Prof. Dr. Urs Jenal

Tejada-Arranz, Alejandro, Plack, Annika, Antelo-Varela, Minia, Kaczmarczyk, Andreas, Klotz, Alexander, Jenal, Urs, & Basler, Marek. (2025). Mechanisms of Pseudomonas aeruginosa resistance to Type VI Secretion System attacks [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.10.26.620397

Kaczmarczyk, Andreas, van Vliet, Simon, Jakob, Roman Peter, Dias Teixeira, Raphael, Scheidat, Inga, Reinders, Alberto, Klotz, Alexander, Maier, Timm, & Jenal, Urs. (2024). A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-48295-0

Maffei, Enea, Woischnig, Anne-Kathrin, Burkolter, Marco R., Heyer, Yannik, Humolli, Dorentina, Thürkauf, Nicole, Bock, Thomas, Schmidt, Alexander, Manfredi, Pablo, Egli, Adrian, Khanna, Nina, Jenal, Urs, & Harms, Alexander. (2024). Phage Paride can kill dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa by direct lytic replication. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44157-3

Kurmashev, Amanzhol, Boos, Julia A., Laventie, Benoît-Joseph, Swart, A. Leoni, Sütterlin, Rosmarie, Junne, Tina, Jenal, Urs, & Hierlemann, Andreas. (2024). Transwell-Based Microfluidic Platform for High-Resolution Imaging of Airway Tissues. Advanced Materials Technologies, 9(20). https://doi.org/10.1002/admt.202400326

Santi, Isabella, Dias Teixeira, Raphael, Manfredi, Pablo, Hernandez Gonzalez, Hector, Spiess, Daniel C, Mas, Guillaume, Klotz, Alexander, Kaczmarczyk, Andreas, Zamboni, Nicola, Hiller, Sebastian, & Jenal, Urs. (2024). Toxin-mediated depletion of NAD and NADP drives persister formation in a human pathogen [Journal-article]. The EMBO Journal, 43(21), 5211–5236. https://doi.org/10.1038/s44318-024-00248-5

Leoni Swart, A., Laventie, Benoît-Joseph, Sütterlin, Rosmarie, Junne, Tina, Lauer, Luisa, Manfredi, Pablo, Jakonia, Sandro, Yu, Xiao, Karagkiozi, Evdoxia, Okujava, Rusudan, & Jenal, Urs. (2024). Pseudomonas aeruginosa breaches respiratory epithelia through goblet cell invasion in a microtissue model. Nature Microbiology, 9(7), 1725–1737. https://doi.org/10.1038/s41564-024-01718-6

Maffei, Enea, Manner, Christina, Jenal, Urs, & Harms, Alexander. (2024). Complete genome sequence of Pseudomonas aeruginosa phage Knedl. Microbiology Resource Announcements, 13(4). https://doi.org/10.1128/mra.01174-23

Pérez-Burgos, María, Herfurth, Marco, Kaczmarczyk, Andreas, Harms, Andrea, Huber, Katrin, Jenal, Urs, Glatter, Timo, & Søgaard-Andersen, Lotte. (2024). A deterministic, c-di-GMP-dependent genetic program ensures the generation of phenotypically similar, symmetric daughter cells during cytokinesis [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.02.06.579105

Sollier, Julie, Basler, Marek, Broz, Petr, Dittrich, Petra S., Drescher, Knut, Egli, Adrian, Harms, Alexander, Hierlemann, Andreas, Hiller, Sebastian, King, Carolyn G., McKinney, John D., Moran-Gilad, Jacob, Neher, Richard A., Page, Malcolm G. P., Panke, Sven, Persat, Alexandre, Picotti, Paola, Rentsch, Katharina M., Rivera-Fuentes, Pablo, et al. (2024). Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions. Nature Microbiology, 9(1), 1–3. https://doi.org/10.1038/s41564-023-01566-w

Kurmashev, Amanzhol, Boos, Julia A., Laventie, Benoît-Joseph, Swart, A. Leoni, Sütterlin, Rosmarie, Junne, Tina, Jenal, Urs, & Hierlemann, Andreas. (2023). Transwell-based microphysiological platform for high-resolution imaging of airway tissues [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.11.22.567838

Santi, Isabella, Dias Teixeira, Raphael, Manfredi, Pablo, Spiess, Daniel, Mas, Guillaume, Klotz, Alexander, Zamboni, Nicola, Hiller, Sebastian, & Jenal, Urs. (2023). Toxin-mediated depletion of nicotinamide dinucleotides drives persister formation in a human pathogen [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.09.28.559889

Swart, A. Leoni, Laventie, Benoît-Joseph, Sütterlin, Rosmarie, Junne, Tina, Yu, Xiao, Karagkiozi, Evdoxia, Okujava, Rusudan, & Jenal, Urs. (2023). Goblet cell invasion promotes breaching of respiratory epithelia by an opportunistic human pathogen [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.08.13.553119

Klotz, Alexander, Kaczmarczyk, Andreas, & Jenal, Urs. (2023). A Synthetic Cumate-Inducible Promoter for Graded and Homogenous Gene Expression in Pseudomonas aeruginosa. Applied and Environmental Microbiology, 89(6). https://doi.org/10.1128/aem.00211-23

Dubey, Badri Nath, Shyp, Viktoriya, Fucile, Geoffrey, Sondermann, Holger, Jenal, Urs, & Schirmer, Tilman. (2023). Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization. Scientific reports, 13(1), 2727. https://doi.org/10.1038/s41598-023-29110-0

Manner, Christina, Dias Teixeira, Raphael, Saha, Dibya, Kaczmarczyk, Andreas, Zemp, Raphaela, Wyss, Fabian, Jaeger, Tina, Laventie, Benoit-Joseph, Boyer, Sebastien, Malone, Jacob G., Qvortrup, Katrine, Andersen, Jens Bo, Givskov, Michael, Tolker-Nielsen, Tim, Hiller, Sebastian, Drescher, Knut, & Jenal, Urs. (2023). A genetic switch controls Pseudomonas aeruginosa surface colonization. Nature Microbiology, 8(8), 1520–1533. https://doi.org/10.1038/s41564-023-01403-0

Kaczmarczyk, Andreas, van Vliet, Simon, Jakob, Roman Peter, Reinders, Alberto, Klotz, Alexander, Maier, Timm, & Jenal, Urs. (2022). A Novel Biosensor Reveals Dynamic Changes of C-di-GMP in Differentiating Cells with Ultra-High Temporal Resolution [Posted-content]. bioRxiv. https://doi.org/10.1101/2022.10.18.512705

Dubey, Badri Nath, Shyp, Viktoriya, Fucile, Geoffrey, Jenal, Urs, & Schirmer, Tilman. (2022). High-resolution crystal structure of a metabolic switch protein in a complex with monomeric c-di-GMP reveals a potential mechanism for c-di-GMP dimerization [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.07.30.502141

Povolo, Vanessa R, D’Souza, Glen G, Kaczmarczyk, Andreas, Stubbusch, Astrid KM, Jenal, Urs, & Ackermann, Martin. (2022). Extracellular appendages govern spatial dynamics and growth of Caulobacter crescentus on a prevalent biopolymer [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.06.13.495907

Anglada-Girotto, Miquel, Handschin, Gabriel, Ortmayr, Karin, Campos, Adrian I., Gillet, Ludovic, Manfredi, Pablo, Mulholland, Claire V., Berney, Michael, Jenal, Urs, Picotti, Paola, & Zampieri, Mattia. (2022). Combining CRISPRi and metabolomics for functional annotation of compound libraries. Nature Chemical Biology, 18(5), 482–491. https://doi.org/10.1038/s41589-022-00970-3

Anglada-Girotto, Miquel, Handschin, Gabriel, Ortmayr, Karin, Campos, Adrian I., Gillet, Ludovic, Manfredi, Pablo, Mulholland, Claire V., Berney, Michael, Jenal, Urs, Picotti, Paola, & Zampieri, Mattia. (2022). Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries. Nature Chemical Biology, 18(5), 575. https://doi.org/10.1038/s41589-022-01028-0

Haas, Thomas M., Laventie, Benoit-Joseph, Lagies, Simon, Harter, Caroline, Prucker, Isabel, Ritz, Danilo, Batcha, Raspudin Saleem, Qiu, Danye, Hüttel, Wolfgang, Andexer, Jennifer, Kammerer, Bernd, Jenal, Urs, & Jessen, Henning Jacob. (2022). Photoaffinity capture compounds to profile the Magic Spot Nucleotide interactomes. Angewandte Chemie International Edition, 61(22), e202201731. https://doi.org/10.1002/anie.202201731

Jenal, Urs. (2022). Killing the messenger to evade bacterial defences. Nature, 605(7910), 431–432. https://doi.org/10.1038/d41586-022-01127-x

Maffei, Enea, Burkolter, Marco, Heyer, Yannik, Egli, Adrian, Jenal, Urs, & Harms, Alexander. (2022). Phage Paride hijacks bacterial stress responses to kill dormant, antibiotic-tolerant cells. bioRxiv, 477855. https://doi.org/10.1101/2022.01.26.477855

Sauter, Nora, Sangermani, Matteo, Hug, Isabelle, Jenal, Urs, & Pfohl, Thomas. (2022). Bacteria-on-a-bead: probing the hydrodynamic interplay of dynamic cell appendages during cell separation. Communications Biology, 5(1), 1093. https://doi.org/10.1038/s42003-022-04026-z

Steiner, Elisabeth, Shilling, Rebecca E., Richter, Anja M., Schmid, Nadine, Fazli, Mustafa, Kaever, Volkhard, Jenal, Urs, Tolker-Nielsen, Tim, & Eberl, Leo. (2022). The BDSF quorum sensing receptor RpfR regulates Bep exopolysaccharide synthesis in Burkholderia cenocepacia via interaction with the transcriptional regulator BerB. NPJ Biofilms and Microbiomes, 8(1), 93. https://doi.org/10.1038/s41522-022-00356-2

Haas, Thomas M., Laventie, Benoît-Joseph, Lagies, Simon, Harter, Caroline, Prucker, Isabel, Ritz, Danilo, Batcha, Raspudin Saleem, Qiu, Danye, Hüttel, Wolfgang, Andexer, Jennifer, Jenal, Urs, & Jessen, Henning J. (2021). Photoaffinity capture compounds to profile the Magic Spot Nucleotide interactomes [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.12.15.472736

Sellner, B., Prakapaite, R., Van Berkum, M., Heinemann, M., Harms, A., & Jenal, U. (2021). A New Sugar for an Old Phage: A c-di-GMP-Dependent Polysaccharide Pathway Sensitizes Escherichia coli for Bacteriophage Infection. mBio, 12(6). https://doi.org/10.1128/mbio.03246-21

Fuentes, Diego Antonio Fernandez, Manfredi, Pablo, Jenal, Urs, & Zampieri, Mattia. (2021). Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli. Nature Communications, 12(1), 3204. https://doi.org/10.1038/s41467-021-23522-0

Reinders, Alberto, Sellner, Benjamin, Fadel, Firas, van Berkum, Margo, Kaczmarczyk, Andreas, Ozaki, Shogo, Rueher, Johanna, Manfredi, Pablo, Sangermani, Matteo, Harms, Alexander, Perez, Camilo, Schirmer, Tilman, & Jenal, Urs. (2021). Digital control of c-di-GMP in E. coli balances population-wide developmental transitions and phage sensitivity [bioRxiv]. 40. https://doi.org/10.1101/2021.10.01.462762

Santi, Isabella, Manfredi, Pablo, & Jenal, Urs. (2021). The Use of Experimental Evolution to Study the Response of Pseudomonas aeruginosa to Single or Double Antibiotic Treatment. Methods in Molecular Biology, 2357, 177–194. https://doi.org/10.1007/978-1-0716-1621-5_12

Santi, Isabella, Manfredi, Pablo, Maffei, Enea, Egli, Adrian, & Jenal, Urs. (2021). Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections. mBio, 12(1), e03482–20. https://doi.org/10.1128/mbio.03482-20

Sellner, Benjamin, Prakapaitė, Rūta, van Berkum, Margo, Heinemann, Matthias, Harms, Alexander, & Jenal, Urs. (2021). A new sugar for an old phage: A c-di-GMP dependent polysaccharide pathway sensitizes E. coli for bacteriophage infection. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.09.27.461960

Shyp, Viktoriya, Dubey, Badri Nath, Böhm, Raphael, Hartl, Johannes, Nesper, Jutta, Vorholt, Julia A., Hiller, Sebastian, Schirmer, Tilman, & Jenal, Urs. (2021). Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus. Nature Microbiology, 6(1), 59–72. https://doi.org/10.1038/s41564-020-00809-4

Manfredi, Pablo, Santi, Isabella, Maffei, Enea, Lezan, Emmanuelle, Schmidt, Alexander, & Jenal, Urs. (2021). Defining Proteomic Signatures to Predict Multidrug Persistence in Pseudomonas aeruginosa. In Verstraeten, Natalie; Michiels, Jan (Ed.), Bacterial Persistence: Methods and Protocols (pp. 161–175). Springer. https://doi.org/10.1007/978-1-0716-1621-5_11

Coppine, Jérôme, Kaczmarczyk, Andreas, Petit, Kenny, Brochier, Thomas, Jenal, Urs, & Hallez, Régis. (2020). Regulation of Bacterial Cell Cycle Progression by Redundant Phosphatases. Journal of Bacteriology, 202(17), e00345–20. https://doi.org/10.1128/jb.00345-20

Dubey, Badri N., Agustoni, Elia, Böhm, Raphael, Kaczmarczyk, Andreas, Mangia, Francesca, von Arx, Christoph, Jenal, Urs, Hiller, Sebastian, Plaza-Menacho, Iván, & Schirmer, Tilman. (2020). Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberation. Proceedings of the National Academy of Sciences of the United States of America, 117(2), 1000–1008. https://doi.org/10.1073/pnas.1911427117

Hartl, Johannes, Kiefer, Patrick, Kaczmarczyk, Andreas, Mittelviefhaus, Maximilian, Meyer, Fabian, Vonderach, Thomas, Hattendorf, Bodo, Jenal, Urs, & Vorholt, Julia A. (2020). Untargeted metabolomics links glutathione to bacterial cell cycle progression. Nature Metabolism, 2(2), 153–166. https://doi.org/10.1038/s42255-019-0166-0

Hee, Chee-Seng, Habazettl, Judith, Schmutz, Christoph, Schirmer, Tilman, Jenal, Urs, & Grzesiek, Stephan. (2020). Intercepting second-messenger signaling by rationally designed peptides sequestering c-di-GMP. Proceedings of the National Academy of Sciences of the United States of America, 117(29), 17211–17220. https://doi.org/10.1073/pnas.2001232117

Kaczmarczyk, Andreas, Hempel, Antje M., von Arx, Christoph, Böhm, Raphael, Dubey, Badri N., Nesper, Jutta, Schirmer, Tilman, Hiller, Sebastian, & Jenal, Urs. (2020). Precise Timing of Transcription by c-di-GMP Coordinates Cell Cycle and Morphogenesis in Caulobacter. Nature Communications, 11(1), 816. https://doi.org/10.1038/s41467-020-14585-6

Laventie, Benoît-Joseph, & Jenal, Urs. (2020). Surface Sensing and Adaptation in Bacteria. Annual review of microbiology, 74, 735–760. https://doi.org/10.1146/annurev-micro-012120-063427

Ozaki, Shogo, Jenal, Urs, & Katayama, Tsutomu. (2020). Novel Divisome-Associated Protein Spatially Coupling the Z-Ring with the Chromosomal Replication Terminus in Caulobacter crescentus. mBio, 11(2), e00487–20. https://doi.org/10.1128/mbio.00487-20

Rossmann, Florian M., Hug, Isabelle, Sangermani, Matteo, Jenal, Urs, & Beeby, Morgan. (2020). In situ structure of the Caulobacter crescentus flagellar motor and visualization of binding of a CheY-homolog. Molecular microbiology, 114(3), 443–453. https://doi.org/10.1111/mmi.14525

Santi, Isabella, Manfredi, Pablo, Maffei, Enea, Egli, Adrian, & Jenal, Urs. (2020). Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections. bioRxiv. https://doi.org/10.1101/2020.10.23.352104

Balaban, N. Q., Helaine, S., Lewis, K., Ackermann, M., Aldridge, B., Andersson, D. I., Brynildsen, M. P., Bumann, D., Camilli, A., Collins, J. J., Dehio, C., Fortune, S., Ghigo, J.-M., Hardt, W.-D., Harms, A., Heinemann, M., Hung, D. T., Jenal, U., Levin, B. R., et al. (2019). Publisher Correction: Definitions and guidelines for research on antibiotic persistence (Nature Reviews Microbiology, (2019), 17, 7, (441-448), 10.1038/s41579-019-0196-3). Nature Reviews Microbiology, 17(7). https://doi.org/10.1038/s41579-019-0207-4

Sangermani, Matteo, Hug, Isabelle, Sauter, Nora, Pfohl, Thomas, & Jenal, Urs. (2019). Tad pili play a dynamic role in caulobacter crescentus surface colonization. mBio, 10(3). https://doi.org/10.1128/mBio.01237-19

Dubey, Badri N., Agustoni, Elia, Böhm, Raphael, Kaczmarczyk, Andreas, Mangia, Francesca, von Arx, Christoph, Jenal, Urs, Hiller, Sebastian, Plaza-Menacho, Iván, & Schirmer, Tilman. (2019). Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberation [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/675454

Kaczmarczyk, Andreas, Hempel, Antje M., von Arx, Christoph, Böhm, Raphael, Dubey, Badri N., Nesper, Jutta, Schirmer, Tilman, Hiller, Sebastian, & Jenal, Urs. (2019). Precise transcription timing by a second-messenger drives a bacterial G1/S cell cycle transition [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/675330

Jenal, Urs, Sangermani, Matteo, Hug, Isabelle, Sauter, Nora, & Pfohl, Thomas. (2019). Tad pili play a dynamic role in Caulobacter crescentus surface colonization. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/526160

Balaban, Nathalie Q., Helaine, Sophie, Lewis, Kim, Ackermann, Martin, Aldridge, Bree, Andersson, Dan I., Brynildsen, Mark P., Bumann, Dirk, Camilli, Andrew, Collins, James J., Dehio, Christoph, Fortune, Sarah M., Ghigo, Jean-Marc, Hardt, Wolf-Dietrich, Harms, Alexander, Heinemann, Matthias, Hung, Deborah T., Jenal, Urs, Levin, Bruce R., et al. (2019). Definitions and guidelines for research on antibiotic persistence. Nature Reviews Microbiology, 17(7), 441–448. https://doi.org/10.1038/s41579-019-0196-3

Laventie, Benoît-Joseph, Sangermani, Matteo, Estermann, Fabienne, Manfredi, Pablo, Planes, Rémi, Hug, Isabelle, Jaeger, Tina, Meunier, Etienne, Broz, Petr, & Jenal, Urs. (2019). A surface-induced asymmetric program promotes tissue colonization by Pseudomonas aeruginosa. Cell Host & Microbe, 25(1), 140–+. https://doi.org/10.1016/j.chom.2018.11.008

Lori, C., Kaczmarczyk, A., de Jong, I., & Jenal, U. (2018). A Single-Domain Response Regulator Functions as an Integrating Hub To Coordinate General Stress Response and Development in Alphaproteobacteria. mBio, 9(3), e00809–18. https://doi.org/10.1128/mbio.00809-18

Lori, C., Kaczmarczyk, A., de Jong, I., & Jenal, U. (2018). Erratum for Lori et al., “A Single-Domain Response Regulator Functions as an Integrating Hub To Coordinate General Stress Response and Development in Alphaproteobacteria”. mBio, 9(5), e01534–18. https://doi.org/10.1128/mbio.01534-18

Wennemers, Helma, Foletti, Carlotta, Kramer, Rolf, Mauser, Harald, Jenal, Urs, & Bleicher, Konrad. (2018). Functionalized Proline-Rich Peptides Bind the Bacterial Second Messenger c-di-GMP. Angewandte Chemie (International Ed. In English), 57(26), 7729–7733. https://doi.org/10.1002/anie.201801845

Hug, Isabelle, Deshpande, Siddharth, Sprecher, Kathrin S., Pfohl, Thomas, & Jenal, Urs. (2017). Second messenger-mediated tactile response by a bacterial rotary motor. Science, 358(6362), 531–534. https://doi.org/10.1126/science.aan5353

Jenal, Urs, Reinders, Alberto, & Lori, Christian. (2017). Cyclic di-GMP: second messenger extraordinaire. Nature Reviews Microbiology, 15(5), 271–284. https://doi.org/10.1038/nrmicro.2016.190

Laventie, Benoît-Joseph, Glatter, Timo, & Jenal, Urs. (2017). Pull-Down with a c-di-GMP-Specific Capture Compound Coupled to Mass Spectrometry as a Powerful Tool to Identify Novel Effector Proteins. Methods in Molecular Biology, 1657, 361–376. https://doi.org/10.1007/978-1-4939-7240-1_28

Moreira, Ricardo N., Dressaire, Clémentine, Barahona, Susana, Galego, Lisete, Kaever, Volkhard, Jenal, Urs, & Arraiano, Cecília M. (2017). BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation. mBio, 8(5), 17. https://doi.org/10.1128/mbio.00443-17

Nesper, Jutta, Hug, Isabelle, Kato, Setsu, Hee, Chee-Seng, Habazettl, Judith Maria, Manfredi, Pablo, Grzesiek, Stephan, Schirmer, Tilman, Emonet, Thierry, & Jenal, Urs. (2017). Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators. eLife, 6, e28842. https://doi.org/10.7554/elife.28842

Schmid, Nadine, Suppiger, Angela, Steiner, Elisabeth, Pessi, Gabriella, Kaever, Volkhard, Fazli, Mustafa, Tolker-Nielsen, Tim, Jenal, Urs, & Eberl, Leo. (2017). High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111. Microbiology, 163(5), 754–764. https://doi.org/10.1099/mic.0.000452

Sedlmayer, Ferdinand, Jaeger, Tina, Jenal, Urs, & Fussenegger, Martin. (2017). Quorum-Quenching Human Designer Cells for Closed-Loop Control of Pseudomonas aeruginosa Biofilms. Nano Letters, 17(8), 5043–5050. https://doi.org/10.1021/acs.nanolett.7b02270

Sprecher, Kathrin S., Hug, Isabelle, Nesper, Jutta, Potthoff, Eva, Mahi, Mohamed-Ali, Sangermani, Matteo, Kaever, Volkhard, Schwede, Torsten, Vorholt, Julia, & Jenal, Urs. (2017). Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein. mBio, 8(2), e00294–17. https://doi.org/10.1128/mbio.00294-17

Valentini, M., Laventie, B.-J., Moscoso, J. A., Jenal, U., & Filloux, A. (2016). Erratum: The Diguanylate Cyclase HsbD Intersects with the HptB Regulatory Cascade to Control Pseudomonas aeruginosa Biofilm and Motility (PLoS Genet (2016) 12:10 (e1006354) DOI: 10.1371/journal.pgen.1006354). PLoS Genetics, 12(11). https://doi.org/10.1371/JOURNAL.PGEN.1006473

Broder, Ursula N., Jaeger, Tina, & Jenal, Urs. (2016). LadS is a calcium-responsive kinase that induces acute-to-chronic virulence switch in Pseudomonas aeruginosa. Nature Microbiology, 2, 16184. https://doi.org/10.1038/nmicrobiol.2016.184

Dubey, Badri N., Lori, Christian, Ozaki, Shogo, Fucile, Geoffrey, Plaza-Menacho, Ivan, Jenal, Urs, & Schirmer, Tilman. (2016). Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking. Science Advances, 2(9), e1600823. https://doi.org/10.1126/sciadv.1600823

Hengge, Regine, Galperin, Michael Y, Ghigo, Jean-Marc, Gomelsky, Mark, Green, Jeffrey, Hughes, Kelly T, Jenal, Urs, & Landini, Paolo. (2016). Systematic nomenclature for GGDEF and EAL domain-containing Cyclic di-GMP turnover proteins of Escherichia coli. Journal of Bacteriology, 198(1), 7–11. https://doi.org/10.1128/jb.00424-15

Hengge, Regine, Gründling, Angelika, Jenal, Urs, Ryan, Robert, & Yildiz, Fitnat. (2016). Bacterial Signal Transduction by Cyclic Di-GMP and Other Nucleotide Second Messengers. Journal of Bacteriology, 198(1), 15–26. https://doi.org/10.1128/jb.00331-15

Reinders, Alberto, Hee, Chee-Seng, Ozaki, Shogo, Mazur, Adam, Boehm, Alex, Schirmer, Tilman, & Jenal, Urs. (2016). Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Journal of Bacteriology, 198(3), 448–462. https://doi.org/10.1128/jb.00604-15

Rotem, Or, Nesper, Jutta, Borovok, Ilya, Gorovits, Rena, Kolot, Mikhail, Pasternak, Zohar, Shin, Irina, Glatter, Timo, Pietrokovski, Shmuel, Jenal, Urs, & Jurkevitch, Edouard. (2016). An extended cyclic di-GMP network in the predatory bacterium Bdellovibrio bacteriovorus. Journal of Bacteriology, 198(1), 127–137. https://doi.org/10.1128/jb.00422-15

Valentini, Martina, Laventie, Benoît-Joseph, Moscoso, Joana, Jenal, Urs, & Filloux, Alain. (2016). The Diguanylate Cyclase HsbD Intersects with the HptB Regulatory Cascade to Control Pseudomonas aeruginosa Biofilm and Motility. PLoS Genetics, 12(10), e1006354. https://doi.org/10.1371/journal.pgen.1006354

Laventie, Benoît-Joseph, Nesper, Jutta, Ahrné, Erik, Glatter, Timo, Schmidt, Alexander, & Jenal, Urs. (2015). Capture compound mass spectrometry - a powerful tool to identify novel c-di-GMP effector proteins. Journal of Visualized Experiments, 97 , e51404(97), e51404. https://doi.org/10.3791/51404

Lori, Christian, Ozaki, Shogo, Steiner, Samuel, Böhm, Raphael, Abel, Sören, Dubey, Badri N., Schirmer, Tilman, Hiller, Sebastian, & Jenal, Urs. (2015). Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication. Nature, 523(7559), 236–239. https://doi.org/10.1038/nature14473

Manfredi, Pablo, & Jenal, Urs. (2015). Bacteria in the CF Lung: Isolation Drives Diversity. Cell Host & Microbe, 18(3), 268–269. https://doi.org/10.1016/j.chom.2015.08.013

Fei, Na, Häussinger, Daniel, Blümli, Seraina, Laventie, Benoît-Joseph, Bizzini, Lorenzo D, Zimmermann, Kaspar, Jenal, Urs, & Gillingham, Dennis. (2014). Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides. Chemical Communications, 50(62), 8499–8502. https://doi.org/10.1039/c4cc01919a

Fumeaux, Coralie, Radhakrishnan, Sunish Kumar, Ardissone, Silvia, Théraulaz, Laurence, Frandi, Antonio, Martins, Daniel, Nesper, Jutta, Abel, Sören, Jenal, Urs, & Viollier, Patrick H. (2014). Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators. Nature Communications, 5, 4081. https://doi.org/10.1038/ncomms5081

Moscoso, Joana A., Jaeger, Tina, Valentini, Martina, Hui, Kailyn, Jenal, Urs, & Filloux, Alain. (2014). The Diguanylate Cyclase SadC Is a Central Player in Gac/Rsm-Mediated Biofilm Formation in Pseudomonas aeruginosa. Journal of Bacteriology, 196(23), 4081–4088. https://doi.org/10.1128/jb.01850-14

Ozaki, Shogo, Schalch-Moser, Annina, Zumthor, Ludwig, Manfredi, Pablo, Ebbensgaard, Anna, Schirmer, Tilman, & Jenal, Urs. (2014). Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control. Molecular Microbiology, 94(3), 580–594. https://doi.org/10.1111/mmi.12777

Sundriyal, Amit, Massa, Claudia, Samoray, Dietrich, Zehender, Fabian, Sharpe, Timothy, Jenal, Urs, & Schirmer, Tilman. (2014). Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP. Journal of Biological Chemistry, 289(10), 6978–6990. https://doi.org/10.1074/jbc.m113.516195

Boos, W., Parkinson, J. S., Jenal, U., Vogel, J., & Søgaard-Andersen, L. (2013). Alexander Böhm (1971-2012). Molecular Microbiology, 88(2), 219–221. https://doi.org/10.1111/mmi.12198

Abel, Sören, Bucher, Tabitha, Nicollier, Micaël, Hug, Isabelle, Kaever, Volkhard, Abel Zur Wiesch, Pia, & Jenal, Urs. (2013). Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle. PLoS Genetics, 9(9), e1003744. https://doi.org/10.1371/journal.pgen.1003744

Davis, N. J., Cohen, Y., Sanselicio, S., Fumeaux, C., Ozaki, S., Luciano, J., Guerrero-Ferreira, R. C., Wright, E. R., Jenal, U., & Viollier, P. H. (2013). De- and repolarization mechanism of flagellar morphogenesis during a bacterial cell cycle. Genes and Development, 27(18), 2049–2062. https://doi.org/10.1101/gad.222679.113

Jenal, Urs. (2013). Think globally, act locally: how bacteria integrate local decisions with their global cellular programme. The EMBO Journal, 32(14), 1972–1974. https://doi.org/10.1038/emboj.2013.140

Renggli, Sabine, Keck, Wolfgang, Jenal, Urs, & Ritz, Daniel. (2013). The role of auto-fluorescence in flow-cytometric analysis of Escherichia coli treated with bactericidal antibiotics. Journal of Bacteriology, 195(18), 4067–4073. https://doi.org/10.1128/jb.00393-13

Renggli, Sabine, Keck, Wolfgang, Jenal, Urs, & Ritz, Daniel. (2013). Role of autofluorescence in flow cytometric analysis of Escherichia coli treated with bactericidal antibiotics. Journal of Bacteriology, 195(18), 4067–4073. https://doi.org/10.1128/jb.00393-13

Steiner, S., Lori, C., Boehm, A., & Jenal, U. (2013). Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction. The EMBO journal, 32(3), 354–368. https://doi.org/10.1038/emboj.2012.315

Wegrzyn, Katarzyna, Witosinska, Monika, Schweiger, Pawel, Bury, Katarzyna, Jenal, Urs, & Konieczny, Igor. (2013). RK2 plasmid dynamics in Caulobacter crescentus cells - two modes of DNA replication initiation. Microbiology, 159(Pt 6), 1010–1022. https://doi.org/10.1099/mic.0.065490-0

Zähringer, Franziska, Lacanna, Egidio, Jenal, Urs, Schirmer, Tilman, & Boehm, Alex. (2013). Structure and signaling mechanism of a zinc-sensory diguanylate cyclase. Structure: with folding and design, 21(7), 1149–1157. https://doi.org/10.1016/j.str.2013.04.026

Hardwick, S. W., Gubbey, T., Hug, I., Jenal, U., & Luisi, B. F. (2012). Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly. Biology Open, 2(4), 120028. https://doi.org/10.1098/rsob.120028

Malone, J. G., Jaeger, T., Manfredi, P., Dötsch, A., Blanka, A., Bos, R., Cornelis, G. R., Häussler, S., & Jenal, U. (2012). The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent pseudomonas aeruginosa in cystic fibrosis airways. PLoS Pathogens, 8(6). https://doi.org/10.1371/journal.ppat.1002760

Nesper, J., Reinders, A., Glatter, T., Schmidt, A., & Jenal, U. (2012). A novel capture compound for the identification and analysis of cyclic di-GMP binding proteins. Journal of Proteomics, 75(15), 4874–4878. https://doi.org/10.1016/j.jprot.2012.05.033

Petters, Tobias, Zhang, Xin, Nesper, Jutta, Treuner-Lange, Anke, Gomez-Santos, Nuria, Hoppert, Michael, Jenal, Urs, & Søgaard-Andersen, Lotte. (2012). The orphan histidine protein kinase SgmT is a c-di-GMP receptor and regulates composition of the extracellular matrix together with the orphan DNA binding response regulator DigR in Myxococcus xanthus. Molecular microbiology, 84(1), 147–165. https://doi.org/10.1111/j.1365-2958.2012.08015.x

Abel, Sören, Chien, Peter, Wassmann, Paul, Schirmer, Tilman, Kaever, Volkhard, Laub, Michael T, Baker, Tania A, & Jenal, Urs. (2011). Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks. Molecular Cell, 43(4), 550–560. https://doi.org/10.1016/j.molcel.2011.07.018

Habazettl, Judith, Allan, Martin G, Jenal, Urs, & Grzesiek, Stephan. (2011). Solution structure of the PilZ domain protein PA4608 complex with cyclic di-GMP identifies charge clustering as molecular readout. Journal of Biological Chemistry, 286(16), 14304–14314. https://doi.org/10.1074/jbc.m110.209007

Levi, A., Folcher, M., Jenal, U., & Shuman, H. A. (2011). Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of Legionella pneumophila. mBio, 2(1), e00316–10. https://doi.org/10.1128/mbio.00316-10

Abgottspon, Daniela, Rölli, Gina, Hosch, Lucie, Steinhuber, Andrea, Jiang, Xiaohua, Schwardt, Oliver, Cutting, Brian, Smiesko, Martin, Jenal, Urs, Ernst, Beat, & Trampuz, Andrej. (2010). Development of an aggregation assay to screen FimH antagonists. Journal of Microbiological Methods, 82(3), 249–255. https://doi.org/10.1016/j.mimet.2010.06.015

Boehm, Alex, Kaiser, Matthias, Li, Hui, Spangler, Christian, Kasper, Christoph Alexander, Ackermann, Martin, Kaever, Volkhard, Sourjik, Victor, Roth, Volker, & Jenal, Urs. (2010). Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity. Cell, 141(1), 107–116. https://doi.org/10.1016/j.cell.2010.01.018

Diepold, A., Amstutz, M., Abel, S., Sorg, I., Jenal, U., & Cornelis, G. R. (2010). Deciphering the assembly of the Yersinia type III secretion injectisome. The EMBO journal, 29(11), 1928–1940. https://doi.org/10.1038/emboj.2010.84

Malone, J. G., Jaeger, T., Spangler, C., Ritz, D., Spang, A., Arrieumerlou, C., Kaever, V., Landmann, R., & Jenal, U. (2010). YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa. PLoS Pathogens, 6(3), e1000804. https://doi.org/10.1371/journal.ppat.1000804

Spangler, Christian, Böhm, Alex, Jenal, Urs, Seifert, Roland, & Kaever, Volkhard. (2010). A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate. Journal of Microbiological Methods, 81(3), 226–231. https://doi.org/10.1016/j.mimet.2010.03.020

Abel, Sören, & Jenal, Urs. (2010). Role of cyclic di-GMP in Caulobacter crescentus development and cell cycle control. In Second messenger cyclic Di-GMP (pp. 120–136). ASM Press. https://doi.org/10.1128/9781555816667.ch9

Jenal, U. (2009). The role of proteolysis in the Caulobacter crescentus cell cycle and development. Research in Microbiology, 160(9), 687–695. https://doi.org/10.1016/j.resmic.2009.09.006