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Prof. Dr.
Dennis Gillingham
Department of Chemistry
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Publications
39 found
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Gillingham, Dennis G, & Sauter, Basilius. (2024). 3.2.3.1 Macrocyclic DELs. In Scheuermann, J.; Li, Y. (ed.), & Fürstner, A.;Carreira, E. M.;Faul, M.;Kobayashi, S.;Koch, G.;Molander, G. A.;Nevado, C.;Trost, B. M.;You, S.-L. (trans.), DNA-Encoded Libraries: Vol. 2023/5 (1 ed., p. 561–). Georg Thieme Verlag KG. https://doi.org/10.1055/sos-sd-241-00235
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Jauslin, Werner Theodor, Schild, Matthias, Schaefer, Thorsten, Borsari, Chiara, Orbegozo, Clara, Bissegger, Lukas, Zhanybekova, Saule, Ritz, Danilo, Schmidt, Alexander, Wymann, Matthias, & Gillingham, Dennis. (2024). Correction: A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα [Journal-article]. Chemical Science, 15(4), 1520. https://doi.org/10.1039/d4sc90011a
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Jauslin, Werner Theodor, Schild, Matthias, Schaefer, Thorsten, Borsari, Chiara, Orbegozo, Clara, Bissegger, Lukas, Zhanybekova, Saule, Ritz, Danilo, Schmidt, Alexander, Wymann, Matthias, & Gillingham, Dennis. (2023). A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα [Journal-article]. Chemical Science, 15(2), 683–691. https://doi.org/10.1039/d3sc04629j
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Schneider, Lukas A., Sauter, Basilius, Dagher, Koder, & Gillingham, Dennis. (2023). Recording Binding Information Directly into DNA-Encoded Libraries Using Terminal Deoxynucleotidyl Transferase [Journal-article]. Journal of the American Chemical Society, 145(38), 20874–20882. https://doi.org/10.1021/jacs.3c05961
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Kozicka, Zuzanna, Suchyta, Dakota J., Focht, Vivian, Kempf, Georg, Petzold, Georg, Jentzsch, Marius, Zou, Charles, Di Genua, Cristina, Donovan, Katherine A., Coomar, Seemon, Cigler, Marko, Mayor-Ruiz, Cristina, Schmid-Burgk, Jonathan L., Häussinger, Daniel, Winter, Georg E., Fischer, Eric S., Słabicki, Mikołaj, Gillingham, Dennis, Ebert, Benjamin L., & Thomä, Nicolas H. (2023). Design principles for cyclin K molecular glue degraders. Nature Chemical Biology, 20, 93–102. https://doi.org/10.1038/s41589-023-01409-z
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Murawska, Gosia M., Vogel, Caspar, Jan, Max, Lu, Xinyan, Schild, Matthias, Slabicki, Mikolaj, Zou, Charles, Zhanybekova, Saule, Manojkumar, Manisha, Petzold, Georg, Kaiser, Peter, Thomä, Nicolas, Ebert, Benjamin, & Gillingham, Dennis. (2022). Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron. ACS Chemical Biology. https://doi.org/10.1021/acschembio.1c00771
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Cai, Pinwen, Schneider, Lukas A., Stress, Cedric, & Gillingham, Dennis. (2021). Building Boron Heterocycles into DNA-Encoded Libraries. Organic Letters, 23(22), 8772–8776. https://doi.org/10.1021/acs.orglett.1c03262
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Sauter, Basilius, Schneider, Lukas, Stress, Cedric, & Gillingham, Dennis. (2021). An assessment of the mutational load caused by various reactions used in DNA encoded libraries. Bioorganic & Medicinal Chemistry, 52, 116508. https://doi.org/10.1016/j.bmc.2021.116508
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Kilaj, Ardita, Gao, Hong, Tahchieva, Diana, Ramakrishnan, Raghunathan, Bachmann, Daniel, Gillingham, Dennis, von Lilienfeld, O. Anatole, Kuepper, Jochen, & Willitsch, Stefan. (2020). Quantum-chemistry-aided identification, synthesis and experimental validation of model systems for conformationally controlled reaction studies: separation of the conformers of 2,3-dibromobuta-1,3-diene in the gas phase. Physical Chemistry Chemical Physics, 22(24), 13431–13439. https://doi.org/10.1039/d0cp01396j
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Sauter, Basilius, & Gillingham, Dennis. (2020). DNA Damaging Agents in Chemical Biology and Cancer. Chimia, 74(9), 693–698. https://doi.org/10.2533/chimia.2020.693
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Słabicki, Mikołaj, Kozicka, Zuzanna, Petzold, Georg, Li, Yen-Der, Manojkumar, Manisha, Bunker, Richard D., Donovan, Katherine A., Sievers, Quinlan L., Koeppel, Jonas, Suchyta, Dakota, Sperling, Adam S., Fink, Emma C., Gasser, Jessica A., Wang, Li R., Corsello, Steven M., Sellar, Rob S., Jan, Max, Gillingham, Dennis, Scholl, Claudia, et al. (2020). The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature, 585(7824), 293–297. https://doi.org/10.1038/s41586-020-2374-x
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Stress, Cedric J., Sauter, Basilius, Schneider, Lukas A., Sharpe, Timothy, & Gillingham, Dennis. (2019). Eine DNA‐kodierte Molekülbibliothek mit Elementen natürlicher Makrocyclen [Journal-article]. Angewandte Chemie, 131(28), 9671–9675. https://doi.org/10.1002/ange.201902513
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Räz, Michael H., Sandell, Emma, Patil, Kiran, Gillingham, Dennis G., & Sturla, Shana J. (2019). High Sensitivity of Human Translesion DNA Synthesis Polymerase κ to Variation in O6-Carboxymethylguanine Structures. ACS Chemical Biology, 14(2), 214–222. https://doi.org/10.1021/acschembio.8b00802
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Stress, Cedric J., Sauter, Basilius, Schneider, Lukas A., Sharpe, Timothy, & Gillingham, Dennis. (2019). A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles. Angewandte Chemie International Edition, 58(28), 9570–9574. https://doi.org/10.1002/anie.201902513
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Wang, Yu, Patil, Kiran M., Yan, Shuanghong, Zhang, Panke, Guo, Weiming, Wang, Yuqin, Chen, Hong-Yuan, Gillingham, Dennis, & Huang, Shuo. (2019). Nanopore Sequencing Accurately Identifies the Mutagenic DNA Lesion O; 6; -Carboxymethyl Guanine and Reveals Its Behavior in Replication. Angewandte Chemie International Edition, 58(25), 8432–8436. https://doi.org/10.1002/anie.201902521
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Gillingham, Dennis, & Rasale, Dnyaneshwar. (2018). Direct and Selective Modification of RNA - An Open Challenge in Nucleic Acid Chemistry. Chimia, 72(11), 777–781. https://doi.org/10.2533/chimia.2018.777
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Rasale, Dnyaneshwar, Patil, Kiran, Sauter, Basilius, Geigle, Stefanie, Zhanybekova, Saule, & Gillingham, Dennis. (2018). A new water soluble copper N-heterocyclic carbene complex delivers mild O6G-selective RNA alkylation. Chemical Communications, 54(66), 9174–9177. https://doi.org/10.1039/c8cc04476g
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Sauter, Basilius, & Gillingham, Dennis. (2018). Profiling the Nucleobase and Structure Selectivity of Anticancer Drugs and other DNA Alkylating Agents by RNA Sequencing. ChemBioChem, 19(15), 1638–1642. https://doi.org/10.1002/cbic.201800235
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Zhao, Jingming, Bachmann, Daniel G., Lenz, Markus, Gillingham, Dennis G., & Ward, Thomas R. (2018). An artificial metalloenzyme for carbene transfer based on a biotinylated dirhodium anchored within streptavidin. Catalysis science & technology, 8(9), 2294–2298. https://doi.org/10.1039/c8cy00646f
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Geigle, Stefanie, Wyss, Laura, Sturla, Shana, & Gillingham, Dennis. (2017). Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction. Chemical Science, 8(1), 499–506. https://doi.org/10.1039/c6sc03502g
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Gillingham, Dennis, & Sauter, Basilius. (2017). Genomic Studies Reveal New Aspects of the Biology of DNA Damaging Agents. ChemBioChem, 18(24), 2368–2375. https://doi.org/10.1002/cbic.201700520
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Fei, Na, Sauter, Basilius, & Gillingham, Dennis. (2016). The pKa of Bronsted acids controls their reactivity with diazo compounds. Journal of the Chemical Society, Chemical Communications, 52(47), 7501–7504. https://doi.org/10.1039/c6cc03561b
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Gillingham, Dennis. (2016). The role of boronic acids in accelerating condensation reactions of [small alpha]-effect amines with carbonyls. Organic & Biomolecular Chemistry, 14(32), 7606–7609. https://doi.org/10.1039/c6ob01193d
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Gillingham, Dennis, Geigle, Stefanie, & von Lilienfeld, O. Anatole. (2016). Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics. Chemical Society Reviews, 45(9), 2637–2655. https://doi.org/10.1039/c5cs00271k
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Stress, Cedric, Schmidt, Pascal, & Gillingham, Dennis. (2016). Comparison of boron-assisted oxime and hydrazone formations leads to the discovery of a fluorogenic variant. Organic & Biomolecular Chemistry, 14(24), 5529–5533. https://doi.org/10.1039/c6ob00168h
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Bachmann, Daniel, Schmidt, Pascal, Geigle, Stefanie, Chougnet, Antoinette, Woggon, Wolf-Dietrich, & Gillingham, Dennis. (2015). Modular ligands for dirhodium complexes facilitate catalyst customization. Advanced Synthesis and Catalysis, 357(9), 2033–2038. https://doi.org/10.1002/adsc.201500050
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Gillingham, Dennis, & Shahid, Ramla. (2015). Catalysts for RNA and DNA modification. Current Opinion in Chemical Biology, 25, 110–114. https://doi.org/10.1016/j.cbpa.2014.12.025
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Schmidt, Pascal, Stress, Cedric, & Gillingham, Dennis. (2015). Boronic acids facilitate rapid oxime condensations at neutral pH. Chemical Science, 6(6), 3329–3333. https://doi.org/10.1039/c5sc00921a
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Tishinov, Kiril, & Gillingham, Dennis. (2015). Synthesis of New Alkylated Mononucleotide Analogues and Their Repair Proficiency by the Prokaryotic DNA Repair Protein AlkB. Synlett, 26(19), 2720–2723. https://doi.org/10.1055/s-0035-1560491
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Fei, Na, Häussinger, Daniel, Blümli, Seraina, Laventie, Benoît-Joseph, Bizzini, Lorenzo D, Zimmermann, Kaspar, Jenal, Urs, & Gillingham, Dennis. (2014). Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides. Chemical Communications, 50(62), 8499–8502. https://doi.org/10.1039/c4cc01919a
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Schmidt, Pascal, Zhou, Linna, Tishinov, Kiril, Zimmermann, Kaspar, & Gillingham, Dennis. (2014). Dialdehydes Lead to Exceptionally Fast Bioconjugations at Neutral pH by Virtue of a Cyclic Intermediate. Angewandte Chemie International Edition, 53(41), 10928–10931. https://doi.org/10.1002/anie.201406132
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Bachmann, Daniel G., Wittwer, Christopher C., & Gillingham, Dennis G. (2013). Stereoselective Heck Reactions with Vinyl Sulfoxides, Sulfides and Sulfones. Advanced Synthesis and Catalysis, 355(18), 3703–3707. https://doi.org/10.1002/adsc.201300678
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Gillingham, Dennis, & Fei, Na. (2013). Catalytic X-H insertion reactions based on carbenoids. Chemical Society Reviews, 42(12), 4918–4931. https://doi.org/10.1039/c3cs35496b
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Gillingham, Dennis, & Tishinov, Kiril. (2013). Synthesis of nucleic acid polymers with non-canonical nucleobases. Synlett, 24(8), 893–897. https://doi.org/10.1055/s-0032-1318493
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Tishinov, Kiril, Fei, Na, & Gillingham, Dennis. (2013). Cu(I)-catalysed N-H insertion in water: a new tool for chemical biology. Chemical Science, 4(12), 4401–4406. https://doi.org/10.1039/c3sc51363g
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Gillingham, Dennis, Martinez, Alexandre, & Pianowski, Zbigniew. (2012). Report from the 47th EUCHEMS Conference on Stereochemistry : The Bürgenstock Conference. Chimia, 66(11), 873–875. https://doi.org/10.2533/chimia.2012.873
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Stallforth, Pierre, Matthies, Stefan, Adibekian, Alexander, Gillingham, Dennis, Hilvert, Donald, & Seeberger, Peter. (2012). De novo chemoenzymatic synthesis of sialic acid. Chemical Communications, 48(98), 11987–11989. https://doi.org/10.1039/c2cc37305j
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Tishinov, Kiril, Schmidt, Kristina, Häussinger, Daniel, & Gillingham, Dennis G. (2012). Structure-selective catalytic alkylation of DNA and RNA. Angewandte Chemie International Edition, 51(48), 12000–12004. https://doi.org/10.1002/anie.201205201
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Clemens, M., Gillingham, Dennis, Ward, Thomas R., & Hilvert, Donald. (2011). An Artificial Metalloenzyme for Olefin Metathesis. Journal of the Chemical Society, Chemical Communications, 47(44), 12068–12070. https://doi.org/10.1039/c1cc15005g
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