Prof. Dr. Robin Teufel

Teufel, R., & Müller, M. (2025). Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin [Journal-article]. Angewandte Chemie - International Edition, 64(4). https://doi.org/10.1002/anie.202419620

Teufel, R., & Müller, M. (2025). Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin [Journal-article]. Angewandte Chemie, 137(4). https://doi.org/10.1002/ange.202419620

Zdouc, M., Blin, K., Louwen, N. L., Navarro, J., Loureiro, C., Bader, C., Bailey, C., Barra, L., Booth, T., Bozhüyük, K. J., Cediel-Becerra, J. D., Charlop-Powers, Z., Chevrette, M., Chooi, Y. H., D’Agostino, P., de Rond, T., Del Pup, E., Duncan, K., Gu, W., et al. (2025). MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration [Journal-article]. Nucleic Acids Research, 53(D1), D678–D690. https://doi.org/10.1093/nar/gkae1115

Happi, G. M., Sikam, K. G., Dietl, A., Reinhardt, J. K., Dzouemo, L. C., Konfor, S. M., Rakhmanov, M., Wansi, J. D., & Teufel, R. (2025). Highly oxygenated antiplasmodial and non-hemolytic Δ7,9(11) stigmastane-type steroids from the twigs of Vernonia amygdalina Delile [Journal-article]. Phytochemistry, 229, 114286. https://doi.org/10.1016/j.phytochem.2024.114286

Teufel, R. (2024). Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must. Current Opinion in Chemical Biology, 80. https://doi.org/10.1016/j.cbpa.2024.102464

Mouthé Happi, G., & Teufel, R. (2024). Steroids from the Meliaceae family and their biological activities. Phytochemistry, 221. https://doi.org/10.1016/j.phytochem.2024.114039

Moffat, A. D., Höing, L., Santos-Aberturas, J., Markwalder, T., Malone, J. G., Teufel, R., & Truman, A. W. (2024). Understanding the biosynthesis, metabolic regulation, and anti-phytopathogen activity of 3,7-dihydroxytropolone in Pseudomonas spp [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.04.03.587903

Höing, Lars, Sowa, Sven T., Toplak, Marina, Reinhardt, Jakob K., Jakob, Roman, Maier, Timm, Lill, Markus A., & Teufel, Robin. (2024). Biosynthesis of the bacterial antibiotic 3,7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products [Journal-article]. Chemical Science, 15(20), 7749–7756. https://doi.org/10.1039/d4sc01715c

Benka, M., Görlitz, K., Schöttgen, M. C., Lagies, S., Mohl, D. A., Kather, M., Du Preez-Bruwer, I., Mumbengegwi, D., Teufel, R., Kowarschik, S., Huber, R., Plattner, D. A., & Kammerer, B. (2023). Mass Spectrometric Analysis of Cucurbitacins and Dihydrocucurbitacins from the Tuber of Citrullus naudinianus. Biomolecules, 13(8). https://doi.org/10.3390/biom13081168

Zhang L, Esquembre LA, Xia SN, Oesterhelt F, Hughes CC, Brötz-Oesterhelt H, & Teufel R. (2022). Antibacterial Synnepyrroles from Human-Associated Nocardiopsis sp. Show Protonophore Activity and Disrupt the Bacterial Cytoplasmic Membrane. ACS Chemical Biology, 17(10), 2836–2848. https://doi.org/10.1021/acschembio.2c00460

Toplak M, Nagel A, Frensch B, Lechtenberg T, & Teufel R. (2022). An acetyltransferase controls the metabolic flux in rubromycin polyketide biosynthesis by direct modulation of redox tailoring enzymes. Chemical Science, 13(24), 7157–7164. https://doi.org/10.1039/d2sc01952c

Matthews A, Schönfelder J, Lagies S, Schleicher E, Kammerer B, Ellis HR, Stull F, & Teufel R. (2022). Bacterial flavoprotein monooxygenase YxeK salvages toxic S-(2-succino)-adducts via oxygenolytic C–S bond cleavage. FEBS Journal, 289(3), 787–807. https://doi.org/10.1111/febs.16193

Toplak, Marina, & Teufel, Robin. (2022). Three Rings to Rule Them All: How Versatile Flavoenzymes Orchestrate the Structural Diversification of Natural Products. Biochemistry, 61(2), 47–56. https://doi.org/10.1021/acs.biochem.1c00763

Zhang, Lei, Toplak, Marina, Saleem-Batcha, Raspudin, Höing, Lars Simon, Jakob, Roman, Jehmlich, Nico, von Bergen , Martin, Maier, Timm, & Teufel, Robin. (2022). Bacterial Dehydrogenases Facilitate Oxidative Inactivation and Bioremediation of Chloramphenicol. ChemBioChem, 24(2), e202200632. https://doi.org/10.1002/cbic.202200632

Toplak, M., Saleem‐Batcha, R., Piel, J., & Teufel, R. (2021). Catalytic Control of Spiroketal Formation in Rubromycin Polyketide Biosynthesis [Journal-article]. Angewandte Chemie, 133(52), 27166–27176. https://doi.org/10.1002/ange.202109384

Frensch B, Lechtenberg T, Kather M, Yunt Z, Betschart M, Kammerer B, Lüdeke S, Müller M, Piel J, & Teufel R. (2021). Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides. Nature Communications, 12(1), 1431. https://doi.org/10.1038/s41467-021-21432-9

Duan Y, Toplak M, Hou A, Brock NL, Dickschat JS, & Teufel R. (2021). A Flavoprotein Dioxygenase Steers Bacterial Tropone Biosynthesis via Coenzyme A-Ester Oxygenolysis and Ring Epoxidation. Journal of the American Chemical Society, 143(27), 10413–10421. https://doi.org/10.1021/jacs.1c04996

Toplak, Marina, Matthews, Arne, & Teufel, Robin. (2021). The devil is in the details: The chemical basis and mechanistic versatility of flavoprotein monooxygenases. Archives of Biochemistry and Biophysics, 698, 108732. https://doi.org/10.1016/j.abb.2020.108732

Duan, Ying, Petzold, Melanie, Saleem-Batcha, Raspudin, & Teufel, Robin. (2020). Bacterial Tropone Natural Products and Derivatives: Overview of their Biosynthesis, Bioactivities, Ecological Role and Biotechnological Potential. ChemBioChem, 21(17), 2384–2407. https://doi.org/10.1002/cbic.201900786

Tsypik, Olga, Makitrynskyy, Roman, Frensch, Britta, Zechel, David L, Paululat, Thomas, Teufel, Robin, & Bechthold, Andreas. (2020). Oxidative Carbon Backbone Rearrangement in Rishirilide Biosynthesis. Journal of the American Chemical Society, 142(13), 5913–5917. https://doi.org/10.1021/jacs.9b12736

Matthews A, Saleem-Batcha R, Sanders JN, Stull F, Houk KN, & Teufel R. (2020). Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases. Nat. Chem. Biol., 16, 556–563.

Saleem-Batcha, Raspudin, & Teufel, Robin. (2019). Structural methods for probing the interaction of flavoenzymes with dioxygen and its surrogates. Methods in Enzymology, 620, 349–363. https://doi.org/10.1016/bs.mie.2019.03.016

Spieker, Melanie, Saleem-Batcha, Raspudin, & Teufel, Robin. (2019). Structural and Mechanistic Basis of an Oxepin-CoA Forming Isomerase in Bacterial Primary and Secondary Metabolism. ACS Chemical Biology, 14(12), 2876–2886. https://doi.org/10.1021/acschembio.9b00742

Saleem-Batcha, Raspudin, Stull, Frederick, Sanders, Jacob N, Moore, Bradley S, Palfey, Bruce A, Houk, K N, & Teufel, Robin. (2018). Enzymatic control of dioxygen binding and functionalization of the flavin cofactor. Proceedings of the National Academy of Sciences of the United States of America, 115(19), 4909–4914. https://doi.org/10.1073/pnas.1801189115

Saleem-Batcha, Raspudin, & Teufel, Robin. (2018). Insights into the enzymatic formation, chemical features, and biological role of the flavin-N5-oxide. Current Opinion in Chemical Biology, 47, 47–53. https://doi.org/10.1016/j.cbpa.2018.08.003

Teufel, Robin. (2018). Preparation and Characterization of the Favorskiiase Flavoprotein EncM and Its Distinctive Flavin-N5-Oxide Cofactor. Methods in Enzymology, 604, 523–540. https://doi.org/10.1016/bs.mie.2018.01.036

Teufel, Robin. (2018). Unusual “Head-to-Torso” Coupling of Terpene Precursors as a New Strategy for the Structural Diversification of Natural Products. Methods in Enzymology, 604, 425–439. https://doi.org/10.1016/bs.mie.2018.01.037

Teufel, Robin. (2017). Flavin-catalyzed redox tailoring reactions in natural product biosynthesis. Archives of Biochemistry and Biophysics, 632, 20–27. https://doi.org/10.1016/j.abb.2017.06.008

Teufel, Robin, Agarwal, Vinayak, & Moore, Bradley S. (2016). Unusual flavoenzyme catalysis in marine bacteria. Current Opinion in Chemical Biology, 31, 31–39. https://doi.org/10.1016/j.cbpa.2016.01.001

Bonet, Bailey, Teufel, Robin, Crüsemann, Max, Ziemert, Nadine, & Moore, Bradley S. (2015). Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin. Journal of Natural Products, 78(3), 539–542. https://doi.org/10.1021/np500664q

Teufel, Robin, Stull, Frederick, Meehan, Michael J, Michaudel, Quentin, Dorrestein, Pieter C, Palfey, Bruce, & Moore, Bradley S. (2015). Biochemical Establishment and Characterization of EncM’s Flavin-N5-oxide Cofactor. Journal of the American Chemical Society, 137(25), 8078–8085. https://doi.org/10.1021/jacs.5b03983

Diethelm, Stefan, Teufel, Robin, Kaysser, Leonard, & Moore, Bradley S. (2014). A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins. Angewandte Chemie (International Ed. In English), 53(41), 11023–11026. https://doi.org/10.1002/anie.201405696

Teufel, Robin, Kaysser, Leonard, Villaume, Matthew T, Diethelm, Stefan, Carbullido, Mary K, Baran, Phil S, & Moore, Bradley S. (2014). One-pot enzymatic synthesis of merochlorin A and B. Angewandte Chemie (International Ed. In English), 53(41), 11019–11022. https://doi.org/10.1002/anie.201405694

Teufel, Robin, Miyanaga, Akimasa, Michaudel, Quentin, Stull, Frederick, Louie, Gordon, Noel, Joseph P, Baran, Phil S, Palfey, Bruce, & Moore, Bradley S. (2013). Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature, 503(7477), 552–556. https://doi.org/10.1038/nature12643

Teufel, Robin, Friedrich, Thorsten, & Fuchs, Georg. (2012). An oxygenase that forms and deoxygenates toxic epoxide. Nature, 483(7389), 359–362. https://doi.org/10.1038/nature10862

Teufel, Robin, Gantert, Carla, Voss, Michaela, Eisenreich, Wolfgang, Haehnel, Wolfgang, & Fuchs, Georg. (2011). Studies on the mechanism of ring hydrolysis in phenylacetate degradation: a metabolic branching point. The Journal of Biological Chemistry, 286(13), 11021–11034. https://doi.org/10.1074/jbc.m110.196667

Teufel, R, Mascaraque, V, Ismail, W, Voss, M, Perera, J, Eisenreich, W, Haehnel, W, & Fuchs, G. (2010). Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc Natl Acad Sci U S A, 10(107), 14390–14395. https://doi.org/10.1073/pnas.1005399107

Teufel, Robin, Kung, Johannes W, Kockelkorn, Daniel, Alber, Birgit E, & Fuchs, Georg. (2009). 3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales. Journal of Bacteriology, 191(14), 4572–4581. https://doi.org/10.1128/jb.00068-09