Prof. Dr. med. Michael Osthoff

Michael Osthoff, & Andrea Erba. (2025). Less Is More: Advanced Diagnostic Tests and Smarter Algorithms Are Urgently Needed in Encephalitis With Absent Cerebrospinal Fluid Pleocytosis (Patent No. 6). Clinical Infectious Diseases, 80(6), Article 6. https://doi.org/10.1093/cid/ciae567

Dräger, Sarah, Ewoldt, Tim M.J., Abdulla, Alan, Rietdijk, Wim J.R., Verkaik, Nelianne J., van Vliet, Peter, Purmer, Ilse M., Osthoff, Michael, Koch, Birgit C.P., & Endeman, Henrik on behalf of the DOLPHIN investigators. (2025). Target attainment of beta-lactam antibiotics and ciprofloxacin in critically ill patients and its association with 28-day mortality [Journal-article]. Journal of Critical Care, 85. https://doi.org/10.1016/j.jcrc.2024.154904

Boesing, Maria, Albrich, Werner, Bridevaux, Pierre-Olivier, Charbonnier, Florian, Clarenbach, Christian, Fellrath, Jean-Marc, Gianella, Pietro, Kern, Lukas, Latshang, Tsogyal, Pavlov, Nikolay, Osthoff, Michael, Steurer-Stey, Claudia, von Garnier, Christophe, & Leuppi, Jörg D. (2024). Impfung von erwachsenen Patienten mit chronischen Lungenerkrankungen. Praxis, 113(11/12), 297–305. https://doi.org/10.23785/PRAXIS.2024.11.003

Jost, Lorena, Helmchen, Birgit M, Osthoff, Michael, & Nigg Calanca, Luzia. (2024). A Case of Hypocomplementemic Urticarial Vasculitis Syndrome With Severe Renal and Gastrointestinal Involvement [Journal-article]. Cureus, 16(10). https://doi.org/10.7759/cureus.72113

Blickenstorfer, Yves, Jirasko, Vlastimil, Tanno, Alexander, Dräger, Sarah, Hoven, Darius, Löhle, Josephine, Leuch, Stephan, Mamedava, Yulya, Müller, Sereina Livia, Leuzinger, Karoline, Osthoff, Michael, & Vörös, János. (2024). Iodide based electrochemical gold quantification method for lateral flow assays [Journal-article]. Biosensors and Bioelectronics, 262. https://doi.org/10.1016/j.bios.2024.116524

Bausch, Severin, Dräger, Sarah, Charitos-Fragkakis, Panteleimon, Egli, Adrian, Moser, Stephan, Hinic, Vladimira, Kuehl, Richard, Bassetti, Stefano, Siegemund, Martin, Rentsch, Katharina M., Hermann, Laura, Schöning, Verena, Hammann, Felix, Sendi, Parham, & Osthoff, Michael. (2024). Target Attainment and Population Pharmacokinetics of Cefazolin in Patients with Invasive Staphylococcus aureus Infections: A Prospective Cohort Study [Journal-article]. Antibiotics, 13(10), 928. https://doi.org/10.3390/antibiotics13100928

Rentsch, Katharina M., Khanna, Nina, Halbeisen, Delia, & Osthoff, Michael. (2024). Enhancing Stability and Investigating Target Attainment of Benzylpenicillin in Outpatient Parenteral Antimicrobial Therapy: Insights from In Vitro and In Vivo Evaluations [Journal-article]. Antibiotics, 13(10), 970. https://doi.org/10.3390/antibiotics13100970

Moser, Stephan, Araschmid, Laura, Panagiotou, Anneza, Bonati, Leo H., Breidthardt, Tobias, Fahrni, Gregor, Kaiser, Christoph, Jeger, Raban, Trendelenburg, Marten, & Osthoff, Michael. (2024). Association of Endothelial Cell Activation with Acute Kidney Injury during Coronary Angiography and the Influence of Recombinant Human C1 Inhibitor—A Secondary Analysis of a Randomized, Placebo-Controlled, Double-Blind Trial. Biomedicines, 12(9). https://doi.org/10.3390/biomedicines12091956

Hermann, Laura, Schöning, Verena, Dräger, Sarah, Rentsch, Katharina, Moser, Stephan, Gürtler, Nicolas, Sendi, Parham, Osthoff, Michael, & Hammann, Felix. (2024). Population pharmacokinetics of flucloxacillin as intermittent bolus infusion in patients with Staphylococcus aureus bloodstream infection [Journal-article]. Journal of Antimicrobial Chemotherapy, 79(8), 2031–2039. https://doi.org/10.1093/jac/dkae207

Couchepin, Jade, Reinhold, Ilana, Kronig, Ilona, Guidi, Monia, Buclin, Thierry, Schreiber, Peter Werner, Neofytos, Dionysios, Lamoth, Frederic, Albrich, Werner, Berezowska, Sabina, Berger, Christoph, Bergeron, Anne, Bochud, Pierre-Yves, Boggian, Katia, Conen, Anna, Emonet, Stéphane, Erard, Véronique, Garzoni, Christian, Goldenberger, Daniel, et al. (2024). Isavuconazole for the Treatment of Fungal Infections: A Real-life Experience From the Fungal Infection Network of Switzerland (FUNGINOS). Open Forum Infectious Diseases, 11(5). https://doi.org/10.1093/ofid/ofae223

Dräger, Sarah, Bruni, Flavio, Bernasconi, Melina, Hammann-Hänni, Anya, Jirasko, Vlastimil, Tanno, Alexander, Blickenstorfer, Yves, Leuzinger, Karoline, Hirsch, Hans H., & Osthoff, Michael. (2024). Impact of Swabbing Location, Self-Swabbing, and Food Intake on SARS-CoV-2 RNA Detection. Microorganisms, 12(3). https://doi.org/10.3390/microorganisms12030591

Dräger, Sarah, Ewoldt, Tim M. J., Abdulla, Alan, Rietdijk, Wim J. R., Verkaik, Nelianne, Ramakers, Christian, de Jong, Evelien, Osthoff, Michael, Koch, Birgit C. P., & Endeman, Henrik. (2024). Exploring the Impact of Model-Informed Precision Dosing on Procalcitonin Concentrations in Critically Ill Patients: A Secondary Analysis of the DOLPHIN Trial. Pharmaceutics, 16(2). https://doi.org/10.3390/pharmaceutics16020270

Erba, Andrea, Franzeck, Fabian C., Hinic, Vladimira, Egli, Adrian, & Osthoff, Michael. (2024). Utilization of a Meningitis/Encephalitis PCR panel at the University Hospital Basel – a retrospective study to develop a diagnostic decision rule. Frontiers in Medicine, 11. https://doi.org/10.3389/fmed.2024.1351903

Müller, Sereina Livia, Kaumanns, Anna, Adam, Kai-Manuel, Osthoff, Michael, & Dräger, Sarah. (2024). Misdiagnosed Antibiotic-Induced Liver Injury: Unveiling Acute Hepatitis E in a 65-Year-Old Patient [Journal-article]. American Journal of Case Reports , 25. https://doi.org/10.12659/ajcr.944508

Agnetti, Jessica, Büchler, Andrea C., Osthoff, Michael, Helfenstein, Fabrice, Weisser, Maja, Siegemund, Martin, Bassetti, Stefano, Bingisser, Roland, Schaefer, Dirk J., Clauss, Martin, Hinic, Vladimira, Tschudin-Sutter, Sarah, Bättig, Veronika, Khanna, Nina, & Egli, Adrian. (2023). Identification of microorganisms by a rapid PCR panel from positive blood cultures leads to faster optimal antimicrobial therapy – a before-after study. BMC Infectious Diseases, 23(1). https://doi.org/10.1186/s12879-023-08732-9

Etienne, Samuel, Oliveras, Ruben, Schiboni, Giovanni, Durrer, Lukas, Rochat, Fabien, Eib, Philipp, Zahner, Michele, Osthoff, Michael, Bassetti, Stefano, & Eckstein, Jens. (2023). Free-living core body temperature monitoring using a wrist-worn sensor after COVID-19 booster vaccination: a pilot study. BioMedical Engineering Online, 22(1). https://doi.org/10.1186/s12938-023-01081-3

Ritter F, Staub BM, & Osthoff M. (2023). Appropriateness of inpatient intravenous iron therapy in a Swiss tertiary care hospital. European Journal of Haematology, 111(4), 601–610. https://doi.org/10.1111/ejh.14053

Gross, Sebastian, Becker, Christoph, Beck, Katharina, Memma, Valentina, Gaab, Jens, Schütz, Philipp, Leuppi, Jörg D., Schaefert, Rainer, Langewitz, Wolf, Trendelenburg, Marten, Breidthardt, Tobias, Eckstein, Jens, Osthoff, Michael, Bassetti, Stefano, & Hunziker, Sabina. (2023). Occurrence of sensitive topics during ward round: An ancillary analysis of the BEDSIDE-OUTSIDE trial. BMJ Open, 13(9). https://doi.org/10.1136/bmjopen-2023-073584

Lopez-Morales, Joanan, Vanella, Rosario, Utzinger, Tamara, Schittny, Valentin, Hirsiger, Julia, Osthoff, Michael, Berger, Christoph T., Guri, Yakir, & Nash, Michael A. (2023). Multiplexed on-yeast serological assay for immune escape screening of SARS-CoV-2 variants. iScience, 26(5). https://doi.org/10.1016/j.isci.2023.106648

Romann, Lucas, Werlen, Laura, Rommers, Nikki, Hermann, Anja, Gisler, Isabelle, Bassetti, Stefano, Bingisser, Roland, Siegemund, Martin, Roloff, Tim, Weisser, Maja, Muigg, Veronika, Hinic, Vladimira, Osthoff, Michael, Franzeck, Fabian C., & Egli, Adrian. (2023). Factors impacting the pre-Analytical quality of blood cultures-Analysis at a tertiary medical center. PLoS ONE, 18(3 March). https://doi.org/10.1371/journal.pone.0282918

Schaub, Cédéric, Barnsteiner, Stefanie, Schönenberg, Ladina, Bloch, Nando, Dräger, Sarah, Albrich, Werner C., Conen, Anna, & Osthoff, Michael. (2023). Antibiotic treatment durations for common infectious diseases in Switzerland: comparison between real-life and local and international guideline recommendations. Journal of Global Antimicrobial Resistance, 32, 11–17. https://doi.org/10.1016/j.jgar.2022.12.002

Lopez-Morales, J., Vanella, R., Utzinger, T., Schittny, V., Hirsiger, J., Osthoff, M., Berger, C., Guri, Y., & Nash, M. A. (2023, February 18). Rapidly Adaptable Multiplexed Yeast Surface Display Serological Assay for Immune Escape Screening of SARS-CoV-2 Variants [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.02.17.23286074

Etienne S, Vosbeck J, Bernsmeier C, & Osthoff M. (2023). Prevention of Hepatitis B Reactivation in Patients Receiving Immunosuppressive Therapy: a Case Series and Appraisal of Society Guidelines. Journal of General Internal Medicine, 38(2), 490–501. https://doi.org/10.1007/s11606-022-07806-9

Dräger, Sarah, von Rotz, Matthias, Labhardt, Niklaus D., Siegemund, Martin, Rentsch, Katharina M., Osthoff, Michael, & Franzeck, Fabian C. (2023). Early target attainment with continuous infusion meropenem and piperacillin/tazobactam and utilization of therapeutic drug monitoring in critically ill patients: a retrospective cohort study from 2017 to 2020. Open Forum Infect Dis, 10(4), ofad143. https://doi.org/10.1093/ofid/ofad143

Urwyler, Pascal, Leimbacher, Marina, Charitos, Panteleimon, Moser, Stephan, Heijnen, Ingmar A. F. M., Trendelenburg, Marten, Thoma, Reto, Sumer, Johannes, Camacho-Ortiz, Adrián, Bacci, Marcelo R., Huber, Lars C., Stüssi-Helbling, Melina, Albrich, Werner C., Sendi, Parham, & Osthoff, Michael. (2023). Recombinant C1 inhibitor in the prevention of severe COVID-19: a randomized, open-label, multi-center phase IIa trial. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1255292

Dräger, Sarah, & Osthoff, Michael. (2022). Pitfalls for blood culture diagnostic stewardship. Author’s Reply. European Journal of Internal Medicine, 105, 102–103. https://doi.org/10.1016/j.ejim.2022.09.003

Frei NE, Dräger S, Weisser M, & Osthoff M. (2022). Antibiotic treatment duration in diverticulitis, complicated urinary tract infection, and endocarditis: a retrospective, single-center study. International Journal of Infectious Diseases, 124, 89–95. https://doi.org/10.1016/j.ijid.2022.09.025

Glatz TS, Hinic V, Martinez AE, Eckstein F, Bassetti S, & Osthoff M. (2022). [Better Late than Never - Fever of Unknown Origin in a Patient with a Prosthetic Valve]. Praxis, 111(15), 889–893. https://doi.org/10.1024/1661-8157/a003942

Gürtler N, Osthoff M, Egli A, Halter J, Khanna N, Tschudin-Sutter S, & Bassetti S. (2022). Nosocomial human parainfluenza virus type 3 outbreak in immunocompromised patients, and possible lessons from the SARS-CoV-2 pandemic [W.B. Saunders Ltd]. Journal of Hospital Infection, 129, 117–119. https://doi.org/10.1016/j.jhin.2022.07.002

Urwyler, Pascal, Moser, Stephan, Trendelenburg, Marten, Sendi, Parham, & Osthoff, Michael. (2022). Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progression. Molecular Immunology, 150, 99–113. https://doi.org/10.1016/j.molimm.2022.08.008

Bruni F, Charitos P, Lampart M, Moser S, Siegemund M, Bingisser R, Osswald S, Bassetti S, Twerenbold R, Trendelenburg M, Rentsch KM, & Osthoff M. (2022). Complement and endothelial cell activation in COVID-19 patients compared to controls with suspected SARS-CoV-2 infection: A prospective cohort study. Frontiers in Immunology, 13, 941742. https://doi.org/10.3389/fimmu.2022.941742

Darie, Andrei M, Khanna, Nina, Jahn, Kathleen, Osthoff, Michael, Bassetti, Stefano, Osthoff, Mirjam, Schumann, Desiree M, Albrich, Werner C, Hirsch, Hans, Brutsche, Martin, Grize, Leticia, Tamm, Michael, & Stolz, Daiana. (2022). Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II): a multicentre, randomised controlled trial. The Lancet Respiratory Medicine, 10(9), 877–887. https://doi.org/10.1016/S2213-2600(22)00086-8

Dräger, Sarah, Giehl, Céline, Søgaard, Kirstine Kobberøe, Egli, Adrian, de Roche, Mirjam, Huber, Lars C., & Osthoff, Michael. (2022). Do we need blood culture stewardship programs? A quality control study and survey to assess the appropriateness of blood culture collection and the knowledge and attitudes among physicians in Swiss hospitals. European Journal of Internal Medicine, 103, 50–56. https://doi.org/10.1016/j.ejim.2022.04.028

Dräger, Sarah, Jahn, Kathleen, Vogt, Moritz, Hopfer, Helmut, Kyburz, Diego, & Osthoff, Michael. (2022). Reversed Halo Sign on Chest Computed Tomography in a 33-Year-Old Man Without Immunosuppression. American Journal of Medicine, 135(9), e318–e320. https://doi.org/10.1016/j.amjmed.2022.04.009

Etienne S, Leuzinger K., Hirsch HH, & Osthoff M. (2022). Challenges of Primary Care Medicine in a Tertiary Care Setting—The Case of Primary CMV Infection Compared to Primary EBV Infection: A Retrospective Cohort Study. Frontiers in Medicine, 9, 880610. https://doi.org/10.3389/fmed.2022.880610

Bausch S, Araschmid LJ, Hardmeier M, & Osthoff M. (2022). Cefepime-Induced Neurotoxicity in the Setting of Acute Kidney Injury: A Case Series and Discussion of Preventive Measures. (Patent No. 6). 14(6), Article 6. https://doi.org/10.7759/cureus.26392

Bassetti S, Tschudin-Sutter S, Egli A, & Osthoff M. (2022). Optimizing antibiotic therapies to reduce the risk of bacterial resistance. European Journal of Internal Medicine, 99, 7–12. https://doi.org/10.1016/j.ejim.2022.01.029

Ritter, Fabian, Franzeck, Fabian, Geisshardt, Julian, Walker, Ulrich A., & Osthoff, Michael. (2022). Gout Arthritis During Admission for Decompensated Heart Failure—A Descriptive Analysis of Risk Factors, Treatment and Prognosis. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.789414

Gross S., Beck K., Becker C., Gamp M., Mueller J., Loretz N., Amacher S.A., Bohren C., Gaab J., Schuetz P., Mueller B., Fux C.A., Leuppi J.D., Schaefert R., Langewitz W., Trendelenburg M., Breidthardt T., Eckstein J., Osthoff M., et al. (2022). Perception of physicians and nursing staff members regarding outside versus bedside ward rounds: Ancillary analysis of the randomised BEDSIDE-OUTSIDE trial. Swiss Medical Weekly, 152(3-4). https://doi.org/10.4414/smw.2022.w30112

Weis C, Cuénod A, Rieck B, Dubuis O, Graf S, Lang C, Oberle M, Brackmann M, Søgaard KK, Osthoff M, Borgwardt K, & Egli A. (2022). Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning. Nature Medicine, 28(1), 164–174. https://doi.org/10.1038/s41591-021-01619-9

Leuzinger, Karoline, Osthoff, Michael, Dräger, Sarah, Pargger, Hans, Siegemund, Martin, Bassetti, Stefano, Bingisser, Roland, Nickel, Christian H., Tschudin-Sutter, Sarah, Khanna, Nina, Rentsch, Katharina, Battegay, Manuel, Egli, Adrian, & Hirsch, Hans H. (2021). Comparing immunoassays for sars-cov-2 antibody detection in patients with and without laboratory-confirmed sars-cov-2 infection. Journal of Clinical Microbiology, 59(12), e0138121. https://doi.org/10.1128/JCM.01381-21

Søgaard KK, Baettig V, Osthoff M, Marsch S, Leuzinger K, Schweitzer M, Meier J, Bassetti S, Bingisser R, Nickel CH, Khanna N, Tschudin-Sutter S, Weisser M, Battegay M, Hirsch HH, Pargger H, Siegemund M, & Egli A. (2021). Community-acquired and hospital-acquired respiratory tract infection and bloodstream infection in patients hospitalized with COVID-19 pneumonia. Journal of Intensive Care, 9(1), 10. https://doi.org/10.1186/s40560-021-00526-y

Urwyler, Pascal, Charitos, Panteleimon, Moser, Stephan, Heijnen, Ingmar A. F. M., Trendelenburg, Marten, Thoma, Reto, Sumer, Johannes, Camacho-Ortiz, Adrián, Bacci, Marcelo R., Huber, Lars C., Stüssi-Helbling, Melina, Albrich, Werner C., Sendi, Parham, & Osthoff, Michael. (2021). Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomized, parallel-group, open-label, multi-center pilot trial (PROTECT-COVID-19). Trials, 22(1). https://doi.org/10.1186/s13063-020-04976-x

Vogt S, Leuppi JD, Schuetz P, Mueller B, Volken C, Dräger S, Trendelenburg M, Rutishauser J, Rutishauser J, & Osthoff M. (2021). Association of mannose-binding lectin, ficolin-2 and immunoglobulin concentrations with future exacerbations in patients with chronic obstructive pulmonary disease: secondary analysis of the randomized controlled REDUCE trial. Respiratory Research, 22(1), 227. https://doi.org/10.1186/s12931-021-01822-9

Charitos P., Heijnen IAFM, Egli A, Bassetti S., Trendelenburg M., & Osthoff M. (2021). Functional Activity of the Complement System in Hospitalized COVID-19 Patients: A Prospective Cohort Study. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.765330

Adam KM, Osthoff M, Lamoth F, Conen A, Erard V, Boggian K, Schreiber PW, Zimmerli S, Bochud PY, Neofytos D, Fleury M, Fankhauser H, Goldenberger D, Mühlethaler K, Riat A, Zbinden R, Kronenberg A, Quiblier C, Marchetti O, et al. (2021). Trends of the epidemiology of Candidemia in Switzerland: A 15-year FUNGINOS survey. Open Forum Infectious Diseases, 8(10), ofab471. https://doi.org/10.1093/ofid/ofab471

Becker C, Gamp M., Schuetz P., Beck K., Vincent A, Hochstrasser S., Metzger K., Widmer M., Thommen E, Mueller B, Fux CA, Leuppi JD, Schaefert R, Langewitz W., Trendelenburg M., Breidthardt T, Eckstein J, Osthoff M, Bassetti S., & Hunziker S. (2021). Effect of bedside compared with outside the room patient case presentation on patients’ knowledge about their medical care: A randomized, controlled, multicenter trial. Annals of Internal Medicine, 174(9), 1282–1292. https://doi.org/10.7326/m21-0909

Diebold M, Martinez AE, Adam KM, Bassetti S, Osthoff M, Kassi E, Steiger J, Pargger H, Siegemund M, Battegay M, Khanna N, Schaub S, Wesch C, Dickenmann M, & Weisser M. (2021). Temporal trends of COVID-19 related in-hospital mortality and demographics in Switzerland - a retrospective single centre cohort study. Swiss Medical Weekly, 151(29-30), w20572. https://doi.org/10.4414/smw.2021.20572

Moser, Stephan, Rehm, Sophia, Guertler, Nicolas, Hinic, Vladimira, Dräger, Sarah, Bassetti, Stefano, Rentsch, Katharina M., Sendi, Parham, & Osthoff, Michael. (2021). Probability of pharmacological target attainment with flucloxacillin in Staphylococcus aureus bloodstream infection: A prospective cohort study of unbound plasma and individual MICs. Journal of Antimicrobial Chemotherapy, 76(7), 1845–1854. https://doi.org/10.1093/jac/dkab089

Brasier, Noé, Widmer, Andreas F., Osthoff, Michael, & Eckstein, Jens. (2021). Digital biomarkers from sweat analysis for therapeutic drug monitoring in soft tissue infections. DigiBiom 2021 - Proceedings of the 2021 Future of Digital Biomarkers, null, 45–50. https://doi.org/10.1145/3469266.3471179

Leuzinger K, Gosert R, Søgaard KK, Naegele K, Bielicki J, Roloff T, Bingisser R, Nickel CH, Khanna N, Sutter ST, Widmer AF, Rentsch K, Pargger H, Siegemund M, Stolz D, Tamm M, Bassetti S, Osthoff M, Battegay M, et al. (2021). Epidemiology and precision of SARS-CoV-2 detection following lockdown and relaxation measures. Journal of Medical Virology, 93(4), 2374–2384. https://doi.org/10.1002/jmv.26731

Capoferri G, Osthoff M, Egli A, Stoeckle M, & Bassetti S. (2021). Relative bradycardia in patients with COVID-19 (Patent No. 2). Clinical Microbiology and Infection, 27(2), Article 2. https://doi.org/10.1016/j.cmi.2020.08.013

Brasier, Noé, Osthoff, Michael, De Ieso, Fiorangelo, & Eckstein, Jens. (2021). Next-Generation Digital Biomarkers for Tuberculosis and Antibiotic Stewardship: Perspective on Novel Molecular Digital Biomarkers in Sweat, Saliva, and Exhaled Breath. Journal of Medical Internet Research, 23(8), e25907. https://doi.org/10.2196/25907

Brasier N, Widmer A, Osthoff M, Mutke M, De Ieso F, Brasier-Lutz P, Brown K, Yao L, Broeckling CD, Prenni J, & Eckstein J. (2021). The Detection of Vancomycin in Sweat: A Next-Generation Digital Surrogate Marker for Antibiotic Tissue Penetration: A Pilot Study. Digital Biomarkers, 5(1), 24–28. https://doi.org/10.1159/000512947

Jautz J, Potlukova E, Zeeh F, & Osthoff M. (2021). More than meets the eye: Bacteremic pneumococcal pneumonia as the initial presentation of multiple myeloma. American Journal of Case Reports, 22(1), 1–4. https://doi.org/10.12659/AJCR.927904

Mari, Alfredo, Roloff, Tim, Stange, Madlen, Søgaard, Kirstine K., Asllanaj, Erblin, Tauriello, Gerardo, Alexander, Leila Tamara, Schweitzer, Michael, Leuzinger, Karoline, Gensch, Alexander, Martinez, Aurélien E., Bielicki, Julia, Pargger, Hans, Siegemund, Martin, Nickel, Christian H., Bingisser, Roland, Osthoff, Michael, Bassetti, Stefano, Sendi, Parham, et al. (2021). Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance. Microorganisms, 9(5), 1094. https://doi.org/10.3390/microorganisms9051094

Merlo P, Rochlitz C, & Osthoff M. (2021). The Alkaline Phosphatase Flare Phenomenon: A Transient Substantial Increase in Alkaline Phosphatase Concentration in a Prostate Cancer Patient after Starting GnRH Agonist Treatment (Patent No. 1). Case Reports in Oncology, 14(1), Article 1. https://doi.org/10.1159/000513427

Stange, Madlen, Mari, Alfredo, Roloff, Tim, Seth-Smith, Helena M. B., Schweitzer, Michael, Brunner, Myrta, Leuzinger, Karoline, Sogaard, Kirstine K., Gensch, Alexander, Tschudin-Sutter, Sarah, Fuchs, Simon, Bielicki, Julia, Pargger, Hans, Siegemund, Martin, Nickel, Christian H., Bingisser, Roland, Osthoff, Michael, Bassetti, Stefano, Schneider-Sliwa, Rita, et al. (2021). SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event. PLOS Pathogens, 17(3). https://doi.org/10.1371/journal.ppat.1009374

Kieninger-Gräfitsch A, Vogt S, Ribi C, Dubler D, Chizzolini C, Huynh-Do U, Osthoff M, & Trendelenburg M. (2020). No association of complement mannose-binding lectin deficiency with cardiovascular disease in patients with Systemic Lupus Erythematosus. Scientific Reports, 10(1), 3693. https://doi.org/10.1038/s41598-020-60523-3

Brasier, N., Osthoff, M., De Ieso, F., & Eckstein, J. (2020, November 20). Next-Generation Digital Biomarkers for Tuberculosis and Antibiotic Stewardship: Perspective on Novel Molecular Digital Biomarkers in Sweat, Saliva, and Exhaled Breath (Preprint) [Posted-content]. JMIR Publications Inc. https://doi.org/10.2196/preprints.25907

Schaub, Cédéric, Dräger, Sarah, Hinic, Vladimira, Bassetti, Stefano, Frei, Reno, & Osthoff, Michael. (2020). Relevance of Dermabacter hominis isolated from clinical samples, 2012–2016: a retrospective case series. Diagnostic Microbiology and Infectious Disease, 98(2). https://doi.org/10.1016/j.diagmicrobio.2020.115118

Häfelfinger, Romina, Burgener, Anne-Valérie, Osthoff, Michael, & Potlukova, Eliska. (2020). Simultaneous VZV and HSV-1 reactivation after minor head injury. European Journal of Case Reports in Internal Medicine, 7(12). https://doi.org/10.12890/2020_001746

Urwyler, Pascal, Moser, Stephan, Charitos, Panteleimon, Heijnen, Ingmar A. F. M., Rudin, Melanie, Sommer, Gregor, Giannetti, Bruno M., Bassetti, Stefano, Sendi, Parham, Trendelenburg, Marten, & Osthoff, Michael. (2020). Treatment of COVID-19 With Conestat Alfa, a Regulator of the Complement, Contact Activation and Kallikrein-Kinin System. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.02072

Weis, C., Cuénod, A., Rieck, B., Llinares-López, F., Dubuis, O., Graf, S., Lang, C., Oberle, M., Brackmann, M., Søgaard, K. K., Osthoff, M., Borgwardt, K., & Egli, A. (2020, July 30). Direct Antimicrobial Resistance Prediction from clinical MALDI-TOF mass spectra using Machine Learning [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2020.07.30.228411

Schunemann M.J., Vosbeck J., Antwi K., Bassetti S, & Osthoff M. (2020). Wither Away: Weight Loss and Persistent Inflammation in a Woman With Whipple Disease. American Journal of Medicine, 133(6), e223–e226. https://doi.org/10.1016/j.amjmed.2019.08.058

Gürtler, Nicolas, Linnemann, Doris, Moser, Stephan, Dräger, Sarah, & Osthoff, Michael. (2020). Hämatochezie und rechtsseitiger Oberbauchschmerz nach Punktion eines Leberabszesses bei einem 75-Jährigen Hematochezia and right-sided upper abdominal pain after puncture of a liver abscess in a 75-year-old male. Der Internist, 61(5), 513–517. https://doi.org/10.1007/s00108-020-00781-5

Panagiotou A, Trendelenburg M, Heijnen IAFM, Moser S, Bonati LH, Breidthardt T, Fahrni G, Kaiser C, Jeger R, & Osthoff M. (2020). A Randomized Trial of Recombinant Human C1-Esterase-Inhibitor in the Prevention of Contrast-Induced Kidney Injury. JACC: Cardiovascular Interventions, 13(7), 833–842. https://doi.org/10.1016/j.jcin.2019.11.021

Erba A, Beuret M, Daly ML, Khanna, Nina, & Osthoff M. (2020). OPAT in Switzerland: single-center experience of a model to treat complicated infections. Infection, 48(2), 231–240. https://doi.org/10.1007/s15010-019-01381-8

Brasier, Noé, Widmer, Andreas, Osthoff, Michael, Mutke, Markus, De Ieso, Fiorangelo, Brasier-Lutz, Pascale, Wolfe, Lisa, Aithal, Vikas, Broeckling, Corey, Prenni, Jessica, & Eckstein, Jens. (2020). Non-invasive Drug Monitoring of β-Lactam Antibiotics Using Sweat Analysis-A Pilot Study. Frontiers in Medicine, 7(476). https://doi.org/10.3389/fmed.2020.00476

Diebold M, Kuster S, & Osthoff M. (2020). Reversible Hippocratic Fingers in a Patient with Pneumonia. American Journal of Medicine, 133(1), e9–e10. https://doi.org/10.1016/j.amjmed.2019.07.010

Marzolini, Catia, Stader, Felix, Stoeckle, Marcel, Franzeck, Fabian, Egli, Adrian, Bassetti, Stefano, Hollinger, Alexa, Osthoff, Michael, Weisser, Maja, Gebhard, Caroline E., Baettig, Veronika, Geenen, Julia, Khanna, Nina, Tschudin-Sutter, Sarah, Müller, Daniel, Hirsch, Hans H., Battegay, Manuel, & Sendi, Parham. (2020). Effect of Systemic Inflammatory Response to SARS-CoV-2 on Lopinavir and Hydroxychloroquine Plasma Concentrations. Antimicrobial Agents and Chemotherapy, 64(9), e01177–20. https://doi.org/10.1128/aac.01177-20

Rabes, Clemens, Bläuer, Cornelia, Büche, Volker, Gisler Ries, Isabelle, Knüppel Lauener, Susanne, Kuehl, Richard, Osthoff, Michael, Pfeiffer, Marlen, Probst, Silvia, Todorov, Victor, & Panfil, Eva-Maria. (2020). Zwischen Traum und Trauma - Aufbau und Betrieb einer Kohortenstation für Patient_innen mit COVID-19 in einem Akutspital. Pflege, 33(4), 247–255. https://doi.org/10.1024/1012-5302/a000746

Vogt, Severin, Trendelenburg, Marten, Tamm, Michael, Stolz , Daiana, Hostettler, Katrin Esther, & Osthoff, Michael. (2020). Local and Systemic Concentration of Pattern Recognition Receptors of the Lectin Pathway of Complement in a Cohort of Patients With Interstitial Lung Diseases. Frontiers in Immunology, 11, 562564. https://doi.org/10.3389/fimmu.2020.562564

Gürtler, Nicolas, Erba A, Giehl, Céline, Tschudin-Sutter, Sarah, Bassetti S, & Osthoff M. (2019). Appropriateness of antimicrobial prescribing in a Swiss tertiary care hospital: A repeated point prevalence survey. Swiss Medical Weekly, 149(41-42), w20135. https://doi.org/10.4414/smw.2019.20135

Gürtler N, Denz A, Egli A, Widmer AF, & Osthoff M. (2019). Influence of a resin-based blood culture medium on the time to clearance of methicillin-susceptible Staphylococcus aureus bloodstream infection – A retrospective cohort study. Diagnostic Microbiology and Infectious Disease, 95(1), 25–27. https://doi.org/10.1016/j.diagmicrobio.2019.04.010

Wójtowicz A, Bibert S, Taffé P, Bernasconi E, Furrer H, Günthard HF, Hoffmann M, Osthoff M, Cavassini M, Bochud PY, & Swiss HIV Cohort Study. (2019). IL-4 polymorphism influences susceptibility to Pneumocystis jirovecii pneumonia in HIV-positive patients. Aids, 33(11), 1719–1727. https://doi.org/10.1097/qad.0000000000002283

Gürtler N, Osthoff M, Rueter F, Wüthrich D, Zimmerli L, Egli A, & Bassetti S. (2019). Prosthetic valve endocarditis caused by Pseudomonas aeruginosa with variable antibacterial resistance profiles: A diagnostic challenge. BMC Infectious Diseases, 19(1), 530. https://doi.org/10.1186/s12879-019-4164-3

Osthoff M, Jaeger VK, Heijnen IAFM, Trendelenburg M, Jordan S, Distler O, & Walker U.A. (2019). Role of lectin pathway complement proteins and genetic variants in organ damage and disease severity of systemic sclerosis: A cross-sectional study. Arthritis Research and Therapy, 21(1). https://doi.org/10.1186/s13075-019-1859-1

Leuppi-Taegtmeyer AB, Decosterd L, Osthoff M, Mueller NJ, Buclin T, & Corti N. (2019). Multicenter population pharmacokinetic study of colistimethate sodium and colistin dosed as in normal renal function in patients on continuous renal replacement therapy. Antimicrobial Agents and Chemotherapy, 63(2). https://doi.org/10.1128/AAC.01957-18

Thoma R, Häuptle P, Degen L, Bassetti S, & Osthoff M. (2018). Escherichia coli bloodstream infection preceding the diagnosis of rectal carcinoma. (Patent No. 11). 2018(11), Article 11. https://doi.org/10.1093/omcr/omy084

Gürtler, Nicolas, Hirt-Minkowski, Patricia, Brunner, Simon S, König, Katrin, Glatz, Katharina, Reichenstein, David, Bassetti, Stefano, & Osthoff, Michael. (2018). Sodium polystyrene sulfonate and cytomegalovirus-associated hemorrhagic duodenitis: More than meets the eye. American Journal of Case Reports, 19, 912–916. https://doi.org/10.12659/AJCR.910655

Panagiotou A, Trendelenburg M, & Osthoff M. (2018). The Lectin pathway of complement in myocardial ischemia/reperfusion injury-review of its significance and the potential impact of therapeutic interference by C1 esterase inhibitor. Frontiers in Immunology, 9(MAY), 1151. https://doi.org/10.3389/fimmu.2018.01151

Bibert S, Wójtowicz A, Taffé P, Tarr PE, Bernasconi E, Furrer H, Günthard HF, Hoffmann M, Kaiser L, Osthoff M, Fellay J, Cavassini M, Bochud PY, & Swiss HIV Cohort Study. (2018). Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi’s sarcoma. AIDS, 32(18), 2759–2765. https://doi.org/10.1097/QAD.0000000000002004

Seth-Smith, Helena M. B., Imkamp, Frank, Tagini, Florian, Cuénod, Aline, Hömke, Rico, Jahn, Kathleen, Tschacher, Anne, Grendelmeier, Peter, Bättig, Veronika, Erb, Stefan, Reinhard, Miriam, Rütimann, Gottfried, Borrell, Sonia, Gagneux, Sebastien, Casanova, Carlo, Droz, Sara, Osthoff, Michael, Tamm, Michael, Nübel, Ulrich, et al. (2018). Discovery and characterization of Mycobacterium basiliense sp. nov., a nontuberculous mycobacterium isolated from human lungs. Frontiers in Microbiology, 9, 3184. https://doi.org/10.3389/fmicb.2018.03184

Trauer J, Muhi S, McBryde ES, Al Harbi SA, Arabi YM, Boyle AJ, Cartin-Ceba R, Chen W, Chen YT, Falcone M, Gajic O, Godsell J, Gong MN, Kor D, Lösche W, McAuley DF, O’Neal HR Jr, Osthoff M, Otto GP, et al. (2017). Quantifying the effects of prior acetyl-salicylic acid on sepsis-related deaths: An individual patient data meta-analysis using propensity matching. Critical Care Medicine, 45(11), 1871–1879. https://doi.org/10.1097/CCM.0000000000002654

Osthoff M, Bielicki J, Widmer AF, & For Swissnoso. (2017). Evaluation of existing and desired antimicrobial stewardship activities and strategies in Swiss hospitals. Swiss Medical Weekly, 147(41-42), w14512. https://doi.org/10.4414/smw.2017.14512

Osthoff M, Walder B, Delhumeau C, Trendelenburg M, & Turck N. (2017). Association of Lectin Pathway Protein Levels and Genetic Variants Early after Injury with Outcomes after Severe Traumatic Brain Injury: A Prospective Cohort Study. Journal of Neurotrauma, 34(17), 2560–2566. https://doi.org/10.1089/neu.2016.4941

Banderet, Florian, Blaich, Annette, Soleman, Evelin, Gaia, Valeria, & Osthoff, Michael. (2017). Septic arthritis due to Legionella cincinnatiensis: case report and review of the literature. Infection, 45(4), 551–555. https://doi.org/10.1007/s15010-016-0964-1

Schibli, Adrian, Goldenberger, Daniel, Krieg, Andreas, Hirschmann, Anna, Bruder, Elisabeth, & Osthoff, Michael. (2017). Painless swelling of the forefoot and recurrent subcutaneous abscesses of the lower leg—Two distinct presentations illustrating the spectrum of eumycetoma in a nonendemic country. PLoS Neglected Tropical Diseases, 11(4). https://doi.org/10.1371/journal.pntd.0005360

Osthoff M, Khanna, Nina, & Siegemund, Martin. (2017). The EMPIRICUS trial-the final nail in the coffin of empirical antifungal therapy in the intensive care unit? (Patent No. 3). Journal of Thoracic Disease, 9(3), Article 3. https://doi.org/10.21037/jtd.2017.02.78

Osthoff, M., Gürtler, N., Bassetti, S., Balestra, G., Marsch, S., Pargger, H., Weisser, M., & Egli, A. (2017). Impact of MALDI-TOF-MS-based identification directly from positive blood cultures on patient management: a controlled clinical trial. Clinical Microbiology and Infection, 23(2), 78–85. https://doi.org/10.1016/j.cmi.2016.08.009

Temkin E, Torre-Cisneros J, Beovic B, Benito N, Giannella M, Gilarranz R, Jeremiah C, Loeches B, Machuca I, Jiménez-Martín MJ, Martínez JA, Mora-Rillo M, Navas E, Osthoff M, Pozo JC, Ramos Ramos JC, Rodriguez M, Sánchez-García M, Viale P, et al. (2017). Ceftazidime-avibactam as salvage therapy for infections caused by carbapenem-resistant organisms. Antimicrobial Agents and Chemotherapy, 61(2). https://doi.org/10.1128/AAC.01964-16

Osthoff M., Battig V., & Khanna N. (2016). Isavuconazole Isavuconazol. Therapeutische Umschau, 73(8), 475–481. https://doi.org/10.1024/0040-5930/a000821

Osthoff M, Sidler JA, & Widmer, Andreas F. (2016). The authors reply (Patent No. 8). Critical Care Medicine, 44(8), Article 8. https://doi.org/10.1097/CCM.0000000000001897

Osthoff M, Schibli A, Fadini D, Lardelli P, & Goldenberger D. (2016). Louse-borne relapsing fever - report of four cases in Switzerland, June-December 2015. BMC Infectious Diseases, 16(1), 210. https://doi.org/10.1186/s12879-016-1541-z

Osthoff M, Sidler JA, Lakatos B, Frei R, Dangel M, Weisser M, Battegay M, & Widmer AF. (2016). Low-Dose Acetylsalicylic Acid Treatment and Impact on Short-Term Mortality in Staphylococcus aureus Bloodstream Infection: A Propensity Score-Matched Cohort Study. Critical Care Medicine, 44(4), 773–781. https://doi.org/10.1097/CCM.0000000000001554

Osthoff M, & Erb S. (2016). Neuraminidase inhibitors and influenza infection (Patent No. 3). JAMA Internal Medicine, 176(3), Article 3. https://doi.org/10.1001/jamainternmed.2016.0013

Osthoff, Michael, Siegemund, Martin, Balestra, Gianmarco, Abdul-Aziz, Mohd Hafiz, & Roberts, Jason A. (2016). Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal. Swiss Medical Weekly, 146, w14368. https://doi.org/10.4414/smw.2016.14368

Osthoff, Michael, Osthoff, Michael, Wojtowicz, Agnieszka, Tissot, Frederic, Jørgensen, Clara, Thiel, Steffen, Zimmerli, Stephan, Marchetti, Oscar, Khanna, Nina, Bochud, Pierre-Yves, Trendelenburg, Marten, Fungal Infection Network of Switzerland, & Fungal Infection Network of Switzerland Funginos. (2016). Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland. The Journal of Infection, 72(3), 85–377. https://doi.org/10.1016/j.jinf.2015.12.011

Osthoff M, Dean MM, Baird PN, Richardson AJ, Daniell M, Guymer RH, & Eisen DP. (2015). Association study of mannose-binding lectin levels and genetic variants in lectin pathway proteins with susceptibility to age-related macular degeneration: A case-control study. PLoS ONE, 10(7), e0134107. https://doi.org/10.1371/journal.pone.0134107