Type 2 diabetes, specifically evaluation of new immunomodulatory therapie.

Approved Research Projects

Only the clinical projects are listed (the major research activity is preclinical):

• Bicycle Exercise in Newly Diagnosed Diabetics in the Emergency Room
• Identification of a SIRT1 mutation in a family with type 1 diabetes.
• Open-label study on treatment of primary aldosteronism with everolimus
• Postprandial hypoglycemia with anakinra and empagliflozin in patients after bariatric surgery
• Pancreatic islet transplantation in the anterior chamber of the human eye – a pilot study
• The role of IL-1 in postprandial fatigue.
• GLP-1 secretion is regulated by IL-6 signalling: a randomized, placebo-controlled study
• Exercise and the DPP-IV inhibitor sitagliptin do not improve beta cell function and glucose Homeostasis in long-Lasting Type 1 Diabetes
• Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes
• Interleukin-1 antagonism in type 1 diabetes of long duration
• Development of an Interleukin-1β Vaccine in Patients with Type 2 Diabetes.
• Muscle-Derived IL-6 Is Not Regulated by IL-1 during Exercise. A Double Blind, Placebo-Controlled, Randomized Crossover Study
• Safety, pharmacokinetics, and preliminary efficacy of a specific anti-IL-1alpha therapeutic antibody (MABp1) in patients with type 2 diabetes mellitus
• Infliximab in the treatment of Crohn disease and type 1 diabetes.
• Identification of a SIRT1 mutation in a family with type 1 diabetes.

Collaborations

National Collaborations

- National Collaborations with the Endocrinology Clinics of most hospitals in Switzerland

International Collaborations

- Multiple International Collaborations

Ongoing Research Projects

• Open-label study on treatment of primary aldosteronism with everolimus
• Postprandial hypoglycemia with anakinra and empagliflozin in patients after bariatric surgery.
• Pancreatic islet transplantation in the anterior chamber of the human eye – a pilot study