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Prof. Dr. Christoph Handschin

Faculty of Medicine
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de Smalen, Laura M., & Handschin, Christoph. (2024). Mitochondrial Maintenance in Skeletal Muscle [Journal-article]. Cold Spring Harbor Perspectives in Biology, Online ahead of print. https://doi.org/10.1101/cshperspect.a041514

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Ruiz, Alexis, Benucci, Sofia, Meier, Herve, Schultz, Georg, Buczak, Katarzyna, Handschin, Christoph, Pena, Rodrigo C. G., Treves, Susan, & Zorzato, Francesco. (2024). Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis [Posted-content]. In bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2024.08.09.607317

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Furrer, Regula, & Handschin, Christoph. (2024). Molecular aspects of the exercise response and training adaptation in skeletal muscle [Journal-article]. Free Radical Biology and Medicine, 223, 53–68. https://doi.org/10.1016/j.freeradbiomed.2024.07.026

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Mansingh, Shivani, Maier, Geraldine, Delezie, Julien, Westermark, Pål O., Ritz, Danilo, Duchemin, Wandrille, Santos, Gesa, Karrer-Cardel, Bettina, Steurer, Stefan A., Albrecht, Urs, & Handschin, Christoph. (2024). More than the clock: distinct regulation of muscle function and metabolism by PER2 and RORα. The Journal of Physiology, 602(23), 6373–6402. https://doi.org/10.1113/jp285585

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Lenardič, Ajda, Domenig, Seraina A., Zvick, Joel, Bundschuh, Nicola, Tarnowska-Sengül, Monika, Furrer, Regula, Noé, Falko J., Trautmann, Christine Ling Li, Ghosh, Adhideb, Bacchin, Giada, Gjonlleshaj, Pjeter, Qabrati, Xhem, Masschelein, Evi, De Bock, Katrien, Handschin, Christoph, & Bar-Nur, Ori. (2024). Generation of allogenic and xenogeneic functional muscle stem cells for intramuscular transplantation [Journal-article]. Journal of Clinical Investigation, 134(12). https://doi.org/10.1172/jci166998

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Fröhlich, K., Furrer, R., Schori, C., Handschin, C., & Schmidt, A. (2024). Robust, Precise, and Deep Proteome Profiling Using a Small Mass Range and Narrow Window Data-Independent-Acquisition Scheme [Journal-article]. Journal of Proteome Research, 23(3), 1028–1038. https://doi.org/10.1021/acs.jproteome.3c00736

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Furrer, Regula, & Handschin, Christoph. (2023). Complex regulatory processes control exercise adaptations of skeletal muscle. Nature Metabolism, 5(11), 1856–1857. https://doi.org/10.1038/s42255-023-00894-9

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de Smalen, Laura M., Börsch, Anastasiya, Leuchtmann, Aurel B., Gill, Jonathan F., Ritz, Danilo, Zavolan, Mihaela, & Handschin, Christoph. (2023). Impaired age-associated mitochondrial translation is mitigated by exercise and PGC-1α. Proceedings of the National Academy of Sciences (PNAS), 120(36), e2302360120. https://doi.org/10.1073/pnas.2302360120

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Furrer, Regula, Hawley, John A., & Handschin, Christoph. (2023). The molecular athlete: exercise physiology from mechanisms to medals. Physiological Reviews, 103(3), 1693–1787. https://doi.org/10.1152/physrev.00017.2022

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Furrer, Regula, Heim, Barbara, Schmid, Svenia, Dilbaz, Sedat, Adak, Volkan, Nordström, Karl J V, Ritz, Danilo, Steurer, Stefan A, Walter, Jörn, & Handschin, Christoph. (2023). Molecular control of endurance training adaptation in male mouse skeletal muscle. Nature metabolism, 5(11), 2020–2035. https://doi.org/10.1038/s42255-023-00891-y

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Handschin, Christoph. (2023). Churchill was wrong - do sports! Swiss Medical Forum, 23(26), 1175. https://doi.org/10.4414/smf.2023.09452

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Leuchtmann, Aurel B., Afifi, Yasmine, Ritz, Danilo, & Handschin, Christoph. (2023). Effects of high-resistance wheel running on hallmarks of endurance and resistance training adaptations in mice. Physiological Reports, 11(11), e15701. https://doi.org/10.14814/phy2.15701

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Furrer, Regula, Hawley, John A., & Handschin, Christoph. (2023). The molecular bases of endurance training adaptation. In Mujika, Iñigo (Ed.), & Mujika, Iñigo (Trans.), Endurance Training - Science and practice (2nd edition, pp. 149–159). Iñigo Mujika S.L.U.

Novakova K, Török M, Panajatovic M, Bouitbir J, Duong FHT, Handschin C, & Krähenbühl S. (2022). PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle. International Journal of Molecular Sciences, 23(20). https://doi.org/10.3390/ijms232012304

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Ham DJ, Börsch A, Chojnowska K, Lin S, Leuchtmann AB, Ham AS, Thürkauf M, Delezie J, Furrer R, Burri D, Sinnreich M, Handschin C, Tintignac LA, Zavolan M, Mittal N, & Rüegg MA. (2022). Author Correction: Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. (Patent No. 1). 13(1), Article 1. https://doi.org/10.1038/s41467-022-30189-8

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Furrer, Regula, & Handschin, Christoph. (2022). Drugs, clocks and exercise in ageing: hype and hope, fact and fiction. Journal of Physiology, 601(11), 2057–2068. https://doi.org/10.1113/jp282887

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Ham, Daniel J., Börsch, Anastasiya, Chojnowska, Kathrin, Lin, Shuo, Leuchtmann, Aurel B., Ham, Alexander S., Thürkauf, Marco, Delezie, Julien, Furrer, Regula, Burri, Dominik, Sinnreich, Michael, Handschin, Christoph, Tintignac, Lionel A., Zavolan, Mihaela, Mittal, Nitish, & Rüegg, Markus A. (2022). Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. Nature Communications, 13(1), 2025. https://doi.org/10.1038/s41467-022-29714-6

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Leuchtmann, Aurel B., Furrer, Regula, Steurer, Stefan A., Schneider-Heieck, Konstantin, Karrer-Cardel, Bettina, Sagot, Yves, & Handschin, Christoph. (2022). Interleukin-6 potentiates endurance training adaptation and improves functional capacity in old mice. Journal of Cachexia, Sarcopenia and Muscle, 13(2), 1164–1176. https://doi.org/10.1002/jcsm.12949

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Mansingh, Shivani, & Handschin, Christoph. (2022). Time to Train: The Involvement of the Molecular Clock in Exercise Adaptation of Skeletal Muscle. Frontiers in Physiology, 13, 902031. https://doi.org/10.3389/fphys.2022.902031

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Novakova, Katerina, Török, Michael, Panajatovic, Miljenko, Bouitbir, Jamal, Duong, François H T, Handschin, Christoph, & Krähenbühl, Stephan. (2022). PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle. International Journal of Molecular Sciences, 23(20), 12304. https://doi.org/10.3390/ijms232012304

Pérez-Schindler, Joaquín, Vargas-Fernández, Elyzabeth, Karrer-Cardel, Bettina, Ritz, Danilo, Schmidt, Alexander, & Handschin, Christoph. (2022). Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity. Scientific Reports, 12(1), 11477. https://doi.org/10.1038/s41598-022-15731-4

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Schmid, Svenia, Heim-Kupr, Barbara, Pérez-Schindler, Joaquín, Mansingh, Shivani, Beer, Markus, Mittal, Nitish, Ehrenfeuchter, Nikolaus, & Handschin, Christoph. (2022). PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds. Molecular metabolism, 66, 101643. https://doi.org/10.1016/j.molmet.2022.101643

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Streese, Lukas, Liffert, Jeannine, Vilser, Walthard, Handschin, Christoph, & Hanssen, Henner. (2022). In-vivo assessment of retinal vessel diameters and observer variability in mice: A methodological approach. PloS One, 17(7), e0271815. https://doi.org/10.1371/journal.pone.0271815

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Pérez-Schindler, Joaquín, Vargas-Fernández, Elyzabeth, Karrer-Cardel, Bettina, Ritz, Danilo, Schmidt, Alexander, & Handschin, Christoph. (2021). Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity [Posted-content]. bioRxiv. https://doi.org/10.1101/2021.03.24.436772

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Battey, Edmund, Furrer, Regula, Ross, Jacob, Handschin, Christoph, Ochala, Julien, & Stroud, Matthew J. (2021). PGC-1α regulates myonuclear accretion after moderate endurance training. Journal of Cellular Physiology, Jul 28. https://doi.org/10.1002/jcp.30539

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Furrer, Regula, Jauch, Annaïse J., Rao, Tata Nageswara, Dilbaz, Sedat, Rhein, Peter, Steurer, Stefan A., Recher, Mike, Skoda, Radek C., & Handschin, Christoph. (2021). Remodeling of metabolism and inflammation by exercise ameliorates tumor-associated anemia. Science Advances, 7(37), eabi4852. https://doi.org/10.1126/sciadv.abi4852

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Ham, Daniel J., Börsch, Anastasyia, Chojnowska, Kathrin, Lin, Shuo, Leuchtmann, Aurel B., Ham, Alexander S., Thürkauf, Marco, Delezie, Julien, Furrer, Regula, Burri, Dominik, Sinnreich, Michael, Handschin, Christoph, Tintignac, Lionel A., Zavolan, Mihaela, Mittal, Nitish, & Rüegg, Markus A. (2021). Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. bioRxiv. https://doi.org/10.1101/2021.05.28.446097

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Leuchtmann, Aurel B., Adak, Volkan, Dilbaz, Sedat, & Handschin, Christoph. (2021). The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations. Frontiers in Physiology, 12, 709807. https://doi.org/10.3389/fphys.2021.709807

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Maier, Geraldine, Delezie, Julien, Westermark, Pål O., Santos, Gesa, Ritz, Danilo, & Handschin, Christoph. (2021). Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle. Journal of Physiology, Jun 18, epub ahead of print. https://doi.org/10.1113/jp281535

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Pérez-Schindler, Joaquín, Kohl, Bastian, Schneider-Heieck, Konstantin, Leuchtmann, Aurel B., Henríquez-Olguín, Carlos, Adak, Volkan, Maier, Geraldine, Delezie, Julien, Sakoparnig, Thomas, Vargas-Fernández, Elyzabeth, Karrer-Cardel, Bettina, Ritz, Danilo, Schmidt, Alexander, Hondele, Maria, Jensen, Thomas E., Hiller, Sebastian, & Handschin, Christoph. (2021). RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates. Proceedings of the National Academy of Sciences of the United States of America, 118(36), e2105951118. https://doi.org/10.1073/pnas.2105951118

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Sjögren, Rasmus J. O., Rizo-Roca, David, Chibalin, Alexander V., Chorell, Elin, Furrer, Regula, Katayama, Shintaro, Harada, Jun, Karlsson, Håkan K. R., Handschin, Christoph, Moritz, Thomas, Krook, Anna, Näslund, Erik, & Zierath, Juleen R. (2021). Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes. Diabetologia, 64(9), 2077–2091. https://doi.org/10.1007/s00125-021-05481-9

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Maier, Geraldine, Delezie, Julien, Westermark, Pål O., Santos, Gesa, Ritz, Danilo, & Handschin, Christoph. (2020). Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and Zeitgeber activity of endurance training [Posted-content]. bioRxiv. https://doi.org/10.1101/2020.10.19.345686

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Pérez-Schindler, Joaquín, Kohl, Bastian, Schneider-Heieck, Konstantin, Adak, Volkan, Delezie, Julien, Maier, Geraldine, Sakoparnig, Thomas, Vargas-Fernández, Elyzabeth, Karrer-Cardel, Bettina, Ritz, Danilo, Schmidt, Alexander, Hondele, Maria, Hiller, Sebastian, & Handschin, Christoph. (2020). RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates [Posted-content]. bioRxiv. https://doi.org/10.1101/2020.09.23.310623

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Sjögren, Rasmus J.O., Rizo-Roca, David, Chibalin, Alexander V., Chorell, Elin, Furrer, Regula, Katayama, Shintaro, Harada, Jun, Karlsson, Håkan K.R., Handschin, Christoph, Moritz, Thomas, Krook, Anna, Näslund, Erik, & Zierath, Juleen R. (2020). Branched-Chain Amino Acid Metabolism is Regulated by ERRα in Primary Human Myotubes and is Further Impaired by Glucose Loading in Type 2 Diabetes [Posted-content]. bioRxiv. https://doi.org/10.1101/2020.07.24.218099

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Battilana, Fabienne, Steurer, Stefan, Rizzi, Giorgio, Delgado, Ana C., Tan, Kelly R., & Handschin, Christoph. (2020). Exercise-linked improvement in age-associated loss of balance is associated with increased vestibular input to motor neurons. Aging Cell, 19(12), e13274. https://doi.org/10.1111/acel.13274

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Delezie, Julien, Gill, Jonathan F., Santos, Gesa, Karrer-Cardel, Bettina, & Handschin, Christoph. (2020). PGC-1β-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse. Scientific Reports, 10(1), 16888. https://doi.org/10.1038/s41598-020-73794-7

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Furrer, Regula, & Handschin, Christoph. (2020). Lifestyle vs. pharmacological interventions for healthy aging. Aging, 12(1), 5–7. https://doi.org/10.18632/aging.102741

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Ham, Daniel J., Börsch, Anastasiya, Lin, Shuo, Thürkauf, Marco, Weihrauch, Martin, Reinhard, Judith R., Delezie, Julien, Battilana, Fabienne, Wang, Xueyong, Kaiser, Marco S., Guridi, Maitea, Sinnreich, Michael, Rich, Mark M., Mittal, Nitish, Tintignac, Lionel A., Handschin, Christoph, Zavolan, Mihaela, & Rüegg, Markus A. (2020). The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia. Nature Communications, 11(1), 4510. https://doi.org/10.1038/s41467-020-18140-1

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Leuchtmann, Aurel B., & Handschin, Christoph. (2020). Pharmacological targeting of age-related changes in skeletal muscle tissue. Pharmacological Research, 154, 104191. https://doi.org/10.1016/j.phrs.2019.02.030

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Panajatovic, Miljenko Valentin, Singh, François, Roos, Noëmi Johanna, Duthaler, Urs, Handschin, Christoph, Krähenbühl, Stephan, & Bouitbir, Jamal. (2020). PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice. Acta physiologica (Oxford, England), 228(4), e13402. https://doi.org/10.1111/apha.13402

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Rao TN, Hansen N, Hilfiker J, Rai S, Majewska JM, Leković D, Gezer D, Andina N, Galli S, Cassel T, Geier F, Delezie J, Nienhold R, Hao-Shen H, Beisel C, Di Palma S, Dimeloe S, Trebicka J, Wolf D, et al. (2019). JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms. Blood, 134(21), 1832–1846. https://doi.org/10.1182/blood.2019000162

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Krämer, A. I., & Handschin, C. (2019). How Epigenetic Modifications Drive the Expression and Mediate the Action of PGC-1<em>α</em> In the Regulation of Metabolism [Posted-content]. MDPI AG. https://doi.org/10.20944/preprints201910.0021.v1

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Agudelo, Leandro Z., Ferreira, Duarte M. S., Dadvar, Shamim, Cervenka, Igor, Ketscher, Lars, Izadi, Manizheh, Zhengye, Liu, Furrer, Regula, Handschin, Christoph, Venckunas, Tomas, Brazaitis, Marius, Kamandulis, Sigitas, Lanner, Johanna T., & Ruas, Jorge L. (2019). Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance. Nature Communications, 10(1), 2767. https://doi.org/10.1038/s41467-019-10712-0

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Brinkkoetter, Paul T., Bork, Tillmann, Salou, Sarah, Liang, Wei, Mizi, Athanasia, Özel, Cem, Koehler, Sybille, Hagmann, H. Henning, Ising, Christina, Kuczkowski, Alexander, Schnyder, Svenia, Abed, Ahmed, Schermer, Bernhard, Benzing, Thomas, Kretz, Oliver, Puelles, Victor G., Lagies, Simon, Schlimpert, Manuel, Kammerer, Bernd, et al. (2019). Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Reports, 27(5), 1551–1566. https://doi.org/10.1016/j.celrep.2019.04.012

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Delezie, Julien, Weihrauch, Martin, Maier, Geraldine, Tejero, Rocío, Ham, Daniel J., Gill, Jonathan F., Karrer-Cardel, Bettina, Rüegg, Markus A., Tabares, Lucía, & Handschin, Christoph. (2019). BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. Proceedings of the National Academy of Sciences (PNAS), 116(32), 16111–16120. https://doi.org/10.1073/pnas.1900544116

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Furrer, Regula, & Handschin, Christoph. (2019). Muscle Wasting Diseases: Novel Targets and Treatments. Annual review of pharmacology and toxicology, 59, 315–339. https://doi.org/10.1146/annurev-pharmtox-010818-021041

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Gill, Jonathan F., Delezie, Julien, Santos, Gesa, McGuirk, Shawn, Schnyder, Svenia, Frank, Stephan, Rausch, Martin, St-Pierre, Julie, & Handschin, Christoph. (2019). Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging. Aging cell, 18(5), e12993. https://doi.org/10.1111/acel.12993

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Krämer, Anne I., & Handschin, Christoph. (2019). How Epigenetic Modifications Drive the Expression and Mediate the Action of PGC-1α in the Regulation of Metabolism. International Journal of Molecular Sciences, 20(21), E5449. https://doi.org/10.3390/ijms20215449

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Nageswara Rao, Tata, Hansen, Nils, Hilfiker, Julian, Rai, Shivam, Majewska, Julia-Magdalena, Lekovic, Danijela, Gezer, Deniz, Andina, Nicola, Galli, Serena, Cassel, Teresa, Geier, Florian, Delezie, Julien, Nienhold, Ronny, Hao-Shen, Hui, Beisel, Christian, Di Palma, Serena, Dimeloe, Sarah, Trebicka, Jonel, Wolf, Dominik, et al. (2019). JAK2 mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms. Blood, 134(21), 1832–1846. https://doi.org/10.1182/blood.2019000162

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Furrer, Regula, & Handschin, Christoph. (2019). Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle. In Hormones, Metabolism and the Benefits of Exercise (pp. 57–66). Springer. https://doi.org/10.1007/978-3-319-72790-5_5

Gill, Jonathan F., Delezie, Julien, Santos, Gesa, McGuirk, Shawn, Schnyder, Svenia, Frank, Stephan, Rausch, Martin, St-Pierre, Julie, & Handschin, Christoph. (2018). PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle aging [Posted-content]. bioRxiv. https://doi.org/10.1101/451229

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Salatino S., Kupr B., Baresic M., Omidi S., Van Nimwegen E., & Handschin C. (2018). Corrigendum: The genomic context and corecruitment of SP1 affect ERRα coactivation by PGC-1α in muscle cells (Endocrinology (2016) 30:7 (809-825) DOI: 10.1210/me.2016-1036). Endocrinology, 159(7), 2703. https://doi.org/10.1210/en.2018-00545

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Baum, Oliver, Aaldijk, Dea, Engeli, Anna Lena, Spree, Matthias, Summermatter, Serge, Handschin, Christoph, & Zakrzewicz, Andreas. (2018). Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice. Nitric Oxide: Biology and Chemistry, 77, 35–43. https://doi.org/10.1016/j.niox.2018.04.005

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Delezie, Julien, & Handschin, Christoph. (2018). Endocrine Crosstalk Between Skeletal Muscle and the Brain. Frontiers in Neurology, 9, 698. https://doi.org/10.3389/fneur.2018.00698

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Gill, Jonathan F., Santos, Gesa, Schnyder, Svenia, & Handschin, Christoph. (2018). PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice. Aging Cell, 17(1), e12697. https://doi.org/10.1111/acel.12697

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Haralampieva, Deana, Salemi, Souzan, Betzel, Thomas, Dinulovic, Ivana, Krämer, Stefanie D., Schibli, Roger, Sulser, Tullio, Handschin, Christoph, Ametamey, Simon M., & Eberli, Daniel. (2018). Injected Human Muscle Precursor Cells Overexpressing PGC-1α. Enhance Functional Muscle Regeneration after Trauma. Stem cells international, 2018, 4658503. https://doi.org/10.1155/2018/4658503

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Ruiz, Alexis, Dror, Erez, Handschin, Christoph, Furrer, Regula, Perez-Schindler, Joaquin, Bachmann, Christoph, Treves, Susan, & Zorzato, Francesco. (2018). Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance. Scientific Reports, 8(1), 636. https://doi.org/10.1038/s41598-017-18844-3

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Weihrauch, Martin, & Handschin, Christoph. (2018). Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls. Biochemical Pharmacology, 147, 211–220. https://doi.org/10.1016/j.bcp.2017.10.006

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Whitehead, Natasha, Gill, Jonathan F., Brink, Marijke, & Handschin, Christoph. (2018). Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart. Frontiers in Physiology, 9, 242. https://doi.org/10.3389/fphys.2018.00242

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Pérez-Schindler, Joaquín, & Handschin, Christoph. (2018). Physiological Regulation of Skeletal Muscle Mass: Resistance Exercise- Mediated Muscle Hypertrophy. In Walrand, Stéphane (Ed.), Nutrition and Skeletal Muscle (1st Edition, pp. 139–150). Academic Press. https://doi.org/10.1016/b978-0-12-810422-4.00011-7

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Dinulovic, Ivana, Furrer, Regula, & Handschin, Christoph. (2017). Plasticity of the Muscle Stem Cell Microenvironment. Advances in experimental medicine and biology, 1041, 141–169. https://doi.org/10.1007/978-3-319-69194-7_8

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Furrer, Regula, Eisele, Petra S., Schmidt, Alexander, Beer, Markus, & Handschin, Christoph. (2017). Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP. Scientific Reports, 7, 40789. https://doi.org/10.1038/srep40789

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Haralampieva, Deana, Salemi, Souzan, Dinulovic, Ivana, Sulser, Tullio, Ametamey, Simon, Handschin, Christoph, & Eberli, Daniel. (2017). Human muscle precursor cells overexpressing PGC-1α enhance early skeletal muscle tissue formation. Cell Transplantation, 26(6), 1103–1114. https://doi.org/10.3727/096368917x694868

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Kupr, Barbara, Schnyder, Svenia, & Handschin, Christoph. (2017). Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations. Cold Spring Harbor perspectives in medicine, 7(6), a029835. https://doi.org/10.1101/cshperspect.a029835

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Ross, Jacob Alexander, Pearson, Adam, Levy, Yotam, Cardel, Bettina, Handschin, Christoph, & Ochala, Julien. (2017). Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres. Journal of Cellular Physiology, 232(6), 1270–1274. https://doi.org/10.1002/jcp.25678

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Schnyder, Svenia, Kupr, Barbara, & Handschin, Christoph. (2017). Coregulator-mediated control of skeletal muscle plasticity - A mini-review. Biochimie, 136, 49–54. https://doi.org/10.1016/j.biochi.2016.12.011

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Schnyder, Svenia, Svensson, Kristoffer, Cardel, Bettina, & Handschin, Christoph. (2017). Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice. American Journal of Physiology. Endocrinology and Metabolism, 312(5), E437–E446. https://doi.org/10.1152/ajpendo.00361.2016

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Furrer, Regula, & Handschin, Christoph. (2017). Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle. In Spiegelman, Bruce M. (Ed.), Hormones, Metabolism and the Benefits of Exercise (pp. 57–66). Springer. https://doi.org/10.1007/978-3-319-72790-5_5

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Handschin, Christoph. (2017). Muskeln: mehr als nur “schön anzusehen”. In Füglister, Kurt M.; Hicklin, Martin; Mäser, Pascal (ed.), natura obscura. 200 Naturforschende - 200 Naturphänomene - 200 Jahre Naturforschende Gesellschaft in Basel (pp. 85). Schwabe. http://www.ngib.ch/natura-obscura/

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Albert, Verena, Svensson, Kristoffer, Shimobayashi, Mitsugu, Colombi, Marco, Munoz, Sergio, Jimenez, Veronica, Handschin, Christoph, Bosch, Fatima, & Hall, Michael N. (2016). mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO MOLECULAR MEDICINE, 8, 232–246.

Albert, V., Svensson, K., Shimobayashi, M., Colombi, M., Muñoz, S., Jimenez, V., Handschin, C., Bosch, F., & Hall, M. N. (2016). mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Molecular Medicine, 8(3), 232–246. https://doi.org/10.15252/emmm.201505610

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Dinulovic, Ivana, Furrer, Regula, Beer, Markus, Ferry, Arnaud, Cardel, Bettina, & Handschin, Christoph. (2016). Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche. Skeletal Muscle, 6(1), 39. https://doi.org/10.1186/s13395-016-0111-9

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Dinulovic, Ivana, Furrer, Regula, Di Fulvio, Sabrina, Ferry, Arnaud, Beer, Markus, & Handschin, Christoph. (2016). PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle. Skeletal Muscle, 6(38), 38. https://doi.org/10.1186/s13395-016-0110-x

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Gill, Jonathan F, Delezie, Julien, Santos, Gesa, & Handschin, Christoph. (2016). PGC-1α expression in murine AgRP neurons regulates food intake and energy balance. Molecular metabolism, 5(7), 580–588. https://doi.org/10.1016/j.molmet.2016.05.008

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Haralampieva, Deana, Betzel, Thomas, Dinulovic, Ivana, Salemi, Souzan, Stoelting, Meline, Krämer, Stefanie D, Schibli, Roger, Sulser, Tullio, Handschin, Christoph, Eberli, Daniel, & Ametamey, Simon M. (2016). Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering. Journal of Nuclear Medicine, 57(9), 1467–1473. https://doi.org/10.2967/jnumed.115.170548

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Salatino, Silvia, Kupr, Barbara, Baresic, Mario, van Nimwegen, Erik, & Handschin, Christoph. (2016). The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells. Molecular Endocrinology, 30(7), 809–825. https://doi.org/10.1210/me.2016-1036

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Stölting, Meline N. L., Arnold, Anne Sophie, Haralampieva, Deana, Handschin, Christoph, Sulser, Tullio, & Eberli, Daniel. (2016). Magnetic stimulation supports muscle and nerve regeneration after trauma in mice. Muscle and Nerve, 53(4), 598–607. https://doi.org/10.1002/mus.24780

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Svensson, Kristoffer, Albert, Verena, Cardel, Bettina, Salatino, Silvia, & Handschin, Christoph. (2016). Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice. FASEB Journal, 30(5), 1976–1986. https://doi.org/10.1096/fj.201500128

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Svensson, Kristoffer, Schnyder, Svenia, Cardel, Bettina, & Handschin, Christoph. (2016). Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice. PLoS ONE, 11(7), e0158716. https://doi.org/10.1371/journal.pone.0158716

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Eisele, Petra Sabine, Furrer, Regula, Beer, Markus, & Handschin, Christoph. (2015). The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo. Biochemical and Biophysical Research Communications, 464(3), 692–697. https://doi.org/10.1016/j.bbrc.2015.06.166

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Furrer, Regula, & Handschin, Christoph. (2015). Exercise and PGC-1α in inflammation and chronic disease. Deutsche Zeitschrift für Sportmedizin, 66(12), 317–320. https://doi.org/10.5960/dzsm.2015.185

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Handschin, Christoph. (2015). Caloric restriction and exercise “mimetics″: Ready for prime time? Pharmacological research, 103, 158–166. https://doi.org/10.1016/j.phrs.2015.11.009

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Handschin, Christoph, Mortezavi, Ashkan, Plock, Jan, & Eberli, Daniel. (2015). External physical and biochemical stimulation to enhance skeletal muscle bioengineering [Review of External physical and biochemical stimulation to enhance skeletal muscle bioengineering]. Advanced drug delivery reviews, 82-83, 168–175. https://doi.org/10.1016/j.addr.2014.10.021

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Kupr, Barbara, & Handschin, Christoph. (2015). Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [Review of Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle]. Frontiers in Physiology, 6, 325. https://doi.org/10.3389/fphys.2015.00325

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Schnyder, Svenia, & Handschin, Christoph. (2015). Skeletal muscle as an endocrine organ : PGC-1α, myokines and exercise. Bone, 80, 115–125. https://doi.org/10.1016/j.bone.2015.02.008

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Soler, Fernando, Fernández-Belda, Francisco, Pérez-Schindler, Joaquín, Handschin, Christoph, Fuente, Teodomiro, & Hernandez-Cascales, Jesús. (2015). PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects. Experimental biology and medicine, 240(9), 1205–1213. https://doi.org/10.1177/1535370214560969

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Svensson, Kristoffer, Schnyder, Svenia, Albert, Verena, Cardel, Bettina, Quagliata, Luca, Terracciano, Luigi M., & Handschin, Christoph. (2015). Resveratrol and SRT1720 elicit differential effects in metabolic organs and modulate systemic parameters independently of skeletal muscle peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α). Journal of biological chemistry, 290(26), 16059–16076. https://doi.org/10.1074/jbc.m114.590653

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Arnold, Anne-Sophie, Gill, Jonathan, Christe, Martine, Ruiz, Rocío, McGuirk, Shawn, St-Pierre, Julie, Tabares, Lucía, & Handschin, Christoph. (2014). Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α. Nature communications, 5, 3569. https://doi.org/10.1038/ncomms4569

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Baresic, Mario, Salatino, Silvia, Kupr, Barbara, van Nimwegen, Erik, & Handschin, Christoph. (2014). Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program. Molecular and cellular biology, 34(16), 2996–3012. https://doi.org/10.1128/mcb.01710-13

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Eisele, Petra S, & Handschin, Christoph. (2014). Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Seminars in immunopathology, 36(1), 27–53. https://doi.org/10.1007/s00281-013-0406-4

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Handschin, Christoph. (2014). The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet. Diabetologia, 57(11), 2405–2412. https://doi.org/10.1007/s00125-014-3352-3

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Morand, Réjane, Bouitbir, Jamal, Felser, Andrea, Hench, Jürgen, Handschin, Christoph, Frank, Stephan, & Krähenbühl, Stephan. (2014). Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. European journal of nutrition, 53(6), 1313–1325. https://doi.org/10.1007/s00394-013-0631-6

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Svensson, Kristoffer, & Handschin, Christoph. (2014). Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases [Review of Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases]. Drug discovery today, 19, Article 7. https://doi.org/10.1016/j.drudis.2014.02.013

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Svensson, Kristoffer, & Handschin, Christoph. (2014). MicroRNAs emerge as modulators of NAD+-dependent energy metabolism in skeletal muscle. Diabetes, 63(5), 1451–1453. https://doi.org/10.2337/db14-0166

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Eisele P.S., Salatino S., Sobek J., Hottiger M.O., & Handschin C. (2013). Erratum: The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells (Journal of Biological Chemistry (2013) 288 (2246-2260)). Journal of Biological Chemistry, 288(9), 6589. https://doi.org/10.1074/jbc.a112.375253

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Bentzinger, C. Florian, Lin, Shuo, Romanino, Klaas, Castets, Perrine, Guridi, Maitea, Summermatter, Serge, Handschin, Christoph, Tintignac, Lionel A., Hall, Michael N., & Rüegg, Markus A. (2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle, 3(1), 6. https://doi.org/10.1186/2044-5040-3-6

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Eisele, Petra S., Salatino, Silvia, Sobek, Jens, Hottiger, Michael O., & Handschin, Christoph. (2013). The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. Journal of Biological Chemistry, 288(4), 2246–2260. https://doi.org/10.1074/jbc.m112.375253

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Pérez-Schindler, Joaquín, & Handschin, Christoph. (2013). New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases. Drug Discovery Today. Disease Models, 10(2), e79–e85. https://doi.org/10.1016/j.ddmod.2012.12.002

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Pérez-Schindler, Joaquín, Summermatter, Serge, Santos, Gesa, Zorzato, Francesco, & Handschin, Christoph. (2013). The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling. Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20314–20319. https://doi.org/10.1073/pnas.1312039110

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Stölting, Meline Nogueira Lucena, Ferrari, Stefano, Handschin, Christoph, Becskei, Attila, Provenzano, Maurizio, Sulser, Tullio, & Eberli, Daniel. (2013). Myoblasts inhibit prostate cancer growth by paracrine secretion of tumor necrosis factor-α. Journal of Urology, 189(5), 1952–1959. https://doi.org/10.1016/j.juro.2012.10.071

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