[FG] Bonati Leo

Prevention of stroke and vascular dementia in patients with atherosclerosis and atrial fibrillation in randomised trials and large prospective registries. Use of vascular and cerebral imaging and biomarker analysis for personalized treatment. Coordination of the nationwide acute stroke registry (Swiss Stroke Registry). Ageing brain.

Approved Research Projects

• Main applicant research grant, Foundation for Clinical Research and Medical Image Analysis, Basel (Stiftung zur Förderung der gastroenterologischen und allgemeinen klinischen Forschung sowie der medizinischen Bildauswertung): “Mechanisms of Cognitive Impairment and Neurodegeneration (COIN)”
• Co-applicant SNF longitudinal study grant (33CS30_177520): “Swiss Atrial Fibrillation Cohort Study”
• Co-applicant SNF project grant (32003B_169975): “Safety of Early versus Late initiation of direct oral anti-coagulants in post-ischaemic stroke patients with Non-valvular atrial fibrillation (ELAN safety)”
• Main applicant SNF project grant (32003B_156658): “BIO-PLAQUE: The role of carotid plaque imaging and biomarkers for plaque instability in selecting patients with carotid artery stenosis for endarterectomy or stenting – a translational randomised multi-centre study”
• Main applicant Swiss Heart Foundation research grant: “Cerebral infarction associated with stent treatment versus endarterectomy for asymptomatic carotid artery stenosis – the Magnetic Resonance Imaging Substudy of the Second Asymptomatic Carotid Surgery Trial”
• Main applicant AstraZeneca Externally Sponsored Research grant (ESR-14-10473): “Prevention of Cerebral Ischaemia in Stent Treatment for Carotid Artery Stenosis - A randomised multi-centre phase II trial comparing Ticagrelor versus Clopidogrel with outcome assessment on MRI (PRECISE-MRI)”

Collaborations

National Collaborations

All Stroke Centers

- Prof. Emanuel Carrera, Geneva;

- Prof. Patrik Michel, Lausanne;

- Prof. Marcel Arnold and Urs Fischer, Berne;

- Prof. Andreas Luft, Zurich;

- PD Dr. Carlo Cereda, Lugano,

- Prof. Krassen Nedeltchev, Aarau;

- Dr. Georg Kägi, St. Gallen

all Stroke Units in Switzerland

International Collaborations

- UCL Institute of Neurology, London (Proff. Martin Brown and David Werring)

- Nuffield Department of Vascular Surgery (Prof. Alison Haliday) and Clinical Trial Service Unit (Prof. Richard Peto), University of Oxford

- Department of Neurology, Mayo Clinic Jacksonville FL (Prof. Thomas Brott)