Prof. Dr. med. Mirjam Christ-Crain

Asla, Queralt, Garrido, Maite, Urgell, Eulàlia, Terzan, Sílvia, Santos, Alicia, Fernández, Mercè, Varghese, Nimmy, Atila, Cihan, Calabrese, Anna, Biagetti, Betina, Plessow, Franziska, Gich, Ignasi, Christ-Crain, Mirjam, Eckert, Anne, Webb, Susan M., Lawson, Elizabeth A., & Aulinas, Anna. (2025). Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage: a randomized, crossover, placebo-controlled trial. Scientific Reports, 15(1), 2360. https://doi.org/10.1038/s41598-025-86566-y

Atila, Cihan, Lustenberger, Sven, Chifu, Irina, Ferrante, Emanuele, Erlic, Zoran, Drummond, Juliana B., Indirli, Rita, Drexhage, Roosmarijn, Powlson, Andrew S., Gurnell, Mark, Santana Soares, Beatriz, Hofland, Johannes, Beuschlein, Felix, Fassnacht, Martin, Winzeler, Bettina, Refardt, Julie, & Christ-Crain, Mirjam. (2025). Relationship between plasma urea and copeptin in response to arginine stimulation in healthy adults, patients with vasopressin deficiency and primary polydipsia. Pituitary, 28. https://doi.org/10.1007/s11102-024-01489-7

Newell-Price, John, Drummond, Juliana Beaudette, Gurnell, Mark, Levy, Miles, McCormack, Ann, Cooper, Deborah, Wass, John, Christ-Crain, Mirjam, & Verbalis, Joseph G. (2025). Approach to the Patient With Suspected Hypotonic Polyuria. Journal of Clinical Endocrinology and Metabolism, 110(2), e506–e514. https://doi.org/10.1210/clinem/dgae565

Pelouto, A., Monnerat, S., Refardt, J., Zandbergen, A. A. M., Christ-Crain, M., & Hoorn, E. J. (2025). Clinical factors associated with hyponatremia correction during treatment with oral urea [Journal-article]. Nephrology Dialysis Transplantation, 40(2), 283–293. https://doi.org/10.1093/ndt/gfae164

Perrild, Hans, Luger, Anton, Bertherat, Jerome, Quinton, Richard, Christ-Crain, Mirjam, Brouwer, Teri, & Durkan, Maeve. (2025). Postgraduate training and continuous medical education in endocrinology in Europe. European Journal of Endocrinology, 192(1), C1–C4. https://doi.org/10.1093/ejendo/lvae169

Smit, J. M., Van Der Zee, P. A., Stoof, S. C. M., Van Genderen, M. E., Snijders, D., Boersma, W. G., Confalonieri, P., Salton, F., Confalonieri, M., Shih, M.-C., Meduri, G. U., Dequin, P.-F., Le Gouge, A., Lloyd, M., Karunajeewa, H., Bartminski, G., Fernández-Serrano, S., Suárez-Cuartín, G., van Klaveren, D., et al. (2025). Predicting benefit from adjuvant therapy with corticosteroids in community-acquired pneumonia: a data-driven analysis of randomised trials. The Lancet Respiratory Medicine. https://doi.org/10.1016/S2213-2600(24)00405-3

Gregoriano, Claudia, Wirz, Yannick, Heinsalo, Ashley, Annane, Djilali, Reinhart, Konrad, Bouadma, Lila, Christ-Crain, Mirjam, Kristoffersen, Kristina B., Damas, Pierre, Nobre, Vandack, Oliveira, Carolina F., Shehabi, Yahya, Stolz, Daiana, Verduri, Alessia, Mueller, Beat, & Schuetz, Philipp. (2024). Procalcitonin-guided antibiotic treatment in patients with cancer: a patient-level meta-analysis from randomized controlled trials. BMC Cancer, 24(1). https://doi.org/10.1186/s12885-024-13160-2

Huynh, Tony, Signal, Dana, & Christ-Crain, Mirjam. (2024). Paediatric perspectives in the diagnosis of polyuria-polydipsia syndrome. Clinical Endocrinology, 101(6), 580–592. https://doi.org/10.1111/cen.15011

Karavitaki, Niki, Bettinger, Jeffrey J., Biermasz, Nienke, Christ-Crain, Mirjam, Gadelha, Monica R, Inder, Warrick J, Tsourdi, Elena, Wakeman, Sarah E., & Zatelli, Maria. (2024). Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement. Endocrine Reviews, 45(6), 773–794. https://doi.org/10.1210/endrev/bnae023

Atila, Cihan, Straumann, Isabelle, Vizeli, Patrick, Beck, Julia, Monnerat, Sophie, Holze, Friederike, Liechti, Matthias E., & Christ-Crain, Mirjam. (2024). Oxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA network open, 7(11). https://doi.org/10.1001/jamanetworkopen.2024.45278

Atila, Cihan, Mekkattu, Shalini, Murugesu, Rakithan, Gaisl, Odile, Varghese, Nimmy, Eckert, Anne, & Christ-Crain, Mirjam. (2024). Plasma oxytocin levels in response to glucagon in patients with arginine vasopressin deficiency (central diabetes insipidus) and healthy controls. Endocrine, 86(2), 774–781. https://doi.org/10.1007/s12020-024-03920-2

Bizzozero, Chiara Angela, Monnerat, Sophie, Chapman, Fiona A., Dhaun, Neeraj, Refardt, Julie, & Christ-Crain, Mirjam. (2024). Apelin levels in patients with polyuria-polydipsia syndrome upon copeptin stimulation tests. European Journal of Endocrinology, 191(5), 491–498. https://doi.org/10.1093/ejendo/lvae138

Luger, Anton, Durkan, Maeve, Christ-Crain, Mirjam, & Marques, Pedro. (2024). European Society of Endocrinology Curriculum and Training Recommendation in Endocrinology. European Journal of Endocrinology, 191(5), R71–R77. https://doi.org/10.1093/ejendo/lvae141

Wälchli-Popovic, Milica, Monnerat, Sophie, Taylor, Angela E., Gilligan, Lorna C., Schiffer, Lina, Arlt, Wiebke, Vogt, Deborah R., De Geyter, Christian, Hutter, Nina, Donath, Marc Y., Sartorius, Gideon, & Christ-Crain, Mirjam. (2024). Effects of interleukin-1 receptor antagonism in women with polycystic ovary syndrome—the FertIL trial [Journal-article]. Frontiers in Endocrinology, 15. https://doi.org/10.3389/fendo.2024.1435698

Lamback, E., Filho, F. D. C., Ventura, N., Chimelli, L., Christ-Crain, M., & Gadelha, M. R. (2024). Extraventricular Neurocytoma of the Sellar Region Presenting With Syndrome of Inappropriate Antidiuresis [Journal-article]. JCEM Case Reports, 2(9). https://doi.org/10.1210/jcemcr/luae099

Atila, Cihan, Refardt, Julie, & Christ-Crain, Mirjam. (2024). Correction to: Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency (Nature Reviews Endocrinology, (2024), 20, 8, (487-500), 10.1038/s41574-024-00985-x). Nature Reviews Endocrinology, 20(8). https://doi.org/10.1038/s41574-024-00998-6

Atila, Cihan, Refardt, Julie, & Christ-Crain, Mirjam. (2024). Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency. Nature Reviews Endocrinology, 20(8), 487–500. https://doi.org/10.1038/s41574-024-00985-x

Monnerat, Sophie, Drivakos, Nikolaos, Chapman, Fiona A., Dhaun, Neeraj, Refardt, Julie, & Christ-Crain, Mirjam. (2024). Apelin and Copeptin Levels in Patients With Chronic SIAD Treated With Empagliflozin. Journal of the Endocrine Society, 8(7). https://doi.org/10.1210/jendso/bvae106

Fleseriu, M., Christ-Crain, M., Langlois, F., Gadelha, M., & Melmed, S. (2024). Hypopituitarism. The Lancet, 403(10444), 2632–2648. https://doi.org/10.1016/S0140-6736(24)00342-8

Kriemler, Lilian, Rudin, Salome, Gawinecka, Joanna, Gross, Felix, Arnold, Markus, Schweizer, Juliane, Westphal, Laura, Inauen, Corinne, Pokorny, Thomas, Dittrich, Tolga, Toebak, Anna, Arnold, Marcel, Christ-Crain, Mirjam, von Eckardstein, Arnold, Rentsch, Katharina, Katan, Mira, & De Marchis, Gian Marco. (2024). Discordance between LDL-C and apolipoprotein B is associated with large-artery-atherosclerosis ischemic stroke in patients ⩽70 years of age. European Stroke Journal, 9(2), 494–500. https://doi.org/10.1177/23969873231221619

Refardt, Julie, Atila, Cihan, & Christ-Crain, Mirjam. (2024). New insights on diagnosis and treatment of AVP deficiency. Reviews in Endocrine and Metabolic Disorders, 25(3), 639–649. https://doi.org/10.1007/s11154-023-09862-w

Atila, Cihan, Beck, Julia, Refardt, Julie, Erlic, Zoran, Drummond, Juliana B., Sailer, Clara O., Liechti, Matthias E., Rocha, Beatriz Santana Soares, Beuschlein, Felix, Winzeler, Bettina, & Christ-Crain, Mirjam. (2024). Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia compared to healthy controls. European Journal of Endocrinology, 190(5), 354–362. https://doi.org/10.1093/ejendo/lvae040

Lüthi, Hualin, Lengsfeld, Sophia, Burkard, Thilo, Meienberg, Andrea, Jeanloz, Nica, Vukajlovic, Tanja, Bologna, Katja, Steinmetz, Michelle, Bathelt, Cemile, Sailer, Clara O., Laager, Mirjam, Vogt, Deborah R., Hemkens, Lars G., Speich, Benjamin, Urwyler, Sandrine A., Kühne, Jill, Baur, Fabienne, Lutz, Linda N., Erlanger, Tobias E., et al. (2024). Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trial. eClinicalMedicine, 68. https://doi.org/10.1016/j.eclinm.2024.102429

Lüthi, Hualin, Lengsfeld, Sophia, Burkard, Thilo, Meienberg, Andrea, Jeanloz, Nica, Vukajlovic, Tanja, Bologna, Katja, Steinmetz, Michelle, Bathelt, Cemile, Sailer, Clara O., Laager, Mirjam, Vogt, Deborah R., Hemkens, Lars G., Speich, Benjamin, Urwyler, Sandrine A., Kühne, Jill, Baur, Fabienne, Lutz, Linda N., Erlanger, Tobias E., et al. (2024). Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trial [Journal-article]. eClinicalMedicine, 68, 102429. https://doi.org/10.1016/j.eclinm.2024.102429

Lüthi, Hualin, Lengsfeld, Sophia, Burkard, Thilo, Meienberg, Andrea, Jeanloz, Nica, Vukajlovic, Tanja, Bologna, Katja, Steinmetz, Michelle, Bathelt, Cemile, Sailer, Clara O., Laager, Mirjam, Vogt, Deborah R., Hemkens, Lars G., Speich, Benjamin, Urwyler, Sandrine A., Kühne, Jill, Baur, Fabienne, Lutz, Linda N., Erlanger, Tobias E., et al. (2024). Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trial [Journal-article]. eClinicalMedicine, 68, 102429. https://doi.org/10.1016/j.eclinm.2024.102429

Lüthi, Hualin, Lengsfeld, Sophia, Burkard, Thilo, Meienberg, Andrea, Jeanloz, Nica, Vukajlovic, Tanja, Bologna, Katja, Steinmetz, Michelle, Bathelt, Cemile, Sailer, Clara O., Laager, Mirjam, Vogt, Deborah R., Hemkens, Lars G., Speich, Benjamin, Urwyler, Sandrine A., Kühne, Jill, Baur, Fabienne, Lutz, Linda N., Erlanger, Tobias E., et al. (2024). Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trial [Journal-article]. eClinicalMedicine, 68, 102429. https://doi.org/10.1016/j.eclinm.2024.102429

Refardt, Julie, Vogt, Deborah R., & Christ-Crain, Mirjam. (2024). Arginine or Hypertonic Saline-Stimulated Copeptin to Diagnose AVP Deficiency. New England Journal of Medicine, 390(3), 288–290. https://doi.org/10.1056/NEJMc2314326

Efthymiadis, Agathoklis, Pofi, Riccardo, Rostom, Hussam, James, Tim, Shine, Brian, Guha, Nish, Cudlip, Simon, Christ-Crain, Mirjam, & Pal, Aparna. (2024). Copeptin and the syndrome of inappropriate antidiuresis (SIAD) after pituitary transsphenoidal surgery. Endocrinology, Diabetes and Metabolism, 7(1). https://doi.org/10.1002/edm2.467

Radvanyi, Z., Yoo, E. J., Kandasamy, P., Salas-Bastos, A., Monnerat, S., Refardt, J., Christ-Crain, M., Hayashi, H., Kondo, Y., Jantsch, J., Rubio-Aliaga, I., Sommer, L., Wagner, C. A., Hediger, M. A., Kwon, H. M., Loffing, J., & Pathare, G. (2024). Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation [Journal-article]. Journal of Biological Chemistry, 300(1), 105480. https://doi.org/10.1016/j.jbc.2023.105480

Rudin, Salome, Kriemler, Lilian, Dittrich, Tolga D., Zietz, Annaelle, Schweizer, Juliane, Arnold, Markus, Peters, Nils, Barinka, Filip, Jung, Simon, Arnold, Marcel, Fischer, Urs, Rentsch, Katharina, Christ-Crain, Mirjam, Katan, Mira, & De Marchis, Gian Marco. (2024). Lipoprotein(a) as a blood marker for large artery atherosclerosis stroke etiology: validation in a prospective cohort from a swiss stroke center. Swiss Medical Weekly, 154. https://doi.org/10.57187/s.3633

Sterns RH, Rondon-Berrios H, Adrogué HJ, Berl T, Burst V, Cohen DM, Christ-Crain M, Cuesta M, Decaux G, Emmett M, Garrahy A, Gankam-Kengne F, Hix JK, Hoorn EJ, Kamel KS, Madias NE, Peri A, Refardt J, Rosner MH, et al. (2024). Treatment Guidelines for Hyponatremia Stay the Course. Clinical Journal of the American Society of Nephrology, 19(1), 129–135. https://doi.org/10.2215/CJN.0000000000000244

Baur, Fabienne, Atila, Cihan, Lengsfeld, Sophia, Burkard, Thilo, Meienberg, Andrea, Bathelt, Cemile, Christ-Crain, Mirjam, & Winzeler, Bettina. (2023). Gender differences in weight gain during attempted and successful smoking cessation on dulaglutide treatment: A predefined secondary analysis of a randomised trial. BMJ Nutrition, Prevention and Health, 6(2), 301–309. https://doi.org/10.1136/bmjnph-2023-000781

Blum, Claudine A., Roethlisberger, Eva A., Cesana-Nigro, Nicole, Winzeler, Bettina, Rodondi, Nicolas, Blum, Manuel R., Briel, Matthias, Mueller, Beat, Christ-Crain, Mirjam, & Schuetz, Philipp. (2023). Adjunct prednisone in community-acquired pneumonia: 180-day outcome of a multicentre, double-blind, randomized, placebo-controlled trial. BMC Pulmonary Medicine, 23(1). https://doi.org/10.1186/s12890-023-02794-w

Lengsfeld, Sophia, Burkard, Thilo, Meienberg, Andrea, Jeanloz, Nica, Coynel, David, Vogt, Deborah R., Hemkens, Lars G., Speich, Benjamin, Zanchi, Davide, Erlanger, Tobias E., Christ-Crain, Mirjam, & Winzeler, Bettina. (2023). Glucagon-like peptide-1 analogues: a new way to quit smoking? (SKIP)—a structured summary of a study protocol for a randomized controlled study. Trials, 24(1). https://doi.org/10.1186/s13063-023-07164-9

Sailer CO, Kuehne JM, da Conceição I, Refardt J, Christ-Crain M, & Winzeler B. (2023). Hypothalamic–pituitary–adrenal axis activity in patients with primary polydipsia compared to healthy controls. Clinical Endocrinology, 99(6), 535–544. https://doi.org/10.1111/cen.14835

Monnerat S, Christ-Crain M, & Refardt J. (2023). One Liter a Day, Keeps the Doctor Away (Patent No. 11). Journal of Clinical Endocrinology and Metabolism, 108(11), Article 11. https://doi.org/10.1210/clinem/dgad217

Smit, J. M., Van Der Zee, P. A., Stoof, S. C. M., Van Genderen, M. E., Snijders, D., Boersma, W. G., Confalonieri, P., Salton, F., Confalonieri, M., Shih, M.-C., Meduri, G. U., Dequin, P.-F., Le Gouge, A., Lloyd, M., Karunajeewa, H., Bartminski, G., Fernández-Serrano, S., Suárez-Cuartín, G., van Klaveren, D., et al. (2023). Predicting individualized treatment effects of corticosteroids in community-acquired-pneumonia: a data-driven analysis of randomized controlled trials [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.10.03.23296132

Monnerat S, Refardt J, Potasso L, Meier C, & Christ-Crain M. (2023). An Increase in Plasma Sodium Levels Is Associated With an Increase in Osteoblast Function in Chronic SIAD. Journal of Clinical Endocrinology and Metabolism, 108(10), e1027–e1033. https://doi.org/10.1210/clinem/dgad238

Warren AM, Grossmann M, Christ-Crain M, & Russell N. (2023). Syndrome of Inappropriate Antidiuresis: From Pathophysiology to Management. Endocrine Reviews, 44(5), 819–861. https://doi.org/10.1210/endrev/bnad010

Potasso, Laura, Monnerat, Sophie, Refardt, Julie, Lindner, Gregor, Burst, Volker, Winzeler, Bettina, & Christ-Crain, Mirjam. (2023). Chloride and Potassium Assessment Is a Helpful Tool for Differential Diagnosis of Thiazide-Associated Hyponatremia. Journal of Clinical Endocrinology and Metabolism, 108(9), 2248–2254. https://doi.org/10.1210/clinem/dgad133

Arima H, Cheetham T, Christ-Crain M, Cooper DL, Drummond JB, Gurnell M, Levy M, McCormack A, Newell-Price JD, Verbalis JG, & Wass J. (2023). Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group to Consider Renaming Diabetes Insipidus. Hormone Research in Paediatrics, 96(4), 423–425. https://doi.org/10.1159/000527139

Monnerat, Sophie, Atila, Cihan, Baur, Fabienne, de Jesus, Joyce Santos, Refardt, Julie, Dickenmann, Michael, & Christ-Crain, Mirjam. (2023). Effect of protein supplementation on plasma sodium levels in the syndrome of inappropriate antidiuresis: a monocentric, open-label, proof-of-concept study—the TREASURE study. European Journal of Endocrinology, 189(2), 252–261. https://doi.org/10.1093/ejendo/lvad108

Radvanyi, Z., Yoo, E. J., Kandasamy, P., Salas-Bastos, A., Monnerat, S., Refardt, J., Christ-Crain, M., Hayashi, H., Kondo, Y., Jantsch, J., Rubio-Aliaga, I., Sommer, L., Wagner, C. A., Hediger, M. A., Kwon, H. M., Loffing, J., & Pathare, G. (2023). Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation [Posted-content]. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.06.23.546282

Monnerat S, Atila C, Refardt J, & Christ-Crain M. (2023). Prevalence of Admission Hyponatremia in Patients With Diabetes Treated With and Without an SGLT2 inhibitor. Journal of the Endocrine Society, 7(4), bvad011. https://doi.org/10.1210/jendso/bvad011

Lengsfeld, Sophia, Burkard, Thilo, Meienberg, Andrea, Jeanloz, Nica, Vukajlovic, Tanja, Bologna, Katja, Steinmetz, Michelle, Bathelt, Cemile, Sailer, Clara O., Vogt, Deborah R., Hemkens, Lars G., Speich, Benjamin, Urwyler, Sandrine A., Kühne, Jill, Baur, Fabienne, Lutz, Linda N., Erlanger, Tobias E., Christ-Crain, Mirjam, & Winzeler, Bettina. (2023). Effect of dulaglutide in promoting abstinence during smoking cessation: a single-centre, randomized, double-blind, placebo-controlled, parallel group trial. eClinicalMedicine, 57. https://doi.org/10.1016/j.eclinm.2023.101865

Lengsfeld, Sophia, Burkard, Thilo, Meienberg, Andrea, Jeanloz, Nica, Vukajlovic, Tanja, Bologna, Katja, Steinmetz, Michelle, Bathelt, Cemile, Sailer, Clara O., Vogt, Deborah R., Hemkens, Lars G., Speich, Benjamin, Urwyler, Sandrine A., Kühne, Jill, Baur, Fabienne, Lutz, Linda N., Erlanger, Tobias E., Christ-Crain, Mirjam, & Winzeler, Bettina. (2023). Effect of dulaglutide in promoting abstinence during smoking cessation: a single-centre, randomized, double-blind, placebo-controlled, parallel group trial [Journal-article]. eClinicalMedicine, 57, 101865. https://doi.org/10.1016/j.eclinm.2023.101865

Pelouto A, Refardt JC, Christ-Crain M, Zandbergen AAM, & Hoorn EJ. (2023). Overcorrection and undercorrection with fixed dosing of bolus hypertonic saline for symptomatic hyponatremia. European Journal of Endocrinology, 188(3), 322–330. https://doi.org/10.1093/ejendo/lvad028

Sailer CO, Gaisl O, Beglinger S, Frech-Dörfler M, Sommer V, Lüthy MH, & Christ-Crain M. (2023). Copeptin improves prediction of treatment response in children with monosymptomatic nocturnal enuresis. European Journal of Endocrinology, 188(3), 266–272. https://doi.org/10.1093/ejendo/lvad022

Workeneh BT, Meena P, Christ-Crain M, & Rondon-Berrios H. (2023). Hyponatremia Demystified: Integrating Physiology to Shape Clinical Practice. Advances in Kidney Disease and Health , 30(2), 85–101. https://doi.org/10.1053/j.akdh.2022.11.004

Refardt J, Imber C, Nobbenhuis R, Sailer CO, Haslbauer A, Monnerat S, Bathelt C, Vogt DR, Berres M, Winzeler B, Bridenbaugh SA, & Christ-Crain M. (2023). Treatment Effect of the SGLT2 Inhibitor Empagliflozin on Chronic Syndrome of Inappropriate Antidiuresis: Results of a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial. Journal of the American Society of Nephrology, 34(2), 322–332. https://doi.org/10.1681/ASN.2022050623

Arima H, Cheetham T, Christ-Crain M, Cooper D, Drummond J, Gurnell M, Levy M, McCormack A, Newell-Price J, Verbalis JG, Wass J, & Working Group for Renaming Diabetes Insipidus. (2023). Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group for Renaming Diabetes Insipidus. Journal of Clinical Endocrinology and Metabolism, 108(1), 1–3. https://doi.org/10.1210/clinem/dgac547

Atila, Cihan, Holze, Friederike, Murugesu, Rakithan, Rommers, Nikki, Hutter, Nina, Varghese, Nimmy, Sailer, Clara O, Eckert, Anne, Heinrichs, Markus, Liechti, Matthias E, & Christ-Crain, Mirjam. (2023). Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial. The Lancet Diabetes and Endocrinology, 11, 454–464. https://doi.org/10.1016/S2213-8587(23)00120-1

Probst, L., Monnerat, S., Vogt, D. R., Lengsfeld, S., Burkard, T., Meienberg, A., Bathelt, C., Christ-Crain, M., & Winzeler, B. (2023). Effects of dulaglutide on alcohol consumption during smoking cessation. JCI Insight, 8(22). https://doi.org/10.1172/jci.insight.170419

Roth, Sofia, Flint, Emilio, Ghataore, Lea, Patel, Vishal C., Singanayagam, Arjuna, Vincent, Royce P., Triantafyllou, Evangelos, Ma, Yun, Bernal, William, Auzinger, Georg, Heneghan, Michael, Antoniades, Charalambos, Christ-Crain, Mirjam, McPhail, Mark J.W., Taylor, David R., Wendon, Julia, & Bernsmeier, Christine. (2023). Low Baseline but Not Delta Cortisol Relates to 28-Day Transplant-Free Survival in Acute and Acute-on-Chronic Liver Failure. Gastro Hep Advances, 2(1), 72–82. https://doi.org/10.1016/j.gastha.2022.08.006

Arima H, Bichet DG, Cheetham T, Christ-Crain M, Drummond J, Gurnell M, Levy M, McCormack A, Newell-Price J, Verbalis JG, Wass J, & Cooper D. (2022). Changing the name of diabetes insipidus (Patent No. 6). Pituitary, 25(6), Article 6. https://doi.org/10.1007/s11102-022-01276-2

Borisov AN, Blum CA, Christ-Crain M, & Ebrahimi F. (2022). No obesity paradox in patients with community-acquired pneumonia – secondary analysis of a randomized controlled trial. Nutrition and Diabetes, 12(1), 12. https://doi.org/10.1038/s41387-022-00190-7

Liberale, Luca, Ministrini, Stefano, Arnold, Markus, Puspitasari, Yustina M., Pokorny, Thomas, Beer, Georgia, Scherrer, Natalie, Schweizer, Juliane, Christ-Crain, Mirjam, Montecucco, Fabrizio, Camici, Giovanni G., & Katan Kahles, Mira. (2022). Serum circulating sirtuin 6 as a novel predictor of mortality after acute ischemic stroke. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-23211-y

Nahum U, Refardt J, Chifu I, Fenske WK, Fassnacht M, Szinnai G, Christ-Crain M, & Pfister M. (2022). Machine learning-based algorithm as an innovative approach for the differentiation between diabetes insipidus and primary polydipsia in clinical practice. European Journal of Endocrinology, 187(6), 777–786. https://doi.org/10.1530/EJE-22-0368

Working Group for Renaming Diabetes Insipidus, Arima H, Cheetham T, Christ-Crain M, Cooper D, Gurnell M, Drummond JB, Levy M, McCormack AI, Verbalis J, Newell-Price J, & Wass JAH. (2022). Changing the name of diabetes insipidus: a position statement of The Working Group for Renaming Diabetes Insipidus. Endocrine Connections, 11(11). https://doi.org/10.1530/EC-22-0378

Working Group for Renaming Diabetes Insipidus, Arima H, Cheetham T, Christ-Crain M, Cooper D, Gurnell M, Drummond JB, Levy M, McCormack AI, Verbalis J, Newell-Price J, & Wass JAH. (2022). Changing the name of diabetes insipidus: a position statement of The Working Group for Renaming Diabetes Insipidus. European Journal of Endocrinology, 187(5), P1–P3. https://doi.org/10.1530/EJE-22-0751

Atila C, Loughrey PB, Garrahy A, Winzeler B, Refardt J, Gildroy P, Hamza M., Pal A, Verbalis JG, Thompson CJ, Hemkens L.G., Hunter SJ, Sherlock M, Levy MJ, Karavitaki N., Newell-Price J, Wass JAH, & Christ-Crain M. (2022). Central diabetes insipidus from a patient’s perspective: management, psychological co-morbidities, and renaming of the condition: results from an international web-based survey. The Lancet Diabetes and Endocrinology, 10(10), 700–709. https://doi.org/10.1016/S2213-8587(22)00219-4

Arima H, Cheetham T, Christ-Crain M, Cooper D, Drummond J, Gurnell M, Levy M, McCormack A, Newell-Price J, Verbalis JG, & Wass J. (2022, August 28). Changing the name of diabetes insipidus: a position statement of the working group to consider renaming diabetes insipidus. https://doi.org/10.1111/cen.14819

Atila C, Monnerat S, Urwyler SA, Refardt J, Winzeler B, & Christ-Crain M. (2022). The effect of glucose dynamics on plasma copeptin levels upon glucagon, arginine, and macimorelin stimulation in healthy adults: Data from: Glucacop, Macicop, and CARGO study. Pituitary, 25(4), 636–644. https://doi.org/10.1007/s11102-022-01240-0

Atila C, Gaisl O, Vogt DR, Werlen L, Szinnai G, & Christ-Crain M. (2022). Glucagon-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a double-blind, randomized, placebo-controlled study. European Journal of Endocrinology, 187(1), 65–74. https://doi.org/10.1530/EJE-22-0033

Bicvic A, Scherrer N, Schweizer J, Fluri F, Christ-Crain M, De Marchis GM, Luft AR, & Katan M. (2022). A novel biomarker panel index improves risk stratification after ischemic stroke. European Stroke Journal, 7(2), 158–165. https://doi.org/10.1177/23969873221090798

Christ-Crain M, Refardt J, & Winzeler B. (2022). Approach to the Patient: “Utility of the Copeptin Assay”. Journal of Clinical Endocrinology and Metabolism, 107(6), 1727–1738. https://doi.org/10.1210/clinem/dgac070

Vukajlovic T, Sailer CO, Asmar A, Jensen BL, Vogt DR, Christ-Crain M, & Winzeler B. (2022). Effect of a 3-Week Treatment with GLP-1 Receptor Agonists on Vasoactive Hormones in Euvolemic Participants. Journal of Clinical Endocrinology and Metabolism, 107(6), E2581–E2589. https://doi.org/10.1210/clinem/dgac063

Atila, C., Monnerat, S., Urwyler, S. A., Refardt, J., Winzeler, B., & Christ-Crain, M. (2022, May 12). The effect of glucose dynamics on plasma copeptin levels upon glucagon, arginine, and macimorelin stimulation in healthy adults [Posted-content]. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-1636018/v1

Sailer, C. O., Kühne, J. M., Conceição, I. d., Refardt, J., Christ-Crain, M., & Winzeler, B. (2022, March 3). Hypothalamic-pituitary-adrenal axis activity in patients with primary polydipsia compared to healthy volunteers [Posted-content]. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-1370576/v1

Potasso, Laura, Refardt, Julie, De Marchis, Gian Marco, Wiencierz, Andrea, Wright, Patrick R, Wagner, Benjamin, Dittrich, Tolga, Polymeris, Alexandros A, Gensicke, Henrik, Bonati, Leo H, & Christ-Crain, Mirjam. (2022). Impact of Sodium Levels on Functional Outcomes in Patients with Stroke - A Swiss Stroke Registry Analysis. Journal of Clinical Endocrinology and Metabolism, 107(2), E672–E680. https://doi.org/10.1210/clinem/dgab650

Potasso L, Refardt J, De Marchis GM, Wiencierz A, Wright PR, Wagner B, Dittrich T, Polymeris AA, Gensicke H, Bonati LH, & Christ-Crain M. (2022). Impact of Sodium Levels on Functional Outcomes in Patients with Stroke - A Swiss Stroke Registry Analysis. Journal of Clinical Endocrinology and Metabolism, 107(2), E672–E680. https://doi.org/10.1210/clinem/dgab650

Tritos NA, Fazeli PK, McCormack A, Mallea-Gil SM, Pineyro MM, Christ-Crain M, Frara S, Labadzhyan A, Ioachimescu AG, Shimon I, Takahashi Y, Gurnell M, Fleseriu M, & “Pituitary Society Delphi Collaborative Group”. (2022). Pituitary Society Delphi Survey: An international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas. Pituitary, 25(1), 64–73. https://doi.org/10.1007/s11102-021-01170-3

Arima H, Cheetham T, Christ-Crain M, Cooper DL, Drummond JB, Gurnell M, Levy M, McCormack A, Newell-Price JD, Verbalis JG, & Wass J. (2022). Changing the name of diabetes insipidus: a position statement of the working group to consider renaming diabetes insipidus. Archives of Endocrinology and Metabolism, 66, 868–870. https://doi.org/10.20945/2359-3997000000528

Atila C, Monnerat S, Bingisser R, Siegemund M, Lampart M, Rueegg M, Zellweger N, Osswald S, Rentsch K, Christ-Crain M, & Twerenbold R. (2022). Inverse relationship between IL-6 and sodium levels in patients with COVID-19 and other respiratory tract infections: data from the COVIVA study. Endocrine Connections, 11(10). https://doi.org/10.1530/EC-22-0171

Potasso L, Potasso L, Refardt J., Meier C, & Christ-Crain M. (2022). Effect of hyponatremia normalization on osteoblast function in patients with SIAD. European Journal of Endocrinology, 186(1), 1–8. https://doi.org/10.1530/EJE-21-0604

Wittermans E, van der Zee PA, Qi H., van de Garde EMW, Blum CA, Christ-Crain M., Gommers D, Grutters JC, Voorn GP, Bos WJW, & Endeman H. (2022). Community-acquired pneumonia subgroups and differential response to corticosteroids: a secondary analysis of controlled studies. ERJ Open Research, 8(1). https://doi.org/10.1183/23120541.00489-2021

Working Group for Renaming Diabetes Insipidus, Arima H, Cheetham T, Christ-Crain M, Cooper D, Gurnell M, Drummond JB, Levy M, McCormack AI, Verbalis J, Newell-Price J, & Wass JAH. (2022). Changing the name of diabetes insipidus: a position statement of The Working Group for Renaming Diabetes Insipidus. Endocrine Journal, 69(11), 1281–1284. https://doi.org/10.1507/endocrj.EJ20220831

Berkmann S, Roethlisberger M, Mueller B, Christ-Crain M., Mariani L., Nitzsche E, & Juengling F. (2021). Selective resection of cushing microadenoma guided by preoperative hybrid 18-fluoroethyl-L-tyrosine and 11-C-methionine PET/MRI. Pituitary, 24(6), 878–886. https://doi.org/10.1007/s11102-021-01160-5

Christ-Crain M, & Gaisl O. (2021). Diabetes insipidus. Presse Medicale, 50(4), 104093. https://doi.org/10.1016/j.lpm.2021.104093

Ebrahimi, Fahim, Urwyler, Sandrine Andrea, Betz, Matthias Johannes, Christ, Emanuel Remigius, Schuetz, Philipp, Müller, Beat, Donath, Marc Yves, & Christ-Crain, Mirjam. (2021). Effects of interleukin-1 antagonism and corticosteroids on fibroblast growth factor-21 in patients with metabolic syndrome. Scientific Reports, 11(1), 7911. https://doi.org/10.1038/s41598-021-87207-w

Ebrahimi F., Urwyler S.A., Betz M.J., Christ E.R., Schuetz P., Mueller B., Donath M.Y., & Christ-Crain M. (2021). Effects of interleukin-1 antagonism and corticosteroids on fibroblast growth factor-21 in patients with metabolic syndrome. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-87207-w

Sailer C.O., Refardt J, Blum CA, Schnyder I, Molina-Tijeras J.A., Fenske W., Christ-Crain M., & Christ-Crain M. (2021). Validity of different copeptin assays in the differential diagnosis of the polyuria-polydipsia syndrome. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-89505-9

Raess N., Schuetz P., Cesana-Nigro N., Winzeler B, Urwyler SA, Schaedelin S., Rodondi N, Blum M.R., Briel M., Mueller B, Christ-Crain M., & Blum CA. (2021). Influence of Prednisone on Inflammatory Biomarkers in Community-Acquired Pneumonia: Secondary Analysis of a Randomized Trial. Journal of Clinical Pharmacology, 61(11), 1406–1414. https://doi.org/10.1002/jcph.1914

Refardt J, Pelouto A, Potasso L, Hoorn EJ, & Christ-Crain M. (2021). Hyponatremia Intervention Trial (HIT): Study Protocol of a Randomized, Controlled, Parallel-Group Trial With Blinded Outcome Assessment. Frontiers in Medicine, 8, 729545. https://doi.org/10.3389/fmed.2021.729545

Heilmann E., Gregoriano C., Annane D., Reinhart K., Bouadma L., Wolff M., Chastre J., Luyt C.-E., Tubach F., Branche A.R., Briel M., Christ-Crain M., Welte T., Corti C., De Jong E., Nijsten M., De Lange D.W., Van Oers J.A.H., Beishuizen A., et al. (2021). Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: A patient-level meta-analysis from randomized controlled trials. Age and Ageing, 50(5), 1546–1556. https://doi.org/10.1093/ageing/afab078

Sailer C.O., Winzeler B, Urwyler SA, Schnyder I., Refardt J, Eckert A., Varghese N., Fassnacht M., Chifu I., Lawson E.A., Verbalis J.G., Fenske W., & Christ-Crain M. (2021). Oxytocin levels in response to pituitary provocation tests in healthy volunteers. European Journal of Endocrinology, 185(3), 355–364. https://doi.org/10.1530/EJE-21-0346

Christ-Crain M, Hoorn EJ, Sherlock M, Thompson CJ, & Wass J. (2021). ENDOCRINOLOGY IN THE TIME OF COVID-19-2021 UPDATES: The management of diabetes insipidus and hyponatraemia. (Patent No. 4). 185(4), Article 4. https://doi.org/10.1530/eje-21-0596

Urwyler SA, Lustenberger S, Drummond JR, Soares BS, Vogt DR, Ammer N, Yuen KCJ, Ribeiro-Oliveira A, & Christ-Crain M. (2021). Effects of oral macimorelin on copeptin and anterior pituitary hormones in healthy volunteers. Pituitary, 24(4), 555–563. https://doi.org/10.1007/s11102-021-01132-9

Christ-Crain M, Winzeler B, & Refardt J. (2021). Diagnosis and management of diabetes insipidus for the internist: an update. Journal of Internal Medicine, 290(1), 73–87. https://doi.org/10.1111/joim.13261

Tsagkas C, Schäfer S, Baumgartner A, Müller J, Sinnecker T, Mehling M, van der Stouwe JG, Felder S, Panagiotou A, Potlukova E, Winzeler B, Scholz MC, Timper K, Blackham K, Nickel CH, Christ-Crain M, Bingisser R, Lyrer P, Kappos L, & Yaldizli Ö. (2021). Syndrome of inappropriate antidiuretic hormone secretion and hypothalamic hypocortisolism in neuromyelitis optica. The Lancet, 397(10290), 2194. https://doi.org/10.1016/S0140-6736(21)00986-7

Fischli S, Von Wyl V., Wuillemin W., Von Kanel R., Schütz P, Christ-Crain M., Studer F., Brander L., Schupfer G., Metzger J, & Henzen C. (2021). Impact of adrenal function on Hemostasis/Endothelial function in patients undergoing surgery. Journal of the Endocrine Society, 5(5). https://doi.org/10.1210/jendso/bvab047

Stormann S., Schopohl J., Bullmann C., Terkamp C., Christ-Crain M., Finke R., Flitsch J., Kreitschmann-Andermahr I., Luger A., Stalla G., Houchard A., Helbig D., & Petersenn S. (2021). Multicenter, Observational Study of Lanreotide Autogel for the Treatment of Patients with Acromegaly in Routine Clinical Practice in Germany, Austria and Switzerland. Experimental and Clinical Endocrinology and Diabetes, 129(3), 224–233. https://doi.org/10.1055/a-1247-4713

Heilmann E, Gregoriano C, Wirz Y, Luyt CE, Wolff M, Chastre J, Tubach F, Christ-Crain M, Bouadma L, Annane D, Damas P, Kristoffersen KB, Oliveira CF, Stolz D, Tamm M., de Jong E, Reinhart K, Shehabi Y, Verduri A, et al. (2021). Association of kidney function with effectiveness of procalcitonin-guided antibiotic treatment: A patient-level meta-analysis from randomized controlled trials. Clinical Chemistry and Laboratory Medicine, 59(2), 441–453. https://doi.org/10.1515/cclm-2020-0931

Westphal L.P., Schweizer J., Fluri F., De Marchis GM, Christ-Crain M, Luft A.R., & Katan M. (2021). C-Terminal-Pro-Endothelin-1 Adds Incremental Prognostic Value for Risk Stratification After Ischemic Stroke. Frontiers in Neurology, 11. https://doi.org/10.3389/fneur.2020.629151

Atila C., Sailer C.O., Bassetti S., Tschudin-Sutter S, Bingisser R., Siegemund M, Osswald S, Rentsch K, Rueegg M., Schaerli S., Kuster GM, Twerenbold R, & Christ-Crain M. (2021). Prevalence and outcome of dysnatremia in patients with COVID-19 compared to controls. European Journal of Endocrinology, 184(3), 413–422. https://doi.org/10.1530/EJE-20-1374

Christ-Crain M. (2021). Endocrinological diagnosis and replacement therapy for diabetes insipidus (pp. 147–156). Elsevier. https://doi.org/10.1016/B978-0-12-819949-7.00021-4

Nobbenhuis R, Nobbenhuis R, Refardt J, Vogt D, Sailer CO, Winzeler B, & Christ-Crain M. (2021). Can treatment response to SGLT2-inhibitors in syndrome of inappropriate antidiuresis be predicted by copeptin, natriuretic peptides and inflammatory markers? Biomarkers, 26(7), 647–655. https://doi.org/10.1080/1354750X.2021.1970808

Potasso L, Potasso L, Refardt J., Chifu I., Fassnacht M, Fenske W.K., & Christ-Crain M. (2021). Incidence of hyperkalemia during hypertonic saline test for the diagnosis of diabetes insipidus. Endocrine Connections, 10(4), 401–409. https://doi.org/10.1530/EC-20-0531

Winzeler, Bettina, Sailer, Clara O, Coynel, David, Zanchi, Davide, Vogt, Deborah R, Urwyler, Sandrine A, Refardt, Julie, & Christ-Crain, Mirjam. (2021). A randomized controlled trial of the GLP-1 receptor agonist dulaglutide in primary polydipsia. Journal of Clinical Investigation, 131(20), e151800. https://doi.org/10.1172/jci151800

Winzeler B, Sailer C.O., Coynel D., Zanchi D., Vogt DR, Urwyler SA, Refardt J, & Christ-Crain M. (2021). A randomized controlled trial of the GLP-1 receptor agonist dulaglutide in primary polydipsia. Journal of Clinical Investigation, 131(20). https://doi.org/10.1172/JCI151800