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Prof. Dr. med. Nicolas von der Weid

Department of Clinical Research

Outcomes Research in Pediatric Oncology

Epidemiologie der Spätfolgen nach Kinderkrebs

Interventionsstudie mittels physischer/sportlicher Aktivität (SURfit)

Prävention der Chemotherapie-induzierten Polyneuropathie mittels Sport Training (PrepAir Studie)

Früherkennung kardialer Spätfolgen mittels speckle-tracking Echokardiographie (CardioOnco Studie)

Früherkennung pneumologischer Spätfolgen mittels multi-breath washout (Pulmo Studie)

Massnahmen zur Fertilitätserhaltung bei prä-pubären Kindern

Selected Publications

Streckmann, Fiona, Schindera, Christina, Faude, Oliver, & Von der Weid, Nicolas. (2024). The potential and importance of exercise therapy in pediatric oncology – The PrepAIR study [Journal-article]. Current Issues in Sport Science (CISS), 9, 19. https://doi.org/10.36950/2024.2ciss019

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Kasteler, Rahel, Otth, Maria, Halbeisen, Florian S., Mader, Luzius, Singer, Florian, Rössler, Jochen, von der Weid, Nicolas X., Ansari, Marc, & Kuehni, Claudia E. (2024). Longitudinal assessment of lung function in Swiss childhood cancer survivors—A multicenter cohort study. Pediatric Pulmonology, 59(1), 169–180. https://doi.org/10.1002/ppul.26738

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Rueegg, C. S., Zürcher, S. J., Schindera, C., Jung, R., Deng, W. H., Bänteli, I., Schaeff, J., Hebestreit, H., von der Weid, N. X., & Kriemler, S. (2023). Effect of a 1-year physical activity intervention on cardiovascular health in long-term childhood cancer survivors—a randomised controlled trial (SURfit). British Journal of Cancer, 129(8), 1284–1297. https://doi.org/10.1038/s41416-023-02410-y

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Schindera C, Usemann J, Zuercher SJ, Jung R, Kasteler R, Frauchiger B, Naumann G, Rueegg CS, Latzin P, Kuehni CE, & von der Weid NX. (2021). Pulmonary dysfunction after treatment for childhood cancer comparing multiple-breath washout with spirometry. Annals of the American Thoracic Society, 18(2), 281–289. https://doi.org/10.1513/AnnalsATS.202003-211OC

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Selected Projects & Collaborations

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LeukemiaCort: A Swiss prospective multicenter longitudinal assessment of hypothalamic-pituitary-adrenal axis suppression after glucocorticoid therapy for leukemia and lymphoblastic lymphoma in children. An explorative study.

Research Project  | 4 Project Members

Glucocorticoid therapy is an important component of the treatment regimen for childhood acute lymphoblastic leukaemia and lymphoblastic lymphoma by inducing apoptosis of lymphoblastic cells. However, the use of supraphysiological doses of glucocorticoids can lead to hypothalamic-pituitary-adrenal axis suppression. This suppression can result in a reduced cortisol response, leading to impaired stress response and inadequate host defence against infections, which can ultimately result in morbidity and mortality. To date, there is insufficient high-quality research to inform evidence-based guidelines for glucocorticoid replacement therapy in this populatioon.

Hence, in this prospective multicenter study, we aim to analyze the patterns of suppression of the hypothalamic-pituitary-adrenal axis suppression in children receiving glucocorticoid therapy for acute lymphoblastic leukaemia and lymphoblastic lymphoma.