[FG] Siegemund Martin

Research Focus

Critical Care & Respiratory Medicine

Area of Research

Sepsis, with a focus on acute therapy of severe sepsis and septic and hemorrhagic shock, specifically the influence of crystalloid and colloidal fluids and blood products on course and outcome in ICU patients

Approved Research Projects

Delirium(recruitment ended or study published):

• BADEN Prevention and Reduction of Incidence of Postoperative Delirium Trial (PRIDE): a phase IV multicenter, randomized, placebo-controlled, double-blind clinical trial of ketamine versus haloperidol for prevention of postoperative delirium. PMID: 33120302 and PMID: 29482596
• Dexmedetomidine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis: PMID: 30238227
• Reviews: PMID: 26456271, PMID: 31263968
• Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial: PMID: 28710219

Nutrition / GIT

• The Basel Enteral High Protein Study (BEntHiPro): NCT02678325
• Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU (SUP-ICU): DOI: 10.1056 / NEJMoa1714919

Volume resuscitation / Sepsis (recruitment ended or study published):

• Impact of amount of fluid for circulatory resuscitation on renal function in patients in shock: evaluating the influence of intra-abdominal pressure, renal resistive index, sublingual microcirculation and total body water measured by bio-impedance analysis on hemodynamic parameters for guidance of volume resuscitation in shock therapy: a protocol for the VoluKid pilot study – an observational clinical trial: rrtjournal.biomedcentral.com/articles/10.1186/s41100-018-0156-9
• Impact of Fluid Resuscitation Protocol on the Incidence of Reoperation for Bleeding After Emergency Cardiopulmonary Bypass Grafting (Volu-CABG): NCT04533698
• Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (CLASSIC): NCT02079402

Oxygen Therapy

Past studies:

• Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure (HOT-ICU): DOI: 10.1056 / NEJMoa2032510

Ongoing Research Projects

Oxygen Therapy

Ongoing studies:

• Handling Oxygenation Targets in COVID-10 (HOT-COVID): NCT04425031

Atrial Fibrillation

Ongoing studies:

• Non-invasive Evaluation of New-onset Atrial Fibrillation After Cardiac Surgery The Basel CardioInsightTM - 3D Mapping (BigMap) Study: NCT04964765

Delirium

Ongoing studies:

• Circadian Melatonin Rhythms in Critically Ill Patients With Delirium: NCT04721613
• Study protocol for a prospective randomized double-blind placebo-controlled clinical trial investigating a Bett Outcome with Melatonin compared to Placebo Administered to normalize sleep-wake cycle and treat hypoactive ICU Delirium: The Basel BOMP-AID study: PMID: 32354780

Nutrition / GIT

Ongoing studies:

• Protein delivery in intermittent and continuous enteral nutrition with a protein-rich formula in critically ill patients – a protocol for the prospective randomized controlled proof-of-concept Protein Bolus Nutrition (Pro BoNo) study: PMID: 32843075

Volume resuscitation / Sepsis

Ongoing studies:

01/11/22 4

• Prospective Study to Discover New Biomarkers for Early Detection of Sepsis and Prediction of Sepsis-related Mortality in Patients With Severe Community Acquired Pneumonia (sCAP OMICS Study): NCT04280354
• NCCR AntiResist: Mono-center Study to Identify New Approaches to Combat Antibiotic-resistant Bacteria. NCT05017766

Coagulation / Blood Transfusion

Planned studies:

• Basel Bedside Assessment of Microcirculatory Transfusion Levels II: Microcirculation dependent Red Blood Cell Transfusion Thresholds: A prospective, randomized-controlled, single-centre interventional study (BaMiTral II)

Ongoing studies:

• Enhancement of the Haemostatic Effect of Platelets in the Presence of High Normal Concentrations of Van Willebrand Factor (The Basel Will-Plate Study): NCT04555785