Prof. Dr. Roderick Lim

Kapinos, Larisa E., Kalita, Joanna, Kassianidou, Elena, Rencurel, Chantal, & Lim, Roderick Y. H. (2024). Mechanism of exportin retention in the cell nucleus [Journal-article]. Journal of Cell Biology, 223(2). https://doi.org/10.1083/jcb.202306094

Svirelis, Justas, Adali, Zeynep, Emilsson, Gustav, Medin, Jesper, Andersson, John, Vattikunta, Radhika, Hulander, Mats, Järlebark, Julia, Kolman, Krzysztof, Olsson, Oliver, Sakiyama, Yusuke, Lim, Roderick Y. H., & Dahlin, Andreas. (2023). Stable trapping of multiple proteins at physiological conditions using nanoscale chambers with macromolecular gates [Journal-article]. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40889-4

Diez, Lisa, Kapinos, Larisa E., Lim, Roderick Y. H., & Wegmann, Susanne. (2023). Analysis of Tau/Nucleoporin Interactions by Surface Plasmon Resonance Spectroscopy. In Cieplak, Andrzej Stanisław (Ed.), Protein Aggregation (pp. 95–109). Springer. https://doi.org/10.1007/978-1-0716-2597-2_8

Kapinos, Larisa E., & Lim, Roderick Y. H. (2023). Multivalent Interactions with Intrinsically Disordered Proteins Probed by Surface Plasmon Resonance. In Goldberg, Martin W. (Ed.), The Nuclear Pore Complex (Vol. 2502, pp. 311–328). Springer. https://doi.org/10.1007/978-1-0716-2337-4_21

Diez, Lisa, Kapinos, Larisa E., Hochmair, Janine, Huebschmann, Sabrina, Dominguez-Baquero, Alvaro, Vogt, Amelie, Rankovic, Marija, Zweckstetter, Markus, Lim, Roderick Y. H., & Wegmann, Susanne. (2022). Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98. International Journal of Molecular Sciences, 23(7), 3495. https://doi.org/10.3390/ijms23073495

Kalita, Joanna, Kapinos, Larisa E., Zheng, Tiantian, Rencurel, Chantal, Zilman, Anton, & Lim, Roderick Y. H. (2022). Karyopherin enrichment and compensation fortifies the nuclear pore complex against nucleocytoplasmic leakage. Journal of Cell Biology, 221(3), e202108107. https://doi.org/10.1083/jcb.202108107

Tarvirdipour, Shabnam, Skowicki, Michal, Schoenenberger, Cora-Ann, Kapinos, Larisa E., Lim, Roderick Y. H., Benenson, Yaakov, & Palivan, Cornelia G. (2022). A self-assembling peptidic platform to boost the cellular uptake and nuclear delivery of oligonucleotides. Biomaterials Science, 10(15), 4309–4323. https://doi.org/10.1039/d2bm00826b

Hoogenboom, Bart W., Hough, Loren E., Lemke, Edward A., Lim, Roderick Y. H., Onck, Patrick R., & Zilman, Anton. (2021). Physics of the nuclear pore complex: Theory, modeling and experiment. Physics Reports, 921, 1–53. https://doi.org/10.1016/j.physrep.2021.03.003

Kalita, Joanna, Kapinos, Larisa E., & Lim, Roderick Y. H. (2021). On the asymmetric partitioning of nucleocytoplasmic transport - recent insights and open questions. Journal of Cell Science, 134(7), jcs240382. https://doi.org/10.1242/jcs.240382

Sharma, Deepika, Lim, Roderick Y. H., Pfohl, Thomas, & Ekinci, Yasin. (2021). Optimization of Nanofluidic Devices for Geometry-Induced Electrostatic Trapping. Particle & Particle Systems Characterization, 38(2), 2170003. https://doi.org/10.1002/ppsc.202170003

Sharma, Deepika, Lim, Roderick Y. H., Pfohl, Thomas, & Ekinci, Yasin. (2021). Surface-modified elastomeric nanofluidic devices for single nanoparticle trapping. Microsystems & Nanoengineering, 7(1), 46. https://doi.org/10.1038/s41378-021-00273-y

Avsar, Saziye Yorulmaz, Kapinos, Larisa E., Schoenenberger, Cora-Ann, Schertler, Gebhard F. X., Muhle, Jonas, Meger, Benoit, Lim, Roderick Y. H., Ostermaier, Martin K., Lesca, Elena, & Palivan, Cornelia G. (2020). Immobilization of arrestin-3 on different biosensor platforms for evaluating GPCR binding. Physical Chemistry Chemical Physics, 22(41), 24086–24096. https://doi.org/10.1039/d0cp01464h

Barbato, Suncica, Kapinos, Larisa E., Rencurel, Chantal, & Lim, Roderick Y. H. (2020). Karyopherin enrichment at the nuclear pore complex attenuates Ran permeability. Journal of Cell Science, 133(3), aheadofrint. https://doi.org/10.1242/jcs.238121

Santos, José Carlos, Boucher, Dave, Schneider, Larisa Kapinos, Demarco, Benjamin, Dilucca, Marisa, Shkarina, Kateryna, Heilig, Rosalie, Chen, Kaiwen W., Lim, Roderick Y. H., & Broz, Petr. (2020). Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria. Nature Communications, 11(1), 3276. https://doi.org/10.1038/s41467-020-16889-z

Zelmer, Christina, Zweifel, Ludovit P., Kapinos, Larisa E., Craciun, Ioana, Güven, Zekiye P., Palivan, Cornelia G., & Lim, Roderick Y. H. (2020). Organelle-specific targeting of polymersomes into the cell nucleus. Proceedings of the National Academy of Sciences of the United States of America, 117(6), 2770–2778. https://doi.org/10.1073/pnas.1916395117

Kassianidou, Elena, Kalita, Joanna, & Lim, Roderick Y. H. (2019). The role of nucleocytoplasmic transport in mechanotransduction. Experimental Cell Research, 377(1-2), 86–93. https://doi.org/10.1016/j.yexcr.2019.02.009

Panatala, Radhakrishnan, Barbato, Suncica, Kozai, Toshiya, Luo, Jinghui, Kapinos, Larisa E., & Lim, Roderick Y. H. (2019). Nuclear Pore Membrane Proteins Self-Assemble into Nanopores. Biochemistry, 58(6), 484–488. https://doi.org/10.1021/acs.biochem.8b01179

Eftekharzadeh, Bahareh, Daigle, J. Gavin, Kapinos, Larisa E., Coyne, Alyssa, Schiantarelli, Julia, Carlomagno, Yari, Cook, Casey, Miller, Sean J., Dujardin, Simon, Amaral, Ana S., Grima, Jonathan C., Bennet, Rachel E., Tepper, Katharina, DeTure, Michael, Vanderburgh, Charles R., Corjuc, Bianca T., Devos, Sarah L., Gonzalez, Jose Antonio, Chew, Jeannie, et al. (2018). Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease. Neuron, 99(5), 925–940. https://doi.org/10.1016/j.neuron.2018.07.039

Emilsson, Gustav, Sakiyama, Yusuke, Malekian, Bita, Xiong, Kunli, Adali-Kaya, Zeynep, Lim, Roderick Y. H., & Dahlin, Andreas B. (2018). Gating Protein Transport in Solid State Nanopores by Single Molecule Recognition. ACS Central Science, 4(8), 1007–1014. https://doi.org/10.1021/acscentsci.8b00268

Emilsson, Gustav, Xiong, Kunli, Sakiyama, Yusuke, Malekian, Bita, Gagnér, Viktor Ahlberg, Schoch, Rafael L., Lim, Roderick Y. H., & Dahlin, Andreas B. (2018). Polymer brushes in solid-state nanopores form an impenetrable entropic barrier for proteins. Nanoscale, 10(10), 4663–4669. https://doi.org/10.1039/c7nr09432a

Ganier, Olivier, Schnerch, Dominik, Oertle, Philipp, Lim, Roderick Y. H., Plodinec, Marija, & Nigg, Erich A. (2018). Structural centrosome aberrations promote non-cell-autonomous invasiveness. The EMBO journal, e98576. https://doi.org/10.15252/embj.201798576

Malekian, Bita, Schoch, Rafael L., Robson, Timothy, Ferrand-Drake del Castillo, Gustav, Xiong, Kunli, Emilsson, Gustav, Kapinos, Larisa E., Lim, Roderick Y. H., & Dahlin, Andreas B. (2018). Detecting Selective Protein Binding inside Plasmonic Nanopores: Towards a Mimic of the Nuclear Pore Complex. Frontiers in Chemistry, 6, 637. https://doi.org/10.3389/fchem.2018.00637

Zanetti-Dällenbach, Rosanna, Plodinec, Marija, Oertle, Philipp, Redling, Katharina, Obermann, Ellen C., Lim, Roderick Y. H., & Schoenenberger, Cora-Ann. (2018). Length Scale Matters: Real-Time Elastography versus Nanomechanical Profiling by Atomic Force Microscopy for the Diagnosis of Breast Lesions. BioMed Research International, 2018, 3840597. https://doi.org/10.1155/2018/3840597

Benning, Friederike M. C., Sakiyama, Yusuke, Mazur, Adam, Bukhari, Habib S. T., Lim, Roderick Y. H., & Maier, Timm. (2017). High-Speed Atomic Force Microscopy Visualization of the Dynamics of the Multienzyme Fatty Acid Synthase. ACS Nano, 11(11), 10852–10859. https://doi.org/10.1021/acsnano.7b04216

Emilsson, Gustav, Schoch, Rafael L., Oertle, Philipp, Xiong, Kunli, Lim, Roderick Y. H., & Dahlin, Andreas B. (2017). Surface plasmon resonance methodology for monitoring polymerization kinetics and morphology changes of brushes - evaluated with poly(N-isopropylacrylamide). Applied Surface Science, 396, 384–392. https://doi.org/10.1016/j.apsusc.2016.10.165

Kapinos, Larisa E., Huang, Binlu, Rencurel, Chantal, & Lim, Roderick Y. H. (2017). Karyopherins regulate nuclear pore complex barrier and transport function. Journal of Cell Biology, 216(11), 3609–3624. https://doi.org/10.1083/jcb.201702092

Luo, Wangxi, Ruba, Andrew, Takao, Daisuke, Zweifel, Ludovit P., Lim, Roderick Y. H., Verhey, Kristen J., & Yang, Weidong. (2017). Axonemal Lumen Dominates Cytosolic Protein Diffusion inside the Primary Cilium. Scientific Reports, 7(1), 15793. https://doi.org/10.1038/s41598-017-16103-z

Sakiyama, Yusuke, Panatala, Radhakrishnan, & Lim, Roderick Y. H. (2017). Structural dynamics of the nuclear pore complex. Seminars in Cell and Developmental Biology, 68, 27–33. https://doi.org/10.1016/j.semcdb.2017.05.021

Schoch, Rafael L., Emilsson, Gustav, Dahlin, Andreas B., & Lim, Roderick Y. H. (2017). Protein exclusion is preserved by temperature sensitive PEG brushes. Polymer, 132, 362–367. https://doi.org/10.1016/j.polymer.2017.10.063

Sharma, Deepika, Gerspach, Michael Adrian, Pfohl, Thomas, Lim, Roderick Y. H., & Ekinci, Yasin. (2017). Single positively charged particle trapping in nanofluidic systems. Microelectronic Engineering, 175, 43–49. https://doi.org/10.1016/j.mee.2017.01.001

Sakiyama, Yusuke, Mazur, Adam, Kapinos, Larisa E., & Lim, Roderick Y. H. (2016). Spatiotemporal dynamics of the nuclear pore complex transport barrier resolved by high-speed atomic force microscopy. Nature Nanotechnology, 11(8), 719–723. https://doi.org/10.1038/nnano.2016.62

Vovk, Andrei, Gu, Chad, Opferman, Michael G, Kapinos, Larisa E, Lim, Roderick Yh, Coalson, Rob D, Jasnow, David, & Zilman, Anton. (2016). Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex. eLife, 5, e10785. https://doi.org/10.7554/elife.10785.001

Vujica, Suncica, Zelmer, Christina, Panatala, Radhakrishnan, & Lim, Roderick Y H. (2016). Nucleocytoplasmic Transport: A Paradigm for Molecular Logistics in Artificial Systems. Chimia, 70(6), 413–417. https://doi.org/10.2533/chimia.2016.413

Zweifel, Ludovit P., Shorubalko, Ivan, & Lim, Roderick Y. H. (2016). Helium scanning transmission ion microscopy and electrical characterization of glass nanocapillaries with reproducible tip geometries. ACS nano, 10(2), 1918–1925. https://doi.org/10.1021/acsnano.5b05754

Emilsson, Gustav, Schoch, Rafael L, Feuz, Laurent, Höök, Fredrik, Lim, Roderick Y H, & Dahlin, Andreas B. (2015). Strongly Stretched Protein Resistant Poly(ethylene glycol) Brushes Prepared by Grafting-To. ACS Applied Materials & Interfaces, 7(14), 7505–7515. https://doi.org/10.1021/acsami.5b01590

Lim, Roderick Y. H., Huang, Binlu, & Kapinos, Larisa E. (2015). How to operate a nuclear pore complex by Kap-centric control. Nucleus (Austin, Tex.), 6(5), 366–372. https://doi.org/10.1080/19491034.2015.1090061

Plodinec, Marija, & Lim, Roderick Y. H. (2015). Nanomechanical characterization of living mammary tissues by atomic force microscopy. Methods in Molecular Biology, 1293, 231–246. https://doi.org/10.1007/978-1-4939-2519-3_14

Wagner, Raphael S., Kapinos, Larisa E., Marshall, Neil J., Stewart, Murray, & Lim, Roderick Y. H. (2015). Promiscuous Binding of Karyopherinβ1 Modulates FG Nucleoporin Barrier Function and Expedites NTF2 Transport Kinetics. Biophysical Journal, 108(4), 918–927. https://doi.org/10.1016/j.bpj.2014.12.041

Fuxreiter, Monika, Toth-Petroczy, Agnes, Kraut, Daniel A., Matouschek, Andreas T., Lim, Roderick Y. H., Xue, Bin, Kurgan, Lukasz, & Uversky, Vladimir N. (2014). Disordered Proteinaceous Machines. Chemical Reviews, 114(13), 6806–6843. https://doi.org/10.1021/cr4007329

Kapinos, Larisa E., Schoch, Rafael L., Wagner, Raphael S., Schleicher, Kai D., & Lim, Roderick Y. H. (2014). Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins. Biophysical Journal, 106(8), 1751–1762. https://doi.org/10.1016/j.bpj.2014.02.021

Schleicher, Kai D, Dettmer, Simon L, Kapinos, Larisa E, Pagliara, Stefano, Keyser, Ulrich F, Jeney, Sylvia, & Lim, Roderick Y H. (2014). Selective transport control on molecular velcro made from intrinsically disordered proteins. Nature Nanotechnology, 9(7), 525–530. https://doi.org/10.1038/nnano.2014.103

Halfter, Willi, Monnier, Christophe, Müller, David, Oertle, Philipp, Uechi, Guy, Balasubramani, Manimalha, Safi, Farhad, Lim, Roderick, Loparic, Marko, & Henrich, Paul Bernhard. (2013). The Bi-Functional Organization of Human Basement Membranes. PLoS ONE, 8(7), e67660. https://doi.org/10.1371/journal.pone.0067660

Schoch, Rafael L, & Lim, Roderick Y H. (2013). Non-interacting molecules as innate structural probes in surface plasmon resonance. Langmuir, 29(12), 4068–4076. https://doi.org/10.1021/la3049289

Henrich, Paul B., Monnier, Christophe A., Halfter, Willi, Haritoglou, Christos, Strauss, Rupert W., Lim, Roderick Y. H., & Loparic, Marko. (2012). Nanoscale topographic and biomechanical studies of the human internal limiting membrane. Investigative ophthalmology & visual science, 53(6), 2561–2570. https://doi.org/10.1167/iovs.11-8502

Lim, Roderick Y H, & Herrmann, Harald. (2012). From structural architecture to cellular organization : celebrating the scientific contributions of Ueli Aebi on the occasion of his retirement. Journal of Structural Biology, 177(1), 1–2. https://doi.org/10.1016/j.jsb.2011.12.011

Plodinec, Marija, Loparic, Marko, Monnier, Christophe A, Obermann, Ellen C, Zanetti-Dallenbach, Rosanna, Oertle, Philipp, Hyotyla, Janne T, Aebi, Ueli, Bentires-Alj, Mohamed, Lim, Roderick Y H, & Schoenenberger, Cora-Ann. (2012). The nanomechanical signature of breast cancer. Nature Nanotechnology, 7(11), 757–765. https://doi.org/10.1038/nnano.2012.167

Schoch, Rafael L., Kapinos, Larisa E., & Lim, Roderick Y. H. (2012). Nuclear transport receptor binding avidity triggers a self-healing collapse transition in FG-nucleoporin molecular brushes. Proceedings of the National Academy of Sciences of the United States of America, 109(42), 16911–16916. https://doi.org/10.1073/pnas.1208440109

Hyotyla, J. T., & Lim, R. Y. H. (2012). Atomic force microscopy. In Supramolecular chemistry. From molecules to nanomaterials: Vol. Vol. 2: Techniques (pp. 659–668). Wiley-Blackwell. https://doi.org/10.1002/9780470661345.smc043

Hyotyla, Janne T, Deng, Jie, & Lim, Roderick Y H. (2011). Synthetic Protein Targeting by the Intrinsic Biorecognition Functionality of Poly(ethylene glycol) Using PEG Antibodies as Biohybrid Molecular Adaptors. ACS Nano, 5(6), 5180–5187. https://doi.org/10.1021/nn201327y

Kowalczyk, Stefan W, Kapinos, Larisa, Blosser, Timothy R, Magalhães, Tomás, van Nies, Pauline, Lim, Roderick Y H, & Dekker, Cees. (2011). Single-molecule transport across an individual biomimetic nuclear pore complex. Nature Nanotechnology, 6(7), 433–438. https://doi.org/10.1038/nnano.2011.88

Backmann, Natalija, Kappeler, Natascha, Braun, Thomas, Huber, François, Lang, Hans-Peter, Gerber, Christoph, & Lim, Roderick Y. H. (2010). Sensing surface PEGylation with microcantilevers. Beilstein Journal of Nanotechnology, 1, 3–13. https://doi.org/10.3762/bjnano.1.2

Peleg, O., & Lim, R. Y. H. (2010). Converging on the function of intrinsically disordered nucleoporins in the nuclear pore complex. Biological Chemistry, 391(7), 719–730. https://doi.org/10.1515/bc.2010.092

Elad, Nadav, Maimon, Tal, Frenkiel-Krispin, Daphna, Lim, Roderick Y H, & Medalia, Ohad. (2009). Structural analysis of the nuclear pore complex by integrated approaches. Current Opinion in Structural Biology, 19(2), 226–232. https://doi.org/10.1016/j.sbi.2009.02.009

Lim, Roderick Y H, & Deng, Jie. (2009). Interaction forces and reversible collapse of a polymer brush-gated nanopore. ACS Nano, 3(10), 2911–2918. https://doi.org/10.1021/nn900152m

Lim, Roderick Y. H., Aebi, Ueli, & Fahrenkrog, Birthe. (2008). Towards reconciling structure and function in the nuclear pore complex. Histochemistry and Cell Biology, 129(2), 105–116. https://doi.org/10.1007/s00418-007-0371-x

Lim, Roderick Y H. (2007). Gate-crashing the nuclear pore complex. Structure: With Folding and Design, 15(8), 889–891. https://doi.org/10.1016/j.str.2007.07.005

Lim, Roderick Y H, Fahrenkrog, Birthe, Köser, Joachim, Schwarz-Herion, Kyrill, Deng, Jie, & Aebi, Ueli. (2007). Nanomechanical basis of selective gating by the nuclear pore complex. Science, 318(5850), 640–643. https://doi.org/10.1126/science.1145980

Lim, Roderick Y H, Köser, Joachim, Huang, Ning-Ping, Schwarz-Herion, Kyrill, & Aebi, Ueli. (2007). Nanomechanical interactions of phenylalanine-glycine nucleoporins studied by single molecule force-volume spectroscopy. Journal of Structural Biology, 159(2), 277–289. https://doi.org/10.1016/j.jsb.2007.01.018

Lim, Roderick Y H, Aebi, Ueli, & Stoffler, Daniel. (2006). From the trap to the basket : getting to the bottom of the nuclear pore complex. Chromosoma, 115(1), 15–26. https://doi.org/10.1007/s00412-005-0037-1

Lim, Roderick Y. H., & Fahrenkrog, Birthe. (2006). The nuclear pore complex up close. Current Opinion in Cell Biology, 18(3), 342–347. https://doi.org/10.1016/j.ceb.2006.03.006

Lim, Roderick Y. H., Huang, Ning-Ping, Köser, Joachim, Deng, Jie, Lau, K. H. Aaron, Schwarz-Herion, Kyrill, Fahrenkrog, Birthe, & Aebi, Ueli. (2006). Flexible phenylalanine-glycine nucleoporins as entropic barriers to nucleocytoplasmic transport. Proceedings of the National Academy of Sciences of the United States of America, 103(25), 9512–9517. https://doi.org/10.1073/pnas.0603521103

Lim, Roderick Y H, & Aebi, Ueli. (2005). In silico access to the nuclear pore complex. Structure: With Folding and Design, 13(12), 1741–1743. https://doi.org/10.1016/j.str.2005.11.002

Lim, Roderick Y. H., & O’Shea, S. J. (2004). Discrete solvation layering in confined binary liquids. Langmuir, 20(12), 4916–4919. https://doi.org/10.1021/la036200g

Lim, R., Li, S. F. Y., & O’Shea, S. J. (2002). Solvation forces using sample-modulation atomic force microscopy. Langmuir, 18(16), 6116–6124. https://doi.org/10.1021/la011789+

Lim, R., & O’Shea, S. J. (2002). Solvation forces in branched molecular liquids. Physical Review Letters, 88(24), 246101. https://doi.org/10.1103/physrevlett.88.246101

Loh, K. P., Xie, X. N., Lim, Y. H., Teo, E. J., Zheng, J. C., & Ando, T. (2002). Surface oxygenation studies on (100)-oriented diamond using an atom beam source and local anodic oxidation. Surface Science, 505(1-3), 93–114. https://doi.org/10.1016/s0039-6028(02)01103-2

Tripathy, S., Chua, S. J., Ramam, A., Sia, E. K., Pan, J. S., Lim, R., Yu, G., & Shen, Z. X. (2002). Electronic and vibronic properties of Mg-doped GaN: The influence of etching and annealing. Journal of Applied Physics, 91(5), 3398–3407. https://doi.org/10.1063/1.1446236

Xie, X. N., Lim, R., Li, J., Li, S. F. Y., & Loh, K. P. (2001). Atomic hydrogen beam etching of carbon superstructures on 6H-SiC(0001) studied by reflection high-energy electron diffraction. Diamond and Related Materials, 10(3-7), 1218–1223. https://doi.org/10.1016/s0925-9635(00)00398-8

Lim, R., Li, J., Li, S. F. Y., Feng, Z., & Valiyaveettil, S. (2000). The formation of two-dimensional supramolecular chiral lamellae by diamide molecules at the solution/graphite interface: A scanning tunneling microscopy study. Langmuir, 16(17), 7023–7030. https://doi.org/10.1021/la000083x