Prof. Dr. Dennis Gillingham

Lu, Xinyan, Sauter, Basilius, Keller, Aramis, Zhanybekova, Saule, & Gillingham, Dennis. (2025). Exploring the Potential of Homologous Recombination Protein PALB2 in Synthetic Lethal Combinations [Journal-article]. ACS Chemical Biology, 20(5), 1099–1106. https://doi.org/10.1021/acschembio.5c00111

Cai, Pinwen, Disraeli, Chiara, Sauter, Basilius, Zhanybekova, Saule, & Gillingham, Dennis. (2025). A method to identify small molecule/protein pairs susceptible to protein ubiquitination by the CRBN E3 ligase. Chemical Science, 16(18), 7730–7738. https://doi.org/10.1039/d5sc01251a

Sauter, Basilius, Cai, Pinwen, Dagher, Koder, Disraeli, Chiara, Kakkolliyil Prakash, Athira, Schneider, Lukas, Cores Esperon, Angel, & Gillingham, Dennis. (2025). Challenges and Opportunities in DNA Encoded Library Screens [Journal-article]. CHIMIA, 79(3), 158–161. https://doi.org/10.2533/chimia.2025.158

Cai, Pinwen, Disraeli, Chiara, Sauter, Basilius, Zhanybekova, Saule, & Gillingham, Dennis. (2025). A method to identify small molecule/protein pairs susceptible to protein ubiquitination by the CRBN E3 ligase [Posted-content]. In Chemrxiv. Cambridge University Press. https://doi.org/10.26434/chemrxiv-2024-8v8km-v2

Cai, Pinwen, Sauter, Basilius, Zhanybekova, Saule, & Gillingham, Dennis. (2024). A method to identify small molecule/protein pairs susceptible to protein ubiquitination [Posted-content]. In Chemrxiv. Cambridge University Press. https://doi.org/10.26434/chemrxiv-2024-8v8km

Gillingham, Dennis G, & Sauter, Basilius. (2024). 3.2.3.1 Macrocyclic DELs. In Scheuermann, J.; Li, Y. (ed.), & Fürstner, A.;Carreira, E. M.;Faul, M.;Kobayashi, S.;Koch, G.;Molander, G. A.;Nevado, C.;Trost, B. M.;You, S.-L. (trans.), DNA-Encoded Libraries: Vol. 2023/5 (1 ed., p. 561–). Georg Thieme Verlag KG. https://doi.org/10.1055/sos-sd-241-00235

Jauslin, Werner Theodor, Schild, Matthias, Schaefer, Thorsten, Borsari, Chiara, Orbegozo, Clara, Bissegger, Lukas, Zhanybekova, Saule, Ritz, Danilo, Schmidt, Alexander, Wymann, Matthias, & Gillingham, Dennis. (2024). Correction: A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα [Journal-article]. Chemical Science, 15(4), 1520. https://doi.org/10.1039/d4sc90011a

Kozicka, Zuzanna, Suchyta, Dakota J., Focht, Vivian, Kempf, Georg, Petzold, Georg, Jentzsch, Marius, Zou, Charles, Di Genua, Cristina, Donovan, Katherine A., Coomar, Seemon, Cigler, Marko, Mayor-Ruiz, Cristina, Schmid-Burgk, Jonathan L., Häussinger, Daniel, Winter, Georg E., Fischer, Eric S., Słabicki, Mikołaj, Gillingham, Dennis, Ebert, Benjamin L., & Thomä, Nicolas H. (2024). Design principles for cyclin K molecular glue degraders. Nature Chemical Biology, 20(1), 93–102. https://doi.org/10.1038/s41589-023-01409-z

Lüthi, Hans P., Gillingham, Dennis, Hartrampf, Nina, & Reymond, Jean-Louis. (2024). The Swiss Summer School on Chemical Biology, Bergün/Bravuogn, August 25–29, 2024. Chimia, 78, 793–796. https://doi.org/10.2533/chimia.2024.793

Jauslin, Werner Theodor, Schild, Matthias, Schaefer, Thorsten, Borsari, Chiara, Orbegozo, Clara, Bissegger, Lukas, Zhanybekova, Saule, Ritz, Danilo, Schmidt, Alexander, Wymann, Matthias, & Gillingham, Dennis. (2023). A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα [Journal-article]. Chemical Science, 15(2), 683–691. https://doi.org/10.1039/d3sc04629j

Schneider, Lukas A., Sauter, Basilius, Dagher, Koder, & Gillingham, Dennis. (2023). Recording Binding Information Directly into DNA-Encoded Libraries Using Terminal Deoxynucleotidyl Transferase [Journal-article]. Journal of the American Chemical Society, 145(38), 20874–20882. https://doi.org/10.1021/jacs.3c05961

Coomar, Seemon, Mota, Pedro, Penson, Alexander, Schwaller, Jurg, Abdel-Wahab, Omar, & Gillingham, Dennis. (2023). Overlaid Transcriptional and Proteome Analyses Identify Mitotic Kinesins as Important Targets of Arylsulfonamide-Mediated RBM39 Degradation. Molecular Cancer Research, 21(8), OF1–OF11. https://doi.org/10.1158/1541-7786.mcr-22-0541

Auberson, Yves P., Benfatti, Fides, Gillingham, Dennis, & Hartrampf, Nina. (2023). An Active Member of the EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society**. ChemMedChem, 18(11). https://doi.org/10.1002/cmdc.202300014

Baron, Leeroy, Hadjerci, Justine, Thoidingjam, Leishemba, Plays, Marina, Bucci, Romain, Morris, Nolwenn, Müller, Sebastian, Sindikubwabo, Fabien, Solier, Stéphanie, Cañeque, Tatiana, Colombeau, Ludovic, Blouin, Cedric M., Lamaze, Christophe, Puisieux, Alain, Bono, Yannick, Gaillet, Christine, Laraia, Luca, Vauzeilles, Boris, Taran, Frédéric, et al. (2023). PSL Chemical Biology Symposia Third Edition: A Branch of Science in its Explosive Phase. ChemBioChem, 24(8). https://doi.org/10.1002/cbic.202300093

Murawska, Gosia M., Vogel, Caspar, Jan, Max, Lu, Xinyan, Schild, Matthias, Slabicki, Mikolaj, Zou, Charles, Zhanybekova, Saule, Manojkumar, Manisha, Petzold, Georg, Kaiser, Peter, Thomä, Nicolas, Ebert, Benjamin, & Gillingham, Dennis. (2022). Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron. ACS Chemical Biology. https://doi.org/10.1021/acschembio.1c00771

Duca, Maria, Gillingham, Dennis, Olsen, Christian Adam, Sbardella, Gianluca, Skaanderup, Philip R., van der Stelt, Mario, Vauzeilles, Boris, Vázquez, Olalla, & Auberson, Yves P. (2021). The Chemical Biology-Medicinal Chemistry Continuum: EFMC′s Vision. ChemBioChem, 22(19), 2823–2825. https://doi.org/10.1002/cbic.202100319

Gillingham, Dennis. (2021). Fantastic molecular glues and where to find them. Chimia, 75(5), 439–441. https://doi.org/10.2533/chimia.2021.439

Cai, Pinwen, Schneider, Lukas A., Stress, Cedric, & Gillingham, Dennis. (2021). Building Boron Heterocycles into DNA-Encoded Libraries. Organic Letters, 23(22), 8772–8776. https://doi.org/10.1021/acs.orglett.1c03262

Sauter, Basilius, Schneider, Lukas, Stress, Cedric, & Gillingham, Dennis. (2021). An assessment of the mutational load caused by various reactions used in DNA encoded libraries. Bioorganic & Medicinal Chemistry, 52, 116508. https://doi.org/10.1016/j.bmc.2021.116508

Kilaj, Ardita, Gao, Hong, Tahchieva, Diana, Ramakrishnan, Raghunathan, Bachmann, Daniel, Gillingham, Dennis, von Lilienfeld, O. Anatole, Kuepper, Jochen, & Willitsch, Stefan. (2020). Quantum-chemistry-aided identification, synthesis and experimental validation of model systems for conformationally controlled reaction studies: separation of the conformers of 2,3-dibromobuta-1,3-diene in the gas phase. Physical Chemistry Chemical Physics, 22(24), 13431–13439. https://doi.org/10.1039/d0cp01396j

Sauter, Basilius, & Gillingham, Dennis. (2020). DNA Damaging Agents in Chemical Biology and Cancer. Chimia, 74(9), 693–698. https://doi.org/10.2533/chimia.2020.693

Słabicki, Mikołaj, Kozicka, Zuzanna, Petzold, Georg, Li, Yen-Der, Manojkumar, Manisha, Bunker, Richard D., Donovan, Katherine A., Sievers, Quinlan L., Koeppel, Jonas, Suchyta, Dakota, Sperling, Adam S., Fink, Emma C., Gasser, Jessica A., Wang, Li R., Corsello, Steven M., Sellar, Rob S., Jan, Max, Gillingham, Dennis, Scholl, Claudia, et al. (2020). The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature, 585(7824), 293–297. https://doi.org/10.1038/s41586-020-2374-x

Stress, Cedric J., Sauter, Basilius, Schneider, Lukas A., Sharpe, Timothy, & Gillingham, Dennis. (2019). Eine DNA‐kodierte Molekülbibliothek mit Elementen natürlicher Makrocyclen [Journal-article]. Angewandte Chemie, 131(28), 9671–9675. https://doi.org/10.1002/ange.201902513

Geigle, Stefanie, Rasale, Dnyaneshwar B., & Gillingham, Dennis. (2019). Synthesis of Various Water Soluble and Stable Copper Complexes Bearing N-Heterocyclic Carbene Ligands and Their Activity in DNA Alkylation. Helvetica Chimica Acta, 102(1). https://doi.org/10.1002/hlca.201800183

Räz, Michael H., Sandell, Emma, Patil, Kiran, Gillingham, Dennis G., & Sturla, Shana J. (2019). High Sensitivity of Human Translesion DNA Synthesis Polymerase κ to Variation in O6-Carboxymethylguanine Structures. ACS Chemical Biology, 14(2), 214–222. https://doi.org/10.1021/acschembio.8b00802

Stress, Cedric J., Sauter, Basilius, Schneider, Lukas A., Sharpe, Timothy, & Gillingham, Dennis. (2019). A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles. Angewandte Chemie International Edition, 58(28), 9570–9574. https://doi.org/10.1002/anie.201902513

Wang, Yu, Patil, Kiran M., Yan, Shuanghong, Zhang, Panke, Guo, Weiming, Wang, Yuqin, Chen, Hong-Yuan, Gillingham, Dennis, & Huang, Shuo. (2019). Nanopore Sequencing Accurately Identifies the Mutagenic DNA Lesion O; 6; -Carboxymethyl Guanine and Reveals Its Behavior in Replication. Angewandte Chemie International Edition, 58(25), 8432–8436. https://doi.org/10.1002/anie.201902521

Gillingham, Dennis, & Rasale, Dnyaneshwar. (2018). Direct and Selective Modification of RNA - An Open Challenge in Nucleic Acid Chemistry. Chimia, 72(11), 777–781. https://doi.org/10.2533/chimia.2018.777

Rasale, Dnyaneshwar, Patil, Kiran, Sauter, Basilius, Geigle, Stefanie, Zhanybekova, Saule, & Gillingham, Dennis. (2018). A new water soluble copper N-heterocyclic carbene complex delivers mild O6G-selective RNA alkylation. Chemical Communications, 54(66), 9174–9177. https://doi.org/10.1039/c8cc04476g

Sauter, Basilius, & Gillingham, Dennis. (2018). Profiling the Nucleobase and Structure Selectivity of Anticancer Drugs and other DNA Alkylating Agents by RNA Sequencing. ChemBioChem, 19(15), 1638–1642. https://doi.org/10.1002/cbic.201800235

Zhao, Jingming, Bachmann, Daniel G., Lenz, Markus, Gillingham, Dennis G., & Ward, Thomas R. (2018). An artificial metalloenzyme for carbene transfer based on a biotinylated dirhodium anchored within streptavidin. Catalysis science & technology, 8(9), 2294–2298. https://doi.org/10.1039/c8cy00646f

Geigle, Stefanie, Wyss, Laura, Sturla, Shana, & Gillingham, Dennis. (2017). Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction. Chemical Science, 8(1), 499–506. https://doi.org/10.1039/c6sc03502g

Gillingham, Dennis, & Sauter, Basilius. (2017). Genomic Studies Reveal New Aspects of the Biology of DNA Damaging Agents. ChemBioChem, 18(24), 2368–2375. https://doi.org/10.1002/cbic.201700520

Fei, Na, Sauter, Basilius, & Gillingham, Dennis. (2016). The pKa of Bronsted acids controls their reactivity with diazo compounds. Journal of the Chemical Society, Chemical Communications, 52(47), 7501–7504. https://doi.org/10.1039/c6cc03561b

Gillingham, Dennis. (2016). The role of boronic acids in accelerating condensation reactions of [small alpha]-effect amines with carbonyls. Organic & Biomolecular Chemistry, 14(32), 7606–7609. https://doi.org/10.1039/c6ob01193d

Gillingham, Dennis, Geigle, Stefanie, & von Lilienfeld, O. Anatole. (2016). Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics. Chemical Society Reviews, 45(9), 55–2637. https://doi.org/10.1039/c5cs00271k

Stress, Cedric, Schmidt, Pascal, & Gillingham, Dennis. (2016). Comparison of boron-assisted oxime and hydrazone formations leads to the discovery of a fluorogenic variant. Organic & Biomolecular Chemistry, 14(24), 33–5529. https://doi.org/10.1039/c6ob00168h

Bachmann, Daniel, Schmidt, Pascal, Geigle, Stefanie, Chougnet, Antoinette, Woggon, Wolf-Dietrich, & Gillingham, Dennis. (2015). Modular ligands for dirhodium complexes facilitate catalyst customization. Advanced Synthesis and Catalysis, 357(9), 2033–2038. https://doi.org/10.1002/adsc.201500050

Gillingham, Dennis, & Shahid, Ramla. (2015). Catalysts for RNA and DNA modification. Current Opinion in Chemical Biology, 25, 4–110. https://doi.org/10.1016/j.cbpa.2014.12.025

Schmidt, Pascal, Stress, Cedric, & Gillingham, Dennis. (2015). Boronic acids facilitate rapid oxime condensations at neutral pH. Chemical Science, 6(6), 3329–3333. https://doi.org/10.1039/c5sc00921a

Tishinov, Kiril, & Gillingham, Dennis. (2015). Synthesis of New Alkylated Mononucleotide Analogues and Their Repair Proficiency by the Prokaryotic DNA Repair Protein AlkB. Synlett, 26(19), 2720–2723. https://doi.org/10.1055/s-0035-1560491

Fei, Na, Häussinger, Daniel, Blümli, Seraina, Laventie, Benoît-Joseph, Bizzini, Lorenzo D, Zimmermann, Kaspar, Jenal, Urs, & Gillingham, Dennis. (2014). Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides. Chemical Communications, 50(62), 502–8499. https://doi.org/10.1039/c4cc01919a

Schmidt, Pascal, Zhou, Linna, Tishinov, Kiril, Zimmermann, Kaspar, & Gillingham, Dennis. (2014). Dialdehydes Lead to Exceptionally Fast Bioconjugations at Neutral pH by Virtue of a Cyclic Intermediate. Angewandte Chemie International Edition, 53(41), 31–10928. https://doi.org/10.1002/anie.201406132

Bachmann, Daniel G., Wittwer, Christopher C., & Gillingham, Dennis G. (2013). Stereoselective Heck Reactions with Vinyl Sulfoxides, Sulfides and Sulfones. Advanced Synthesis and Catalysis, 355(18), 3703–3707. https://doi.org/10.1002/adsc.201300678

Gillingham, Dennis, & Fei, Na. (2013). Catalytic X-H insertion reactions based on carbenoids. Chemical Society Reviews, 42(12), 31–4918. https://doi.org/10.1039/c3cs35496b

Gillingham, Dennis, & Tishinov, Kiril. (2013). Synthesis of nucleic acid polymers with non-canonical nucleobases. Synlett, 24(8), 893–897. https://doi.org/10.1055/s-0032-1318493

Tishinov, Kiril, Fei, Na, & Gillingham, Dennis. (2013). Cu(I)-catalysed N-H insertion in water: a new tool for chemical biology. Chemical Science, 4(12), 4401–4406. https://doi.org/10.1039/c3sc51363g

Gillingham, Dennis, Martinez, Alexandre, & Pianowski, Zbigniew. (2012). Report from the 47th EUCHEMS Conference on Stereochemistry : The Bürgenstock Conference. Chimia, 66(11), 873–875. https://doi.org/10.2533/chimia.2012.873

Stallforth, Pierre, Matthies, Stefan, Adibekian, Alexander, Gillingham, Dennis, Hilvert, Donald, & Seeberger, Peter. (2012). De novo chemoenzymatic synthesis of sialic acid. Chemical Communications, 48(98), 9–11987. https://doi.org/10.1039/c2cc37305j

Tishinov, Kiril, Schmidt, Kristina, Häussinger, Daniel, & Gillingham, Dennis G. (2012). Structure-selective catalytic alkylation of DNA and RNA. Angewandte Chemie International Edition, 51(48), 4–12000. https://doi.org/10.1002/anie.201205201

Clemens, M., Gillingham, Dennis, Ward, Thomas R., & Hilvert, Donald. (2011). An Artificial Metalloenzyme for Olefin Metathesis. Journal of the Chemical Society, Chemical Communications, 47(44), 12068–12070. https://doi.org/10.1039/c1cc15005g