Dr. med. Severina Maria Leu

Amer Salem, Michèle, Boulay, Jean-Louis, Ritz, Marie-Françoise, Halbeisen, Florian Samuel, Tschan, Viviane J., Schmidt, Alexander, Buczak, Katarzyna, Hutter, Gregor, & Leu, Severina. (2025). Quantitative Proteomic Analysis Reveals Different Functional Subtypes among IDH -Wildtype Glioblastoma. Journal of Proteome Research, 24(7), 3610–3624. https://doi.org/10.1021/acs.jproteome.5c00199

Westarp, E., Leu, S., Guzman, R., & Soleman, J. (2025). Hydrocephalus in surgically treated glioblastoma patients – To treat or not to treat? [Journal-article]. World Neurosurgery, 124167. https://doi.org/10.1016/j.wneu.2025.124167

Var, Vichyat, Leu, Severina M., Rommers, Nikki, Psychogios, Marios N., Cordier, Prof. Dominik, & Todea, Ramona A. (2025). Differentiation of tumor progression from pseudoprogression in glioblastoma patients with GRASP DCE-MRI and DSC-MRI. Journal of Neuroradiology, 101354. https://doi.org/10.1016/j.neurad.2025.101354

Hench, Jürgen, Hultschig, Claus, Brugger, Jon, Mariani, Luigi, Guzman, Raphael, Soleman, Jehuda, Leu, Severina, Benton, Miles, Stec, Irenäus Maria, Hench, Ivana Bratic, Hoffmann, Per, Harter, Patrick, Weber, Katharina J, Albers, Anne, Thomas, Christian, Hasselblatt, Martin, Schüller, Ulrich, Restelli, Lisa, Capper, David, et al. (2024). EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics [Journal-article]. Acta Neuropathologica Communications, 12(1). https://doi.org/10.1186/s40478-024-01759-2

Leu, Severina, Hutter, Gregor, & Boulay, Jean-Louis. (2023). Proteome-based insights for IDH-mutant glioma classification. Cell Reports Medicine, 4(1). https://doi.org/10.1016/j.xcrm.2022.100909

Leu S, Cahill J, & Grundy PL. (2023). A prospective study of shared decision-making in brain tumor surgery. Acta Neurochirurgica, 165(1), 15–25. https://doi.org/10.1007/s00701-022-05451-z

Leu, Severina, Halbeisen, Florian, Mariani, Luigi, & Soleman, Jehuda. (2021). Intraoperative ultrasound-guided compared to stereotactic navigated ventriculoperitoneal shunt placement: study protocol for a randomised controlled study. Trials, 22(1). https://doi.org/10.1186/s13063-021-05306-5

Maas, Sybren L.N., Stichel, Damian, Hielscher, Thomas, Sievers, Philipp, Berghoff, Anna S., Schrimpf, Daniel, Sill, Martin, Euskirchen, Philipp, Blume, Christina, Patel, Areeba, Dogan, Helin, Reuss, David, Dohmen, Hildegard, Stein, Marco, Reinhardt, Annekathrin, Suwala, Abigail K., Wefers, Annika K., Baumgarten, Peter, Ricklefs, Franz, et al. (2021). Integrated Molecular-Morphologic Meningioma Classification: A Multicenter Retrospective Analysis, Retrospectively and Prospectively Validated. Journal of Clinical Oncology, 39(34), 3839–3852. https://doi.org/10.1200/JCO.21.00784

Filippi V, Leu SM, Marengo L, & Hoesli I. (2021). Anaplastic astrocytoma during pregnancy: The importance of an effective multidisciplinary approach. BMJ Case Reports, 14(4). https://doi.org/10.1136/bcr-2021-242135

Leu S, Kamenova M, Mariani L, & Soleman J. (2021). Ultrasound-Guided Insertion of the Ventricular Catheter in Ventriculoperitoneal Shunt Surgery: Evaluation of Accuracy and Feasibility in a Prospective Cohort. Journal of Neurological Surgery, Part A: Central European Neurosurgery, 82(1), 9–17. https://doi.org/10.1055/s-0040-1714388

Schaefer, Thorsten, Ramadoss, Archana, Leu, Severina, Tintignac, Lionel, Tostado, Cristobal, Bink, Andrea, Schürch, Christoph, Müller, Joëlle, Schärer, Jonas, Moffa, Giusi, Demougin, Philippe, Moes, Suzette, Stippich, Christoph, Falbo, Simona, Neddersen, Heike, Bucher, Heiner, Frank, Stephan, Jenö, Paul, Lengerke, Claudia, et al. (2019). Regulation of Glioma Cell Invasion by 3q26 Gene Products PIK3CA, SOX2 and OPA1. Brain Pathology, 29(3), 336–350. https://doi.org/10.1111/bpa.12670

Leu S, Boulay JL, Thommen S, Bucher HC, Stippich C, Mariani L, & Bink A. (2018). Preoperative Two-Dimensional Size of Glioblastoma is Associated with Patient Survival. World Neurosurgery, 115, e448–e463. https://doi.org/10.1016/j.wneu.2018.04.067

Roethlisberger, Michel, Moffa, Giusi, Fisch, Urs, Wiggli, Benedikt, Schoen, Stephan, Kelly, Christopher, Leu, Severina, Croci, Davide, Zumofen, Daniel W., Cueni, Nadine, Nogarth, Danica, Schulz, Marianne, Bucher, Heiner C., Weisser-Rohacek, Maja, Wasner, Morten-Goetz, Widmer, Andreas F., & Mariani, Luigi. (2018). Effectiveness of a Chlorhexidine Dressing on Silver-coated External Ventricular Drain-associated Colonization and Infection: A Prospective Single-blinded Randomized Controlled Clinical Trial. Clinical Infectious Diseases, 67(12), 1868–1877. https://doi.org/10.1093/cid/ciy393

Hainc N, Stippich C, Stieltjes B, Leu S, & Bink A. (2017). Experimental texture analysis in glioblastoma: A methodological study. Investigative Radiology, 52(6), 367–373. https://doi.org/10.1097/RLI.0000000000000354

Kamenova, Maria, Leu, Severina, Mariani, Luigi, Schaeren, Stefan, & Soleman, Jehuda. (2016). Management of Incidental Dural Tear During Lumbar Spine Surgery. To Suture or Not to Suture? World Neurosurgery, 87, 62–455. https://doi.org/10.1016/j.wneu.2015.11.045

Leu, Severina, Kamenova, Maria, Mehrkens, Arne, Mariani, Luigi, Schären, Stefan, & Soleman, Jehuda. (2016). Preoperative and Postoperative Factors and Laboratory Values Predicting Outcome in Patients Undergoing Lumbar Fusion Surgery. World Neurosurgery, 92, 323–338. https://doi.org/10.1016/j.wneu.2016.05.011

Leu, Severina, von Felten, Stefanie, Frank, Stephan, Boulay, Jean-Louis, & Mariani, Luigi. (2016). IDH mutation is associated with higher risk of malignant transformation in low-grade glioma. Journal of Neuro-Oncology, 127(2), 72–363. https://doi.org/10.1007/s11060-015-2048-y

Leu S, Valavanis A, & Baltsavias G. (2015). Langer-Giedion syndrome associated with congenital dural arterio-venous fistula. Child’s Nervous System, 31(5), 801–804. https://doi.org/10.1007/s00381-014-2570-9

Leu, Severina, Von Felten, Stefanie, Frank, Stephan, Vassella, Erik, Vajtai, Istvan, Taylor, Elisabeth, Schulz, Marianne, Hutter, Gregor, Hench, Jurgen, Schucht, Philippe, Boulay, Jean-Louis, & Mariani, Luigi. (2013). IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival. Neuro-Oncology, 15, 469–479. https://doi.org/10.1093/neuonc/nos317