[FG] Christ-Crain Mirjam

Leibnitz, S. et al. (2026) ‘Effects of GLP-1 Receptor Agonists on Copeptin in Euvolemic Participants’, European Journal of Endocrinology [Preprint]. Available at: https://doi.org/10.1093/ejendo/lvag005.

Leibnitz, Svenja, Christ-Crain, Mirjam and Atila, Cihan (2026) ‘Oxytocin: a neglected hormone in pituitary disease – From function to the diagnosis of a deficiency, resulting clinical relevance, and potential treatment options in endocrinology’, Archives of Endocrinology and Metabolism, 70. Available at: https://doi.org/10.20945/2359-4292-2025-0259.

Savelberg, Angelique B.M.C., Hoorn, Ewout J. and Refardt, Julie C. (2026) ‘Management of Chronic Hyponatremia in the Outpatient Setting’, American Journal of Kidney Diseases, 87, pp. 87–92. Available at: https://doi.org/10.1053/j.ajkd.2025.06.024.

Sailer, C.O. et al. (2025) ‘Changes in fibroblast growth factor 21 levels associated with alcohol consumption and smoking cessation’, Endocrine Connections, 15(1). Available at: https://doi.org/10.1530/ec-25-0713.

Atila, C., Refardt, J. and Christ-Crain, M. (2025) ‘Arginine Vasopressin Deficiency and Oxytocin Deficiency in the Endocrine Clinic’, The Journal of Clinical Endocrinology & Metabolism [Preprint]. Available at: https://doi.org/10.1210/clinem/dgaf651.

Asla, Queralt et al. (2025) ‘Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage: a randomized, crossover, placebo-controlled trial’, Scientific Reports, 15(1), p. 2360. Available at: https://doi.org/10.1038/s41598-025-86566-y.

Asla, Queralt et al. (2025) ‘Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage’, Journal of Clinical Endocrinology and Metabolism. 01.04.2025, 110, pp. e4205–e4214. Available at: https://doi.org/10.1210/clinem/dgaf201.

Christ-Crain, M. et al. (2025) ‘Correction to: Diabetes insipidus (Nature Reviews Disease Primers, (2019), 5, 1, (54), 10.1038/s41572-019-0103-2)’, Nature Reviews Disease Primers, 11(1). Available at: https://doi.org/10.1038/s41572-025-00629-y.

Potasso, Laura, Christ-Crain, Mirjam and Refardt, Julie (2025) ‘Impact of hyponatremia on bone, a narrative review’, European Journal of Endocrinology, 193, pp. R89–R97. Available at: https://doi.org/10.1093/ejendo/lvaf241.

Potasso, Laura et al. (2025) ‘Normalization of hyponatremia in hospitalized patients decreases osteoclast activity’, European Journal of Endocrinology, 193, pp. 651–658. Available at: https://doi.org/10.1093/ejendo/lvaf242.

Riehle, Friederike et al. (2025) ‘Effect of oral urea ingestion on growth hormone levels in healthy adults - a secondary analysis of a randomized, double-blind, placebo-controlled cross-over trial’, Pituitary, 28. Available at: https://doi.org/10.1007/s11102-025-01577-2.

Vogt, K. et al. (2025) ‘Validation of new diagnostic indices to simplify hyponatremia therapy assessment in patients on thiazide diuretics: study protocol of a randomized, controlled, parallel-group trial (THAT-Study)’, Trials, 26(1). Available at: https://doi.org/10.1186/s13063-025-08925-4.

Beck, J. (2025) ‘Treatment of chronic hyponatremia and controversy about osmotic demyelination syndrome’, Best Practice & Research Clinical Endocrinology & Metabolism [Preprint]. Available at: https://doi.org/10.1016/j.beem.2025.102067.

Christ-Crain, Mirjam (2025) ‘Arginine Vasopressin (AVP) Deficiency: Diagnosis and Treatment-An Update’, Indian Journal of Endocrinology and Metabolism, 29, pp. 603–609. Available at: https://doi.org/10.4103/ijem.ijem_995_25.

Jha, Vivek et al. (2025) ‘Late Diagnosis of X-Linked Arginine Vasopressin Resistance Presenting With Flow Uropathy in Adulthood’, Jcem Case Reports, 3. Available at: https://doi.org/10.1210/jcemcr/luaf236.

Nikaj, Andi, Atila, Cihan and Christ-Crain, Mirjam (2025) ‘Response to the comment on ‘disrupted ACTH and cortisol response to osmotic and non-osmotic stress in patients with arginine vasopressin deficiency’’, European Journal of Endocrinology, 193, pp. L27–L28. Available at: https://doi.org/10.1093/ejendo/lvaf225.

Beck, Julia et al. (2025) ‘Blood pressure changes during smoking cessation in a randomized, double-blind, placebo-controlled trial of dulaglutide treatment’, European Journal of Preventive Cardiology, 32. Available at: https://doi.org/10.1093/eurjpc/zwaf055.

Fleseriu, M. et al. (2025) ‘Pituitary incidentaloma: a Pituitary Society international consensus guideline statement’, Nature Reviews Endocrinology, 21. Available at: https://doi.org/10.1038/s41574-025-01134-8.

Netzer, Seraina et al. (2025) ‘Association Between Hyponatremia and Mortality and Readmission in Multimorbid Older Adults—A Cohort Study’, Journal of Clinical Medicine, 14. Available at: https://doi.org/10.3390/jcm14207146.

van der Groef, R. et al. (2025) ‘Long-term antitumour effects of pasireotide in acromegaly’, 193. Available at: https://doi.org/10.1093/ejendo/lvaf194.

Monnerat, S., Christ-Crain, M. and Refardt, J. (2025) ‘Hyponatraemia in ageing’, Nature Reviews Endocrinology, 21. Available at: https://doi.org/10.1038/s41574-025-01138-4.

Hepprich, Matthias et al. (2025) ‘Exenatide for diagnosing endogenous hyperinsulinemic hypoglycemia: a randomized placebo-controlled, double-blind, cross-over proof-of-principle study’, European Journal of Endocrinology. 01.08.2025, 193(2), pp. 247–254. Available at: https://doi.org/10.1093/ejendo/lvaf153.

Nikaj, A. et al. (2025) ‘Disrupted ACTH and cortisol response to osmotic and non-osmotic stress in patients with arginine vasopressin deficiency’, European Journal of Endocrinology, 193. Available at: https://doi.org/10.1093/ejendo/lvaf119.

Atila, C. et al. (2025) ‘The effect of MDMA on anterior pituitary hormones: a secondary analysis of a randomized placebo-controlled trial’, Endocrine Connections, 14(6). Available at: https://doi.org/10.1530/ec-25-0254.

Atila, Cihan et al. (2025) ‘A novel diagnostic score for diagnosing arginine vasopressin deficiency (central diabetes insipidus) or primary polydipsia with basal laboratory and clinical parameters: results from two international multicentre prospective diagnostic studies’, Lancet Diabetes and Endocrinology, 13, pp. 505–515. Available at: https://doi.org/10.1016/s2213-8587(25)00053-1.

Atila, Cihan et al. (2025) ‘A post-hoc internal validation of arginine-stimulated copeptin cut-offs for diagnosing AVP deficiency (central diabetes insipidus)’, Pituitary, 28(3). Available at: https://doi.org/10.1007/s11102-025-01523-2.

Luger, A. et al. (2025) ‘Response to commentary: Strengthening endocrinology training: Integrating nonclinical competencies, patient, and trainee perspectives for better implementation strategies’, European Journal of Endocrinology, 192(6), pp. L28–L29. Available at: https://doi.org/10.1093/ejendo/lvaf111.

Siebenhüner, A.R. et al. (2025) ‘Impact of multikinase inhibitors in reshaping the treatment of advanced gastroenteropancreatic neuroendocrine tumors’, Endocrine-Related Cancer, 32(6). Available at: https://doi.org/10.1530/erc-25-0052.

Atila, C. et al. (2025) ‘Neurophysin I: a reliable, novel, and robust biomarker for oxytocin’, European Journal of Endocrinology, 192(4), pp. 502–510. Available at: https://doi.org/10.1093/ejendo/lvaf078.

Atila, Cihan et al. (2025) ‘Neurophysin I: a reliable, novel, and robust biomarker for oxytocin’, European Journal of Endocrinology, 192(4), pp. 502–510. Available at: https://doi.org/10.1093/ejendo/lvaf078.

Sven Lustenberger et al. (2025) ‘Urea-stimulated copeptin: a novel diagnostic approach in polyuria polydipsia syndrome’, European Journal of Endocrinology, 192(4), pp. 437–444. Available at: https://doi.org/10.1093/ejendo/lvaf058.

Smit, J.M. et al. (2025) ‘Predicting benefit from adjuvant therapy with corticosteroids in community-acquired pneumonia: a data-driven analysis of randomised trials’, The Lancet Respiratory Medicine, 13(3), pp. 221–233. Available at: https://doi.org/10.1016/s2213-2600(24)00405-3.

Atila, Cihan et al. (2025) ‘Relationship between plasma urea and copeptin in response to arginine stimulation in healthy adults, patients with vasopressin deficiency and primary polydipsia’, Pituitary, 28(1). Available at: https://doi.org/10.1007/s11102-024-01489-7.

Newell-Price, John et al. (2025) ‘Approach to the Patient With Suspected Hypotonic Polyuria’, Journal of Clinical Endocrinology and Metabolism, 110(2), pp. e506–e514. Available at: https://doi.org/10.1210/clinem/dgae565.

Pelouto, A. et al. (2025) ‘Clinical factors associated with hyponatremia correction during treatment with oral urea’, Nephrology Dialysis Transplantation, 40(2), pp. 283–293. Available at: https://doi.org/10.1093/ndt/gfae164.

Perrild, Hans et al. (2025) ‘Postgraduate training and continuous medical education in endocrinology in Europe’, European Journal of Endocrinology, 192(1), pp. C1–C4. Available at: https://doi.org/10.1093/ejendo/lvae169.

Refardt, Julie (2025) ‘Special considerations of hyponatremia in the elderly patient’, Best Practice and Research Clinical Endocrinology and Metabolism [Preprint]. Available at: https://doi.org/10.1016/j.beem.2025.102040.

Varaldo, Emanuele and Potasso, Laura (2025) ‘Hyponatremia and bone pathophysiology: An integrated preclinical and clinical perspective’, Best Practice and Research Clinical Endocrinology and Metabolism [Preprint]. Available at: https://doi.org/10.1016/j.beem.2025.102028.

Huynh, Tony, Signal, Dana and Christ-Crain, Mirjam (2024) ‘Paediatric perspectives in the diagnosis of polyuria-polydipsia syndrome’, Clinical Endocrinology, 101(6), pp. 580–592. Available at: https://doi.org/10.1111/cen.15011.

Karavitaki, Niki et al. (2024) ‘Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement’, Endocrine Reviews, 45(6), pp. 773–794. Available at: https://doi.org/10.1210/endrev/bnae023.

Atila, Cihan et al. (2024) ‘Oxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia A Secondary Analysis of 4 Randomized Clinical Trials’, JAMA network open, 7(11). Available at: https://doi.org/10.1001/jamanetworkopen.2024.45278.

Bizzozero, Chiara Angela et al. (2024) ‘Apelin levels in patients with polyuria-polydipsia syndrome upon copeptin stimulation tests’, European Journal of Endocrinology, 191(5), pp. 491–498. Available at: https://doi.org/10.1093/ejendo/lvae138.

Luger, Anton et al. (2024) ‘European Society of Endocrinology Curriculum and Training Recommendation in Endocrinology’, European Journal of Endocrinology, 191(5), pp. R71–R77. Available at: https://doi.org/10.1093/ejendo/lvae141.

Wälchli-Popovic, Milica et al. (2024) ‘Effects of interleukin-1 receptor antagonism in women with polycystic ovary syndrome—the FertIL trial’, Frontiers in Endocrinology. 11.09.2024, 15. Available at: https://doi.org/10.3389/fendo.2024.1435698.

Agrawal, Nidhi et al. (2024) ‘How to manage Cushing’s disease after failed primary pituitary surgery’, European Journal of Endocrinology, 191(3), pp. R37–R54. Available at: https://doi.org/10.1093/ejendo/lvae110.

Lengsfeld, S. et al. (2024) ‘Effects of the glucagon-like peptide-1 receptor agonist dulaglutide on sexuality in healthy men: a randomised, double-blind, placebo-controlled crossover study’, eBioMedicine, 107. Available at: https://doi.org/10.1016/j.ebiom.2024.105284.

Lamback, E. et al. (2024) ‘Extraventricular Neurocytoma of the Sellar Region Presenting With Syndrome of Inappropriate Antidiuresis’, JCEM Case Reports, 2(9). Available at: https://doi.org/10.1210/jcemcr/luae099.

Atila, Cihan, Refardt, Julie and Christ-Crain, Mirjam (2024) ‘Correction to: Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency (Nature Reviews Endocrinology, (2024), 20, 8, (487-500), 10.1038/s41574-024-00985-x)’, Nature Reviews Endocrinology, 20(8). Available at: https://doi.org/10.1038/s41574-024-00998-6.

Monnerat, Sophie et al. (2024) ‘Apelin and Copeptin Levels in Patients With Chronic SIAD Treated With Empagliflozin’, Journal of the Endocrine Society, 8(7). Available at: https://doi.org/10.1210/jendso/bvae106.

Fleseriu, M. et al. (2024) ‘Hypopituitarism’, The Lancet, 403(10444), pp. 2632–2648. Available at: https://doi.org/10.1016/s0140-6736(24)00342-8.

Ebrahimi, Fahim, Andereggen, Lukas and Christ, Emanuel R. (2024) ‘Morbidities and mortality among hospitalized patients with hypopituitarism: Prevalence, causes and management’, Reviews in Endocrine and Metabolic Disorders. 27.05.2024, 25(3), pp. 599–608. Available at: https://doi.org/10.1007/s11154-024-09888-8.

Kriemler, Lilian et al. (2024) ‘Discordance between LDL-C and apolipoprotein B is associated with large-artery-atherosclerosis ischemic stroke in patients ⩽70 years of age’, European Stroke Journal, 9(2), pp. 494–500. Available at: https://doi.org/10.1177/23969873231221619.

Rasiah, Roshaani et al. (2024) ‘Hospital Outcomes in Medical Patients With Alcohol-Related and Non–Alcohol-Related Wernicke Encephalopathy’, Mayo Clinic Proceedings, 99(5), pp. 740–753. Available at: https://doi.org/10.1016/j.mayocp.2023.07.021.

Schelldorfer, Andreas et al. (2024) ‘Rate of cardiovascular events up to 8 years after uncomplicated myocarditis: a nationwide cohort study’, European Heart Journal: Acute Cardiovascular Care, 13(5), pp. 401–410. Available at: https://doi.org/10.1093/ehjacc/zuae021.

Hofland, Johannes et al. (2024) ‘Approach to the Patient: Insulinoma’, Journal of Clinical Endocrinology and Metabolism, 109(4), pp. 1109–1118. Available at: https://doi.org/10.1210/clinem/dgad641.

Beck, Julia et al. (2024) ‘Impact of sex on treatment decisions and outcome in patients with neuroendocrine neoplasms’, Endocrine-Related Cancer, 31(3). Available at: https://doi.org/10.1530/erc-23-0235.

Lüthi, Hualin et al. (2024) ‘Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trial’, eClinicalMedicine, 68, p. 102429. Available at: https://doi.org/10.1016/j.eclinm.2024.102429.

Refardt, Julie, Vogt, Deborah R. and Christ-Crain, Mirjam (2024) ‘Arginine or Hypertonic Saline-Stimulated Copeptin to Diagnose AVP Deficiency’, New England Journal of Medicine, 390(3), pp. 288–290. Available at: https://doi.org/10.1056/nejmc2314326.

Christ-Crain, Mirjam, Thompson, Christopher J. and Verbalis, Joseph G. (2024) ‘Posterior Pituitary’, in Williams Textbook of Endocrinology 15th Edition. (Williams Textbook of Endocrinology 15th Edition), pp. 296–323.e9. Available at: https://doi.org/10.1016/B978-0-323-93230-1.00008-7.

Efthymiadis, Agathoklis et al. (2024) ‘Copeptin and the syndrome of inappropriate antidiuresis (SIAD) after pituitary transsphenoidal surgery’, Endocrinology, Diabetes and Metabolism, 7(1). Available at: https://doi.org/10.1002/edm2.467.

Radvanyi, Z. et al. (2024) ‘Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation’, Journal of Biological Chemistry, 300(1), p. 105480. Available at: https://doi.org/10.1016/j.jbc.2023.105480.

Sterns RH et al. (2024) ‘Treatment Guidelines for Hyponatremia Stay the Course’, Clinical Journal of the American Society of Nephrology, 19(1), pp. 129–135. Available at: https://doi.org/10.2215/cjn.0000000000000244.

Urwyler, Sandrine A et al. (2024) ‘Efficacy of cabergoline in non-irradiated patients with acromegaly: a multi-centre cohort study’, European Journal of Endocrinology, 190(1), pp. 113–120. Available at: https://doi.org/10.1093/ejendo/lvae003.

Blum, Claudine A. et al. (2023) ‘Adjunct prednisone in community-acquired pneumonia: 180-day outcome of a multicentre, double-blind, randomized, placebo-controlled trial’, BMC Pulmonary Medicine, 23(1). Available at: https://doi.org/10.1186/s12890-023-02794-w.

Hepprich, Matthias, Ebrahimi, Fahim and Christ, Emanuel (2023) ‘Dyslipidaemia and growth hormone deficiency – A comprehensive review’, Best Practice and Research: Clinical Endocrinology and Metabolism, 37(6). Available at: https://doi.org/10.1016/j.beem.2023.101821.

Légeret, Corinne et al. (2023) ‘Prevalence of markers of beta cell autoimmunity and thyroid disease in children with coeliac disease’, BMC Pediatrics, 23(1). Available at: https://doi.org/10.1186/s12887-023-04294-6.

Lengsfeld, Sophia et al. (2023) ‘Glucagon-like peptide-1 analogues: a new way to quit smoking? (SKIP)—a structured summary of a study protocol for a randomized controlled study’, Trials, 24(1). Available at: https://doi.org/10.1186/s13063-023-07164-9.

Sailer CO et al. (2023) ‘Hypothalamic–pituitary–adrenal axis activity in patients with primary polydipsia compared to healthy controls’, Clinical Endocrinology, 99(6), pp. 535–544. Available at: https://doi.org/10.1111/cen.14835.

Borisov, Angel N. et al. (2023) ‘Canagliflozin and Metabolic Associated Fatty Liver Disease in Patients With Diabetes Mellitus: New Insights From CANVAS’, Journal of Clinical Endocrinology and Metabolism, 108(11), pp. 2940–2949. Available at: https://doi.org/10.1210/clinem/dgad249.

Kutz, Alexander et al. (2023) ‘Comparative Cardiovascular Effectiveness and Safety of SGLT-2 Inhibitors, GLP-1 Receptor Agonists, and DPP-4 Inhibitors According to Frailty in Type 2 Diabetes’, Diabetes Care, 46(11), pp. 2004–2014. Available at: https://doi.org/10.2337/dc23-0671.

Monnerat S, Christ-Crain M and Refardt J (2023) ‘One Liter a Day, Keeps the Doctor Away’, Journal of Clinical Endocrinology and Metabolism. Endocrine Society, 108(11). Available at: https://doi.org/10.1210/clinem/dgad217.

Smit, J.M. et al. (2023) ‘Predicting individualized treatment effects of corticosteroids in community-acquired-pneumonia: a data-driven analysis of randomized controlled trials’. Cold Spring Harbor Laboratory. Available at: https://doi.org/10.1101/2023.10.03.23296132.

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Monnerat S et al. (2023) ‘An Increase in Plasma Sodium Levels Is Associated With an Increase in Osteoblast Function in Chronic SIAD’, Journal of Clinical Endocrinology and Metabolism, 108(10), pp. e1027–e1033. Available at: https://doi.org/10.1210/clinem/dgad238.

Warren AM et al. (2023) ‘Syndrome of Inappropriate Antidiuresis: From Pathophysiology to Management’, Endocrine Reviews, 44(5), pp. 819–861. Available at: https://doi.org/10.1210/endrev/bnad010.

Potasso, Laura et al. (2023) ‘Chloride and Potassium Assessment Is a Helpful Tool for Differential Diagnosis of Thiazide-Associated Hyponatremia’, Journal of Clinical Endocrinology and Metabolism, 108(9), pp. 2248–2254. Available at: https://doi.org/10.1210/clinem/dgad133.

Arima H et al. (2023) ‘Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group to Consider Renaming Diabetes Insipidus’, Hormone Research in Paediatrics, 96(4), pp. 423–425. Available at: https://doi.org/10.1159/000527139.

Radvanyi, Z. et al. (2023) ‘Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation’. Cold Spring Harbor Laboratory. Available at: https://doi.org/10.1101/2023.06.23.546282.

Urwyler, Sandrine A. and Karavitaki, Niki (2023) ‘Refractory lactotroph adenomas’, Pituitary, 26(3), pp. 273–277. Available at: https://doi.org/10.1007/s11102-023-01305-8.

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Ebrahimi F and Christ E (2023) ‘Why do patients with hypopituitarism still present an increased mortality?’, Annales d’Endocrinologie, 84(2), pp. 285–290. Available at: https://doi.org/10.1016/j.ando.2023.02.002.

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Lengsfeld, Sophia et al. (2023) ‘Effect of dulaglutide in promoting abstinence during smoking cessation: a single-centre, randomized, double-blind, placebo-controlled, parallel group trial’, eClinicalMedicine, 57. Available at: https://doi.org/10.1016/j.eclinm.2023.101865.

Lengsfeld, Sophia et al. (2023) ‘Effect of dulaglutide in promoting abstinence during smoking cessation: a single-centre, randomized, double-blind, placebo-controlled, parallel group trial’, eClinicalMedicine, 57, p. 101865. Available at: https://doi.org/10.1016/j.eclinm.2023.101865.

Pelouto A et al. (2023) ‘Overcorrection and undercorrection with fixed dosing of bolus hypertonic saline for symptomatic hyponatremia’, European Journal of Endocrinology, 188(3), pp. 322–330. Available at: https://doi.org/10.1093/ejendo/lvad028.

Sailer CO et al. (2023) ‘Copeptin improves prediction of treatment response in children with monosymptomatic nocturnal enuresis’, European Journal of Endocrinology, 188(3), pp. 266–272. Available at: https://doi.org/10.1093/ejendo/lvad022.

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Refardt J et al. (2023) ‘Treatment Effect of the SGLT2 Inhibitor Empagliflozin on Chronic Syndrome of Inappropriate Antidiuresis: Results of a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial’, Journal of the American Society of Nephrology, 34(2), pp. 322–332. Available at: https://doi.org/10.1681/asn.2022050623.

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Arima H et al. (2023) ‘Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group for Renaming Diabetes Insipidus’, Journal of Clinical Endocrinology and Metabolism, 108(1), pp. 1–3. Available at: https://doi.org/10.1210/clinem/dgac547.

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