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Prof. Dr. Pablo Sinues

Department of Biomedical Engineering
Profiles & Affiliations

Translational Medicine Breath Research

Ultimately, I aim to improve diagnosis for certain diseases, to better phenotype complex pathophysiological processes, as well as to personalize therapy. My breath analysis lab houses a state-of-the art mass spectrometric analytical platform for real-time analysis of exhaled breath and an efficient numerically-optimized Secondary Electrospray Ionization source coupled with a high resolution mass spectrometer. In addition, the lab is equipped with an Ultra High Pressure Liquid Chromatography system, which, coupled with the mass spectrometer, is dedicated for metabolite identification. Bio-informatic tools developed in my lab unravel biochemical information encoded in the mass spectral fingerprints of our patients.

Selected Publications

Gisler A., Singh K.D., Zeng J., Osswald M., Awchi M., Decrue F., Schmidt F., Sievi N.A., Chen X., Usemann J., Frey U., Kohler M., Li X., & Sinues P. (2022). An interoperability framework for multicentric breath metabolomic studies. iScience, 25(12). https://doi.org/10.1016/j.isci.2022.105557

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Arnold K., Chen X., Zhang H., Singh K.D., Yin Z., Yao Y., Luan T., Sinues P., & Li X. (2022). In vivo detection of metabolic 2H-incorporation upon ingestion of 2H2O. Journal of Bio-X Research, 5(2), 81–89. https://doi.org/10.1097/jbr.0000000000000121

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Singh KD, Osswald M, Ziesenitz VC, Awchi M, Usemann J, Imbach LL, Kohler M, García-Gómez D, van den Anker J, Frey U, Datta AN, & Sinues P. (2021). Personalised therapeutic management of epileptic patients guided by pathway-driven breath metabolomics. Communications Medicine, 1, 21. https://doi.org/10.1038/s43856-021-00021-3

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