Faculty of Medicine
Faculty of Medicine
UNIverse - Public Research Portal

[FG] Lyrer Philippe

Research Group Philippe Lyrer

Research Focus

Neurology


Area of Research

Clinical stroke research. Carotid and vertebral artery dissection. Genetics in stroke. Thrombolysis and thrombectomy (coagulation inhibition) in acute stroke, evidence-based therapy. Non-vitamin K antagonists and stroke, cerebral hemorrhage, stroke in the elderly, neurorehabilitation after stroke


Approved Research Projects

  • TREAT-CAD (PI) “ Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection“ (TREAT-CAD), Co-applicant
  • ESTREL( local PI) “Enhancement of Stroke Rehabilitation With Levodopa (ESTREL)”, Co-applicant
  • TICH-NOAC (Co-Chair) Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist (TICH-NOAC), Sponsor Investigator
  • TELESTROKE (Chair) Telemedical onsite identification of stroke victims: Stiftung propatient USB, Principal Investigator
  • Metabolic Mechanisms of cerebral small vessel disease, Lab Project, Principal Investigator
  • MAAESTRO “Electronic monitoring and improvement of adherence to direct oral anticoagulant treatment – a randomised crossover study of an educational and reminderbased intervention in ischaemic stroke patients under polypharmacy, Principal Investigator
  • Investigator-initiated Research Initiatives (European Research Consortia)
  • Cervical Artery Dissection in Ischemic Stroke Patients (CADISP), Founding member, Investigator
  • Thrombolysis in Ischemic Stroke Patients (TRISP), Investigator
  • Novel Oral AntiCoagulants in Stroke Patients (NOACISP), Sponsor Investigator


Collaborations

National Collaborations

- TICH-NOAC (planned to be extended to GB and DK)

- ESTREL

International Collaborations

- ECST-2

- CADISP (Cervical artery dissection in stroke patients)

- GLORIA – AF (submitted database analysis and publications)


Ongoing Research Projects

  • TICH-NOAC: Treatment of cerebral haemorrhage due to NOAC-intake with tranexamid acid, a RCT: accomplishing the goal 109 randomized patients
  • “Enhancement of Stroke Rehabilitation With Levodopa (ESTREL)”
  • Databank cleaning, adjudication of outcome events “ Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection“ (TREAT-CAD)
  • “New Oral Anticoagulants in Stroke Patients” (NOACISP) – acute register and follow –up, completion of follow-up for 1000 patients
  • TELESTROKE: expansion to clinical application
  • ECST-2 The 2nd European Carotid Surgery Trial, sub-Investigator, Steering Committee Member, Adjudicator
  • OPTIMIZE: Prospective non-interventional study for the optimized treatment of refractory hypercholesterolemia in patients with heterozygous familial hypercholesterolemia or clinically apparent atherosclerotic cardiovascular disease with alirocumab (Praluent®)
  • ACTIMIS: randomized, double blind, multicenter, multinational, placebo controlled, single parallel escalating dose safety and efficacy study of act017 used as an add-on therapy on top of standard of care, in the 4.5 hrs post onset of acute ischemic stroke symptoms.
  • Administrative and regulatory support of research projects for members of the stroke team (Twist, TRISP, ACST2, Precise-MRI, ELAN)