Prof. Dr. Ueli Aebi

Plodinec, Marija, Loparic, Marko, Monnier, Christophe A, Obermann, Ellen C, Zanetti-Dallenbach, Rosanna, Oertle, Philipp, Hyotyla, Janne T, Aebi, Ueli, Bentires-Alj, Mohamed, Lim, Roderick Y H, & Schoenenberger, Cora-Ann. (2012). The nanomechanical signature of breast cancer. Nature Nanotechnology, 7(11), 757–765. https://doi.org/10.1038/nnano.2012.167

Goldsbury, Claire, Baxa, Ulrich, Simon, Martha N, Steven, Alasdair C, Engel, Andreas, Wall, Joseph S, Aebi, Ueli, & Müller, Shirley A. (2011). Amyloid structure and assembly : insights from scanning transmission electron microscopy. Journal of Structural Biology, 173(1), 1–13. https://doi.org/10.1016/j.jsb.2010.09.018

Kapinos, Larisa E, Burkhard, Peter, Herrmann, Harald, Aebi, Ueli, & Strelkov, Sergei V. (2011). Simultaneous formation of right- and left-handed anti-parallel coiled-coil interfaces by a coil2 fragment of human lamin A. Journal of Molecular Biology, 408(1), 135–146. https://doi.org/10.1016/j.jmb.2011.02.037

Haas, Philippe, Then, Patrick, Wild, Andreas, Grange, Wilfried, Zorman, Sylvain, Hegner, Martin, Calame, Michel, Aebi, Ueli, Flammer, Josef, & Hecht, Bert. (2010). Fast quantitative single-molecule detection at ultralow concentrations. Analytical Chemistry, 82(14), 6299–6302. https://doi.org/10.1021/ac100779c

Haas, Philippe, Then, Patrick, Wild, Andreas, Grange, Wilfried, Zorman, Sylvain, Hegner, Martin, Calame, Michel, Aebi, Ueli, Flammer, Josef, & Hecht, Bert. (2010). Quantitative Single-Molecule Detection at Ultralow Concentrations. Analytical Chemistry, 82(14), 6299–6302. https://doi.org/10.1021/ac100779c

Huang, Ning-Ping, Stubenrauch, Mike, Köser, Joachim, Taschner, Nicole, Aebi, Ueli, & Stolz, Martin. (2010). Towards monitoring transport of single cargos across individual nuclear pore complexes by time-lapse atomic force microscopy. Journal of Structural Biology, 171(2), 154–162. https://doi.org/10.1016/j.jsb.2010.04.004

Kapinos, Larisa E, Schumacher, Jens, Mücke, Norbert, Machaidze, Gia, Burkhard, Peter, Aebi, Ueli, Strelkov, Sergei V, & Herrmann, Harald. (2010). Characterization of the head-to-tail overlap complexes formed by human lamin A, B1 and B2 “half-minilamin” dimers. Journal of Molecular Biology, 396(3), 719–731. https://doi.org/10.1016/j.jmb.2009.12.001

Loparic, Marko, Wirz, Dieter, Daniels, A U, Raiteri, Roberto, Vanlandingham, Mark R, Guex, Geraldine, Martin, Ivan, Aebi, Ueli, & Stolz, Martin. (2010). Micro- and nanomechanical analysis of articular cartilage by indentation-type atomic force microscopy: validation with a gel-microfiber composite. Biophysical Journal, 98(11), 2731–2740. https://doi.org/10.1016/j.bpj.2010.02.013

Machaidze, Gia, Sokoll, Andrea, Shimada, Atsushi, Lustig, Ariel, Mazur, Antonina, Wittinghofer, Alfred, Aebi, Ueli, & Mannherz, Hans Georg. (2010). Actin filament bundling and different nucleating effects of mouse Diaphanous-related formin FH2 domains on actin/ADF and actin/cofilin complexes. Journal of Molecular Biology, 403(4), 529–545. https://doi.org/10.1016/j.jmb.2010.09.017

Nicolet, Stefan, Herrmann, Harald, Aebi, Ueli, & Strelkov, Sergei V. (2010). Atomic structure of vimentin coil 2. Journal of Structural Biology, 170(2), 369–376. https://doi.org/10.1016/j.jsb.2010.02.012

Vonwil, Daniel, Schuler, Martin, Barbero, Andrea, Ströbel, Simon, Wendt, David, Textor, Marcus, Aebi, Ueli, & Martin, Ivan. (2010). An RGD-restricted substrate interface is sufficient for the adhesion, growth and cartilage forming capacity of human chondrocytes. European cells & materials, 20, 316–328. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21069635

Bär, Harald, Sharma, Sarika, Kleiner, Helga, Mücke, Norbert, Zentgraf, Hanswalter, Katus, Hugo A, Aebi, Ueli, & Herrmann, Harald. (2009). Interference of amino-terminal desmin fragments with desmin filament formation. Cell Motility and the Cytoskeleton, 66(11), 986–999. https://doi.org/10.1002/cm.20396

Ben-Harush, Kfir, Wiesel, Naama, Frenkiel-Krispin, Daphna, Moeller, Dorothee, Soreq, Eyal, Aebi, Ueli, Herrmann, Harald, Gruenbaum, Yosef, & Medalia, Ohad. (2009). The supramolecular organization of the C. elegans nuclear lamin filament. Journal of Molecular Biology, 386(5), 1392–1402. https://doi.org/10.1016/j.jmb.2008.12.024

Frenkiel-Krispin, Daphna, Maco, Bohumil, Aebi, Ueli, & Medalia, Ohad. (2009). Structural Analysis of a Metazoan Nuclear Pore Complex Reveals of Fused Concentric Ring Architecture. Journal of Molecular Biology, 395(3), 578–586. https://doi.org/10.1016/j.jmb.2009.11.010

Georgakopoulou, Sofia, Möller, Dorothee, Sachs, Nadine, Herrmann, Harald, & Aebi, Ueli. (2009). Near-UV circular dichroism reveals structural transitions of vimentin subunits during intermediate filament assembly. Journal of Molecular Biology, 386(2), 544–553. https://doi.org/10.1016/j.jmb.2008.12.053

Herrmann, H., Strelkov, S. V., Burkhard, P., & Aebi, U. (2009). Intermediate filaments : primary determinants of cell architecture and plasticity. Journal of Clinical Investigation, 119(7), 1772–1783. https://doi.org/10.1172/jci38214

Huang, N.-P., Stubenrauch, M., Koeser, J., Strasser, P., Taschner, N., Aebi, U., & Stolz, M. (2009). Towards Watching the Nuclear Pore Complex (NPC) at Work : In Situ Binding of Gold-Conjugated Cargoes to the Nucleoporins Monitored by Time-Lapse Scanning Force Microscopy. Journal of Structural Biology, submitted(submitted), 154–162.

Kaba, S.A., Brando, C., Guo, Q., Mittelholzer, C., Raman, S., Trope, D., Aebi, U., Burkhard, P., & Lanar, D.E. (2009). A Non-Adjuvanted Polypeptide Nanoparticle Vaccine Confers Long-Lasting Protection Against Rodent Malaria. Journal of Immunology, in press(in press), 7268–7277.

Kayser, Hartmut, Mann, Karlheinz, Machaidze, Gia, Nimtz, Manfred, Ringler, Philippe, Müller, Shirley A, & Aebi, Ueli. (2009). Isolation, characterisation and molecular imaging of a high-molecular-weight insect biliprotein, a member of the hexameric arylphorin protein family. Journal of Molecular Biology, 389(1), 74–89. https://doi.org/10.1016/j.jmb.2009.03.075

Meier, Markus, Padilla, G Pauline, Herrmann, Harald, Wedig, Tatjana, Hergt, Michaela, Patel, Trushar R, Stetefeld, Jörg, Aebi, Ueli, & Burkhard, Peter. (2009). Vimentin Coil 1A : a molecular switch involved in the initiation of filament elongation. Journal of Molecular Biology, 390(2), 245–261. https://doi.org/10.1016/j.jmb.2009.04.067

Schroeder, Ulrich, Graff, Alexandra, Buchmeier, Sabine, Rigler, Per, Silvan, Unai, Tropel, David, Jockusch, Brigitte M, Aebi, Ueli, Burkhard, Peter, & Schoenenberger, Cora-Ann. (2009). Peptide Nanoparticles Serve as a Powerful Platform for the Immunogenic Display of Poorly Antigenic Actin Determinants. Journal of Molecular Biology, 386(5), 1368–1381. https://doi.org/10.1016/j.jmb.2008.11.023

Stolz, Martin, Gottardi, Riccardo, Raiteri, Roberto, Miot, Sylvie, Martin, Ivan, Imer, Raphael, Staufer, Urs, Raducanu, Aurelia, Dueggelin, Marcel, Baschong, Werner, Daniels, A. U., Friederich, Niklaus F., Aszodi, Attila, & Aebi, Ueli. (2009). Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy. Nature Nanotechnology, 4(3), 186–192. https://doi.org/10.1038/nnano.2008.410

Plodinec, M., Loparic, M., & Aebi, U. (2009). Atomic force microscopy for Biological Imaging and Mechanical testing across Length Scales. In Goldman, RD, Swedlow, JL, Spector, DL (Ed.), Live Cell Imaging: A Laboratory Manual (p. S. 183–203). Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/pdb.top86

Georgakopoulou, S., Wedig, T., Sachs, N., Herrmann, H., & Aebi, U. (2008). Structural transitions during the assembly of vimentin intermediate filaments by near-UV circular dichroism. The FEBS Journal, 275, 164.

Kreplak, Laurent, Herrmann, Harald, & Aebi, Ueli. (2008). Tensile properties of single desmin intermediate filaments. Biophysical Journal, 94(7), 2790–2799. https://doi.org/10.1529/biophysj.107.119826

Kreplak, Laurent, Richter, Karsten, Aebi, Ueli, & Herrmann, Harald. (2008). Electron microscopy of intermediate filaments : teaming up with atomic force and confocal laser scanning microscopy. Methods in Cell Biology, 88, 273–297. https://doi.org/10.1016/s0091-679x(08)00415-9

Lim, Roderick Y. H., Aebi, Ueli, & Fahrenkrog, Birthe. (2008). Towards reconciling structure and function in the nuclear pore complex. Histochemistry and Cell Biology, 129(2), 105–116. https://doi.org/10.1007/s00418-007-0371-x

Lim, R. Y. H., Fahrenkrog, B., Deng, J., Kapinos, L., Koeser, J., & Aebi, U. (2008). Tinkering with a cellular nanomachine by a minimalist approach. The FEBS Journal, 275, 7.

Müller, Shirley A., Aebi, Ueli, & Engel, Andreas. (2008). What transmission electron microscopes can visualize now and in the future. Journal of Structural Biology, 163(3), 235–245. https://doi.org/10.1016/j.jsb.2008.05.008

Rowat, Amy C, Lammerding, Jan, Herrmann, Harald, & Aebi, Ueli. (2008). Towards an integrated understanding of the structure and mechanics of the cell nucleus. Bioessays, 30(3), 226–236. https://doi.org/10.1002/bies.20720

Shumaker, Dale K., Solimando, Liliana, Sengupta, Kaushik, Shimi, Takeshi, Adam, Stephen A., Grunwald, Antje, Strelkov, Sergei V., Aebi, Ueli, Cardoso, M. Cristina, & Goldman, Robert D. (2008). The highly conserved nuclear lamin Ig-fold binds to PCNA : its role in DNA replication. The Journal of cell biology, 181(2), 269–280. https://doi.org/10.1083/jcb.200708155

Wiesel, Naama, Mattout, Anna, Melcer, Shai, Melamed-Book, Naomi, Herrmann, Harald, Medalia, Ohad, Aebi, Ueli, & Gruenbaum, Yosef. (2008). Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins. Proceedings of the National Academy of Sciences of the United States of America, 105(1), 180–185. https://doi.org/10.1073/pnas.0708974105

Bär, Harald, Mücke, Norbert, Katus, Hugo A, Aebi, Ueli, & Herrmann, Harald. (2007). Assembly Defects of Desmin Disease Mutants Carrying Deletions in the a-helical Rod Domain Are Rescued by Wild-Type Protein. Journal of Structural Biology, 158(1), 107–115. https://doi.org/10.1016/j.jsb.2006.10.029

Boerries, Melanie, Most, Patrick, Gledhill, Jonathan R, Walker, John E, Katus, Hugo A, Koch, Walter J, Aebi, Ueli, & Schoenenberger, Cora-Ann. (2007). Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes. Molecular and Cellular Biology, 27(12), 4365–4373. https://doi.org/10.1128/mcb.02045-06

Foisner, R., Aebi, U., Bonne, G., Gruenbaum, Y., & Novelli, G. (2007). Nuclear Envelope-linked Rare Human Deseases : From Molecular Pathophysiology towards Clinical Applications. Neuromuscular Disorders, 17, 655–660. https://doi.org/10.1016/j.nmd.2007.04.003

Goldie, K.M., Wedig, T., Mitra, A., Aebi, U., Herrmann, H., & Hoenger, A. (2007). Dissecting the 3-D Structure of vimentin Intermediate Filaments by Cro-Electron Tomography. Journal of Structural Biology, 158, 378–385. https://doi.org/10.1016/j.jsb.2006.12.007

Herrmann, Harald, Bär, Harald, Kreplak, Laurent, Strelkov, Sergei V, & Aebi, Ueli. (2007). Intermediate Filaments: from Cell Architecture to Nanomechanics. Nature Reviews. Molecular Cell Biology, 8(7), 562–573. https://doi.org/10.1038/nrm2197

Imer, Raphael, Akiyama, Terunobu, de Rooij, Nico F., Stolz, Martin, Aebi, Ueli, Kilger, Robert, Friederich, Niklaus F., Wirz, Dieter, Daniels, A. U., & Staufer, Urs. (2007). In Situ Measurements of Human Articular Cartilage Stiffness by Means of a Scanning Force Microscope. Journal of Physics. Conference Series, 61, 467–471. https://doi.org/10.1088/1742-6596/61/1/094

Kirmse, Robert, Portet, Stephanie, Mücke, Norbert, Aebi, Ueli, Herrmann, Harald, & Langowski, Jörg. (2007). A Quantitative Kinetic Model for the in Vitro Assembly of Intermediate Filaments from Tetrameric Vimentin. Journal of Biological Chemistry, 282(25), 18563–18572. https://doi.org/10.1074/jbc.m701063200

Kreplak, Laurent, Wang, Huaibin, Aebi, Ueli, & Kong, Xiang-Peng. (2007). Atomic force microscopy of Mammalian urothelial surface. Journal of Molecular Biology, 374(2), 365–373. https://doi.org/10.1016/j.jmb.2007.09.040

Lim, Roderick Y H, Fahrenkrog, Birthe, Köser, Joachim, Schwarz-Herion, Kyrill, Deng, Jie, & Aebi, Ueli. (2007). Nanomechanical basis of selective gating by the nuclear pore complex. Science, 318(5850), 640–643. https://doi.org/10.1126/science.1145980

Lim, Roderick Y H, Köser, Joachim, Huang, Ning-Ping, Schwarz-Herion, Kyrill, & Aebi, Ueli. (2007). Nanomechanical interactions of phenylalanine-glycine nucleoporins studied by single molecule force-volume spectroscopy. Journal of Structural Biology, 159(2), 277–289. https://doi.org/10.1016/j.jsb.2007.01.018

Parry, D.A.D., strelkov, S., Burkhard, P., Aebi, U., & Herrmann, H. (2007). Intermediate Filaments : Towards a Molecular Description of the Assembly Process and their Structure. Experimental Cell Research, 313, 2204–2216. https://doi.org/10.1016/j.yexcr.2007.04.009

Staufer, U., Akiyama, T., Gullo, M. R., Han, A., Imer, R., de Rooij, N. F., Aebi, U., Engel, A., Frederix, P. L. T. M., Stolz, M., Friederich, N. F., & Wirz, D. (2007). Micro- and Nanosystems for Biology and Medicine. Microelectronic Engineering, 84(5-8), 1681–1684. https://doi.org/10.1016/j.mee.2007.01.244

Stolz, Martin, Aebi, Ueli, & Stoffler, Daniel. (2007). Developing scanning probe-based nanodevices--stepping out of the laboratory into the clinic. Nanomedicine, 3(1), 53–62. https://doi.org/10.1016/j.nano.2007.01.001

Bär, Harald, Mücke, Norbert, Ringler, Philippe, Müller, Shirley A, Kreplak, Laurent, Katus, Hugo A, Aebi, Ueli, & Herrmann, Harald. (2006). Impact of disease mutations on the desmin filament assembly process. Journal of Molecular Biology, 360(5), 1031–1042. https://doi.org/10.1016/j.jmb.2006.05.068

Foeger, Nicole, Wiesel, Naama, Lotsch, Dorothee, Mücke, Norbert, Kreplak, Laurent, Aebi, Ueli, Gruenbaum, Yosef, & Herrmann, Harald. (2006). Solubility Properties and Specific Assembly Pathways of the B-type Lamin from Caenorhabditis elegans. Journal of Structural Biology, 155(2), 340–350. https://doi.org/10.1016/j.jsb.2006.03.026

Guzmán, C, Jeney, S, Kreplak, L, Kasas, S, Kulik, A J, Aebi, U, & Forró, L. (2006). Exploring the Mechanical Properties of Single Vimentin Intermediate Filaments by Atomic Force Microscopy. Journal of Molecular Biology, 360(3), 623–630. https://doi.org/10.1016/j.jmb.2006.05.030

Imer, R., Akiyama, T., De Rooij, N.F., Stolz, M., Aebi, U., Friederich, N.F., Koenig, U., Wirz, D., Daniels, A.U., & Staufer, U. (2006). Development of an Atomic Force Microscope for Arthoscopic Knee Cartilage Inspection. Japanese Journal of Applied Physics. Part 1, Regular Papers, Short Notes & Review Papers, 45, 2319–2323. https://doi.org/10.1143/jjap.45.2319

Jockusch, Brigitte M, Schoenenberger, Cora-Ann, Stetefeld, Jörg, & Aebi, Ueli. (2006). Tracking down the different forms of nuclear actin. Trends in Cell Biology, 16(8), 391–396. https://doi.org/10.1016/j.tcb.2006.06.006

Kreplak, Laurent, & Aebi, Ueli. (2006). From the polymorphism of amyloid fibrils to their assembly mechanism and cytotoxicity. Advances in Protein Chemistry, 73, 217–233. https://doi.org/10.1016/s0065-3233(06)73007-8

Lill, Yoriko, Lill, Markus A, Fahrenkrog, Birthe, Schwarz-Herion, Kyrill, Paulillo, Sara, Aebi, Ueli, & Hecht, Bert. (2006). Single Hepatitis-B Virus Core Capsid Binding to Individual Nuclear Pore Complexes in HeLa Cells. Biophysical Journal, 91(8), 3123–3130. https://doi.org/10.1529/biophysj.106.087650

Lim, Roderick Y H, Aebi, Ueli, & Stoffler, Daniel. (2006). From the trap to the basket : getting to the bottom of the nuclear pore complex. Chromosoma, 115(1), 15–26. https://doi.org/10.1007/s00412-005-0037-1

Lim, Roderick Y. H., Huang, Ning-Ping, Köser, Joachim, Deng, Jie, Lau, K. H. Aaron, Schwarz-Herion, Kyrill, Fahrenkrog, Birthe, & Aebi, Ueli. (2006). Flexible phenylalanine-glycine nucleoporins as entropic barriers to nucleocytoplasmic transport. Proceedings of the National Academy of Sciences of the United States of America, 103(25), 9512–9517. https://doi.org/10.1073/pnas.0603521103

Maco, Bohumil, Fahrenkrog, Birthe, Huang, Ning-Ping, & Aebi, Ueli. (2006). Nuclear pore complex structure and plasticity revealed by electron and atomic force microscopy. Methods in Molecular Biology, 322, 273–288. https://doi.org/10.1007/978-1-59745-000-3

Raman, Senthilkumar, Machaidze, Gia, Lustig, Ariel, Aebi, Ueli, & Burkhard, Peter. (2006). Structure-based design of peptides that self-assemble into regular polyhedral nanoparticles. Nanomedicine, 2(2), 95–102. https://doi.org/10.1016/j.nano.2006.04.007

Schaefer, T., Maco, B., Petgalski, E., Tollervey, D., Boettcher, B., Aebi, U., & Hurt, E. (2006). Phosphorylation by Casein KInase 1 Isoform Hrr25 and Subsequent Dephosphorylation Regulate the Structural Reorganization of the 40S Subunit During Ribosome Biogenesis. Nature, 441, 651–655.

Sokolova, Anna V, Kreplak, Laurent, Wedig, Tatjana, Mücke, Norbert, Svergun, Dmitri I, Herrmann, Harald, Aebi, Ueli, & Strelkov, Sergei V. (2006). Monitoring Intermediate Filament Assembly with Small-angle X-ray Scattering Reveals the Molecular Architecture of Assembly Intermediates. Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16206–16211. https://doi.org/10.1073/pnas.0603629103

von Bergen, Martin, Barghorn, Stefan, Müller, Shirley A, Pickhardt, Marcus, Biernat, Jacek, Mandelkow, Eva-Maria, Davies, Peter, Aebi, Ueli, & Mandelkow, Eckhard. (2006). The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis. Biochemistry, 45(20), 6446–6457. https://doi.org/10.1021/bi052530j

Aebi, U., & Baschong, W. (2006). Glycerol Spraying/Low Angle Rotary Metal Shadowing. In J.E. Celis, ed. (Ed.), Cell Biology: A Laboratory Hand Book (p. S. 242–246). Elsevier. https://doi.org/10.1016/b978-012164730-8/50152-0

Baschong, W., & Aebi, U. (2006). Negative Staining. In J.E. Celis, ed. (Ed.), Cell Biology: A Laboratory Hand Book (p. S. 233–240). Elsevier. https://doi.org/10.1016/b978-012164730-8/50151-9

Fahrenkrog, B., & Aebi, U. (2006). The Nuclear Pore Complex. In W. Birchmeier, ed. (Ed.), Encyclopedic Reference of Genomics and Proteomics. https://doi.org/10.1007/3-540-29623-9_3000