Nürnberger S, Lyundup A, Redl H, Hilpert M, Pigeot S, Krasheninnikov M, Krasilnikova O, Klabukov I, Parshin V, Martin I, Lardinois D, & Barbero A. (2022). Engineering of Tracheal Grafts Based on Recellularization of Laser-Engraved Human Airway Cartilage Substrates. Cartilage, 13(1), 19476035221075951. https://doi.org/10.1177/19476035221075951

Ismail T, Haumer A, Lunger A, Osinga R, Kaempfen A, Saxer F, Wixmerten A, Miot S, Thieringer F, Beinemann J, Kunz C, Jaquiéry C, Weikert T, Kaul F, Scherberich A, Schaefer DJ, & Martin I. (2021). Case Report: Reconstruction of a Large Maxillary Defect With an Engineered, Vascularized, Prefabricated Bone Graft [Frontiers Media S.A.]. Frontiers in Oncology, 11, 775136. https://doi.org/10.3389/fonc.2021.775136

Acevedo L., Iselin L., Berkelaar MHM, Salzmann G.M., Wolf F, Feliciano S., Vogel N., Pagenstert G, Martin I, Pelttari K, Barbero A, & Arnold MP. (2021). Comparison of Human Articular Cartilage Tissue and Chondrocytes Isolated from Peripheral versus Central Regions of Traumatic Lesions. Cartilage, 13(2_suppl), 68S–81S. https://doi.org/10.1177/1947603520958154

Viswanathan S., Ciccocioppo R., Galipeau J., Krampera M., Le Blanc K., Martin I., Moniz K., Nolta J., Phinney D.G., Shi Y., Szczepiorkowski Z.M., Tarte K., Weiss D.J., & Ashford P. (2021). Consensus International Council for Commonality in Blood Banking Automation–International Society for Cell & Gene Therapy statement on standard nomenclature abbreviations for the tissue of origin of mesenchymal stromal cells. Cytotherapy, 23(12), 1060–1063. https://doi.org/10.1016/j.jcyt.2021.04.009

Hirsiger, Julia R., Tamborrini, Giorgio, Harder, Dorothee, Bantug, Glenn R., Hoenger, Gideon, Recher, Mike, Marx, Christian, Li, Quan-Zhen, Martin, Ivan, Hess, Christoph, Scherberich, Arnaud, Daikeler, Thomas, & Berger, Christoph T. (2021). Chronic inflammation and extracellular matrix-specific autoimmunity following inadvertent periarticular influenza vaccination. Journal of Autoimmunity, 124. https://doi.org/10.1016/j.jaut.2021.102714

Gryadunova A., Kasamkattil J., Gay M.H.P., Dasen B, Pelttari K, Mironov V., Martin I., Scharen S., Barbero A, Krupkova O., & Mehrkens A. (2021). Nose to Spine: spheroids generated by human nasal chondrocytes for scaffold-free nucleus pulposus augmentation. Acta Biomaterialia, 134, 240–251. https://doi.org/10.1016/j.actbio.2021.07.064

García-García, Andrés, Klein, Thibaut, Born, Gordian, Hilpert, Morgane, Scherberich, Arnaud, Lengerke, Claudia, Skoda, Radek C., Bourgine, Paul E., & Martin, Ivan. (2021). Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches. Proceedings of the National Academy of Sciences of the United States of America, 118(40). https://doi.org/10.1073/pnas.2114227118

Pigeot, Sébastien, Klein, Thibaut, Gullotta, Fabiana, Dupard, Steven J., Garcia Garcia, Alejandro, García-García, Andres, Prithiviraj, Sujeethkumar, Lorenzo, Pilar, Filippi, Miriam, Jaquiery, Claude, Kouba, Loraine, Asnaghi, M. Adelaide, Raina, Deepak Bushan, Dasen, Boris, Isaksson, Hanna, Önnerfjord, Patrik, Tägil, Magnus, Bondanza, Attilio, Martin, Ivan, & Bourgine, Paul E. (2021). Manufacturing of Human Tissues as off-the-Shelf Grafts Programmed to Induce Regeneration. Advanced Materials, 33(43). https://doi.org/10.1002/adma.202103737

Rua L.A., Mumme M, Manferdini C., Darwiche S., Khalil A, Hilpert M., Buchner D.A., Lisignoli G., Occhetta P, von Rechenberg B., Haug M, Schaefer DJ, Jakob M., Caplan A., Martin I., Barbero A, & Pelttari K. (2021). Engineered nasal cartilage for the repair of osteoarthritic knee cartilage defects. Science Translational Medicine, 13(609), eaaz4499. https://doi.org/10.1126/scitranslmed.aaz4499

Pirosa, Alessandro, Tankus, Esma Bahar, Mainardi, Andrea, Occhetta, Paola, Dönges, Laura, Baum, Cornelia, Rasponi, Marco, Martin, Ivan, & Barbero, Andrea. (2021). Modeling in vitro osteoarthritis phenotypes in a vascularized bone model based on a bone-marrow derived mesenchymal cell line and endothelial cells. International Journal of Molecular Sciences, 22(17). https://doi.org/10.3390/ijms22179581

Haeusner S., Herbst L., Bittorf P., Schwarz T., Henze C., Mauermann M, Ochs J., Schmitt R., Blache U., Wixmerten A, Miot S, Martin I., & Pullig O. (2021). From Single Batch to Mass Production–Automated Platform Design Concept for a Phase II Clinical Trial Tissue Engineered Cartilage Product. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.712917

Secerovic A., Pusic M., Kostesic P., Vuckovic M., Vukojevic R., Skokic S., Sasi B., Vukasovic Barisic A., Hudetz D, Vnuk D., Maticic D., Urlic I., Mumme M, Martin I., & Ivkovic A. (2021). Nasal Chondrocyte–Based Engineered Grafts for the Repair of Articular Cartilage “Kissing” Lesions: A Pilot Large-Animal Study. American Journal of Sports Medicine, 49(8), 2187–2198. https://doi.org/10.1177/03635465211014190

Asnaghi M.A., Barthlott T., Gullotta F., Strusi V., Amovilli A, Hafen K, Srivastava G, Oertle P., Toni R., Wendt D., Holländer GA, & Martin I. (2021). Thymus Extracellular Matrix-Derived Scaffolds Support Graft-Resident Thymopoiesis and Long-Term In Vitro Culture of Adult Thymic Epithelial Cells. Advanced Functional Materials, 31(20). https://doi.org/10.1002/adfm.202010747

Galipeau J., Krampera M., Leblanc K., Nolta J.A., Phinney D.G., Shi Y., Tarte K., Viswanathan S., & Martin I. (2021). Mesenchymal stromal cell variables influencing clinical potency: the impact of viability, fitness, route of administration and host predisposition. Cytotherapy, 23(5), 368–372. https://doi.org/10.1016/j.jcyt.2020.11.007

Gay MHP, Baldomero H, Farge-Bancel D, Robey PG, Rodeo S, Passweg J, Müller-Gerbl M, & Martin I. (2021). The survey on cellular and tissue-engineered therapies in Europe in 2016 and 2017. Tissue Engineering - Part A, 27(5-6), 336–350. https://doi.org/10.1089/ten.tea.2020.0092

Power L, Acevedo L, Yamashita R., Rubin D., Martin I., & Barbero A. (2021). Deep learning enables the automation of grading histological tissue engineered cartilage images for quality control standardization. Osteoarthritis and Cartilage, 29(3), 433–443. https://doi.org/10.1016/j.joca.2020.12.018

Born, Gordian, Nikolova, Marina, Scherberich, Arnaud, Treutlein, Barbara, García-García, Andrés, & Martin, Ivan. (2021). Engineering of fully humanized and vascularized 3D bone marrow niches sustaining undifferentiated human cord blood hematopoietic stem and progenitor cells. Journal of Tissue Engineering, 12. https://doi.org/10.1177/20417314211044855

García-García, Andrés, & Martin, Ivan. (2021). Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing. Molecular and Cellular Oncology, 8(6). https://doi.org/10.1080/23723556.2021.2007030

Ziadlou R, Rotman S, Teuschl A., Salzer E, Barbero A, Martin I., Alini M., Eglin D., & Grad S. (2021). Optimization of hyaluronic acid-tyramine/silk-fibroin composite hydrogels for cartilage tissue engineering and delivery of anti-inflammatory and anabolic drugs. Materials Science and Engineering C, 120, 111701. https://doi.org/10.1016/j.msec.2020.111701

Martin I., Bayon Y., Yu T.T.L., & Vertes A.A. (2020). Editorial: Clinical Translation and Commercialisation of Advanced Therapy Medicinal Products. Frontiers in Bioengineering and Biotechnology, 8. https://doi.org/10.3389/fbioe.2020.619698

Chawla S, Berkelaar MHM, Dasen B, Halleux C, Guth-Gundel S., Kramer I, Ghosh S., Martin I., Barbero A, & Occhetta P. (2020). Blockage of bone morphogenetic protein signalling counteracts hypertrophy in a human osteoarthritic micro-cartilage model. Journal of Cell Science, 133(23). https://doi.org/10.1242/jcs.249094

Gu Y, Schwarz B, Forget A, Barbero A, Barbero A, Martin I, & Shastri VP. (2020). Advanced bioink for 3D bioprinting of complex free-standing structures with high stiffness. Bioengineering, 7(4), 1–15. https://doi.org/10.3390/bioengineering7040141

Ismail T, Lunger A, Haumer A, Todorov A, Menzi N, Schweizer T, Bieback K, Bürgin J, Schaefer DJ, Martin I, & Scherberich A. (2020). Platelet-rich plasma and stromal vascular fraction cells for the engineering of axially vascularized osteogenic grafts. Journal of Tissue Engineering and Regenerative Medicine, 14(12), 1908–1917. https://doi.org/10.1002/term.3141

Khoury M, Rocco PRM, Phinney DG, Krampera M, Martin I, Viswanathan S, Nolta JA, LeBlanc K, Galipeau J, & Weiss DJ. (2020). Cell-based therapies for coronavirus disease 2019: proper clinical investigations are essential. Cytotherapy, 22(11), 602–605. https://doi.org/10.1016/j.jcyt.2020.04.089

Power LJ, Fasolato C, Barbero A, Wendt DJ, Wixmerten A, Martin I, & Asnaghi MA. (2020). Sensing tissue engineered cartilage quality with Raman spectroscopy and statistical learning for the development of advanced characterization assays. Biosensors and Bioelectronics, 166, 112467. https://doi.org/10.1016/j.bios.2020.112467

Pigeot S., Bourgine PE, Claude J., Scotti C, Papadimitropoulos A, Todorov A., Epple C., Peretti G.M., & Martin I. (2020). Orthotopic bone formation by streamlined engineering and devitalization of human hypertrophic cartilage. International Journal of Molecular Sciences, 21(19), 1–14. https://doi.org/10.3390/ijms21197233

Ziadlou R, Barbero A, Martin I, Wang X, Qin L, Alini M, & Grad S. (2020). Anti‐inflammatory and chondroprotective effects of vanillic acid and epimedin C in human osteoarthritic chondrocytes. Biomolecules, 10(6), 1–28. https://doi.org/10.3390/biom10060932

Mumme M, Wixmerten A, & Martin I. (2020). Reply to comment on: Mumme M, et al. Tissue engineering for paediatric patients. Swiss Med Wkly. 2019.149.w20032 (Patent Nos. 21–22). Swiss Medical Weekly, 150(21-22), Article 21–22. https://doi.org/10.4414/smw.2020.20240

Chabannon C, Ciccocioppo R, & Martin I. (2020). Welcome to ISCT 2020 Paris Virtual (Patent No. 5). Cytotherapy, 22(5), Article 5. https://doi.org/10.1016/j.jcyt.2020.04.096

Asnaghi M.A., Power L., Barbero A, Haug M, Koppl R., Wendt D, & Martin I. (2020). Biomarker Signatures of Quality for Engineering Nasal Chondrocyte-Derived Cartilage. Frontiers in Bioengineering and Biotechnology, 8, 283. https://doi.org/10.3389/fbioe.2020.00283

Horton ER, Vallmajo-Martin Q, Martin I, Snedeker JG, Ehrbar M, & Blache U. (2020). Extracellular Matrix Production by Mesenchymal Stromal Cells in Hydrogels Facilitates Cell Spreading and Is Inhibited by FGF-2. Advanced Healthcare Materials, 9(7), e1901669. https://doi.org/10.1002/adhm.201901669

Pagella P, Miran S, Neto E, Martin I, Lamghari M, & Mitsiadis TA. (2020). Human dental pulp stem cells exhibit enhanced properties in comparison to human bone marrow stem cells on neurites outgrowth. FASEB Journal, 34(4), 5499–5511. https://doi.org/10.1096/fj.201902482r

Huang RL, Guerrero J, Senn AS, Kappos EA, Liu K, Li Q, Dufrane D, Schaefer DJ, Martin I, & Scherberich A. (2020). Dispersion of ceramic granules within human fractionated adipose tissue to enhance endochondral bone formation. Acta Biomaterialia, 102, 458–467. https://doi.org/10.1016/j.actbio.2019.11.046

Lehoczky G, Wolf F, Mumme M, Gehmert S, Miot S, Haug M, Jakob M, Martin I, Barbero A, & Barbero A. (2020). Intra-individual comparison of human nasal chondrocytes and debrided knee chondrocytes: Relevance for engineering autologous cartilage grafts. Clinical Hemorheology and Microcirculation, 74(1), 67–78. https://doi.org/10.3233/ch-199236

Lehoczky, Gyözö, Wolf, Francine, Mumme, Marcus, Gehmert, Sebastian, Miot, Sylvie, Haug, Martin, Jakob, Marcel, Martin, Ivan, & Barbero, Andrea. (2020). Intra-individual comparison of human nasal chondrocytes and debrided knee chondrocytes: Relevance for engineering autologous cartilage grafts. Clinical Hemorheology and Microcirculation, 74(1), 67–78. https://doi.org/10.3233/ch-199236

Mumme, Marcus, Wixmerten, Anke, Steinwachs, Matthias, & Martin, Ivan. (2020). Expanded cells, bone marrow, adipose tissue: what is (not) allowed in Switzerland: Focus: cartilage regeneration and arthrosis. Arthroskopie, 33, 89–93. https://doi.org/10.1007/s00142-020-00346-6

59. Manfredonia C, Muraro MG, Hirt C, Mele V, Governa V, Papadimitropoulos A, Däster S, Soysal SD, Droeser RA, Mechera R, Oertli D, Rosso R, Bolli M, Zettl A, Terracciano LM, Spagnoli GC, Martin I, & Iezzi G. (2019). Maintenance of primary human colorectal cancer microenvironment using a perfusion bioreactor-based 3D culture system. Advanced Biosystems, 3(4), e1800300.

Wixmerten, Anke, Miot, Sylvie, & Martin, Ivan. (2019). Roadmap and Challenges for Investigator Initiated Clinical Trials With Advanced Therapy Medicinal Products (ATMPs). In Reis, Rui (ed.), Encyclopedia of Tissue Engineering and Regenerative Medicine (Vol. 1, pp. 57–70). Elsevier. https://doi.org/10.1016/b978-0-12-801238-3.11119-5

Filippi M, Dasen B, Guerrero J, Garello F, Isu G, Born G, Ehrbar M, Martin I, & Scherberich A. (2019). Magnetic nanocomposite hydrogels and static magnetic field stimulate the osteoblastic and vasculogenic profile of adipose-derived cells. Biomaterials, 223, 119468. https://doi.org/10.1016/j.biomaterials.2019.119468

Ziadlou R, Barbero A, Stoddart MJ, Wirth M, Li Z, Martin I, Wang XL, Qin L, Alini M, & Grad S. (2019). Regulation of inflammatory response in human osteoarthritic chondrocytes by novel herbal small molecules. International Journal of Molecular Sciences, 20(22). https://doi.org/10.3390/ijms20225745

Vukasovic A, Asnaghi MA, Kostesic P, Quasnichka H, Cozzolino C, Pusic M, Hails L, Trainor N, Krause C, Figallo E, Filardo G, Kon E, Wixmerten A, Maticic D, Pellegrini G, Kafienah W, Hudetz D, Smith T, Martin I, et al. (2019). Bioreactor-manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies. Cell Proliferation, 52(6), e12653. https://doi.org/10.1111/cpr.12653

Lunger A, Ismail T, Todorov A, Buergin J, Lunger F, Oberhauser I, Haug M, Kalbermatten DF, Largo RD, Martin I, Scherberich A, & Schaefer DJ. (2019). Improved Adipocyte Viability in Autologous Fat Grafting with Ascorbic Acid-Supplemented Tumescent Solution. Annals of Plastic Surgery, 83(4), 464–467. https://doi.org/10.1097/SAP.0000000000001857

Viswanathan S, Shi Y, Galipeau J, Krampera M, Leblanc K, Martin I, Nolta J, Phinney DG, & Sensebe L. (2019). Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature. Cytotherapy, 21(10), 1019–1024. https://doi.org/10.1016/j.jcyt.2019.08.002

Bourgine PE, Fritsch K, Pigeot S, Takizawa H, Kunz L, Kokkaliaris KD, Coutu DL, Manz MG, Martin I, & Schroeder T. (2019). Fate Distribution and Regulatory Role of Human Mesenchymal Stromal Cells in Engineered Hematopoietic Bone Organs. iScience, 19, 504–513. https://doi.org/10.1016/j.isci.2019.08.006

García-García, Andrés, & Martin, Ivan. (2019). Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing. Frontiers in Immunology, 10, 2256. https://doi.org/10.3389/fimmu.2019.02256

Occhetta, Paola, Mainardi, Andrea, Votta, Emiliano, Vallmajo-Martin, Queralt, Ehrbar, Martin, Martin, Ivan, Barbero, Andrea, & Rasponi, Marco. (2019). Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model [Journal-article]. Nature Biomedical Engineering, 3(7), 545–557. https://doi.org/10.1038/s41551-019-0406-3

Fritsch K., Pigeot S., Feng X., Bourgine P.E., Schroeder T., Martin I., Manz M.G., & Takizawa H. (2019). Erratum to “Engineered humanized bone organs maintain human hematopoiesis in vivo”: (Experimental Hematology (2018) 61 (45–51.e5), (S0301472X18300389), (10.1016/j.exphem.2018.01.004)). Experimental Hematology, 72, 72. https://doi.org/10.1016/j.exphem.2019.01.007

Manfredonia C, Muraro MG, Hirt C, Mele V, Governa V, Papadimitropoulos A, Däster S, Soysal SD, Droeser RA, Mechera R, Oertli D, Rosso R, Bolli M, Zettl A, Terracciano LM, Spagnoli GC, Martin I, & Iezzi G. (2019). Maintenance of Primary Human Colorectal Cancer Microenvironment Using a Perfusion Bioreactor-Based 3D Culture System. Advanced Biosystems, 3(4), e1800300. https://doi.org/10.1002/adbi.201800300

Mumme M, Wixmerten A, Miot S., Barbero A., Kaempfen A., Saxer F., Gehmert S, Krieg A., Schaefer D.J., Jakob M, & Martin I. (2019). Tissue engineering for paediatric patients. Swiss Medical Weekly, 149, w20032. https://doi.org/10.4414/smw.2019.20032

Epple C, Haumer A, Ismail T, Lunger A, Scherberich A, Schaefer DJ, & Martin I. (2019). Prefabrication of a large pedicled bone graft by engineering the germ for de novo vascularization and osteoinduction. Biomaterials, 192, 118–127. https://doi.org/10.1016/j.biomaterials.2018.11.008

Stüdle C, Occhetta P, Geier F, Mehrkens A, Barbero A., & Martin I. (2019). Challenges Toward the Identification of Predictive Markers for Human Mesenchymal Stromal Cells Chondrogenic Potential. Stem Cells Translational Medicine, 8(2), 194–204. https://doi.org/10.1002/sctm.18-0147

Blache U, Horton ER, Xia T, Schoof EM, Blicher LH, Schönenberger A, Snedeker JG, Martin I, Erler JT, & Ehrbar M. (2019). Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments. Life Science Alliance, 2(3). https://doi.org/10.26508/lsa.201900304

Gay M.H.P., Mehrkens A., Rittmann M., Haug M., Barbero A., Martin I., & Schaeren S. (2019). Nose to back: Compatibility of nasal chondrocytes with environmental conditions mimicking a degenerated intervertebral disc. European Cells and Materials, 37, 214–323. https://doi.org/10.22203/ECM.V037A13

Martin I., Galipeau J., Kessler C., Blanc K.L., & Dazzi F. (2019). Challenges for mesenchymal stromal cell therapies. Science Translational Medicine, 11(480). https://doi.org/10.1126/scitranslmed.aat2189

Martin, Ivan, Malda, Jos, & Rivron, Nicolas C. (2019). Organs by design: can bioprinting meet self-organisation? Current opinion in organ transplantation, 24(5), 562–567. https://doi.org/10.1097/mot.0000000000000679

Power, Laura, Wixmerten, Anke, Wendt, David, Barbero, Andrea, & Martin, Ivan. (2019). Raman spectroscopy quality controls for GMP compliant manufacturing of tissue engineered cartilage. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 10881. https://doi.org/10.1117/12.2507951

Devaud YR, Avilla-Royo E, Trachsel C, Grossmann J, Martin I, Lutolf MP, & Ehrbar M. (2018). Label-Free Quantification Proteomics for the Identification of Mesenchymal Stromal Cell Matrisome Inside 3D Poly(Ethylene Glycol) Hydrogels. Advanced Healthcare Materials, 7(21), e1800534. https://doi.org/10.1002/adhm.201800534

Piuzzi NS, Dominici M, Long M, Pascual-Garrido C, Rodeo S, Huard J, Guicheux J, McFarland R, Goodrich LR, Maddens S, Robey PG, Bauer TW, Barrett J, Barry F, Karli D, Chu CR, Weiss DJ, Martin I, Jorgensen C, & Muschler GF. (2018). Proceedings of the signature series symposium “cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies—promise, facts and fantasy,” international society for cellular therapies, montreal, canada, may 2, 2018. Cytotherapy, 20(11), 1381–1400. https://doi.org/10.1016/j.jcyt.2018.09.001

Gullotta F., Izzo D., Scalera F., Palazzo B., Martin I., Sannino A., & Gervaso F. (2018). Biomechanical evaluation of hMSCs-based engineered cartilage for chondral tissue regeneration. Journal of the Mechanical Behavior of Biomedical Materials, 86, 294–304. https://doi.org/10.1016/j.jmbbm.2018.06.040

Guerrero J, Pigeot S, Müller J, Schaefer DJ, Martin I, & Scherberich A. (2018). Fractionated human adipose tissue as a native biomaterial for the generation of a bone organ by endochondral ossification. Acta Biomaterialia, 77, 142–154. https://doi.org/10.1016/j.actbio.2018.07.004

Lee JY, Matthias N, Pothiawala A, Ang BK, Lee M, Li J, Sun D, Pigeot S, Martin I, Huard J, Huang Y, & Nakayama N. (2018). Pre-transplantational Control of the Post-transplantational Fate of Human Pluripotent Stem Cell-Derived Cartilage. Stem Cell Reports, 11(2), 440–453. https://doi.org/10.1016/j.stemcr.2018.06.021

Blache U., Vallmajo-Martin Q., Horton E.R., Guerrero J., Djonov V., Scherberich A., Scherberich A., Erler J.T., Martin I., Snedeker J.G., Milleret V., & Ehrbar M. (2018). Notch-inducing hydrogels reveal a perivascular switch of mesenchymal stem cell fate. EMBO Reports, 19(8). https://doi.org/10.15252/embr.201845964

Sarem M., Heizmann M., Barbero A., Martin I., & Prasad Shastri V. (2018). Hyperstimulation of CaSR in human MSCs by biomimetic apatite inhibits endochondral ossification via temporal down-regulation of PTH1R. Proceedings of the National Academy of Sciences of the United States of America, 115(27), E6135–E6144. https://doi.org/10.1073/pnas.1805159115

Rossi E., Mracsko E., Papadimitropoulos A., Allafi N., Reinhardt D., Mehrkens A., Martin I., Knuesel I., & Scherberich A. (2018). An In Vitro Bone Model to Investigate the Role of Triggering Receptor Expressed on Myeloid Cells-2 in Bone Homeostasis. Tissue Engineering - Part C: Methods, 24(7), 391–398. https://doi.org/10.1089/ten.tec.2018.0061

Stüdle C, Vallmajó-Martín Q, Haumer A, Guerrero J, Centola M, Mehrkens A, Schaefer DJ, Ehrbar M, Barbero A, & Martin I. (2018). Spatially confined induction of endochondral ossification by functionalized hydrogels for ectopic engineering of osteochondral tissues. Biomaterials, 171, 219–229. https://doi.org/10.1016/j.biomaterials.2018.04.025

Bourgine PE, Klein T, Paczulla AM, Shimizu T, Kunz L, Kokkaliaris KD, Coutu DL, Lengerke C, Skoda R, Schroeder T, & Martin I. (2018). In vitro biomimetic engineering of a human hematopoietic niche with functional properties. Proceedings of the National Academy of Sciences of the United States of America, 115(25), E5688–E5695. https://doi.org/10.1073/pnas.1805440115

Asnaghi MA, Duhr R, Quasnichka H, Hollander AP, Kafienah W, Martin I, & Wendt D. (2018). Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid. Journal of Tissue Engineering and Regenerative Medicine, 12(6), 1402–1411. https://doi.org/10.1002/term.2671

Rossi E, Guerrero J, Aprile P, Tocchio A, Kappos EA, Gerges I, Lenardi C, Martin I, & Scherberich A. (2018). Decoration of RGD-mimetic porous scaffolds with engineered and devitalized extracellular matrix for adipose tissue regeneration. Acta Biomaterialia, 73, 154–166. https://doi.org/10.1016/j.actbio.2018.04.039

Fritsch K., Pigeot S., Feng X., Bourgine P.E., Schroeder T., Martin I., Manz M.G., & Takizawa H. (2018). Engineered humanized bone organs maintain human hematopoiesis in vivo. Experimental Hematology, 61, 45–51. https://doi.org/10.1016/j.exphem.2018.01.004

Occhetta P., Pigeot S., Rasponi M., Dasen B., Mehrkens A., Ullrich T., Kramer I., Guth-Gundel S., Barbero A., & Martin I. (2018). Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis. Proceedings of the National Academy of Sciences of the United States of America, 115(18), 4625–4630. https://doi.org/10.1073/pnas.1720658115

Haumer A., Bourgine P.E., Occhetta P., Born G., Tasso R., & Martin I. (2018). Delivery of cellular factors to regulate bone healing. Advanced Drug Delivery Reviews, 129, 285–294. https://doi.org/10.1016/j.addr.2018.01.010

Menzi N, Osinga R, Todorov A, Schaefer DJ, Martin I, & Scherberich A. (2018). Wet milling of large quantities of human excision adipose tissue for the isolation of stromal vascular fraction cells. Cytotechnology, 70(2), 807–817. https://doi.org/10.1007/s10616-018-0190-z

Loeffler D., Wang W., Hopf A., Hilsenbeck O., Bourgine P.E., Rudolf F., Martin I., & Schroeder T. (2018). Mouse and human HSPC immobilization in liquid culture by CD43- or CD44-antibody coating. Blood, 131(13), 1425–1429. https://doi.org/10.1182/blood-2017-07-794131