Neuropharmacology (Simmler)

Petrelli, Francesco et al. (2023) ‘Disruption of Astrocyte-Dependent Dopamine Control in the Developing Medial Prefrontal Cortex Leads to Excessive Grooming in Mice’, Biological Psychiatry, 93(11), pp. 966–975. Available at: https://doi.org/10.1016/j.biopsych.2022.11.018.

Simmler, Linda D et al. (2022) ‘Dual action of ketamine confines addiction liability’, Nature, 608(7922), pp. 368–373. Available at: https://doi.org/10.1038/s41586-022-04993-7.

Davis, Gwynne L et al. (2021) ‘Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice’, Nature Communications, 12(1), p. 6040. Available at: https://doi.org/10.1038/s41467-021-26247-2.

Li, Yue et al. (2021) ‘Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction’, Science, 373(6560), pp. 1252–1256. Available at: https://doi.org/10.1126/science.abi9086.

Hadjas, Lotfi C et al. (2020) ‘Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice’, Neuropsychopharmacology, 45(12), pp. 2020–2029. Available at: https://doi.org/10.1038/s41386-020-0747-3.

Hadjas, Lotfi C, Lüscher, Christian and Simmler, Linda D (2019) ‘Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder.’, Scientific reports, 9(1), p. 12061. Available at: https://doi.org/10.1038/s41598-019-48637-9.

Simmler, Linda D and Blakely, Randy D (2019) ‘The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action.’, ACS chemical neuroscience, 10(7), pp. 3053–3060. Available at: https://doi.org/10.1021/acschemneuro.9b00005.

Simmler, Linda D and Ozawa, Takaaki (2019) ‘Neural circuits in goal-directed and habitual behavior: Implications for circuit dysfunction in obsessive-compulsive disorder.’, Neurochemistry international, 129, p. 104464. Available at: https://doi.org/10.1016/j.neuint.2019.104464.

Simmler, Linda D. and Liechti, Matthias E. (2018) ‘Pharmacology of MDMA- and Amphetamine-Like New Psychoactive Substances’, Handbook of experimental pharmacology, 252, pp. 143–164. Available at: https://doi.org/10.1007/164_2018_113.

Nackenoff, Alex G et al. (2017) ‘Serotonin Transporter-Independent Actions of the Antidepressant Vortioxetine As Revealed Using the SERT Met172 Mouse.’, ACS chemical neuroscience, 8(5), pp. 1092–1100. Available at: https://doi.org/10.1021/acschemneuro.7b00038.

Simmler, Linda D. and Liechti, Matthias E. (2017) ‘Interactions of Cathinone NPS with Human Transporters and Receptors in Transfected Cells’, Current Topics in Behavioral Neurosciences, 32, pp. 49–72. Available at: https://doi.org/10.1007/7854_2016_20.

Simmler, Linda D. et al. (2016) ‘In vitro characterization of psychoactive substances at rat, mouse, and human trace amine-associated receptor 1’, The Journal of Pharmacology and Experimental Therapeutics, 357(1), pp. 134–44. Available at: https://doi.org/10.1124/jpet.115.229765.

Hysek, C. M. et al. (2014) ‘MDMA enhances emotional empathy and prosocial behavior’, Social cognitive and affective neuroscience, 9(11), pp. 1645–52. Available at: https://doi.org/10.1093/scan/nst161.

Schmid, Yasmin et al. (2014) ‘Differential effects of MDMA and methylphenidate on social cognition’, Journal of psychopharmacology, 28(9), pp. 847–56. Available at: https://doi.org/10.1177/0269881114542454.

Simmler, L. D. et al. (2014) ‘Monoamine transporter and receptor interaction profiles of a new series of designer cathinones’, Neuropharmacology, 79, pp. 152–60. Available at: https://doi.org/10.1016/j.neuropharm.2013.11.008.

Simmler, Linda D. et al. (2014) ‘Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives’, Biochemical Pharmacology, 88(2), pp. 237–44. Available at: https://doi.org/10.1016/j.bcp.2014.01.024.

Vollbrecht, Peter J et al. (2014) ‘Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1.’, Journal of neurochemistry, 130(1), pp. 109–14. Available at: https://doi.org/10.1111/jnc.12697.

Hysek, C. M. et al. (2013) ‘a-Adrenergic receptors contribute to the acute effects of MDMA in humans’, Journal of clinical psychopharmacology, Vol. 33, H. 5, pp. 658–666. Available at: https://doi.org/10.1097/jcp.0b013e3182979d32.

Simmler, Linda D, Wandeler, Rebecca and Liechti, Matthias E (2013) ‘Bupropion, methylphenidate, and 3,4-methylenedioxypyrovalerone antagonize methamphetamine-induced efflux of dopamine according to their potencies as dopamine uptake inhibitors: implications for the treatment of methamphetamine dependence.’, BMC research notes, 6, p. 220. Available at: https://doi.org/10.1186/1756-0500-6-220.

Hysek, C. M. et al. (2012) ‘Effects of the α₂-adrenergic agonist clonidine on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine in healthy volunteers’, Journal of pharmacology and experimental therapeutics, Vol. 340, H. 2, pp. 286–294. Available at: https://doi.org/10.1124/jpet.111.188425.

Hysek, C. M. et al. (2012) ‘Duloxetine inhibits effects of MDMA (‘ecstasy’) in vitro and in humans in a randomized placebo-controlled laboratory study’, PLoS ONE, 7(5). Available at: https://doi.org/10.1371/journal.pone.0036476.

Hysek, C. et al. (2012) ‘Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans’, British journal of pharmacology, 166(8), pp. 2277–88. Available at: https://doi.org/10.1111/j.1476-5381.2012.01936.x.

Simmler, L. D. et al. (2012) ‘Pharmacological characterization of designer cathinones in vitro’, British journal of pharmacology, 168(2), pp. 458–70. Available at: https://doi.org/10.1111/j.1476-5381.2012.02145.x.

Hysek, C. M. et al. (2011) ‘The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA (‘Ecstasy’) in Humans’, Clinical pharmacology and therapeutics, 90(2), pp. 246–255. Available at: https://doi.org/10.1038/clpt.2011.78.

Simmler, L. D., Hysek, C. M. and Liechti, M. E. (2011) ‘Sex differences in the effects of MDMA (ecstasy) on plasma copeptin in healthy subjects’, Journal of clinical endocrinology and metabolism, 96(9), pp. 2844–50. Available at: https://doi.org/10.1210/jc.2011-1143.

Vejnovic, Ivana, Simmler, Linda and Betz, Gabriele (2010) ‘Investigation of different formulations for drug delivery through the nail plate.’, International journal of pharmaceutics, 386(1-2), pp. 185–94. Available at: https://doi.org/10.1016/j.ijpharm.2009.11.019.