PD Dr. med. Matthias Hepprich

Ferreira, A., Züger, T., Donath, M. Y., & Hepprich, M. (2026). The power of lifestyle intervention to induce glycaemic control in a patient with newly diagnosed type 2 diabetes and HbA1c > 10% [Journal-article]. Endocrinology, Diabetes &Amp; Metabolism Case Reports, 2026(2). https://doi.org/10.1530/edm-25-0188

Fischer, J. S., Hepprich, M., Cattaneo, M., Seeger, L., Dobler, S., & Donath, M. Y. (2026). Acute Interleukin-1ß antagonism decreases systemic inflammation, increases GLP-1 release and modulates insulin secretion in individuals with prediabetes [Journal-article]. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00527.2025

de Paula Souza, Joyce, Fischer, Justus S., Jeanneau, Karine, Allard, Cyril, Angevaare, Eline, Aschenbrenner, Dominik, Bodendorf, Ursula, Demarco, Benjamin, Gounarides, John S., Killmer, Saskia, Kovarik, Jiri, Pfister, Sabina, Yin, Hong, Ratnarasa, Vithushan, Böni-Schnetzler, Marianne, Hepprich, Matthias, Meier, Daniel T., Wieczorek, Grazyna, & Donath, Marc Y. (2025). Blood Characteristics of Adults With Type 2 Diabetes and Response of Their Peripheral Blood Mononuclear Cells to Inhibitors of the NLRP3 Inflammasome and Caspase-1. Canadian Journal of Diabetes, 49, 388–400. https://doi.org/10.1016/j.jcjd.2025.06.008

Fragozo-Ramos, Maria Carolina, Schenker, Gabriela, Hepprich, Matthias, Gallo-Villegas, Jaime, Züger, Thomas, & Garcia-Tirado, Jose. (2025). GIP/GLP-1RA as adjunctive to automated insulin delivery in adults with Type 1 diabetes (the AID-JUNCT trial): Study protocol for a prospective, randomized, clinical trial. Plos One, 20. https://doi.org/10.1371/journal.pone.0335060

Hepprich, Matthias, Romberg, Christina, Mudry, Jonathan, Refardt, Julie, Wild, Damian, Antwi, Kwadwo, & Christ, Emanuel. (2025). Exenatide for diagnosing endogenous hyperinsulinemic hypoglycemia: a randomized placebo-controlled, double-blind, cross-over proof-of-principle study. European Journal of Endocrinology, 193(2), 247–254. https://doi.org/10.1093/ejendo/lvaf153

Hepprich, M., Fischer, J., Cattaneo, M., Ferreira, A., Herzig, D., Bally, L., & Donath, M. (2025). Canakinumab for the treatment of postprandial hypoglycaemia: Study protocol for a randomised, placebo-controlled, parallel-group, double-blind, multicentric, superiority trial - The CanpHy study [Journal-article]. BMJ Open , 15(5), e097981. https://doi.org/10.1136/bmjopen-2024-097981

Pereira, Milton, Liang, Jonathan, Edwards-Hicks, Joy, Meadows, Allison M., Hinz, Christine, Liggi, Sonia, Hepprich, Matthias, Mudry, Jonathan, Han, Kim, Griffin, Julian L., Fraser, Iain, Sack, Michael N., Hess, Christoph, & Bryant, Clare E. (2024). Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting. Cell Reports, 43(2). https://doi.org/10.1016/j.celrep.2024.113700

Hepprich, Matthias, Ebrahimi, Fahim, & Christ, Emanuel. (2023). Dyslipidaemia and growth hormone deficiency – A comprehensive review. Best Practice and Research: Clinical Endocrinology and Metabolism, 37(6). https://doi.org/10.1016/j.beem.2023.101821

Hepprich, M., Roser, P., Stiebitz, S., Felix, B., Schultes, B., Schmitz, D., Rutishauser, J., Schubert, S., Aberle, J., & Rudofsky, G. (2023). Awareness and knowledge of diabetic ketoacidosis in people with type 1 diabetes: a cross-sectional, multicenter survey. BMJ Open Diabetes Research and Care, 11. https://doi.org/10.1136/bmjdrc-2023-003662

Ferreira, Antonio, Schönenberger, Katja A., Potoczna, Natascha, Vogt, Andreas, Gerber, Philipp A., Zehetner, Jörg, Giachino, Daniel, Nett, Philipp, Gawinecka, Joanna, Cossu, Luca, Fuster, Daniel G., Dalla Man, Chiara, Facchinetti, Andrea, Melmer, Andreas, Nakas, Christos T., Hepprich, Matthias, Donath, Marc Y., Herzig, David, & Bally, Lia. (2023). Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Once Daily Empagliflozin 25 mg for the Treatment of Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass. Diabetes Technology and Therapeutics, 25(7), 467–475. https://doi.org/10.1089/dia.2023.0036

Komminoth, Mathis, Donath, Marc Y., Hepprich, Matthias, Schuetz, Philipp, Blum, Claudine A., Mueller, Beat, Reny, Jean-Luc, Gosselin, Pauline, Breville, Gautier, Brändle, Michael, Henzen, Christoph, Leuppi, Jörg D., Kistler, Andreas D., Thurnheer, Robert, Beuschlein, Felix, Rudofsky, Gottfried, Aeberli, Daniel, Villiger, Peter M., Böhm, Stephan, et al. (2023). Glucocorticoid withdrawal and glucocorticoidinduced adrenal insufficiency: Study protocol of the randomized controlled «TOASST” (Taper Or Abrupt Steroid STop) multicenter trial. PLoS ONE, 18(4 April). https://doi.org/10.1371/journal.pone.0281585

Matthias Hepprich, Kwadwo Antwi, Patricia Wiesner, Claudia Cavelti-Weder, Marc Y. Donath, Emanuel R. Christ, & Damian Wild. (2022). Glucagon-Like Peptide-1 Receptor Pet/Ct in Patients with and Without Post Gastric Bypass Hypoglycemia: A Prospective, Matched Case-Control Study. J Gastrointest Dig Systems, 12. https://doi.org/10.4172/2161-069x.1000686

Hepprich, Matthias, Mudry, Jonathan M., Gregoriano, Claudia, Jornayvaz, Francois R., Carballo, Sebastian, Wojtusciszyn, Anne, Bart, Pierre-Alexandre, Chiche, Jean-Daniel, Fischli, Stefan, Baumgartner, Thomas, Cavelti-Weder, Claudia, Braun, Dominique L., Günthard, Huldrych F., Beuschlein, Felix, Conen, Anna, West, Emily, Isenring, Egon, Zechmann, Stefan, Bucklar, Gabriela, et al. (2022). Canakinumab in patients with COVID-19 and type 2 diabetes – A multicentre, randomised, double-blind, placebo-controlled trial. eClinicalMedicine, 53. https://doi.org/10.1016/j.eclinm.2022.101649

Koehler V.F., Fuss CT, Berr C.M., Frank-Raue K., Raue F., Hoster E, Hepprich M., Christ E, Pusl T., Reincke M, Spitzweg C., & Kroiss M. (2022). Medullary thyroid cancer with ectopic Cushing’s syndrome: A multicentre case series. Clinical Endocrinology, 96(6), 847–856. https://doi.org/10.1111/cen.14617

Hepprich, M., Antwi, K., Wiesner, P., Cavelti-Weder, C., Donath, M. Y., Christ, E. R., & Wild, D. (2022, April 26). Glucagon-like peptide-1 receptor PET/CT in patients with and without post gastric bypass hypoglycemia – a prospective, matched case-control study [Posted-content]. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-1561857/v1

Tynes M., Hepprich M., & Timper K. (2021). Regular intake of energy drinks and multivitamin supplements is associated with elevated plasma vitamin B6 levels in post-bariatric patients. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-97205-7

Zweck E., Hepprich M, & Donath M.Y. (2021). Predictors of Postprandial Hypoglycemia After Gastric Bypass Surgery: a Retrospective Case-Control Study. Obesity Surgery, 31(6), 2497–2502. https://doi.org/10.1007/s11695-021-05277-1

Janiaud P, Axfors C, Schmitt AM, Gloy V, Ebrahimi F, Hepprich M, Smith ER, Haber NA, Khanna N, Moher D, Goodman SN, Ioannidis JPA, & Hemkens LG. (2021). Association of Convalescent Plasma Treatment with Clinical Outcomes in Patients with COVID-19: A Systematic Review and Meta-analysis. JAMA - Journal of the American Medical Association, 325(12), 1185–1195. https://doi.org/10.1001/jama.2021.2747

Schiavon M., Herzig D., Hepprich M, Donath M.Y., Bally L., & Dalla Man C. (2021). Model-Based Assessment of C-Peptide Secretion and Kinetics in Post Gastric Bypass Individuals Experiencing Postprandial Hyperinsulinemic Hypoglycemia. Frontiers in Endocrinology, 12. https://doi.org/10.3389/fendo.2021.611253

Hepprich M, Zillig D., Florian-Reynoso M.A., Donath M.Y., & Rudofsky G. (2021). Switch-to-Semaglutide Study (STS-Study): a Retrospective Cohort Study. Diabetes Therapy, 12(3), 943–954. https://doi.org/10.1007/s13300-021-01016-y

Hepprich, M., Donath, M. Y., & Hemkens, L. G. (2021). Patient involvement to inform the design of a clinical trial in postbariatric hypoglycaemia [Posted-content]. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-55915/v2

Hepprich M, Donath MY, & Hemkens L.G. (2020). Patient involvement to inform the design of a clinical trial in postbariatric hypoglycaemia. BMC Medical Research Methodology, 20(1), 290. https://doi.org/10.1186/s12874-020-01171-z

Antwi K, Hepprich M, Müller NA, Reubi JC, Fani M, Rottenburger C, Nicolas G, Kaul F, Christ ER, & Wild D. (2020). Pitfalls in the Detection of Insulinomas With Glucagon-Like Peptide-1 Receptor Imaging. Clinical Nuclear Medicine, 45(9), E386–E392. https://doi.org/10.1097/rlu.0000000000003124

Hepprich M, Wiedemann SJ, Schelker BL, Trinh B, Stärkle A, Geigges M, Löliger J, Böni-Schnetzler M, Rudofsky G, & Donath MY. (2020). Postprandial Hypoglycemia in Patients after Gastric Bypass Surgery Is Mediated by Glucose-Induced IL-1β. Cell Metabolism, 31(4), 699–709. https://doi.org/10.1016/j.cmet.2020.02.013

Hepprich M, Antwi K, Waser B, Reubi JC, Wild D, & Christ ER. (2020). Brunner’s Gland Hyperplasia in a Patient after Roux-Y Gastric Bypass: An Important Pitfall in GLP-1 Receptor Imaging [Hindawi Limited]. Case Reports in Endocrinology, 2020, 4510910. https://doi.org/10.1155/2020/4510910

Hepprich, Matthias, Schelker, Benjamin, Staerkle, Alessandra, Trinh, Beckey, Wiedemann, Sophia, Boni-Schnetzler, Marianne, Rudofsky, Gottfried, & Donath, Marc. (2019). Novel insights into postprandial hypoglycemia after gastric bypass: Empagliflozin as well as Anakinra reduce symptomatic episodes by lowered insulin secretion. 60, S62–S63. SPRINGER HEIDELBERG.

Hepprich, Matthias, Lorscheider, Johannes, Peters, Nils, & Betz, Matthias Johannes. (2019). Hypothyroidism manifesting as multiple cranial neuropathies: a case report. Journal of Medical Case Reports, 13(1), 180. https://doi.org/10.1186/s13256-019-2124-6

Hepprich, M., Wiedemann, S. J., Schelker, B. L., Trinh, B., Staerkle, A., Geigges, M., Löliger, J., Böni-Schnetzler, M., Rudofsky, G., & Donath, M. (2019). Postprandial Hypoglycemia in Patients after Bariatric Surgery is Mediated by Glucose-Induced Il-1β [Journal-article]. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3455476

Trinh, B., Hepprich, M., Betz, M. J., Burkard, T., Cavelti Weder, C., Seelig, E., Meienberg, F., Kratschmar, D. V., Beuschlein, F., Reincke, M., Odermatt, A., Hall, M. N., Donath, M., & Swierczynska, M. M. (2019). Treatment of Primary Aldosteronism with mTORC1 Inhibitors [Journal-article]. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3315815

Trinh, Beckey, Hepprich, Matthias, Betz, Matthias J., Burkard, Thilo, Cavelti-Weder, Claudia, Seelig, Eleonora, Meienberg, Fabian, Kratschmar, Denise V., Beuschlein, Felix, Reincke, Martin, Odermatt, Alex, Hall, Michael N., Donath, Marc Y., & Swierczynska, Marta M. (2019). Treatment of Primary Aldosteronism with mTORC1 Inhibitors. The Journal of Clinical Endocrinology and Metabolism, 104(10), 4703–4714. https://doi.org/10.1210/jc.2019-00563

Lehrskov LL, Dorph E, Widmer AM, Hepprich M, Siegenthaler J, Timper K, & Donath MY. (2018). The role of IL-1 in postprandial fatigue. Molecular Metabolism, 12, 107–112. https://doi.org/10.1016/j.molmet.2018.04.001

Gerber-Hollbach, Nadine, Donath, Marc, Goldblum, David, Hasler, Pascal W., Trinh, Beckey, Siegenthaler, Judith, Hepprich, Matthias, Berney, Thierry, Bosco, Domenico, Steiger, Juerg, Dickenmann, Michael, Henzen, Christoph, Meyer, Jeremy, & Berggren, Per-Olof. (2017). FIRST-IN-MAN PANCREATIC ISLET TRANSPLANTATION IN THE ANTERIOR CHAMBER OF THE HUMAN EYE. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC.