Regulatory Toxicology (Wilks)

Duthaler, U. et al. (2024) ‘Effect of protein binding on the pharmacokinetics of the six substrates in the Basel phenotyping cocktail in healthy subjects and patients with liver cirrhosis’, European Journal of Pharmaceutical Sciences, 202, p. 106885. Available at: https://doi.org/10.1016/j.ejps.2024.106885.

Wälchli-Popovic, Milica et al. (2024) ‘Effects of interleukin-1 receptor antagonism in women with polycystic ovary syndrome—the FertIL trial’, Frontiers in Endocrinology. 11.09.2024, 15. Available at: https://doi.org/10.3389/fendo.2024.1435698.

Verouti, S. et al. (2024) ‘Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity’, Pflügers Archiv - European Journal of Physiology [Preprint]. Available at: https://doi.org/10.1007/s00424-024-03014-y.

Gómez, C. et al. (2024) ‘Identification of a human blood biomarker of pharmacological 11β-hydroxysteroid dehydrogenase 1 inhibition’, British Journal of Pharmacology, 181(5), pp. 698–711. Available at: https://doi.org/10.1111/bph.16251.

Abegg, Vanessa Fabienne et al. (2024) ‘Mechanisms of hepatocellular toxicity associated with the components of St. John’s Wort extract hypericin and hyperforin in HepG2 and HepaRG cells’, Toxicology Letters, 393, pp. 1–13. Available at: https://doi.org/10.1016/j.toxlet.2024.01.008.

Bircher, Andreas J. et al. (2024) ‘Skin Prick Test as a Provocation Test – Severe Anaphylactic Reaction to Skin Tests with Ceftriaxone in Two Occupationally Exposed Workers’, Laryngo- Rhino- Otologie, 103, pp. 128–132. Available at: https://doi.org/10.1055/a-2109-3463.

Thomas, P. et al. (2024) ‘A literature review and expert consensus statement on diagnostics in suspected metal implant allergy’, Journal of the European Academy of Dermatology and Venereology [Preprint]. Available at: https://doi.org/10.1111/jdv.20026.

Kolesnyk, Serhii et al. (2023) ‘A battery of in silico models application for pesticides exerting reproductive health effects: Assessment of performance and prioritization of mechanistic studies’, Toxicology in Vitro, 93, p. 105706. Available at: https://doi.org/10.1016/j.tiv.2023.105706.

Jäger, Marie-Christin et al. (2023) ‘Virtual screening and biological evaluation to identify pharmaceuticals potentially causing hypertension and hypokalemia by inhibiting steroid 11β-hydroxylase’, Toxicology and Applied Pharmacology, 475, p. 116638. Available at: https://doi.org/10.1016/j.taap.2023.116638.

Kędzierski, Jacek et al. (2023) ‘Assessment of the inhibitory potential of anabolic steroids towards human AKR1D1 by computational methods and in vitro evaluation’, Toxicology Letters, 384, pp. 1–13. Available at: https://doi.org/10.1016/j.toxlet.2023.07.006.

Krähenbühl, L. and Krähenbühl, S. (2023) ‘Rats with Long-Term Cholestasis Have a Decreased Cytosolic but Maintained Mitochondrial Hepatic CoA Pool’, International Journal of Molecular Sciences, 24(5). Available at: https://doi.org/10.3390/ijms24054365.

Berber, M. et al. (2023) ‘Calcineurin regulates aldosterone production via dephosphorylation of NFATC4’, JCI Insight, 8(14). Available at: https://doi.org/10.1172/jci.insight.157027.

Jäger, M.-C. et al. (2023) ‘Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays’, Current Research in Toxicology, 5. Available at: https://doi.org/10.1016/j.crtox.2023.100119.

Schreier, V.N., Odermatt, A. and Welle, F. (2023) ‘Migration Modeling as a Valuable Tool for Exposure Assessment and Risk Characterization of Polyethylene Terephthalate Oligomers’, Molecules, 28(1). Available at: https://doi.org/10.3390/molecules28010173.

Duthaler, Urs et al. (2022) ‘Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently’, Clinical Pharmacokinetics, 61, pp. 1039–1055. Available at: https://doi.org/10.1007/s40262-022-01119-0.

Morris, D.J., Brem, A.S. and Odermatt, A. (2021) ‘Modulation of 11β-hydroxysteroid dehydrogenase functions by the cloud of endogenous metabolites in a local microenvironment: The glycyrrhetinic acid-like factor (GALF) hypothesis’, Journal of Steroid Biochemistry and Molecular Biology, 214. Available at: https://doi.org/10.1016/j.jsbmb.2021.105988.

Weingartner, M. et al. (2021) ‘Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice’. Cold Spring Harbor Laboratory. Available at: https://doi.org/10.1101/2021.02.03.429530.

EFSA Panel on Plant Protection Products and their Residues (EFSA PPR Panel) et al. (2021) ‘Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on testing and interpretation of comparative; in vitro; metabolism studies.’, EFSA journal. European Food Safety Authority, 19(12), p. e06970. Available at: https://doi.org/10.2903/j.efsa.2021.6970.

Firman, James W et al. (2021) ‘Exploring the Potential of ToxCast Data in Supporting Read-Across for Evaluation of Food Chemical Safety.’, Chemical research in toxicology, 34(2), pp. 300–312. Available at: https://doi.org/10.1021/acs.chemrestox.0c00240.

Olesti, Eulalia et al. (2021) ‘Approaches in metabolomics for regulatory toxicology applications’, The Analyst, 146(6), pp. 1820–1834. Available at: https://doi.org/10.1039/d0an02212h.

Mayr, F. et al. (2020) ‘Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction’. MDPI AG. Available at: https://doi.org/10.20944/preprints202007.0495.v1.

Odermatt, A., Nguyen, M.-V. and Thompson, G.R. (2020) ‘Reply to DiPippo and Kontoyiannis’, Clinical Infectious Diseases, 71(2). Available at: https://doi.org/10.1093/cid/ciz945.

FitzGerald, Rex E. (2020) ‘Adverse Outcome Pathway Bridge Building from Research to Regulation’, Chemical research in toxicology, 33(4), pp. 849–851. Available at: https://doi.org/10.1021/acs.chemrestox.9b00527.

FitzGerald, Rex E. (2020) ‘Perspective on Health Effects of Endocrine Disruptors with a Focus on Data Gaps’, Chemical research in toxicology, 33(6), pp. 1284–1291. Available at: https://doi.org/10.1021/acs.chemrestox.9b00529.

Punt, Ans et al. (2020) ‘Potential of ToxCast Data in the Safety Assessment of Food Chemicals.’, Toxicological sciences : an official journal of the Society of Toxicology, 174(2), pp. 326–340. Available at: https://doi.org/10.1093/toxsci/kfaa008.

Roth, Nicolas, Sandström, Jenny and Wilks, Martin F (2020) ‘A case study applying pathway-oriented thinking to problem formulation for planning a systematic review.’, Environment international, 140, p. 105768. Available at: https://doi.org/10.1016/j.envint.2020.105768.

Wilks, Martin F (2020) ‘Bringing Chemistry to Medicine - The Contribution of Paracelsus to Modern Toxicology.’, Chimia, 74(6), pp. 507–508. Available at: https://doi.org/10.2533/chimia.2020.507.

Aicher, Lothar and Wilks, Martin F. (2020) ‘From risk assessment to regulation’, in Colosio, Claudio; Tsatsakis, Aristidis M.; Mandić-Rajćević, Stefan; Alegakis, Athanasios (ed.) Exposure and Risk Assessment of Pesticide Use in Agriculture - Approaches, Tools and Advances. London: Academic Press (Exposure and Risk Assessment of Pesticide Use in Agriculture - Approaches, Tools and Advances), pp. 3–23. Available at: https://doi.org/10.1016/b978-0-12-812466-6.00012-9.

Grill, M., Patt, M. and Odermatt, A. (2019) ‘Novel Protective Group Synthesis of Androgen Receptor Modulators with Steroidal and Nonsteroidal Scaffolds’. American Chemical Society (ACS). Available at: https://doi.org/10.26434/chemrxiv.11346962.v1.

Bal-Price, Anna et al. (2019) ‘Corrigendum to Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity’, ALTEX, 36(3), p. 506. Available at: https://doi.org/10.14573/altex.1904112.

Beilmann, Mario et al. (2019) ‘Optimizing drug discovery by Investigative Toxicology: Current and future trends’, ALTEX, 36(2), pp. 289–313. Available at: https://doi.org/10.14573/altex.1808181.

Sanvido, Olivier et al. (2019) ‘Authors” response to the letter to the editor by Jowsey et al’, Regulatory toxicology and pharmacology : RTP, 103, pp. 330–331. Available at: https://doi.org/10.1016/j.yrtph.2019.01.008.

Sych, Janice et al. (2019) ‘Intake of Processed Meat and Association with Sociodemographic and Lifestyle Factors in a Representative Sample of the Swiss Population’, Nutrients, 11(11), p. 2556. Available at: https://doi.org/10.3390/nu11112556.

Bal-Price, Anna et al. (2018) ‘International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes’, Archives of Toxicology, 89(2), pp. 269–87. Available at: https://doi.org/10.1007/s00204-015-1464-2.

Bal-Price, Anna et al. (2018) ‘Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity’, ALTEX, 35(3), pp. 306–352. Available at: https://doi.org/10.14573/altex.1712081.

Fritsche, Ellen et al. (2018) ‘Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes’, Toxicology and applied pharmacology, 354, pp. 3–6. Available at: https://doi.org/10.1016/j.taap.2018.02.004.

Gawarammana, Indika et al. (2018) ‘High-dose immunosuppression to prevent death after paraquat self-poisoning - a randomised controlled trial’, Clinical toxicology, 56(7), pp. 633–639. Available at: https://doi.org/10.1080/15563650.2017.1394465.

Mech, A. et al. (2018) ‘Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation’, Nanotoxicology, 13(1), pp. 119–141. Available at: https://doi.org/10.1080/17435390.2018.1513092.

Sanvido, Olivier et al. (2018) ‘A quantitative risk assessment for skin sensitizing plant protection products: Linking derived No-Effect levels (DNELs) with agricultural exposure models’, Regulatory toxicology and pharmacology, 98, pp. 171–183. Available at: https://doi.org/10.1016/j.yrtph.2018.07.022.

Frey, Noel et al. (2017) ‘The Epidemiology of Stevnes-Johnson Syndrome and Toxic Epidermal Necrolysis in the UK’, Journal of Investigative Dermatology, 137, pp. 1240–1247. Available at: https://doi.org/10.1016/j.jid.2017.01.031.

Fritsche, Ellen et al. (2017) ‘OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes’, ALTEX, 34(2), pp. 311–315. Available at: https://doi.org/10.14573/altex.1701171.

Hartung, Thomas et al. (2017) ‘Systems Toxicology: Real World Applications and Opportunities’, Chemical research in toxicology, 30(4), pp. 870–882. Available at: https://doi.org/10.1021/acs.chemrestox.7b00003.

Mamoulakis, Charalampos et al. (2017) ‘Contrast-induced nephropathy: Basic concepts, pathophysiological implications and prevention strategies’, Pharmacology & therapeutics, 180, pp. 99–112. Available at: https://doi.org/10.1016/j.pharmthera.2017.06.009.

Aghagolzadeh, P. et al. (2016) ‘Calcification of vascular smooth muscle cells is induced by secondary calciprotein particles and enhanced by tumor necrosis factor-α’, Atherosclerosis, 251, pp. 404–414. Available at: https://doi.org/10.1016/j.atherosclerosis.2016.05.044.

Chapman, K.E. and Odermatt, A. (2010) ‘Steroids: Modulators of inflammation and immunity’, Journal of Steroid Biochemistry and Molecular Biology, 120(2-3), pp. 67–68. Available at: https://doi.org/10.1016/j.jsbmb.2010.04.022.

Bruggisser, Marcel et al. (2010) ‘Retrospective analysis of stimulant abuse cases reported to the Swiss Toxicological Information Centre during 1997-2009’, Swiss medical weekly, 140, p. w13115. Available at: https://doi.org/10.4414/smw.2010.13115.

Aubry, E.M. and Odermatt, A. (2009) ‘Retinoic acid reduces glucocorticoid sensitivity in C2C12 myotubes by decreasing 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor activities’, Endocrinology, 150(6), pp. 2700–2708. Available at: https://doi.org/10.1210/en.2008-1618.

Atanasov, A.G. and Odermatt, A. (2007) ‘Readjusting the glucocorticoid balance: An opportunity for modulators of 11β-hydroxysteroid dehydrogenase type 1 activity?’, Endocrine, Metabolic and Immune Disorders - Drug Targets, 7(2), pp. 125–140. Available at: https://doi.org/10.2174/187153007780832082.